Journal of Ultrasound in Medicine最新文献

{"title":"Study of Histotripsy With Subsequent Heating on In Vitro VX2 Cancer Cells","authors":"Qizheng Dai PhD,&nbsp;Lisa X. Xu PhD,&nbsp;Aili Zhang PhD,&nbsp;J. Brian Fowlkes PhD","doi":"10.1002/jum.16649","DOIUrl":"10.1002/jum.16649","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Focused ultrasound has emerged as a precise and minimally invasive modality for effective cancer treatment. In this study, we propose a novel method that integrates the mechanical effects of focused ultrasound, known as histotripsy, with heating to enhance both the immediate and sustained cytotoxic effects on cancer cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Our investigation focused on VX2 cancer cells in suspension, examining five experimental groups: blank control, negative control, heating alone, histotripsy alone, and histotripsy with subsequent heating. B-mode ultrasound imaging was utilized to visualize cavitation bubble cloud formation and its motion during histotripsy. The suspension was contained in individually sealed compartments obtained from bubble wrap (referred to as bubble wrap compartments) embedded within the agarose phantom. Residual living cells were examined immediately after treatment and cultured for 96 hours to analyze the growth patterns. Additionally, CFDA SE staining was employed to assess cell proliferation. Furthermore, both intracellular and extracellular heat shock protein 70 (HSP70) levels were measured to investigate the potential initiation of an immune response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The combination of histotripsy and subsequent heating significantly reduced the normalized concentration of living cells immediately after treatment. It also decreased the proliferation rate of residual cells compared with the other experimental groups. Histotripsy with subsequent heating also increased the generation and release of HSP70, which might potentially enhance an innate anti-tumor immune response in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Histotripsy and subsequent heating improved the immediate lethal impact on VX2 cancer cells and curtailed the proliferation of residual cancer cells in suspension. This study presents a promising strategy for cancer therapy in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"883-902"},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity of Lung Point-of-Care Ultrasound (POCUS) to Predict Oxygen Requirements in Emerging Viral Infections","authors":"Daniel L. Theodoro MD,&nbsp;Di Coneybeare MD,&nbsp;Penelope Lema MD,&nbsp;Nicholas Renz MD,&nbsp;Laura Wallace MD,&nbsp;Enyo Ablordeppey MD,&nbsp;Sean Stickles MD,&nbsp;Alek Rosenthal MD,&nbsp;Ian Holley MD,&nbsp;Sirivalli Chamarti MD,&nbsp;Josie Acuña MD,&nbsp;James Patterson MD,&nbsp;Rachel Ancona PhD,&nbsp;Srikar Adhikari MD","doi":"10.1002/jum.16647","DOIUrl":"10.1002/jum.16647","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The prognostic characteristics of lung point-of-care ultrasound (L-POCUS) to predict respiratory decompensation in patients with emerging infections remains unstudied. Our objective was to examine whether scored lung ultrasounds predict hypoxia among a nonhypoxic, ambulatory population of patients with COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a diagnostic case–control study. Three academic emergency departments across the United States collected a convenience sample of nonhypoxic subjects with COVID-19, scored subjects' hemithorax at 7 locations using lung ultrasound, and followed outcomes for 40 days. We defined cases as hypoxia (≤91% by pulse oxygenation) from 2 hours after index presentation to day 40. Follow-up was by telephone plus home pulse oximeter and by chart review. We conducted a logistic regression to test the association between L-POCUS scores and hypoxia. To evaluate lung ultrasound score prediction of a hypoxic event, we calculated sensitivity and specificity at optimal cut off scores and report receiver operating characteristic curve and area under the curve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We enrolled 163 subjects but excluded 15 (3 duplicate entries; 12 lost to follow up). Median age was 41 years (interquartile range [IQR] 31–56); 83 (56%) were female, and median body mass index was 29 (IQR 25–35). We classified 47 of 148 as hypoxic cases (32%, 95% confidence interval [CI]: 25–40), leaving 101 controls. L-POCUS scores associated with hypoxia by logistic regression (odds ratio = 1.05, 95% CI: 1.02–1.08), with a 5% increase in odds of hypoxia for each 1-unit increase in L-POCUS score. The optimal cut-off score was 15 (sensitivity, 0.60; specificity, 0.73) and the area under the curve was 0·66 (95% CI 0·58–0·75). The correctly classified proportion was 69% (95% CI: 61–76).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Among nonhypoxic COVID-19 patients, higher L-POCUS rubric scores were associated with hypoxia but no scoring threshold strongly predicts hypoxia at 40 days.