Journal of Ultrasound in Medicine最新文献

{"title":"Role of Multiparametric Ultrasound in Determining the Presence of Tumor-Infiltrating Lymphocytes in Invasive Breast Cancer Insights From B-Mode, SWE, and SMI Modalities: Insights From B-Mode, SWE, and SMI Modalities.","authors":"Yasemin Kayadibi, Gul Esen, Seda Aladag Kurt, Ceyda Sönmez Wetherilt, Tulin Ozturk, Yasemin Nur Icten, Fusun Taskin","doi":"10.1002/jum.70022","DOIUrl":"https://doi.org/10.1002/jum.70022","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between tumor-infiltrating lymphocyte (TIL) levels and multiparametric ultrasonography (US) findings combining B-mode US, shear wave elastography (SWE), and superb microvascular imaging (SMI) in patients with invasive breast cancer, and to explore the potential of sonographic imaging modalities in predicting the tumor immune microenvironment.</p><p><strong>Methods: </strong>This retrospective study included 148 patients diagnosed with invasive breast carcinoma between September 2021 and December 2024. Patient age, medical history, and immunohistopathological characteristics (grade, hormone positivity, Ki-67 ratio, subtype) of the lesions were recorded. TIL levels were assessed on hematoxylin-eosin (H&E) stained slides by pathologists following the International TILs Working Group guidelines, and lesions were categorized by different TIL levels (presence/absence, ≥10%, ≥20%, ≥30%). US evaluations were performed using a Toshiba Aplio A system (Canon, Tokyo, Japan) with a 12-16 MHz breast probe. Imaging assessments included B-mode ultrasound (morphology, echogenic halo sign), SWE (E-mean, E-ratio, stiff rim sign), and SMI (Adler classification, SMI vascular index). Associations between TIL levels and imaging parameters were analyzed using Chi-square tests for categorical and Student's t-tests for continuous variables (SWE and SMI).</p><p><strong>Results: </strong>TIL was detected in 121 of 148 lesions (81.8%). TIL value was >10% in 33 lesions, >20% in 12, and >30% in 8 lesions. On B-mode US, round/oval tumor shape (p = .003 at level of TIL > 20%, p = .001 at level of TIL > 30%) and non-parallel orientation (p = .023) were more prevalent in TIL positive lesions. On SWE, tumors with TIL levels ≥10% were significantly associated with higher E-mean values (130 ± 24.7 vs. 107.9 ± 36, p = .001) and the presence of a stiff rim sign (p < .001). Penetrating vascular structures were more commonly observed on SMI in lesions with TIL ≥ 10% (p = .023), along with a higher mean vascular index (p = .036). No significant difference was found in other US-SWE and SMI findings (all p > .4).</p><p><strong>Conclusion: </strong>Our findings suggest that US features, particularly vascularity on SMI and stiffness on SWE, may reflect TIL presence in breast cancer. However, methodological variations and differing TIL levels across studies may influence inconsistent associations, especially with SWE. Further comprehensive studies are needed to clarify this relationship.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIUM Official Statement: Guidelines for Cleaning and Preparing External- and Internal-Use Ultrasound Transducers and Equipment Between Patients as Well as Safe Handling and Use of Ultrasound Coupling Gel, 2025 Revision.","authors":"","doi":"10.1002/jum.70014","DOIUrl":"https://doi.org/10.1002/jum.70014","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrasheath Tendon Subluxation Beyond the Ankle: The First Case Series in the Hand.","authors":"Hannah Lamberg, Molly N Pantelic, Erika Mojica, Heidi Ehrich, Dana Rowland, Shannon Wood, Gunjan Malhotra, Steven B Soliman","doi":"10.1002/jum.70020","DOIUrl":"https://doi.org/10.1002/jum.70020","url":null,"abstract":"<p><p>Peroneal tendon intrasheath subluxation is a well-established phenomenon in musculoskeletal ultrasound. However, until now, intrasheath tendon subluxation has not been described in the hand. This unique case series presents the first three reported cases of intrasheath tendon subluxation in the hand. We discuss the anatomy of the flexor and extensor tendons, highlight dynamic sonographic findings, and propose possible mechanisms for this entity. Outside of the ankle, intrasheath subluxation is an uncommon finding, infrequently considered, and easily overlooked, particularly without the use of dynamic ultrasound. Knowledge of this entity and its sonographic features is crucial for its accurate diagnosis.