Journal of Ultrasound in Medicine最新文献

{"title":"Beyond Risk Stratification: Can Muscle Ultrasound Echo Intensity Monitor Skeletal Muscle Quality During Weight-Loss Therapy?","authors":"Qian He, Yan Li, Liwei Wu, Xiaoju Li, Yingxu Li, Juanjuan Zhou, Tianxi Liu","doi":"10.1002/jum.70467","DOIUrl":"https://doi.org/10.1002/jum.70467","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening the Evaluation of Handheld Ultrasound Devices for Lung Ultrasound in Pneumonia.","authors":"Syeda Kashaf Batool Zaidi, Laiba Azeem, Iflah Noor","doi":"10.1002/jum.70521","DOIUrl":"https://doi.org/10.1002/jum.70521","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Additive Models to Adaptive Multimodal Learning for Thyroid Nodules in Hashimoto's Thyroiditis.","authors":"Kaijian Yang","doi":"10.1002/jum.70518","DOIUrl":"https://doi.org/10.1002/jum.70518","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the Clinical Indication for Real-Time Artificial Intelligence-Assisted Ultrasound in Breast Lesions with Low Suspicion of Malignancy.","authors":"Jeeyeon Lee, Bora Yang, Won Hwa Kim, Jaeil Kim, Ho Yong Park, Byeongju Kang, Joon Suk Moon, Hai Lin Park","doi":"10.1002/jum.70439","DOIUrl":"https://doi.org/10.1002/jum.70439","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate whether real-time artificial intelligence (AI) breast ultrasound (US) can identify a subgroup of breast imaging reporting and data system (BI-RADS) category 4A lesions without suspicious mammographic (MMG) findings in whom unnecessary biopsy may be safely avoided.</p><p><strong>Methods: </strong>This retrospective analysis of single-center biopsy registry included 641 consecutive US BI-RADS 4A lesions that underwent vacuum-assisted breast biopsy. Before conducting biopsy, the lesions were reassessed using a real-time AI US system (CadAI-B®), and MMG findings were classified as suspicious or non-suspicious based on formal reports. Seven prespecified biopsy-decision strategies were evaluated, including 3 AI-only strategies, 3 mammography-gated AI strategies, and the current standard strategy of biopsy all BI-RADS 4A lesions. The primary outcomes were biopsy reduction rate, missed cancers, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy, with final pathology as the reference standard.</p><p><strong>Results: </strong>Among 641 cases of US BI-RADS 4A lesions, 26 cases of malignancies (4.1%) were identified, including 14 cases of ductal carcinoma in situ (DCIS), 11 cases of invasive ductal carcinomas, and 1 case of apocrine carcinoma. AI reassigned 289 cases of lesions (45.1%) to BI-RADS categories 1-3. AI-only biopsy-deferral strategies missed 30.8% and 38.5% of malignancies when biopsy was deferred for AI BI-RADS ≤2 and ≤3 lesions, respectively, with DCIS accounting for most missed cancers. In contrast, among lesions without suspicious MMG findings, no malignancies were observed in AI BI-RADS 1-3 lesions. The sequential strategy of deferring biopsy only for lesions with AI BI-RADS ≤3 and non-suspicious MMG findings reduced biopsies by 43.5% (279/641) while maintaining 100.0% sensitivity (95% CI, 87.1-100.0%) and increasing specificity to 45.4% (95% CI, 41.4-49.4%).</p><p><strong>Conclusion: </strong>Real-time AI breast US alone could not safely support biopsy deferral in US BI-RADS 4A lesions. However, after suspicious MMG findings had been excluded, AI identified a low-risk subgroup in whom unnecessary biopsy could be substantially reduced without compromising cancer detection. These findings suggest that the clinical utility of real-time AI breast US lies in patients without suspicious MMG findings. Prospective multicenter validation is warranted before clinical implementation.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting Detection, Genetic Yield, and Pregnancy Outcomes in Prenatal Cleft Lip and Palate.","authors":"Saman Naz, Muhammad Safwan, Abdihamid Hirsi Abdulle","doi":"10.1002/jum.70519","DOIUrl":"https://doi.org/10.1002/jum.70519","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Intensity Pulsed Ultrasound Prevents Hypoxia-Induced Skeletal Muscle Atrophy in Association with HIF-1α Suppression.","authors":"Sufang Kang, Wenkang Yan, Yanan Yu, Wanzhao Wang, Xiushan Fan, Lijun Sun, Liang Tang, Dean Ta","doi":"10.1002/jum.70489","DOIUrl":"https://doi.org/10.1002/jum.70489","url":null,"abstract":"<p><strong>Objectives: </strong>Hypoxia is a known contributor to muscle atrophy. While low-intensity pulsed ultrasound (LIPUS) has been shown to promote myogenic cell proliferation and differentiation, its effect on hypoxia-induced muscle atrophy remains unclear. This study aimed to investigate whether LIPUS can alleviate hypoxia-induced muscle atrophy and to elucidate the underlying molecular mechanisms.