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"869-881"},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Erosion of Rabbit Liver Induced by Locally Injected Phase-Shift Acoustic Droplets and With Lauromacrogol","authors":"Hui Li MS,&nbsp;Qingyue Deng MS,&nbsp;Zhiping Cai BMed,&nbsp;Qin Wang BMed,&nbsp;Leidan Huang MD,&nbsp;Yuejuan Gao MD,&nbsp;Xiaoxiao Dong MD,&nbsp;Litao Sun MD,&nbsp;Zheng Liu MD","doi":"10.1002/jum.16650","DOIUrl":"10.1002/jum.16650","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Our previous studies have found that low-frequency, low-pressure, weakly focused ultrasound (FUS) can induce acoustic droplet vaporization (ADV) of perfluoropentane (PFP) droplets and result in localized liver and prostate tissue controllable cavitation resonance and mechanical damage. To further investigate the mechanical erosion induced by ultrasound and locally injected phase-shift acoustic droplets in rabbit liver.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The liver of each rabbit was treated with perfluoromethylcyclopentane (PFMCP) alone, FUS combined with PFMCP (FUS + PFMCP), and FUS combined with PFP (FUS + PFP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two-dimensional ultrasound images showed that immediately after the completion of FUS + PFP group treatments, a high echogenicity bubble cloud could be observed, while there were no significant differences in the PFMCP and FUS + PFMCP group before and after treatment. The liver necrotic area in the FUS + PFP group was 6.2 times that of the FUS + PFMCP group (<i>P</i> &lt; .05), whereas no liver necrosis was observed in the PFMCP group. At the same time, the number of vacuoles in the liver in the FUS + PFP group was approximately 70 times that of the FUS + PFMCP group (<i>P</i> &lt; .001), whereas no vacuoles were observed in the PFMCP group (<i>P</i> &lt; .001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both FUS + PFMCP and PFMCP alone have poor mechanical erosion in liver tissue, and may even cause no damage. Only PFP droplets combined with FUS can cause significant mechanical destruction of liver tissue, leading to tissue necrosis in the droplet injection area.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"903-914"},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Carotid Artery Remodeling Characteristics and Early Carotid Atherosclerosis","authors":"Yujia Yang MD,&nbsp;Yang Hua MD,&nbsp;Lingyun Jia MD, PhD","doi":"10.1002/jum.16651","DOIUrl":"10.1002/jum.16651","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study analyzed carotid artery remodeling characteristics in early carotid atherosclerosis (ECAS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The 1021 participants were evaluated using ultrasonography and categorized into three groups: Group A, 391 participants with increased intima-media thickness (IMT); Group B, 300 participants with atherosclerotic plaque only on the carotid bulb (CB); and the control group (330 participants). The ratios of the diameters in the CB to those in the common carotid artery (<i>D</i>_CCA) and internal carotid artery (<i>D</i>_ICA) were defined as carotid index1 (CI₁) and 2 (CI₂).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Group A had a higher <i>D</i>_CCA, <i>D</i>_CB, and CI₂ than the controls (<i>P</i> &lt; .05). Group B had a smaller <i>D</i>_CB, CI₁, and CI₂ than Group A, and higher <i>D</i>_CCA and smaller CI₁ than the controls (<i>P</i> &lt; .05). Logistic regression showed that CI₂ was a positive influencing factor for increased IMT (OR: 3.42, 95% CI: 1.74–6.70, <i>P</i> &lt; .001), and CI₁ was a negative independent factor for CB plaque formation (OR: 0.11, 95% CI: 0.04–0.28, <i>P</i> &lt; .001). Multiple linear regression showed that only in Group B, the vessel side had a significant influence on CI₁ (<i>β</i> = 0.055, <i>P</i> &lt; .05), while age, sex, body mass index, and cerebrovascular risk factors had no significant correlation with CI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The CB and common carotid artery showed positive remodeling with increased IMT, however, the CB showed negative remodeling with plaque formation. CI changes were consistent with CB remodeling. CI was an independent influencing factor for ECAS, and it was only affected by vessel side, providing an objective predictive parameter for ECAS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"915-925"},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Corpus Callosum Anomalies","authors":"Valeria Lanzarone MD,&nbsp;Elisenda Eixarch MD, PhD,&nbsp;Antoni Borrell MD, PhD","doi":"10.1002/jum.16639","DOIUrl":"10.1002/jum.16639","url":null,"abstract":"<p>Anomalies of the corpus callosum (CC) are amongst the most common fetal Central Nervous System (CNS) anomalies detectable on ultrasound. Underlying genetic disease plays an important part in defining prognosis. Associations with aneuploidy and submicroscopic chromosomal deletions or duplications have been well demonstrated using chromosomal microarray analysis. Next-generation sequencing techniques such as exome sequencing, have revolutionized the ability to detect monogenic disease in these fetuses. In the context of important recent publications on exome sequencing in prenatal populations, an updated review of genetic testing options in CC anomalies is presented.