Journal of Ultrasound in Medicine最新文献

{"title":"Ultrasound Evaluation of the Changes of Ophthalmic Artery Doppler and Optic Nerve Sheath in Pregnant Women With FGR","authors":"Yunqi Chen MS,&nbsp;Xiaoli Lv MS,&nbsp;Lijuan Yang MS,&nbsp;Mingmin Wang MS,&nbsp;Dan Hu MS,&nbsp;Min Ren PhD","doi":"10.1002/jum.16660","DOIUrl":"10.1002/jum.16660","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to compare changes in ultrasonic Doppler parameters, particularly the peak ratio (PR) of the ophthalmic artery (OA) and optic nerve sheath diameter (ONSD), in pregnancies complicated by fetal growth restriction (FGR). Furthermore, it sought to evaluate differences in these parameters across various subgroups and analyze the cut-off value of PR for predicting delivery within 1 week in pregnancies complicated by FGR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 62 pregnant women in the mid-to-late stages of gestation were enrolled, comprising 31 participants in the FGR group and 31 in the control group. The general conditions, pregnancy outcomes, Doppler parameters of the OA, and ONSD were compared between the two groups. Comparative analysis was performed to investigate differences in OA Doppler parameters and ONSD across FGR subgroups. The predictive value of PR for delivery within 1 week was assessed using the area under the receiver operating characteristic curve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PR of the OA was significantly elevated in the FGR group compared to the control group, demonstrating a statistically significant difference. The threshold PR value for predicting delivery within 1 week was 0.565, with a sensitivity of 0.88 and a specificity of 0.58.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The PR value of the OA in pregnant women with FGR is significantly increased and may serve as a reliable predictor for pregnancies complicated by FGR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 6","pages":"1007-1015"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16660","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic Optic Nerve Sheath Diameter Technical Pitfalls and Imaging Artifacts","authors":"Mohammad I. Hirzallah MD, MMSc,&nbsp;Aarti Sarwal MD, FAAN, FNCS, FCCM, RPNI,&nbsp;Aaron M. Dentinger PhD,&nbsp;Chiara Robba MD, PhD,&nbsp;Jurgita Valaikienė MD, PhD,&nbsp;Piergiorgio Lochner MD, PhD,&nbsp;Felix Schlachetzki MD,&nbsp;David M. Mills PhD,&nbsp;Michael Ertl MD,&nbsp;Ryan Hakimi DO, MS, NVS, RPNI, CPB, FNCS, FCCM, FAAN,&nbsp;Shreya Bhise MD, MBA,&nbsp;Jakob Pansell PhD","doi":"10.1002/jum.16655","DOIUrl":"10.1002/jum.16655","url":null,"abstract":"<p>Ultrasonographic optic nerve sheath diameter (ONSD) is a non-invasive intracranial pressure (ICP) surrogate. This article discusses the effect of ultrasound settings and imaging artifacts on ONSD assessment. Ultrasound settings that may affect ONSD assessment include gain, dynamic range, frequency, harmonic imaging, and focal zones. Artifacts can be related to imaged structures (acoustic shadowing, enhancement, comet tail, and speckle artifacts) or to beam properties (partial volume and refraction artifacts). In addition, optic nerve sheath (ONS) properties such as echogenicity changes based on ICP or ONS kinking are discussed.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 6","pages":"1103-1120"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duplex Ultrasound in Evaluating Transplanted Renal Artery In-Stent Restenosis","authors":"Fu-shun Pan MD,&nbsp;Dao-peng Yang MD,&nbsp;Rong-hai Deng MD","doi":"10.1002/jum.16656","DOIUrl":"10.1002/jum.16656","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the diagnosis performance of duplex ultrasound (DUS) in predicting transplanted renal artery (TRA) in-stent restenosis (ISR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective study, 112 consecutive patients underwent stenting due to TRA stenosis. DUS were performed within 1 week after stenting for baseline value, and after ≥3 months follow-up for surveillance of ISR. The DUS measurements included peak systolic velocity (PSV) and PSV ratio of renal artery stent to iliac artery (RIR). Receiver operating characteristic (ROC) curves were applied to evaluate the diagnosis performance of DUS parameters in predicting ISR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 69 patients (28 men; age, 38.3 ± 15.1 years) who obtained 92 adequate paired DUS and CTA after stenting, which were classified as ISR group (26 TRAs) and non-ISR group (66 TRAs). There was no difference between the two groups for baseline DUS features, including PSV_B and RIR_B. The late DUS features including stent PSV_L (475.5 vs 261.9 cm/s), RIR_L (4.10 vs 2.18), and stent PSV_L/PSV_B (2.72 vs 1.14) were significantly higher in the ISR group than the non-ISR group (all <i>P</i> &lt; .0001). Stent PSV_L, RIR_L, and PSV_L/PSV_B demonstrated comparable AUCs in predicting ISR. However, the sensitivity and specificity of PSV_L/PSV_B in predicting ISR were 92.3 and 93.5%, respectively, demonstrating higher specificity with equivalent sensitivity than PSV_L and higher sensitivity with equivalent specificity than RIR_L.