</p><p><strong>Methods: </strong>In vitro, C2C12 myoblasts were exposed to chemical hypoxia (CoCl₂) and treated with LIPUS at varying intensities to determine the optimal parameter. In vivo, mice were housed in a 10% hypoxic chamber and received 30 mW/cm² LIPUS irradiation on quadriceps (anterior thigh) and the triceps surae (posterior calf muscles). Muscle mass, cross-sectional area, strength, and molecular markers (HIF-1α, MSTN, AKT/mTOR, mitochondrial dynamics) were assessed. Pharmacologic inhibition of HIF-1α was used to verify its regulatory role in MSTN expression.</p><p><strong>Results: </strong>LIPUS at 30 mW/cm² was identified as the most effective intensity for reversing chemical hypoxia induced inhibition of myoblast proliferation. In physically hypoxic mice, LIPUS significantly attenuated the reduction in muscle fiber cross-sectional area, muscle mass, and strength. Mechanistically, LIPUS suppressed HIF-1α and MSTN expression, reduced mitochondrial fission proteins while increasing fusion proteins, and upregulated the AKT/mTOR anabolic pathway. In vitro, graded inhibition of HIF-1α led to a corresponding reduction in MSTN expression. Notably, correlation analysis revealed a significant positive association between HIF-1α and MSTN protein levels, further supporting their correlative relationship under chemically hypoxic conditions.</p><p><strong>Conclusions: </strong>LIPUS ameliorates hypoxia-induced muscle atrophy, along with the downregulation of HIF-1α, which coordinately regulates mitochondrial dynamics-related proteins and the AKT/mTOR pathway. These findings provide experimental evidence for LIPUS as a potential noninvasive physical therapy for hypoxia-related muscle atrophy.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbubble Timing and Vascular Geometry Are Associated With Vessel-Level Blood-Brain Barrier Opening During Focused Ultrasound.","authors":"Seongdong Park, Hyemin Lee, Seunghwan Choi, Juyoung Park, Sun Kwang Kim, Kisoo Kim","doi":"10.1002/jum.70511","DOIUrl":"https://doi.org/10.1002/jum.70511","url":null,"abstract":"<p><strong>Objectives: </strong>To examine whether minute-scale microbubble handling and injection-to-sonication timing are associated with vessel-level focused ultrasound (FUS)-mediated blood-brain barrier opening (BBBO), and whether control normalization improves longitudinal 2-photon (2P) measurements.</p><p><strong>Methods: </strong>Cranial-windowed mice received FITC-dextran (40 kDa) and SonoVue microbubbles by retro-orbital injection, followed by 1.0 MHz FUS at 0.2-0.4 MPa. Two-photon stacks were acquired over 0-15 minutes. Frangi vesselness and Otsu thresholding defined vessel masks and a perivascular ring for extravasation analysis. Three timing conditions were compared: standard (injection within ~5 seconds of reconstitution, sonication immediately); Microbubble Floating (microbubbles held 2 minutes before injection); and Sonication Delay (sonication started 2 minutes after injection). Per-mouse AUC used 2-way ANOVA; slice-level vessel-area dependence used a linear mixed-effects model with mouse as a random intercept.</p><p><strong>Results: </strong>Control intravascular fluorescence decreased by ~24% over 15 minutes, showing that the intravascular signal is not a stable denominator; control-normalized extravascular AUC was therefore the primary metric. Under the standard protocol, extravascular AUC peaked at 0.3 MPa, but the across-pressure difference was not significant (F(2,6) = 3.36, p = .105). Timing effects were descriptive: relative to standard, both Microbubble Floating and Sonication Delay increased extravascular AUC at 0.2 MPa but decreased it at 0.3 MPa. Vessel area was inversely associated with extravasation at the slice level (β = -0.37 per μm², p = .010), with mouse-level intraclass correlation (ICC = 0.80) indicating dominant between-mouse variability.</p><p><strong>Conclusions: </strong>Microbubble handling and injection-to-sonication timing are potential protocol variables in FUS-BBBO studies. Control-normalized extravascular metrics provide a reproducible framework for vessel-level longitudinal 2-photon quantification.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Applicability Considerations in Ultrasound-Based Machine Learning Models for BI-RADS 4A Lesions","authors":"Qingmin Wang PhD,&nbsp;Fan Wang Master student,&nbsp;Fei Huang PhD candidate","doi":"10.1002/jum.70282","DOIUrl":"10.1002/jum.70282","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"45 11","pages":"2611-2612"},"PeriodicalIF":2.