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 4","pages":"637-652"},"PeriodicalIF":2.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Ventilatory Support Intensity on Respiratory Muscle Ultrasonography Evaluation","authors":"Lydia Magdy Milad MD,&nbsp;Mina Adolf Helmy MD","doi":"10.1002/jum.16648","DOIUrl":"10.1002/jum.16648","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"965"},"PeriodicalIF":2.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of O-RADS US (Version 2019 and Version 2022) Incorporating Acoustic Shadowing by Junior Radiologists","authors":"CuiYi Wu MD,&nbsp;LiHong Wu PhD,&nbsp;JianHong Shang PhD,&nbsp;HongNing Xie PhD,&nbsp;Ruan Peng PhD","doi":"10.1002/jum.16644","DOIUrl":"10.1002/jum.16644","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Acoustic shadowing is an important benign ultrasound (US) feature for adnexal masses (AMs). To validate the diagnostic performance and interobserver agreement of the 2019 version and 2022 version of Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US) and ascertain whether adding acoustic shadowing to O-RADS US v2019 as a benign ultrasound feature can enhance its diagnostic efficacy among junior radiologist.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This retrospective study included consecutive women with suspected adnexal masses who underwent ultrasound examinations between September 2022 and January 2024. One junior doctor (Reader 1, 2 years of experience) classified each AM according to the O-RADS US v2019 and the v2022. Lesions were reclassified according to the US features of acoustic shadowing based on the O-RADS US v2019: the O-RADS category was downgraded by one level with acoustic shadowing and remained unchanged without acoustic shadowing for categories 2–5. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of the two versions of O-RADS and the modified O-RADS model. Two independent junior radiologists (Reader 1 and Reader 2 with 3 years of experience) then classified the 200 AMs randomly selected for a test–retest analysis. Kappa (&lt;i&gt;к&lt;/i&gt;) statistics were used to assess the interobserver agreement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Overall, 1015 women (range, 16–86 years) with 1061 AMs were evaluated. Of the lesions, 864 (81.4%) were benign and 197 (18.6%) were malignant. The area under the ROC curve (AUC) for O-RADS v2019 and v2022 were 0.920 (95% confidence interval [CI]: 0.902, 0.936, &lt;i&gt;P&lt;/i&gt; &lt; .001) and 0.924 (95% CI: 0.906, 0.939, &lt;i&gt;P&lt;/i&gt; &lt; .001), respectively. The modified model based on O-RADS v2019 incorporating acoustic shadowing as a benign US feature showed an improved AUC of 0.934 (95% CI: 0.917, 0.948, &lt;i&gt;P&lt;/i&gt; &lt; .001). A significant difference was observed between the AUCs of the modified O-RADS and two versions of O-RADS models (&lt;i&gt;P&lt;/i&gt; &lt; .005). The inclusion of acoustic shadowing increased specificity by 5.4% in predicting malignant adnexal masses, compared with the O-RADS US v2019 with a specificity of 76.2%. Using the modified O-RADS category 4 as the optimal cut-off value for predicting malignancy showed a sensitivity, specificity, positive predictive value, and negative predictive value were 94.4% (95% CI: 90.2%, 97.2%), 81.6% (95% CI: 78.8%, 84.1%), 53.9% (95% CI: 50.3%, 57.5%), and 98.5% (95% CI: 97.3%, 99.1%), respectively. The inter-observer agreement in the O-RADS category between these two junior radiologists was good (&lt;i&gt;κ&lt;/i&gt; = 0.74, &lt;i&gt;P&lt;/i&gt; &l","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"845-855"},"PeriodicalIF":2.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Atrial Size, Shape, and Contractility in Growth-Restricted and Small-for-Gestational-Age Fetuses","authors":"Greggory R. DeVore MD,&nbsp;Manesha Putra MD,&nbsp;John C. Hobbins MD","doi":"10.1002/jum.16642","DOIUrl":"10.1002/jum.16642","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The size, shape, and contractility of the heart's atrial chambers have not been evaluated in fetuses with growth restriction (FGR) or who are small-for-gestational-age (SGA) as defined by the Delphi consensus protocol. This study aimed to examine the atrial chambers using speckle tracking analysis to identify any changes that may be specific for either growth disturbance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-three fetuses were evaluated with an estimated fetal weight &lt;10th percentile who were classified as FGR or SGA based on the Delphi consensus protocol. The atrial cardiac cycle was defined as end-diastole, end-systole, and end-diastole, equivalent to ventricular end-systole, end-diastole, and end-systole. The atrial size, shape, and contractility were computed from 24 transverse segments and one length measurement identified from speckle tracking analysis of the endocardium