{"title":"AI in Breast Ultrasound: Purpose, Current Boundaries, and Future Directions.","authors":"Deniz Esin Tekcan Sanli, Ahmet Necati Sanli","doi":"10.1002/jum.70009","DOIUrl":"https://doi.org/10.1002/jum.70009","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Burak Kale, Mustafa Faraşat, Gökhan Pekindil, Semin Ayhan, Serdar Tarhan, Tahir Buran
{"title":"Evaluation of Hepatic Steatosis and Fibrosis in Steatotic Liver Disease Ultrasound-Derived Fat Fraction (UDFF) and Auto pSWE by Using Deep Abdominal Transducer (DAX) and Liver Biopsy Correlation.","authors":"Ahmet Burak Kale, Mustafa Faraşat, Gökhan Pekindil, Semin Ayhan, Serdar Tarhan, Tahir Buran","doi":"10.1002/jum.70005","DOIUrl":"https://doi.org/10.1002/jum.70005","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the diagnostic performance of ultrasound-derived fat fraction (UDFF) in detecting and grading hepatosteatosis using liver histology as the reference, and to assess the effectiveness of point shear wave elastography (pSWE), UDFF, and auto-pSWE in diagnosing steatohepatitis and detecting fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>In this prospective study, patients underwent liver biopsy following UDFF and pSWE measurements using deep abdominal transducer (DAX) and conventional abdominal probes by 2 operators. Imaging findings were compared with histopathology to assess diagnostic performance. Associations between nonalcoholic fatty liver disease activity score (NAS), fibrosis stage, and imaging parameters were also evaluated.</p><p><strong>Results: </strong>A total of 121 patients were included. The median age was 50 years, and 57 (41%) were male. Histology confirmed steatotic liver disease in 43 cases. Excellent interobserver agreement was observed for UDFF (ICC = 0.974), pSWE (ICC = 0.958), and auto-pSWE (ICC = 0.960). UDFF showed a stepwise increase with steatosis grade and was moderately correlated with histological fat content (r = 0.676 for Sonographer 1, r = 0.638 for Sonographer 2; P < .001). For detecting S ≥ 1 steatosis, the optimal UDFF thresholds were ≥8.4% (Area Under the Curve (AUC) = 0.968; Se = 92.5%, Sp = 93.2%) for Sonographer 1 and ≥8.6% (AUC = 0.951; Se = 90.0%, Sp = 86.3%) for Sonographer 2. For moderate steatosis (S ≥ 2), the cutoffs were ≥10.4% (AUC = 0.932; Se = 100%, Sp = 79.6%) and ≥10.6% (AUC = 0.925; Se = 100%, Sp = 76.5%), and for severe steatosis (S = 3), ≥18.3% (AUC = 0.961; Se = 100%, Sp = 77.4%) and ≥18.7% (AUC = 0.949; Se = 100%, Sp = 77.4%) for Sonographer 1 and 2, respectively. UDFF positively correlated with body mass index and subcutaneous fat thickness, and negatively with both pSWE and auto-pSWE. A strong correlation was observed between pSWE and auto-pSWE for both observers. A weak positive correlation was found between NAS and auto-pSWE in MASLD cases. The optimal thresholds to detect fibrosis (≥F1) were 5.05 and 4.95 kPa for Sonographer 1, and 5.05 and 4.85 kPa for Sonographer 2, for pSWE and auto-pSWE measurements, respectively.</p><p><strong>Conclusion: </strong>DAX-derived UDFF and auto-pSWE are reproducible, noninvasive biomarkers with strong diagnostic value in assessing steatosis and fibrosis in MASLD.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the Early Cardiovascular Dynamics in TOF Fetuses.","authors":"Kui Zhang, Sen Wang, Chengqiang Jin","doi":"10.1002/jum.70004","DOIUrl":"https://doi.org/10.1002/jum.70004","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alvaro Martino Netto, Victor Arthur Ohannesian, Pedro Henrique Machado Carani, Guilherme Ciconelli Del Guerra, Miguel José Francisco Neto
{"title":"Refining the Use of CEUS in Adnexal Tumors: Diagnostic Parameters and Opportunities for Analytical Advancement.","authors":"Alvaro Martino Netto, Victor Arthur Ohannesian, Pedro Henrique Machado Carani, Guilherme Ciconelli Del Guerra, Miguel José Francisco Neto","doi":"10.1002/jum.70006","DOIUrl":"https://doi.org/10.1002/jum.70006","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Judit Becerra-Hervás MD, Anna Solé-Ribalta PhD, Mònica Girona-Alarcón PhD, Roi Campos MD, Elena Fresán PhD, Nuria Millán PhD, Carme Alejandre PhD, Elisabeth Esteban PhD