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking IVC Filter Thrombosis Diagnosis","authors":"Xue Zhang MD,&nbsp;Jian Zhang PhD,&nbsp;Yinyue Wu MB,&nbsp;Yilun Liu MD,&nbsp;Yinlin Peng MB,&nbsp;Xiaolei Yi PhD","doi":"10.1002/jum.70327","DOIUrl":"10.1002/jum.70327","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To develop and evaluate a precise, ultrasound-based stratification method for diagnosing thrombus within inferior vena cava (IVC) filters, aiming to optimize diagnostic accuracy and guide clinical decision-making regarding filter management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center study, conducted at the Emergency Orthopedics and Trauma Center of Shanghai Sixth People's Hospital, enrolled 323 patients from June 2023 to June 2025 who had undergone IVC filter placement and were suspected of filter-related thrombosis. Thrombus presence and characteristics within and around the filter were assessed using conventional ultrasound (grayscale and color Doppler) and contrast-enhanced ultrasound (CEUS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on the integrated ultrasound findings, patients were stratified into distinct management pathways: Class 0 (no thrombus) was detected in 258 cases, allowing for straightforward clinical planning. Class I/II thrombi (small, low-risk) were identified in 30 patients, enabling direct and successful filter retrieval. Class IIIa thrombi (larger, manageable) were found in 9 patients; CEUS guidance permitted careful intraoperative removal. The remaining 26 patients with Class IIIb thrombi (extensive, high-risk) received tailored treatments (eg, thrombolysis treatment, catheter placement) prior to subsequent filter removal. All filters were successfully retrieved, with surgical specimens confirming the ultrasound diagnoses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A stratified diagnostic approach using conventional and CEUS provides a reliable, noninvasive means to assess IVC filter thrombi. This method streamlines the diagnostic process, avoids unnecessary CEUS in clear cases, and delivers critical information for precise clinical decision-making in complex scenarios. By facilitating appropriate and individualized management plans, this approach can potentially improve patient outcomes and optimize filter retrieval workflows in emergency and trauma settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"45 11","pages":"2453-2461"},"PeriodicalIF":2.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Assessment Using Microvascular Flow Imaging: Reference Ranges and Clinical Application","authors":"Manaphat Suksai MD,&nbsp;Alan Geater PhD,&nbsp;Thitima Suntharasaj MD,&nbsp;Chitkasaem Suwanrath MD, M.Med.Sci,&nbsp;Ninlapa Pruksanusak MD,&nbsp;Natthicha Chainarong MD","doi":"10.1002/jum.70344","DOIUrl":"10.1002/jum.70344","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To establish gestational age-specific reference ranges for the intraplacental vascular index measured using microvascularity-flow ultrasound software (VI^MV) and to evaluate its variation by placental location, parity, and pregnancy outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study enrolled 354 singleton pregnancies, of which 243 (68.64%) uncomplicated cases were used to construct reference ranges. A residual bootstrap method with 500 iterations was applied to square-root–transformed VI^MV values, followed by back-transformation to derive the 5th, 50th, and 95th percentiles with 95% confidence intervals. Group differences were assessed using quantile regression, and associations with Doppler parameters were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>VI^MV increased significantly with advancing gestational age (linear coefficient 1.88, <i>p</i> = .007), following a curvilinear pattern with mild late-gestation downturn (quadratic coefficient − 0.036, <i>p</i> = .011). Posterior placentas showed slightly higher early values, although this difference was not significant; from 31 weeks onward, anterior placentas demonstrated significantly higher VI^MV (mean difference + 15.4, <i>p</i> = .010 at 31–35 weeks; +11.6, <i>p</i> = .003 at 36–40 weeks). Multiparous women showed a modestly higher fitted trajectory and a similar non-significant trend toward higher birthweight, but parity was not independently associated with VI^MV. Pregnancies complicated by maternal disease, hypertensive disorders, or small-for-gestational-age neonates exhibited lower trajectories than uncomplicated pregnancies, although these differences were not statistically significant. VI^MV was inversely associated with uterine and umbilical artery pulsatility indices and positively associated with umbilical vein time-averaged mean velocity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Gestational age–specific VI^MV reference ranges were established. VI^MV may provide an adjunctive quantitative marker for assessing placental vascular adaptation and identifying pregnancies with altered placental perfusion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"45 11","pages":"2499-2511"},"PeriodicalIF":2.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148339017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}