Journal of Ultrasound in Medicine最新文献

{"title":"Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy for Primary Breast Cancer Comparing Interim Shear Wave Elastography Versus Magnetic Resonance Imaging","authors":"Alessandro Garlaschi MD,&nbsp;Nicole Brunetti MD,&nbsp;Simona Tosto MD,&nbsp;Licia Gristina MD,&nbsp;Piero Fregatti MD,&nbsp;Massimo Calabrese MD,&nbsp;Alberto Stefano Tagliafico MD","doi":"10.1002/jum.16765","DOIUrl":"10.1002/jum.16765","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The prediction of pathological complete response (pCR) of primary breast cancer to neoadjuvant chemotherapy (NAC) is crucial for guiding surgical decisions.</p>\u0000 \u0000 <p>This study examined the effectiveness of shear wave elastography (SWE) compared with magnetic resonance imaging (MRI) in predicting the response to NAC in patients with breast lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective, single-center observational study enrolled 110 patients diagnosed with BC who received NAC from January 2022 to May 2024. All patients underwent breast MRI, US, and SWE both at baseline and after treatment.</p>\u0000 \u0000 <p>The treatment response was evaluated using the Miller–Payne (MP) classification, which assigns a score from G1 (no response) to G5 (complete response, absence of malignant cells).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that 43.64% (48/110) of patients achieved a pathological complete response (pCR), while 56.36% (62/110) had a partial response (NpCR). Tissue stiffness analysis using SWE revealed a significant reduction in stiffness, with an average decrease of 10 kPa in more than 50% of patients. Thresholds of 10, 20, 30, and 50 kPa were evaluated to assess their predictive value for pCR. All thresholds demonstrated statistically significant discriminative power (<i>P</i> &lt; .0001), with AUCs of 0.675 (Se 51.6%, Sp 83.3%), 0.751 (Se 70.97%, Sp 79.17%), 0.749 (Se 79.03%, Sp 70.83%) and 0.677 (Se 85.5%, Sp 50.0%), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The Shear Wave Elastography system, which measures tissue stiffness through the speed of shear wave propagation, has proven to be a promising method for monitoring the response to chemotherapy, providing quantitative information that can complement other diagnostic methods such as magnetic resonance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2123-2131"},"PeriodicalIF":2.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “GPT-4o and Specialized AI in Breast Ultrasound Imaging: A Comparative Study on Accuracy, Agreement, Limitations, and Diagnostic Potential”","authors":"Hinpetch Daungsupawong PhD,&nbsp;Viroj Wiwanitkit MD","doi":"10.1002/jum.16768","DOIUrl":"10.1002/jum.16768","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Pulmonary Arterial Elasticity and Ventricular Function in Fetuses With Tetralogy of Fallot","authors":"Yushan Liu MD,&nbsp;Dan Zhou MD,&nbsp;Yang Yang MD,&nbsp;Dan Liu MD,&nbsp;Ganqiong Xu MD,&nbsp;Shi Zeng MD","doi":"10.1002/jum.16740","DOIUrl":"10.1002/jum.16740","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the elasticity of the main pulmonary artery (MPA) and its branches in fetuses with tetralogy of Fallot (TOF) with that of normal fetuses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective study of 42 fetuses with TOF and 84 controls was conducted. The minimum vascular internal diameter in the diastolic period (Dmin) and the maximum diameter in the systolic period (Dmax) of the pulmonary trunk and its branches were measured via M-mode echocardiography. The strain of the MPA, mid-left pulmonary artery (MLPA) and mid-right pulmonary artery (MRPA) was calculated through the formula 100 × (Dmax − Dmin)/Dmin. Correlations between the strain of the pulmonary artery and ventricular function were evaluated in all fetuses with TOF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The strain of the MPA in fetuses with TOF was significantly lower than that in controls (<i>P</i> &lt; .05). Moreover, the strain of the MPA in fetuses with severe TOF was significantly lower than that in fetuses with mild to moderate TOF (<i>P</i> &lt; .05). The systolic and diastolic functions of the right ventricle (RV) are impaired in fetuses with TOF. The isovolumic relaxation time (IRT) and myocardial performance index (MPI) of RV were negatively correlated with the strain of the MPA (<i>r</i> = −0.452 and −0.261, all <i>P</i> &lt; .05), whereas the ejection time (ET) of RV (<i>r</i> = 0.286, <i>P</i> &lt; .05) was positively correlated with the strain of the MPA in fetuses with TOF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The strain of the MPA was obviously decreased in fetuses with TOF during the second and third trimesters of pregnancy. The systolic and diastolic functions of the RV were impaired in fetuses with TOF. The impaired strain of the MPA was correlated with RV function in fetuses with TOF.