Journal of Ultrasound in Medicine最新文献

{"title":"Changes in Contrast-Enhanced Ultrasonography Results, Vascular Endothelial Cell Damage, and Oxidative Stress Indicators in Rabbit Models With Varying Degrees of Testicular Injury.","authors":"Yaxi Zhao, Haifei Wang, Gaofeng Su, Yanbin Zhu","doi":"10.1002/jum.16704","DOIUrl":"https://doi.org/10.1002/jum.16704","url":null,"abstract":"<p><strong>Objective: </strong>It is difficult to quickly assess the degree of testicular injury in patients with blunt testicular trauma, and accurate and rapid assessment of the degree of injury is related to clinical decision-making and treatment outcomes. This study explored the sonographic characteristics of patients with different degrees of blunt testicular trauma via contrast-enhanced ultrasound (CEUS), as well as biomarkers of oxidative stress and vascular endothelial cell injury, to further evaluate the diagnostic value of these parameters in blunt testicular trauma.</p><p><strong>Method: </strong>New Zealand male rabbits were used to establish blunt testicular trauma models of different degrees, including contusion, hematoma, rupture, and control models. Routine ultrasound and CEUS were performed immediately, 2, 4, and 6 h after modeling, and pathological examination was used to confirm the modeling results further. The levels of von Willebrand factor (vWF), endothelin-1 (ET-1), reactive oxygen species (ROS), and nitric oxide (NO) in the serum were analyzed.</p><p><strong>Results: </strong>According to the CEUS results, the arrival time (AT) (F = 35.159, P < .001), time to peak intensity (TTP) (F = 122.434; P < .001), and area under the curve (AUC) (F = 47.444; P < .001) of the time-intensity curves showed significant differences among the groups. There was no significant difference between Hematoma Trauma (HT) (F = 0.178; P = .91) and Peak Intensity (PI) (F = 0.172; P = .92). For biomarkers, there were significant differences in vWF (F = 40.61; P < .001), ROS (F = 106.3; P < .001), NO (F = 79.3; P < .001), and ET-1 (F = 61.94; P < .001) levels among the groups.</p><p><strong>Conclusions: </strong>For blunt testicular trauma, the AT, TTP, and AUC indices of CEUS can more accurately distinguish the degree of testicular injury. Oxidative stress and endothelial cell damage may also be used as biomarkers for evaluating the degree of testicular injury.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Neuromodulation (Low-Intensity Focused Ultrasound) to Treat Knee Osteoarthritis Pain: A Randomized, Observer- and Participant-Masked, Sham-Controlled, Human-Subjects Pilot Study.","authors":"Brian M Ilfeld, Khoa N Cao, Ruben Branson, Philip Bloom","doi":"10.1002/jum.16706","DOIUrl":"https://doi.org/10.1002/jum.16706","url":null,"abstract":"<p><p>Low-intensity focused ultrasound is a non-invasive neuromodulation technique that delivers mechanical forces to a deep location within the body through acoustic pressure waves without affecting tissue between the transducer and focal target. Preliminary studies involving healthy volunteers suggest focused ultrasound reversibly prevents action potential formation similar to a local anesthetic nerve block, but the modality has not been used in patients with existing pain. The current randomized pilot study was undertaken to 1) determine the feasibility and optimize the protocol for a subsequent definitive clinical trial; and 2) monitor for related complications of focused ultrasound when treating knee osteoarthritis pain.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraobserver Reliability of Two-Dimensional Ultrasound Measurements of the Linea Alba in Parous Women During Different Abdominopelvic Exercises.","authors":"Claudia Espinoza-Bravo, Montserrat Rejano-Campo, Fernando Domínguez-Navarro, Bernadette de Gasquet, Laura Fuentes-Aparicio","doi":"10.1002/jum.16697","DOIUrl":"https://doi.org/10.1002/jum.16697","url":null,"abstract":"<p><strong>Objective: </strong>To assess the intraobserver reliability of Diastasis Recti Abdominis (DRA) measurement by ultrasonography during four specific abdominopelvic exercises, evaluating interrecti distance, Linea Alba (LA) thickness, and distortion index in parous women.