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Lobe Development in Fetuses With Congenital Heart Disease and Its Relation to Expected Brain Arterial Oxygen Saturation.","authors":"Xiaowei Xiong, Chenxiao Hou, Jingjing Wang, Wenjia Lei, Xiangli Meng, Na Zhang, Qingqing Wu","doi":"10.1002/jum.70012","DOIUrl":"https://doi.org/10.1002/jum.70012","url":null,"abstract":"<p><strong>Objectives: </strong>To compare fetal head growth and assess differences in fetal frontal lobe development between fetuses with congenital heart disease (CHD) and normal fetuses. To investigate the association between in utero fetal frontal lobe growth and the expected level of cerebral arterial oxygen saturation (SaO₂).</p><p><strong>Methods: </strong>This was a retrospective study, including 634 fetuses diagnosed with CHD and 677 normal fetuses. All these fetuses underwent fetal ultrasound scans after the 19th gestational week from January 2018 to June 2024. Fetuses with CHD were categorized into 3 groups based on the expected level of cerebral arterial SaO₂: normal, mildly to moderately reduced, and severely reduced. CHD cases were also categorized into isolated CHD and non-isolated CHD, as well as classified based on anatomical subtypes. To assess frontal lobe growth and brain development across gestational ages, we measured biparietal diameter (BPD), head circumference (HC), frontal lobe anteroposterior diameter (FAPD), and occipitofrontal diameter (OFD), and then calculated the FAPD/OFD ratio. The BPD, HC, FAPD, and FAPD/OFD ratio were then compared between the CHD subtypes and the normal group.</p><p><strong>Results: </strong>In total, 1196 individual ultrasound scans from 634 CHD fetuses and 3538 from 677 controls after the 19th gestationalweek were available for measurement, respectively. Fetuses with CHD were found to have a slightly smaller BPD, HC, and FAPD than normal fetuses, and the reductions decreased with the advancing gestational age. For the FAPD/OFD ratio, the value showed a consistent lower trend in the CHD group than in the control group, independent of gestational age and HC, with a progressive reduction as cerebral arterial SaO₂ worsened in the CHD group (P < .001). Isolated and non-isolated CHD subgroups did not show any significant difference in the FAPD/OFD ratio (P = .480).</p><p><strong>Conclusion: </strong>Fetuses with CHD exhibit impaired frontal regional growth, which may be associated with hypoxia. The cardiac-induced hemodynamic changes may play a critical role in influencing neurodevelopment, particularly affecting frontal lobe growth. The FAPD/OFD ratio could be a simple and reliable tool to evaluate the development of the frontal lobe.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second Trimester LGA as a Predictor of Adverse Perinatal Outcomes: Does Timing of Fetal Overgrowth Matters?","authors":"Dilara Duygulu Bulan, Zeynep Seyhanli, Ruken Dayanan, Merve Ayas Ozkan, Muradiye Yildirim, Ali Turhan Caglar","doi":"10.1002/jum.70013","DOIUrl":"https://doi.org/10.1002/jum.70013","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the association of large for gestational age (LGA) fetuses diagnosed ultrasonographically in the second trimester with adverse perinatal outcomes and to determine the impact of the timing of fetal overgrowth on neonatal outcomes. Accordingly, we investigated whether pregnancies with LGA diagnosed in the second trimester differed in terms of perinatal complications compared to those diagnosed in the third trimester.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted with pregnant women who presented to the Perinatology Department of Ankara Etlik City Hospital and gave birth to macrosomic fetuses. Patients were grouped as those who were not diagnosed with LGA antenatally and those who were diagnosed with LGA on ultrasound examination in the second and third trimesters.</p><p><strong>Results: </strong>The pregnant women diagnosed with LGA in the second trimester had a higher mean age compared to the AGA group, and the LGA group showed the highest mean age in the third trimester (P = .010). The rate of newborns with APGAR score <7 at 1 minute was significantly higher in the second trimester LGA group compared to the AGA group (P = .029).