{"title":"Lung Ultrasound in Pediatric and Neonatal Pre-Hospital Care","authors":"Judit Becerra-Hervás MD, Anna Solé-Ribalta PhD, Mònica Girona-Alarcón PhD, Roi Campos MD, Elena Fresán PhD, Nuria Millán PhD, Carme Alejandre PhD, Elisabeth Esteban PhD","doi":"10.1002/jum.16754","DOIUrl":"10.1002/jum.16754","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The use of point-of-care ultrasound, particularly lung ultrasound (LUS), has grown in pediatric and neonatal intensive care units and also in pre-hospital settings. However, its application in pre-hospital care of pediatric population remains understudied. The objective of the study is to analyze the utility of the LUS in a Paediatric and Neonatal Transport Unit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a prospective observational study conducted in a specialized Paediatric and Neonatal advanced life support Transport Unit in Catalonia, Spain, between March 2021 and September 2023. Patients who underwent bedside LUS during stabilization or transfer for medical reasons were included. Epidemiologic variables, clinical data, transport-related data, and LUS-related data were recorded and analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the study period, 2452 patients were transferred. In 89 (3.6%) LUS was performed. Seventy LUS were performed for respiratory distress or cyanosis, 50 of these were in neonatal patients in which transient tachypnea and meconium aspiration were the most frequent diagnoses. LUS was also used during hemodynamic assessment of unstable patients and during cardiac arrest resuscitation. Exactly 87.1% of LUS results were confirmed at the receiving hospital. LUS findings led to a change in patient management in 32 (35.9%) patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The rational use of lung ultrasound performed by a pediatric and neonatal transport team can help in diagnostic orientation, management assessment, and improve patient safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2031-2038"},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan Xu, Yi Luo, Mingyu Chen, Qinghai Peng, Chengcheng Niu
{"title":"Super-Resolution Ultrasound Imaging of Renal Microcirculation in a Murine Model of Renal Fibrosis.","authors":"Yan Xu, Yi Luo, Mingyu Chen, Qinghai Peng, Chengcheng Niu","doi":"10.1002/jum.70003","DOIUrl":"https://doi.org/10.1002/jum.70003","url":null,"abstract":"<p><strong>Objectives: </strong>Peripheral kidney microvascular damage and chronic perfusion dysfunction in kidney fibrosis are demonstrated in most chronic kidney diseases. There is an urgent clinical need to develop an in vivo, noninvasive, and quantitative diagnostic tool to monitor the renal microcirculation. The present study aims to investigate the feasibility of super-resolution ultrasound (SRU) imaging in the visualization and quantification of renal microvascular and microcirculation in mice of unilateral ureteral obstruction (UUO).</p><p><strong>Methods: </strong>The SRU for renal micro-vessels imaging in healthy mice was performed and compared with conventional power Doppler ultrasound (US) and micro-computed tomography (CT). Renal fibrosis was prepared in vivo using UUO. B-mode, conventional power Doppler US, and SRU imaging were performed on the sham kidneys and UUO models at 3, 7, and 14 days. Then these kidneys were followed by histopathologic analysis and comparisons with SRU quantification parameters.</p><p><strong>Results: </strong>SRU helped to evaluate the function and structure of vessels in progressive renal disease via quantifying the renal microvascular. The quantitative parameters of SRU based on total blood flow of the kidney were calculated in the sham group, 3, 7, and 14 days after UUO. Renal cortical vessel density (r = 0.881), vessel curvature (r = -0.506), cortical perfusion index (PI) (r = 0.668) showed correlations with pathologically derived vessel density labeled with the expression of CD31. Vessel density (r = -0.615) and cortical curvature (r = -0.842), cortical PI (r = -0.508) also showed correlations with Masson's trichrome stain. Vessel curvature (r = -0.591) showed correlations with the expression of Col-1.</p><p><strong>Conclusion: </strong>SRU imaging provides the noninvasive, dynamic, and longitudinal monitoring of vessel functionality and can provide quantification of renal microvascular changes in a murine model of renal fibrosis.