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 10","pages":"1871-1881"},"PeriodicalIF":2.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Characteristics of Persistent Carotid-Vertebrobasilar Anastomoses Detected by Ultrasound","authors":"Xiang Li MD,&nbsp;Qiuping Li MD,&nbsp;Liyong Du MD,&nbsp;Yumeng Luo MD,&nbsp;Jie Yang MD,&nbsp;Tieying Zhang MD,&nbsp;Jiabin Liu MD","doi":"10.1002/jum.16762","DOIUrl":"10.1002/jum.16762","url":null,"abstract":"<p>In this case series, we aimed to evaluate the ultrasonic characteristics of 35 patients with persistent carotid-vertebrobasilar anastomoses (PCVBA), a rare variant between the anterior and posterior cerebral circulation. Ultrasound detected seven (30.4%, 7/23) primitive trigeminal arteries (PTA), eight (100%, 8/8) primitive hypoglossal arteries (PHA), and four (100%, 4/4) proatlantal intersegmental arteries (PIA). PHA and PIA can be observed as abnormal branches arising from the internal or external carotid artery, most likely accompanied by hypoplastic vertebral arteries with low velocities and high resistances. Still, the basilar arteries had normal blood flows in stark contrast to the vertebral arteries.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2157-2169"},"PeriodicalIF":2.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Median Nerve and Carpal Tunnel Variations","authors":"Enes Gurun MD,&nbsp;Mesut Ozturk MD,&nbsp;Atiye Cenay Karabork Kilic MD,&nbsp;Ahmet Emin Okutan MD","doi":"10.1002/jum.16766","DOIUrl":"10.1002/jum.16766","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2187-2188"},"PeriodicalIF":2.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Institutional Survey of 4-Year Ultrasound Quality Control Findings","authors":"Zaiyang Long PhD,&nbsp;Megan Russ PhD,&nbsp;Sandra Larson PhD,&nbsp;Mark R. Holland PhD,&nbsp;Zheng-Feng Lu PhD,&nbsp;Cameron Kofler PhD,&nbsp;Wei Zhou PhD,&nbsp;Jian-Feng Chen PhD,&nbsp;Zhimin Li PhD,&nbsp;James Zagzebski PhD,&nbsp;Jennifer Stickel PhD,&nbsp;Andreea Dohatcu PhD","doi":"10.1002/jum.16763","DOIUrl":"10.1002/jum.16763","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Periodic quality control (QC) testing of ultrasound (US) imaging systems is essential to ensure and maintain image quality and safety. The study aims to analyze QC findings from medical physics annual surveys of modern clinical US systems in a multi-institutional survey.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>QC results from annual surveys between 2018 and 2021 were retrospectively collected from 12 medical physicists from 11 institutions or consulting companies (hereafter referred to as sites). QC tests were classified as scanner- and transducer-related tests, where scanner-related tests also included evaluation of diagnostic workstation display monitors and routine QC programs if applicable. Test methodology and pass/fail criteria were established by each site. QC findings were defined as results requiring follow-up action by service engineers, vendors, or other personnel. The percentage of annual findings was calculated for each site and averaged across the years of data contributed. Furthermore, findings across all sites were aggregated for an overall analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>QC data from a total of 1069 scanner tests and 4542 transducer tests were collected. The average annual percentage of scanner-related findings varied from 0 to 40.8% among all sites (first quartile 8.7%, median 18.2%, and third quartile 34.1%), while that of transducer-related findings ranged between 0.5% and 19.9% (first quartile 3.9%, median 7.2%, and third quartile 14.5%). For