</p><p><strong>Methods: </strong>Fifty-four parous women were assessed using ultrasound imaging for the LA. Four exercises were evaluated: crunch, abdominal drawing-in maneuver, pelvic floor muscle contraction, and one exercise based on the de Gasquet Method. Each exercise was performed three times. The ultrasound probe was placed 3 cm above and 2 cm below the umbilicus. Interrecti distance (IRD), distortion index, and LA thickness were measured and analyzed using ImageJ software by independent researchers. Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC) with a 95% confidence interval.</p><p><strong>Results: </strong>ICC values for the IRD ranged from 0.84 to 0.99 for the four exercises. The distortion index showed moderate to high reliability (ICC: 0.77-0.98), while LA thickness also demonstrated moderate to high reliability (ICC: 0.75-0.98).</p><p><strong>Conclusion: </strong>The results demonstrate the reliability of ultrasound in measuring key parameters, including LA thickness, distortion, and IRD in women with DRA during various exercises. As a non-invasive tool, it supports evidence-based interventions in postpartum recovery and clinical practice.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Fetal Heart Morphology and Function in Fetuses With Right Ventricular Outflow Obstruction by Fetal Heart Quantitative Technique.","authors":"Chenke Pan, Jinjing Li, Lijian Huang, Bin Ying, Xin Wang, Bowen Zhao","doi":"10.1002/jum.16693","DOIUrl":"https://doi.org/10.1002/jum.16693","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical utility of the fetal heart quantification (Fetal HQ) technique in the assessment of morphological and functional changes in fetuses with right ventricular outflow obstruction (RVOTO).</p><p><strong>Methods: </strong>This study included 53 fetuses with RVOTO and 30 age-matched normal controls. The RVOTO fetuses were divided into 2 groups based on the occurrence of other cardiovascular malformations: the simple pulmonary stenosis (PS group) and the conotruncal defects (CTD group). Size, shape, and contractility parameters of the fetal heart in 4-chamber view (4CV), left ventricle, and right ventricle (LV and RV) detected by fetal HQ.</p><p><strong>Results: </strong>Fetuses with RVOTO exhibited an increased 4CV-width, with normal 4CV-Length. The end-diastolic diameter (ED) of the LV segments 1-22 was significantly greater in RVOTO fetuses. The sphericity index (SI) of the LV 24-segment was significantly smaller in the CTD and PS groups. Global longitudinal strain (GLS) and fractional area change (FAC) of the LV and RV were reduced in RVOTO fetuses.</p><p><strong>Conclusion: </strong>Our results suggested that the characteristic changes in the morphology and function of the RVOTO fetal heart could be detected early by the HQ technique, which has clinical utility in analyzing the morphology of the RVOTO fetal heart in a quantitative manner.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility Analysis of Ultra-Resolution Microscopy Based on Contrast-Enhanced Ultrasound (CEUS) in Benign and Malignant Breast Lesions.","authors":"Peng-Fei Sun, Li-Xue Zhai, Yun-Yun Dong, Xiang-Dong Hu, Min Li, Lin-Xue Qian, Jun-Feng Zhao","doi":"10.1002/jum.16699","DOIUrl":"https://doi.org/10.1002/jum.16699","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the diagnostic value of quantitative analysis using ultra-resolution microscopy (URM) in differentiating benign from malignant breast lesions.</p><p><strong>Material and methods: </strong>This prospective study enrolled 60 patients with 60 breast lesions who underwent contrast-enhanced ultrasound (CEUS) using SonoVue (Bracco Imaging, Italy) between June 2024 and August 2024. Quantitative parameters of microvascular density and velocity maps were generated for the lesion interior, rim region, and combined interior and rim area using URM software on CEUS images. The parameters were analyzed for differences between benign and malignant breast lesions, and their diagnostic efficacy was evaluated.</p><p><strong>Results: </strong>Multivariate analysis indicated that breast malignancy was associated with microvascular ratio and complexity level. The area under the curve (AUC) for the combined diagnostic method that included microvascular parameters at the lesion margin (Rim group) and BI-RADS classification + Rim was higher than other diagnostic approaches (AUC = 0.92), although there was no significant difference when compared with the combined approach of evaluating parameters within the lesion and at the margin alongside BI-RADS (Mass + Rim + BI-RADS group, P = .293). The BI-RADS group showed high sensitivity (100%) and negative predictive value (100%); the Mass group (parameters within the lesion) demonstrated higher sensitivity (87.0%), and the Rim group (parameters at the lesion margin) exhibited the highest specificity (91.9%).