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Color Doppler Ultrasound Pattern of Cutaneous Exosomes at High and Ultra-High Frequency.","authors":"Ximena Wortsman, Natacha Quezada","doi":"10.1002/jum.70000","DOIUrl":"https://doi.org/10.1002/jum.70000","url":null,"abstract":"<p><p>Exosomes are extracellular vesicles that play a crucial role in intercellular communication and are becoming an increasingly popular worldwide aesthetic procedure. To date, the ultrasound changes in the cutaneous layers generated by exosomes have not been reported. We present 3 cases that were ultrasonographically studied before and 3 months after the last exosome procedure, using high (24 MHz) and ultra-high (71 MHz) frequencies. The exosome regions were compared with the contralateral (non-treated) areas and adjacent tissues before and after application. Hyperechoic islets in the upper hypodermis and an increase in dermal vascularity were detected in these cases, forming a consistent pattern in the 3 cases at the exosome regions. This may be related to a mild degree of inflammation and neoangiogenesis in the treated regions. In 1 patient with alopecia, there was evidence of hair follicle growth at the exosome area. Further investigations are needed to examine the persistence of these changes over time and the impact of local trauma on the ultrasonographic abnormalities resulting from the application of these agents. The capability to identify ultrasonographic patterns in cutaneous exosomes may help discriminate them from abnormalities present in dermatologic diseases, particularly when patients do not provide a clear history, and monitor anatomical changes more objectively.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Usefulness of Ultrasonography for the Evaluation and Management of Lung Abscess in Pediatric Patients","authors":"Takahiro Hosokawa MD, Kuntaro Deguchi MD, Haruka Takei MD, Yumiko Sato MD, Yutaka Tanami MD, Kyoichi Deie MD, Hiroshi Kawashima MD, Eiji Oguma MD","doi":"10.1002/jum.16761","DOIUrl":"10.1002/jum.16761","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>No systematic studies have compared lung abscess findings on computed tomography (CT) and ultrasonography.</p>\u0000 \u0000 <p>We aimed to determine the value of ultrasound in managing lung abscesses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-one pediatric patients with lung abscesses who underwent CT and ultrasonography were included in the study. They were classified into those with lung abscess detected and undetected by ultrasonography. In patients with detected lesions via ultrasound, the lesion sizes measured by CT and ultrasonography were compared using Pearson's correlation coefficients. Fisher's exact and Mann–Whitney <i>U</i> tests were used for comparing age and laterality and sizes of the lung abscesses between both groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 21 patients, 17 (81.0%) had lung abscess detected via ultrasonography. The volumes measured by CT and ultrasonography strongly positively correlated (<i>r</i> = .948, <i>p</i> < .001). The ages in the ultrasound-detected and undetected lung abscess groups were not significantly different (60.0 ± 52.2 months [range, 2.9–141.8] vs 51.0 ± 53.4 months [range, 1.4–100.1], respectively; <i>P</i> = .462). The laterality of lung abscesses did not differ significantly between both groups (right/left: 9/8 vs 2/2, respectively; <i>P</i> > .999). The lung abscess sizes in both groups significantly differed (detected vs. undetected; 22,922.5 ± 26,657.8 mm<sup>3</sup> [range, 55.0–83599.4] vs. 1182.5 ± 1543.4 mm<sup>3</sup> [range, 9.4–3349.3], <i>P</i> = .009).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The lung abscess sizes measured by ultrasonography and CT were comparable. In patients with lung abscesses detected by ultrasonography, the effectiveness of the initial treatment of lung abscesses could be evaluated based on lesion size by ultrasonography. This finding is useful for pediatric physicians and surgeons and infection control teams to manage these pediatric patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2091-2102"},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications and Prospects of Ultrasonography in the Study of Anatomical Variations in Carpal Tunnel Syndrome","authors":"Tao Li BM, Chengqiang Jin MM, Lixia Xu MM","doi":"10.1002/jum.16767","DOIUrl":"10.1002/jum.16767","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2189-2190"},"PeriodicalIF":2.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}