scanner-related tests, the top 3 categories of findings were associated with physical and mechanical integrity (171 findings, 74.7%), quantitative testing of the scanner display monitor (40 findings, 17.5%), and scanner port creating artifacts (10 findings, 4.4%). The top 3 findings for transducers related to uniformity and artifact (227 findings, 79.9%), physical and mechanical integrity (44 findings, 15.5%), and sensitivity in fundamental mode (9 findings, 3.2%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Medical physics annual surveys revealed considerable actionable findings of modern US systems, which inform the status of current US QC practices in the United States and may guide future standardization and recommendation of QC tests.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2103-2111"},"PeriodicalIF":2.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Probe Pressure on Appendix Visualization in Pediatric Sonography","authors":"Rayan A. Ahyad MBBS, SBR","doi":"10.1002/jum.16757","DOIUrl":"10.1002/jum.16757","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the influence of ultrasound probe pressure on the visualization of the appendix sonographically.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pediatric outpatients undergoing routine renal ultrasound (US) were approached for additional images using a standardized imaging protocol. The movement of the normal appendix (base and distal parts) was documented while applying probe pressure. The minimum pressure required for appendix identification and the maximum pressure required to elicit movement out of the field-of-view were recorded using a force sensor. Skin thickness was measured at baseline, at first appendix identification, and at maximal pressure. Appendiceal locations and peri-appendicular findings were also recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-six US scans were included in the final analysis. The appendix was identified in all scans. Movement out of the field-of-view was documented in 30 scans, of which 12 showed movement of the entire appendix, 11 of the distal appendix, and seven of the appendicular base only. The mean pressure was lower when the appendix was identified than when its base and distal part moved out of the field-of-view. The mean skin thickness was comparable. Neither pressure nor skin thickness showed a statistically significant correlation with appendix movement out of the field-of-view.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite no statistically significant correlation between the applied pressure and the appendiceal movement, since all the appendices were identified with less pressure than the pressure needed to displace most of them out of the field-of-view, it is possible that the non-visualization of the appendix is attributed to the displacement of the organ due to excessive sonographic pressure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2055-2065"},"PeriodicalIF":2.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corpus Callosum to Choroid Plexus Distance for the Prenatal Diagnosis of Partial Agenesis or Hypoplasia of the Corpus Callosum","authors":"Veronica Stanislao MD,&nbsp;Giuseppe Rizzo MD, PhD,&nbsp;Gianpaolo Grisolia MD,&nbsp;Ricciarda Raffaelli MD, PhD,&nbsp;Maurizio Arduini MD,&nbsp;Alessia Pinto MD,&nbsp;Ilenia Mappa MD,&nbsp;Marlene Pisello MD,&nbsp;Chiara Patelli MD,&nbsp;Benedetto Mazzucca MD,&nbsp;Barbara Matarrelli MD,&nbsp;Asma Khalil MD,&nbsp;Giorgio Pagani MD,&nbsp;Alessandro Lucidi MD,&nbsp;Federico Prefumo MD, PhD,&nbsp;Francesco D'Antonio MD, PhD","doi":"10.1002/jum.16760","DOIUrl":"10.1002/jum.16760","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Prenatal diagnosis of partial agenesis (pACC) or hypoplasia of the corpus callosum (CC) is hindered by the lack of objective and reproducible ultrasound signs. The aim of this study was to report the role of a new ultrasound sign, the distance between the choroid plexus (CP) of the third ventricle and the distal part of the CC, in identifying fetuses with partial agenesis (pACC) or hypoplasia of CC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Retrospective multicenter case–control study including fetuses with pACC or hypoplasia of the CC confirmed at post-natal imaging or autopsy. The distance between the CP of the third ventricle and its ratio with the length of the CC were compared with unaffected cases on stored images assessed by 2 different examiners. Intraclass correlation, Bland–Altman, univariate, and multivariate logistic regression analyses were used to analyze the data.