Impaired Pulmonary Arterial Elasticity and Ventricular Function in Fetuses With Tetralogy of Fallot

IF 2.4 4区医学 Q2 ACOUSTICS

Journal of Ultrasound in Medicine Pub Date : 2025-07-05 DOI:10.1002/jum.16740

Yushan Liu MD, Dan Zhou MD, Yang Yang MD, Dan Liu MD, Ganqiong Xu MD, Shi Zeng MD

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引用次数: 0

Abstract

Objective

To compare the elasticity of the main pulmonary artery (MPA) and its branches in fetuses with tetralogy of Fallot (TOF) with that of normal fetuses.

Methods

A prospective study of 42 fetuses with TOF and 84 controls was conducted. The minimum vascular internal diameter in the diastolic period (Dmin) and the maximum diameter in the systolic period (Dmax) of the pulmonary trunk and its branches were measured via M-mode echocardiography. The strain of the MPA, mid-left pulmonary artery (MLPA) and mid-right pulmonary artery (MRPA) was calculated through the formula 100 × (Dmax − Dmin)/Dmin. Correlations between the strain of the pulmonary artery and ventricular function were evaluated in all fetuses with TOF.

Results

The strain of the MPA in fetuses with TOF was significantly lower than that in controls (P < .05). Moreover, the strain of the MPA in fetuses with severe TOF was significantly lower than that in fetuses with mild to moderate TOF (P < .05). The systolic and diastolic functions of the right ventricle (RV) are impaired in fetuses with TOF. The isovolumic relaxation time (IRT) and myocardial performance index (MPI) of RV were negatively correlated with the strain of the MPA (r = −0.452 and −0.261, all P < .05), whereas the ejection time (ET) of RV (r = 0.286, P < .05) was positively correlated with the strain of the MPA in fetuses with TOF.

Conclusion

The strain of the MPA was obviously decreased in fetuses with TOF during the second and third trimesters of pregnancy. The systolic and diastolic functions of the RV were impaired in fetuses with TOF. The impaired strain of the MPA was correlated with RV function in fetuses with TOF.

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法洛四联症胎儿肺动脉弹性和心室功能受损。

目的：比较法洛四联症（TOF）胎儿与正常胎儿肺动脉主动脉（MPA）及其分支的弹性。方法：对42例TOF胎儿和84例对照组进行前瞻性研究。m型超声心动图测量肺动脉干及其分支舒张期最小血管内径（Dmin）和收缩期最大血管内径（Dmax）。MPA、左中肺动脉（MLPA）和右中肺动脉（MRPA）的应变通过公式100 × (Dmax - Dmin)/Dmin计算。在所有TOF胎儿中评估肺动脉应变与心室功能之间的相关性。结果：TOF胎儿的MPA菌株明显低于对照组(P结论：TOF胎儿在妊娠中晚期MPA菌株明显降低。TOF胎儿右心室收缩和舒张功能受损。TOF胎儿的MPA应变受损与RV功能相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ultrasound in Medicine 医学-核医学

CiteScore

5.10

自引率

4.30%

发文量

205

审稿时长

1.5 months

期刊介绍： The Journal of Ultrasound in Medicine (JUM) is dedicated to the rapid, accurate publication of original articles dealing with all aspects of medical ultrasound, particularly its direct application to patient care but also relevant basic science, advances in instrumentation, and biological effects. The journal is an official publication of the American Institute of Ultrasound in Medicine and publishes articles in a variety of categories, including Original Research papers, Review Articles, Pictorial Essays, Technical Innovations, Case Series, Letters to the Editor, and more, from an international bevy of countries in a continual effort to showcase and promote advances in the ultrasound community. Represented through these efforts are a wide variety of disciplines of ultrasound, including, but not limited to: -Basic Science- Breast Ultrasound- Contrast-Enhanced Ultrasound- Dermatology- Echocardiography- Elastography- Emergency Medicine- Fetal Echocardiography- Gastrointestinal Ultrasound- General and Abdominal Ultrasound- Genitourinary Ultrasound- Gynecologic Ultrasound- Head and Neck Ultrasound- High Frequency Clinical and Preclinical Imaging- Interventional-Intraoperative Ultrasound- Musculoskeletal Ultrasound- Neurosonology- Obstetric Ultrasound- Ophthalmologic Ultrasound- Pediatric Ultrasound- Point-of-Care Ultrasound- Public Policy- Superficial Structures- Therapeutic Ultrasound- Ultrasound Education- Ultrasound in Global Health- Urologic Ultrasound- Vascular Ultrasound