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DUS is an accurate technique to identify TRA-ISR. We suggest all patients should undergo DUS immediately after stenting to establish baseline value and aid in evaluating ISR at late follow-up.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 6","pages":"971-980"},"PeriodicalIF":2.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Microvascular Architecture Imaging in Normal and Congenital Heart Disease Pregnancies","authors":"Peiwen Chen MSc,&nbsp;Sheng Zhao PhD,&nbsp;Liqun Sun PhD,&nbsp;Hui Huang PhD,&nbsp;Chen Cheng PhD,&nbsp;Weiyun Wang MSc,&nbsp;Luming Sun PhD,&nbsp;Jianping Chen MSc,&nbsp;Fang Liu BSc,&nbsp;Shengbao Pan MSc,&nbsp;Dan Wang BSc,&nbsp;Qinghua Li BSc,&nbsp;Zhiyun Tian MSc,&nbsp;Xinlin Chen BSc,&nbsp;Jack Rychik PhD","doi":"10.1002/jum.16657","DOIUrl":"10.1002/jum.16657","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the placental vascular architecture using MV Flow™ imaging for analyzing vascular distribution per region of biological tissue in isolated congenital heart diseases (CHD), CHD associated with extracardiac malformations (EXM) and normal pregnancies, and to explore the relationship of fetal Doppler flow parameters and growth to placental perfusion in these conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Placental microvascular structure was assessed using MV-Flow™ in a total of 227 normal fetuses and 139 with CHD; fetuses with gestational age ranging from 11 to 41 weeks were included. Placental vascular indices (VI^MV %) was acquired at three different segments of each placenta (upper, middle, and lower regions). Doppler pulsatility indices of fetal umbilical artery (UA), middle cerebral artery (MCA), ductus venosus (DV), uterine artery (UtA), and cerebroplacental ratio were measured in both normal and CHD groups. The CHD group was divided into two subgroup based on whether it is associated with EXM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to the control group, the CHD with EXM group exhibited a significantly lower VI^MV % for the upper, middle, and lower regions of the placenta (<i>P</i> = .005; <i>P</i> = .018; <i>P</i> = .039, respectively). In the total CHD group, VI^MV % decreased in the middle segment of placenta in the 2nd trimester compared to the control group. But the VI^MV % of upper and middle segments decreased in the 3rd trimester. Both subgroups, EXM and isolated CHD, showed similar distribution of gestational weeks. Doppler vascular indices were significantly different compared to normal in the total CHD group for UA-pulse index (PI), DV-PI, right UtA-PI, and left UtA-PI, with similar differences from normal for the CHD with EXM group. DV-PI was the only significantly different Doppler vascular parameter for the isolated CHD group compared to normal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>For the first time, MV-Flow™ imaging demonstrated reduced placental vascularity in fetuses with CHD and ECM and in fetuses with isolated CHD in the 3rd trimester of pregnancy. Application of MV-Flow™ as part of serial fetal echocardiographic surveillance in cases of CHD may allow for better understanding of the development of placental abnormalities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 6","pages":"981-990"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Myometrial Vascularity, a Little-Known Complication of Pregnancy","authors":"Ilan E. Timor-Tritsch MD,&nbsp;Francesco D'Antonio MD,&nbsp;A. Monteagudo MD","doi":"10.1002/jum.16646","DOIUrl":"10.1002/jum.16646","url":null,"abstract":"<p>In the last decades, clinicians reported that patients, after failed or terminated intrauterine or cesarean scar pregnancies, demonstrated increased vascularization of the adjacent uterine muscle layers by ultrasound (US). These “earned” the incorrect diagnosis: uterine arterio-venous malformation (AVM). This misnomer was used without etiologic scrutiny by clinicians and repeated in scientific articles and textbooks. Despite the articles written during the same 10–20 years which tried to encourage caretakers of patients to relinquish the term AVM and use the correct term of enhanced myometrial vascularity (EMV). There still is a degree of ignorance as well as a knowledge gap in the obstetrical and radiological community as to the etiology, pathophysiology, and management of the above clinical entity. This article contains previously published, relevant ultrasound-based data on the subject along with our clinical experience highlighted by examples. We aim to fill this gap by providing illustrative clinical cases of the tools we consider relevant to the clinical diagnosis and management of EMV. We emphasize, that in the majority of cases expectant approach, avoids complications resulting from misdiagnosis and unnecessary treatment as well as pointing out the diagnostic importance of determining the parameters in guiding their treatment.