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;One hundred and four (29 with pACC or hypoplasia of the CC and 75 controls) were included in the analysis. At univariate analysis, fetuses with pACC or hypoplasia had a larger transverse diameter (3.9 ± 0.7 versus 5.3 ± 1.6 mm; &lt;i&gt;P&lt;/i&gt; &lt; .001) and an increased area (31.6 ± 8.8 versus 41.6 ± 15.6 mm&lt;sup&gt;2&lt;/sup&gt;; &lt;i&gt;P&lt;/i&gt; &lt; .001) of the CSP compared to unaffected cases. Fetuses with pACC or hypoplasia of the CC had a shorter distance between the CP of the third ventricle and the distal part of the CC (1.6 ± 0.9 versus 8.4 ± 1.8; &lt;i&gt;P&lt;/i&gt; &lt; .001) and a higher ratio between the length of the CC and the distance between the CP of the third ventricle and the CC (13.5 ± 9.3 versus 2.6 ± 0.5; &lt;i&gt;P&lt;/i&gt; &lt; .001) compared to controls. At multivariate logistic regression analysis, the distance between the CP and the CC (OR: 0.67, 95% CI 0.5–0.7, per 1 mm increase; &lt;i&gt;P&lt;/i&gt; &lt; .001) and the ratio between the CC length and the distance between the CP and the CC (OR: 1.4, 95% CI 1.0–1.6; per 1 mm increase; &lt;i&gt;P&lt;/i&gt; &lt; .001) were independently associated with pACC or hypoplasia of the CC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fetuses with pACC or hypoplasia of the CC had a shorter distance between the distal part of the CC and the CP of the third ventricle and a higher ratio of this measurement with the length of the CC. Further prospective study aimed at longitudinally evaluate the relationship between the CC and the CP of the third ventricle are needed to confirm these findings and to elucidate whether these measurements can be integrated in the diagnostic algorithm applied to fetuses with suspected pACC or hypoplasia of the CC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2079-2087"},"PeriodicalIF":2.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ultrasonography Characteristics of Borderline Ovarian Tumor Subtypes","authors":"Roni Yoeli-Bik MD,&nbsp;Ernst Lengyel MD, PhD,&nbsp;Ilan E. Timor-Tritsch MD,&nbsp;Katherine Kurnit MD,&nbsp;Serghei Puiu MD, PhD,&nbsp;Ryan E. Longman MD,&nbsp;Jacques S. Abramowicz MD","doi":"10.1002/jum.16756","DOIUrl":"10.1002/jum.16756","url":null,"abstract":"&lt;p&gt;Approximately 15% of all epithelial ovarian tumors are classified as borderline.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; These tumors harbor malignant histological features but do not invade the stroma and, therefore, have a more clinically indolent course than invasive ovarian cancers.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; The incidence of borderline ovarian tumors varies between 1.8 and 4.8 out of 100,000 women per year.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Borderline ovarian tumors (BOTs) are a heterogeneous group that can be further sub-classified into several subtypes, with serous and mucinous being the most prevalent. Serous BOTs are more commonly diagnosed in North America, Europe, and the Middle East, whereas mucinous BOTs are more frequent in East Asia.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Seromucinous, endometrioid, clear cell, and Brenner BOTs are rare, accounting for &lt;5% of all BOT cases.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;BOTs are often diagnosed more than a decade earlier than invasive epithelial ovarian cancers,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; and a third of the patients are younger than 40 years.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; The symptoms associated with the tumors are vague and non-specific, such as abdominal pain and distention or possible torsion.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Almost a third of patients are asymptomatic at the time of initial diagnosis.