</p><p><strong>Conclusion: </strong>This study found that LGA cases diagnosed in the second trimester were associated with significantly higher rates of adverse perinatal outcomes compared to those diagnosed in the third trimester. The findings suggest that the timing of fetal growth may be a determinant not only for birth weight but also for neonatal morbidity.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-CT Symbiosis in Pediatric Lung Abscess Volume Tracking.","authors":"Guangfei Sun, Yuyan Zhang, Chengqiang Jin, Yanxia Jia","doi":"10.1002/jum.70015","DOIUrl":"https://doi.org/10.1002/jum.70015","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superb Microvascular Imaging and Angiogenesis Markers in IDC: Further Considerations.","authors":"Schawanya Kaewpitoon Rattanapitoon, Nav La, Nathkapach Kaewpitoon Rattanapitoon","doi":"10.1002/jum.70016","DOIUrl":"https://doi.org/10.1002/jum.70016","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Resolution Ultrasound of Clinically Relevant Sensory Nerves of the Arm and the Forearm.","authors":"Federico Zaottini, Riccardo Picasso, Federico Pistoia, Marta Macciò, Giovanni Marcenaro, Maribel Miguel, Ombretta Spingardi, Ellert Jan Barendrecht, Girish Gandikota, Carlo Martinoli","doi":"10.1002/jum.70010","DOIUrl":"https://doi.org/10.1002/jum.70010","url":null,"abstract":"<p><p>Technological advancements in ultrasound systems, particularly the development of high- and ultra-high-frequency transducers, now allow for the detailed evaluation of sub-millimetric sensory nerves in the upper limb, extending to their distal branches. This provides invaluable insights in patients with suspected neuropathies. This review aims to outline the scanning techniques and normal ultrasound appearance of cutaneous nerves of the upper limbs, including the medial cutaneous nerve of the arm, medial cutaneous nerve of the forearm, lateral cutaneous nerve of the forearm, and posterior cutaneous nerve of the forearm. Furthermore, several cases of nerve pathologies where ultrasound has played a crucial role in accurate diagnosis and therapeutic management are presented.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample Size of Trials Investigating the Impact of Point-of-Care Ultrasound-Guided Strategies on Patient Outcomes: A Systematic Review.","authors":"William Beaubien-Souligny, Michel Gouin, Karel Huard","doi":"10.1002/jum.70001","DOIUrl":"https://doi.org/10.1002/jum.70001","url":null,"abstract":"<p><p>Point-of-care ultrasound (POCUS) is increasingly utilized for bedside diagnosis and management in diverse clinical contexts. However, the design of randomized controlled trials (RCTs) evaluating the impact of POCUS-guided strategies on clinical outcomes presents significant challenges. This study aims to explore the assumptions underlying sample size estimation in POCUS-guided trials and assess the adequacy of sample sizes in published trials through a systematic review. We performed a sample size analysis considering varying rates of POCUS-induced management changes and plausible effect sizes on binary and continuous patient-centered outcomes. Additionally, a systematic review of PubMed was conducted to identify RCTs comparing POCUS-guided management to usual care, extracting data on planned and actual sample sizes and justifications for sample size decisions. Sample size estimations revealed a substantial dependence on the proportion of participants experiencing management changes due to POCUS findings. For example, achieving adequate power in a trial with a moderate effect size requires over 1000 participants if POCUS alters management in 50% of cases. Our review included 25 RCTs, with a median sample size of 206 participants (interquartile range 122-250). Only 68% of trials reported sample size justifications, and 41% failed to meet planned recruitment targets, primarily due to recruitment challenges and other logistical barriers. Most trials investigating POCUS-guided strategies are underpowered, underscoring the need for realistic sample size estimations that consider the rate of POCUS-induced management changes and anticipated effect sizes. Future trials should incorporate pilot phases and innovative designs to optimize feasibility and power.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Wave Elastography and Magnetic Resonance Imaging in Predicting Breast Cancer Response to Neoadjuvant Chemotherapy.","authors":"Lixia Xu, Chengqiang Jin, Yanxia Jia","doi":"10.1002/jum.70008","DOIUrl":"https://doi.org/10.1002/jum.70008","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}