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"857-868"},"PeriodicalIF":2.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Imaging Protocol for Latissimus Dorsi and Teres Major in Overhead Athletes","authors":"Robert Pagan-Rosado MD,&nbsp;Brett Kindle MD,&nbsp;Taylor North DO,&nbsp;Jay Smith MD","doi":"10.1002/jum.16654","DOIUrl":"10.1002/jum.16654","url":null,"abstract":"<p>Ultrasound imaging is vital for musculoskeletal assessment due to its real-time, high-resolution capabilities and safety. While protocols exist for rotator cuff evaluation, comprehensive guidelines for imaging the latissimus dorsi and teres major muscles are lacking. This article fills this gap by presenting a detailed ultrasound protocol for these muscles, essential for shoulder stability and movement in overhead athletes. We review their anatomy, propose a standardized examination approach, and discuss clinical indications, aiming to improve diagnostic accuracy and management of these injuries.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"945-954"},"PeriodicalIF":2.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Performance of Lung Ultrasound for Monitoring Interstitial Lung Disease”","authors":"","doi":"10.1002/jum.16658","DOIUrl":"10.1002/jum.16658","url":null,"abstract":"<p>Pitsidianakis G, Vassalou EE, Vasarmidi E, et al. Performance of lung ultrasound for monitoring interstitial lung disease. <i>J Ultrasound Med</i> 2022; 41(5):1077–1084. doi: 10.1002/jum.15790</p><p>The affiliation of authors Georgios Pitsidianakis, Eirini Vasarmidi, Nikolaos Tzanakis, and Katerina M. Antoniou should have appeared as: Department of Respiratory Medicine, University Hospital of Heraklion and School of Medicine University of Crete, Greece.</p><p>We apologize for this error.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 6","pages":"1125"},"PeriodicalIF":2.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16658","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Wave Elastography as a Supplement Tool in Differentiating Benign and Malignant Axillary Lymph Nodes","authors":"Aishwarya Sharma MBBS,&nbsp;Ravinder Kaur MBBS, MD,&nbsp;Narinder Kaur MBBS, MD,&nbsp;Uma Handa MBBS, MD,&nbsp;Usha Dalal MBBS, MS,&nbsp;Anurag Gupta MBBS","doi":"10.1002/jum.16653","DOIUrl":"10.1002/jum.16653","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the efficacy of quantitative shear wave elastography in differentiating benign and malignant axillary lymph nodes (ALN).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Exactly 127 lymph nodes from 127 patients with clinically palpable axillary swelling were examined by both B-mode sonography and elastography from November 2022 to March 2024. Gray-scale sonograms were evaluated based on: the short-axis diameter, shape, hilum, maximum cortical thickness, and border of the ALN. Shear wave elastography determined the mean elasticity modulus (<i>E</i>-mean) and elasticity ratio (<i>E</i>-ratio). Fine needle aspiration cytology or histopathological examination was kept as the gold standard and diagnostic performance shear wave elastography was compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The data showed that out of 127 lymph nodes, 77 (60.6%) were benign and 50 (39.4%) were malignant based on pathological results. The <i>E</i>-mean for malignant lymph nodes (mean, 73.15 kPa) was higher than that for benign lymph nodes (mean, 21.47 kPa; <i>P</i> &lt; .001). The area under the receiver operating characteristic curve for <i>E</i>-ratio in predicting malignant and benign lymph nodes was 0.897 (95% CI: 0.839–0.955). The <i>E</i>-ratio for malignant lymph nodes was also higher (mean, 10.2) than for benign nodes (mean, 2.95; <i>P</i> &lt; .001). The area under the receiver operating characteristic curve for <i>E</i>-ratio in predicting malignant and benign lymph nodes was 0.816 (95% CI: 0.733–0.899).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results showed a significant association between tissue elasticity and pathological correlation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"935-944"},"PeriodicalIF":2.