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Accurate and reliable preoperative diagnostic methods that can differentiate between benign, borderline, and malignant adnexal lesions are needed to help guide effective management. Patients with adnexal masses suspected to be malignant on imaging require prompt referral to gynecologic oncologists in centers of medical excellence for improved outcomes.&lt;span&gt;&lt;sup&gt;8&lt;/sup&gt;&lt;/span&gt; In contrast, presumed benign lesions in asymptomatic patients can be conservatively managed.&lt;span&gt;&lt;sup&gt;8&lt;/sup&gt;&lt;/span&gt; Developing and refining such noninvasive imaging methods is challenging due to the high prevalence of benign adnexal masses, the rarity of BOTs and invasive ovarian carcinomas and their non-specific clinical presentation, and how often the imaging features of different tumor subtypes overlap. Ultrasonography (US) remains the most important and available imaging modality for the initial characterization and risk stratification of adnexal lesions.&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; Despite studies that have aimed to delineate unique sonographic appearances of BOTs,&lt;span&gt;&lt;sup&gt;10-15&lt;/sup&gt;&lt;/span&gt; ultrasound-based diagnoses are confirmed postoperatively in only 29–69% of cases.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; A meta-analysis found a mean sensitivity of 66% and a mean specificity of 85% for diagnosing a BOT on ultrasound imaging,&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt; emphasizing the great challenge of correct diagnosis. Even in the hands of expert ultrasound examiners, the correct classification of BOTs by pattern recognition was reported to have variable efficacy. In one study, only 44% of BOTs were correctly identified, compared with benign lesions (76%) and m","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"2133-2146"},"PeriodicalIF":2.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Radio Frequency Time Series for Tissue Typing","authors":"Mahsa Arab PhD,&nbsp;Ali Fallah PhD,&nbsp;Saeid Rashidi PhD,&nbsp;Maryam Mehdizadeh Dastjerdi PhD,&nbsp;Nasrin Ahmadinejad MD","doi":"10.1002/jum.16745","DOIUrl":"10.1002/jum.16745","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>One of the most promising auxiliaries for screening breast cancer (BC) is ultrasound (US) radio-frequency (RF) time series. It has the superiority of not requiring any supplementary equipment over other methods. This article sought to propound a machine learning (ML) method for the automated categorization of breast lesions—categorized as benign, probably benign, suspicious, or malignant—using features extracted from the accumulated US RF time series.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this research, 220 data points of the categories as mentioned earlier, recorded from 118 patients, were analyzed. The RFTSBU dataset was registered by a SuperSonic Imagine Aixplorer® medical/research system fitted with a linear transducer. The expert radiologist manually selected regions of interest (ROIs) in B-mode images before extracting 283 features from each ROI in the ML approach, utilizing textural features such as Gabor filter (GF), gray-level co-occurrence matrix (GLCM), gray-level run-length matrix (GLRLM), gray-level size zone matrix (GLSZM), and gray-level dependence matrix (GLDM). Subsequently, the particle swarm optimization (PSO) narrowed the features to 131 highly effective ones. Ultimately, the features underwent classification using an innovative multi-origin method classification (MOMC), marking a significant leap in BC diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Employing 5-fold cross-validation, the study achieved notable accuracy rates of 98.57 ± 1.09%, 91.53 ± 0.89%, and 83.71 ± 1.30% for 2-, 3-, and 4-class classifications, respectively, using MOMC-SVM and MOMC-ensemble classifiers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This research introduces an innovative ML-based approach to differentiate between diverse breast lesion types using in vivo US RF time series data. The findings underscore its efficacy in enhancing classification accuracy, promising significant strides in computer-aided diagnosis (CAD) for BC screening.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 11","pages":"1957-1973"},"PeriodicalIF":2.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}