at end-diastole and end-systole. The <i>z</i>-score for each atrial measurement was computed using the mean and standard deviation equations from a control group of 200 fetuses. The <i>z</i>-score values were compared between the control and FGR/SGA fetuses as well as between FGR and SGA fetuses using the Kruskal–Wallis test. A <i>P</i>-value of &lt;.05 was considered significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 63 fetuses with an estimated fetal weight (EFW) &lt;10th percentile, 60% (38/63) were classified as FGR and 40% (25/63) as SGA. The following abnormal atrial measurements were unique to FGR fetuses: decreased end-diastolic left atrial (LA) area, decreased LA base and mid-chamber end-diastolic width, decreased LA base sphericity index, decreased right atrial (RA) mid-chamber sphericity index, decreased LA ejection volume, and decreased LA emptying volume. The following were unique to the SGA fetuses: Increased RA mid-chamber length, decreased LA fractional area change, decreased RA reservoir strain, decreased RA basal-apical length fractional shortening, and decreased LA base width transverse fractional shortening. The significant difference was an increased LA mid-chamber length in the SGA fetuses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fetuses with an EFW &lt;10th percentile who are classified as either SGA or FGR demonstrate unique abnormalities of atrial size, shape, and contractility, thus allowing the examiner to differentiate between FGR and SGA fetuses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"831-843"},"PeriodicalIF":2.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We Should Perform a Systematic Evaluation of the Placenta","authors":"Edgar Hernandez-Andrade MD,&nbsp;Donatella Gerulewicz MD,&nbsp;Eleazar Soto-Torres MD,&nbsp;Farah H. Amro MD,&nbsp;Yinka Oyelese MD,&nbsp;Ramesha Papanna MD,&nbsp;Baha M. Sibai MD,&nbsp;Sean C. Blackwell MD","doi":"10.1002/jum.16645","DOIUrl":"10.1002/jum.16645","url":null,"abstract":"<p>Despite its critical importance, the placenta receives substantially less attention during obstetric ultrasound examinations compared to the fetus. The evaluation of the placenta is typically limited to determining its location within the uterus, particularly its relationship to the cervix. Abnormal placenta findings are the result of gross anomalies identified by chance during obstetric examinations, rather than from a systematic evaluation. Here we describe a standardized protocol evaluating four placental regions: 1) the uterine wall/decidua/chorion interface; 2) the amnion/chorion interface; 3) the placental body; and 4) cord insertion and marginal area, which can improve the identification of placental anomalies in all pregnant subjects.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"955-964"},"PeriodicalIF":2.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear Wave Elastography in AV Fistula Thrombosis","authors":"Ali Dablan MD,&nbsp;Merve Şam Özdemir MD,&nbsp;Mehmet Karagülle MD,&nbsp;Ömer Altun MD,&nbsp;Mehmet Cingöz MD,&nbsp;Mustafa Fatih Arslan MD","doi":"10.1002/jum.16643","DOIUrl":"10.1002/jum.16643","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the role of shear wave elastography (SWE) in distinguishing acute from subacute thrombi in thrombosed arteriovenous fistulas (AVFs) and explore the relationship between thrombus stiffness and outcomes of balloon angioplasty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective study included 44 dialysis patients with thrombosed AVFs from June 2022 to June 2024. Patients underwent Doppler ultrasound and SWE to assess thrombus age, followed by balloon angioplasty. Based on ultrasound findings and clinical history, patients were classified into acute and subacute thrombus groups. SWE was used to measure thrombus stiffness (kPa values). Procedural outcomes, including technical and clinical success, and primary and secondary patency, were compared between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 23 patients with acute and 21 with subacute thrombus. SWE measurements (average, median, and maximum kPa) were significantly higher in subacute thrombi (<i>P</i> &lt; .001). A strong positive correlation existed between thrombus age and kPa values (<i>r</i> = .770, <i>r</i> = .727, <i>r</i> = .835). Receiver operating characteristic analysis showed SWE could effectively distinguish acute from subacute thrombi, with an average cut-off of 31.733 kPa (sensitivity: 90.5%, specificity: 73.9%). No significant correlation was found between SWE values and procedural outcomes (<i>P</i> &gt; .05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SWE is a promising tool for assessing thrombus age in AVF thrombosis, effectively differentiating between acute and subacute thrombi. Although it did not predict procedural success, SWE could complement existing imaging for improved thrombus characterization and treatment planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 5","pages":"795-806"},"PeriodicalIF":2.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}