</p><p><strong>Conclusion: </strong>URM shows potential in distinguishing between benign and malignant breast lesions, offering a precise assessment of lesion hemodynamics and providing valuable information for clinical diagnosis and treatment.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Observational Study of Emergency Department Point-of-Care Ultrasound to Differentiate Between Complicated and Uncomplicated Appendicitis.","authors":"Almaz S Dessie, Maria Kwok, Lisa Mills, Adam Sivitz, Marsha Elkhunovich, Benjamin Nti, Erika Constantine, Kelly Bergmann, Atim Ekpenyong, Amanda Toney, Xiaoyang Li, Peter S Dayan, David Kessler","doi":"10.1002/jum.16702","DOIUrl":"https://doi.org/10.1002/jum.16702","url":null,"abstract":"<p><strong>Objectives: </strong>Acute appendicitis is a common surgical emergency in children. Prior radiology studies have described Puylaert staging on ultrasound to determine the severity of appendicitis. We investigated the feasibility and utility of assessing Puylaert staging on emergency department (ED) point-of-care ultrasound (POCUS) to differentiate uncomplicated from complicated appendicitis in children.</p><p><strong>Methods: </strong>This was a pilot feasibility study of children ages 5-17 diagnosed with acute appendicitis in nine pediatric EDs. POCUS was performed by trained ED physicians. Puylaert staging of the submucosal layer was used to categorize the severity of appendicitis (stages 1-4) and was compared with surgical pathology reports. Test characteristics were computed to evaluate the accuracy of POCUS in differentiating appendicitis severity. Physicians recorded time to complete POCUS, ease of use, and their perception of acceptability by patients and families.</p><p><strong>Results: </strong>Of 72 patients with complete data, all patients with uncomplicated appendicitis were accurately identified using POCUS (Puylaert stage 1 or 2). The sensitivity for identifying complicated appendicitis (Puylaert Stage 3 or 4) was 100% (95% CI: 77%-100%), and specificity was 65% (95% CI: 52%-78%). Ninety four percent of physicians agreed that the POCUS was easy to perform. One hundred percent agreed that it was well accepted by families. The average time to complete POCUS was 8 min.</p><p><strong>Conclusions: </strong>This study supports the feasibility and utility of assessing Puylaert staging by POCUS for children with appendicitis in the ED. High sensitivity to rule out complicated cases coupled with ease of use and perceived patient acceptance make this a potential adjunct to aid in the management of pediatric appendicitis.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Dynamic Contrast-Enhanced Ultrasound Confirms Renal Obstruction: A Feasibility Study.","authors":"Kourosh Kalayeh, Sapan N Ambani, Man Zhang, Stephanie Daignault-Newton, Benjamin L Viglianti, Rashmi Mediratta, William W Schultz, J Brian Fowlkes, Bryan S Sack","doi":"10.1002/jum.16698","DOIUrl":"https://doi.org/10.1002/jum.16698","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To evaluate dynamic contrast-enhanced ultrasound (DCEUS) potential for diagnosing ureteropelvic junction obstruction (UPJO). We hypothesize that DCEUS can identify differences in renal parenchymal microcirculation between normal and obstructed kidneys.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This prospective study included 8 subjects (16 kidneys) with unilateral renal obstruction clinically determined to need surgery and confirmed by nuclear medicine (NM) diuretic half-time ( &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;t&lt;/mi&gt; &lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt; &lt;mo&gt;/&lt;/mo&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;mo&gt;≥&lt;/mo&gt; &lt;mn&gt;20&lt;/mn&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;min&lt;/mi&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ {t}_{1/2}ge 20kern0.5em min $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ). Subjects underwent pre- and post-surgery DCEUS and NM imaging at a tertiary care institution (Dec 2021 to Oct 2024). DCEUS-derived time-intensity curves were analyzed to calculate mean-transit time (MTT), time-to-peak (TTP), and full-width at half-maximum (FWHM). DCEUS MTT was compared between normal and affected kidneys and to NM &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;t&lt;/mi&gt; &lt;mrow&gt;&lt;mn&gt;1&lt;/mn&gt; &lt;mo&gt;/&lt;/mo&gt; &lt;mn&gt;2&lt;/mn&gt;&lt;/mrow&gt; &lt;/msub&gt; &lt;/mrow&gt; &lt;annotation&gt;$$ {t}_{1/2} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; . Statistical significance was determined using two-sided paired and unpaired Student t-tests.