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Different Examination Types and Learning Curves of Radiologists for 5G-Based Robot-Assisted Tele-Ultrasonography","authors":"Tian He,&nbsp;Kai-Feng Yang,&nbsp;Guo-Chao Song,&nbsp;Hui Liu PhD,&nbsp;Guang Xu,&nbsp;Jing Wan,&nbsp;Hui Zhao,&nbsp;Qiao Wang PhD,&nbsp;Chang Liu,&nbsp;Chong-Ke Zhao PhD,&nbsp;Yi-Feng Zhang PhD,&nbsp;Le-Hang Guo PhD,&nbsp;Li-Ping Sun PhD,&nbsp;Hui-Xiong Xu PhD","doi":"10.1002/jum.16638","DOIUrl":"10.1002/jum.16638","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the feasibility of remotely providing routine ultrasound (US) examinations to patients using a fifth-generation-based robot-assisted tele-ultrasonography (RATU) system in a real-world setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between September 2020 and May 2021, we conducted a prospective and large-scale study using the RATU system to provide US examinations for patients on a limited-source island locate. An on-site radiologist on the island performed US examinations, which served as the reference diagnosis. Five tele-radiologists then remotely conducted RATU examinations from Central Shanghai. We compared the diagnostic performance of the RATU examinations to that of the on-site US examinations. Additionally, we assessed the learning curves of the various tele-radiologists. We also distributed 2 questionnaires to evaluate the usefulness of the clinical application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 770 patients were enrolled in the study with a mean age of 55.46 ± 15.02 years (ranging from 19 to 80 years). Out of the total, 501 patients were men, and 269 were women. Across all examination types, the diagnosis in 84.3% (649/770) of RATU examinations was consistent with the on-site US examination. The learning curve was not significantly different between tele-radiologists of different seniority. Furthermore, 86.6% (667/770) of participants accepted the RATU examination, and 97.5% (751/770) of patients were willing to pay a fair price.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RATU's diagnostic performance is still helpful for patients in remote areas, even though it may be slightly inferior to on-site US examination.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 4","pages":"747-758"},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Bone Fracture Healing in a Rabbit Model Using Doppler Imaging Modes, Shear Wave Elastography, X-Ray, and Dual-Energy X-Ray Absorptiometry","authors":"Priscilla Machado MD,&nbsp;Rachel Blackman BS,&nbsp;Ji-Bin Liu MD,&nbsp;Colleen Dempsey EdD,&nbsp;Flemming Forsberg PhD,&nbsp;Traci Fox EdD","doi":"10.1002/jum.16652","DOIUrl":"10.1002/jum.16652","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study investigated methods of evaluating the bone fracture healing process using superb microvascular imaging (SMI; two modes color SMI [cSMI] and monochromeSMI [mSMI]), and shear wave elastography (SWE), relative to X-ray, dual-energy X-ray absorptiometry (DXA), and platelet endothelial cell adhesion molecule 1 (PECAM-1) also know as cluster of differentiation 31 (CD-31) staining in a rabbit model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This IACUC-approved study involved eight rabbits that underwent a bilateral fibula osteotomy and were followed for 7 or 21 days (Groups 1 and 2 with 4 rabbits in each). Ultrasound examinations using cSMI, mSMI, and SWE were performed on Days 0, 4, 7, 14, and 21 post-surgery. At the final time point, rabbits had X-ray imaging followed by euthanasia and DXA scan. Finally, the fracture areas underwent decalcification, and specimens were stained with CD-31 for pathological analysis. Ultrasound and X-ray findings were compared using ANOVAs or paired <i>t</i>-tests with CD-31 stains and DXA was used as a reference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparing SMI ultrasound images between the last time points for Group 1 (Day 7) and Group 2 (Day 21) showed no statistical significance difference for cSMI (<i>P</i> = .14) and mSMI (<i>P</i> = .06), similarly when compared with CD-31 stains there was no statistical significance difference for cSMI in Group 2 (<i>P</i> = .13). The SWE ultrasound images from the last time points in Groups 1 and showed no statistical significance difference (<i>P</i> = .33), the same results were then compared with DXA and also showed no statistical significance difference (<i>P</i> = .14). When comparing results of the X-ray images from the last time points for Groups 1 and 2 a statistical significance difference was found (<i>P</i> = .01), and when X-ray images were compared with DXA there was a statistical significance difference (<i>P</i> &lt; .001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared with CD-31 stains cSMI on Day 21 was not statistically significant (<i>P</i> = .13). Results comparing SWE with DXA were also not statistically significant (<i>P</i> = .14). These results indicate the potential of using certain ultrasound imaging techniques to monitor the bone fracture healing process.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"927-933"},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16652","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}