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;MTT was significantly longer in obstructed kidneys compared to normal kidneys before surgery ( &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mn&gt;52&lt;/mn&gt; &lt;mo&gt;±&lt;/mo&gt; &lt;mn&gt;7&lt;/mn&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;s&lt;/mi&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ 52pm 7kern0.22em mathrm{s} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; vs. &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mn&gt;18&lt;/mn&gt; &lt;mo&gt;±&lt;/mo&gt; &lt;mn&gt;3&lt;/mn&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;s&lt;/mi&gt; &lt;mo&gt;;&lt;/mo&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;P&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mn&gt;.002&lt;/mn&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ 18pm 3kern0.22em mathrm{s};kern0.5em P=.002 $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ) and normalized after pyeloplasty ( &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mn&gt;13&lt;/mn&gt; &lt;mo&gt;±&lt;/mo&gt; &lt;mn&gt;3&lt;/mn&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;s&lt;/mi&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ 13pm 3;mathrm{s} $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; vs. &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mn&gt;14&lt;/mn&gt; &lt;mo&gt;±&lt;/mo&gt; &lt;mn&gt;2&lt;/mn&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;s&lt;/mi&gt; &lt;mo&gt;;&lt;/mo&gt; &lt;mspace&gt;&lt;/mspace&gt; &lt;mi&gt;P&lt;/mi&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mn&gt;.8&lt;/mn&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ 14pm 2;mathrm{s};kern0.5em P=.8 $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ). A point-biserial correlation between DCEUS MTT and NM drainage time categories was found to be &lt;math&gt; &lt;semantics&gt; &lt;mrow&gt;&lt;msub&gt;&lt;mi&gt;r&lt;/mi&gt; &lt;mi&gt;pb&lt;/mi&gt;&lt;/msub&gt; &lt;mo&gt;=&lt;/mo&gt; &lt;mn&gt;0.8&lt;/mn&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ {r}_{pb}=0.8 $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ( &lt;math&gt; &lt;semantics&gt;&lt;mrow&gt;&lt;mi&gt;P&lt;/mi&gt; &lt;mo&gt;&lt;&lt;/mo&gt; &lt;mn&gt;.0001&lt;/mn&gt;&lt;/mrow&gt; &lt;annotation&gt;$$ P&lt;.0001 $$&lt;/annotation&gt;&lt;/semantics&gt; &lt;/math&gt; ). Similar patterns were observed for TTP and FWHM, however, they were not statistically significant. The results showed potential of DCEUS MTT in categorizing kidneys into delayed and normal, according to their NM drainage time (ROC AUC = 0.97, 95% CI = [0.9, 1.0])","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proof of Concept: Super-Resolution Ultrasound and Viscoelastic Imaging of Hepatic Microcirculation for Early Detection and Staging of Liver Fibrosis in a Murine Model.","authors":"Rui Zhang, Jieqiong Wang, Tingting Liu, Yan Wang, Shuai Yang, Fei Yan, Li Xue","doi":"10.1002/jum.16703","DOIUrl":"https://doi.org/10.1002/jum.16703","url":null,"abstract":"<p><strong>Objectives: </strong>Super-resolution ultrasound microvascular imaging (SRUS) has emerged as a noninvasive technology capable of visualizing the microvasculature with exceptional spatial resolution, surpassing the acoustic diffraction limit. This study aims to assess the potential of SRUS in staging liver fibrosis by evaluating its diagnostic performance against ultrasound viscosity imaging.</p><p><strong>Methods: </strong>Liver fibrosis was induced by carbon tetrachloride (CCl₄) in 30 mice. The mice were evenly distributed across five stages (6 mice per stage), categorized from F0 (no fibrosis) to F4 (cirrhosis) based on the extent of collagen deposition. SRUS microvascular imaging and ultrasound viscosity imaging were compared for their efficacy in detecting liver fibrosis stages. Immunohistochemistry and histopathological analyses were conducted to correlate vessel density and collagen deposition.</p><p><strong>Results: </strong>SRUS effectively detected microvascular changes across all fibrosis stages. Significant vessel diameter enlargement was observed at early stages (F1), with further increases in advanced stages (F3-F4). Vessel density significantly decreased in later stages, indicating compromised angiogenesis. Ultrasound viscosity imaging showed marked viscoelastic reductions in fibrosis but lacked sensitivity in early-stage detection. SRUS parameters exhibited strong correlations with histological findings, underscoring their potential diagnostic value. Receiver operating characteristic (ROC) curve analysis further demonstrated the superior sensitivity of SRUS (89.59% [95% confidence interval (CI): 84.87-92.96%]), particularly in distinguishing early-stage fibrosis (F0-F1) from advanced stages (F2-F4) (area under the curve [AUC] = 0.9610, 95% CI: 0.9449-0.9771; P < .001).</p><p><strong>Conclusions: </strong>SRUS microvascular imaging is a promising adjunct to traditional elastography, offering enhanced sensitivity for early-stage liver fibrosis detection. It provides critical insights into microcirculatory dysfunction, complementing stiffness measurements and aiding in accurate diagnosis.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Machine Learning Model for Predicting Axillary Lymph Node Metastasis in Clinically Node Positive Breast Cancer Based on Peritumoral Ultrasound Radiomics and SHAP Feature Analysis”","authors":"","doi":"10.1002/jum.16692","DOIUrl":"10.1002/jum.16692","url":null,"abstract":"<p>Wang SR, Cao CL, Du TT, et al. Machine learning model for predicting axillary lymph node metastasis in clinically node positive breast cancer based on peritumoral ultrasound radiomics and SHAP feature analysis. <i>J Ultrasound Med</i>. 2024;43(9):1611–1625. doi:10.1002/jum.16483</p><p>The author attributions should have been written as: “Si-Rui Wang^†, BMed, Chun-Li Cao^†, MM, Ting-Ting Du, MM, Jin-Li Wang, BMed, Jun Li, PhD, Wen-Xiao Li, MM, Ming Chen, MM. ^†These authors have contributed equally to this work.”</p><p>We apologize for this error.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Fetal Posterior Fossa Anomalies at 11-13⁺⁶ Gestational Weeks in the Midsagittal Cranial Plane by Three-Dimensional Multiplanar Sonography: A Prospective Study.","authors":"Feng-Qin Liu, Ze-Xuan Yang, Lin-Hua Yang, Ji-Mei Xi, Lin Chen, Liu-Ying Zhou, De-Xin Chen","doi":"10.1002/jum.16691","DOIUrl":"https://doi.org/10.1002/jum.16691","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to describe the sonographic appearance of posterior fossa anomalies in fetuses at 11-13⁺⁶ weeks' gestation.</p><p><strong>Methods: </strong>This prospective study included 60 healthy fetuses and 15 fetuses with an abnormal posterior brain at 11-13⁺⁶ weeks' gestation. All three-dimensional images were processed using multiplanar image correlation to view the posterior fontanelle in the midsagittal views. The final diagnosis of all fetuses was confirmed using second-trimester ultrasonography, fetal magnetic resonance imaging, and/or genetic testing.</p><p><strong>Results: </strong>The brainstem morphology, fourth ventricle, choroid plexus of the fourth ventricle, vermis, and physiologic Blake pouch were clearly visualized at 11-13⁺⁶ weeks' gestation through the posterior fontanelle from the midsagittal view. Among the 15 fetuses analyzed, two had abnormal brainstem morphology, which was subsequently diagnosed as Walker-Warburg syndrome. The remaining 13 fetuses were diagnosed with posterior fossa cystic malformations (Dandy-Walker malformation, 2 fetuses; Blake's pouch cyst, 2 fetuses; Noonan syndrome, 1 fetus; trisomy 21, 2 fetuses; trisomy 18, 1 fetus; and transient dilatation of the fourth ventricle, 5 fetuses). The extended anterior membranous area and dysplastic vermis were strong markers of Dandy-Walker malformation. In fetuses with Blake pouch cysts, the vermis was visible, with the choroid plexus of the fourth ventricle located backward.</p><p><strong>Conclusions: </strong>Sonography enables clear visualization of morphological changes in posterior fossa anomalies at 11-13⁺⁶ gestational weeks. An extended anterior membranous area, dysplastic vermis, and abnormal brainstem morphology are direct signs of early recognition of severe posterior fossa anomalies.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}