Journal of Ultrasound in Medicine最新文献

{"title":"Diagnostic Ability of Transabdominal Ultrasonography for Appendiceal Diverticulitis.","authors":"Aya Sato, Yuki Kojima, Shiori Nakamura, Etsuko Maeoka, Yoshimi Nisaka, Masaharu Gunji, Junichi Takamizawa, Masahiko Fujino, Norihiro Yuasa","doi":"10.1002/jum.16713","DOIUrl":"https://doi.org/10.1002/jum.16713","url":null,"abstract":"<p><strong>Objectives: </strong>Appendiceal diverticulitis (AD) is frequently confused with acute appendicitis (AA); however, AD carries a higher risk of perforation and malignancy than AA. We aimed to evaluate the preoperative diagnostic ability of transabdominal ultrasonography (US) for AD.</p><p><strong>Methods: </strong>We included 74 patients who underwent appendectomy with a preoperative diagnosis of AA, AD, and US within a day of surgery. AD was diagnosed using US by identifying protruding, pouch-like hypoechoic structures beyond the appendiceal margin, whereas it was diagnosed using histopathology by identifying the invagination of the appendiceal epithelium into the muscularis propria.</p><p><strong>Results: </strong>The median patient age was 45 years (61% males). Among the patients with a US diagnosis of AD, 9 patients had histopathological AD, while one patient did not. The other 64 patients without a US diagnosis of AD did not have histopathological AD. US showed 100% sensitivity, 98% specificity, 90% positive predictive value, 100% negative predictive value, and 99% accuracy for AD. A retrospective review of US images showed that 8 patients exhibited high echoic rims at the border of the hypoechoic structures among the 9 patients with histopathological AD. When this finding was incorporated into the US diagnosis of AD, the specificity increased to 100%.</p><p><strong>Conclusions: </strong>The diagnostic accuracy of US for AD is high. Not only are protruding pouch-like hypoechoic structures specific for the US diagnosis of AD, but also highly echoic rims at the border.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Phase-Change Droplets and Fast Imaging for Indicator Dilution Measurement of Flow.","authors":"Zachary Zajac, Brandon Helfield, Ross Williams, Paul Sheeran, Charles Tremblay-Darveau, Kimoon Yoo, Peter N Burns","doi":"10.1002/jum.16722","DOIUrl":"https://doi.org/10.1002/jum.16722","url":null,"abstract":"<p><strong>Objectives: </strong>The development of low boiling point liquid droplets as phase-change contrast agents allows for the local creation of microbubbles at a point of interest in vivo. Although there are many possible applications, few investigations have used selectively created microbubble boluses to measure volumetric flowrate. In this study, the flow ratio between two vessels is calculated by vaporizing droplets in each vessel individually.</p><p><strong>Methods: </strong>Proof of principle is demonstrated in vitro by an imaging sequence that vaporizes droplets using a high mechanical index pulse, then images the transit of the resulting microbubbles at a high frame rate using low mechanical index plane waves.</p><p><strong>Results: </strong>It is shown that a linear relationship exists between the concentration of droplets and enhancement of the resulting microbubble bolus. In vitro flow is measured with a mean error of 8% in a 0.66 cm diameter vessel and with a mean error of 33% in a 0.49 cm diameter vessel. The relative volumetric flow between two adjacent vessels is calculated with a mean percentage error of 25% when imaging the region of droplet vaporization for flow ratios between 0.25 and 4.</p><p><strong>Conclusions: </strong>This in vitro study demonstrates the feasibility of using a positive bolus tracer, induced by image-guided ultrasound excitation, to measure flow. Potential applications include measurement of the portal vein to hepatic artery flow ratio, known as the hepatic perfusion index.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Cumulative Fluid Balance and the Degree of Venous Congestion According to VExUS Score in Critically Ill Patients in a General Intensive Care Unit.","authors":"Carmelo José Espinosa-Almanza, Héctor Andrés Ruiz-Ávila, Juan Esteban Gomez-Tobar, Estivalis Acosta-Gutiérrez","doi":"10.1002/jum.16709","DOIUrl":"https://doi.org/10.1002/jum.16709","url":null,"abstract":"<p><strong>Objectives: </strong>The Venous Excess Ultrasound Score (VExUS) assesses venous congestion using point-of-care ultrasound. While validated to predict acute kidney injury, its relationship with cumulative fluid balance and clinical edema remains unclear. This study aimed to evaluate these associations 72 hours after intensive care unit (ICU) admission.</p><p><strong>Methods: </strong>This analytical observational cohort study included adult ICU patients with Foley catheters inserted at admission for fluid balance quantification. Patients on dialysis or with cirrhosis or abdominal hypertension were excluded. The correlation between cumulative fluid balance, edema clinical grade, and VExUS grade was analyzed. Multivariate analysis identified factors associated with significant venous congestion (VExUS grade ≥2), with statistical significance set at P < .05.</p><p><strong>Results: </strong>A total of 123 patients were included, with a mean age of 60 years (SD ±19.2); 59.3% were male. Venous congestion (VExUS grade ≥1) was observed in 36.5% of patients, despite an average cumulative fluid balance of +0.88 L. Each liter of positive cumulative fluid balance increased the risk of significant congestion (VExUS grade ≥2) by 31% (OR = 1.31; 95% CI: 1.07-1.60). The correlation between clinical edema (Godet scale) and VExUS grade was weak (Spearman rho = 0.27), and clinical edema was not associated with significant congestion (OR = 3.22; 95% CI: 0.77-13.56).</p><p><strong>Conclusions: </strong>In ICU patients, fluid overload is an early contributor to significant venous congestion (VExUS grade ≥2) but does not correlate with clinical edema grades, highlighting the limitations of clinical edema in assessing venous congestion.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Diagnostic Performance of Postnatal Ultrasound for Presacral Masses in Pediatric Patients with Anorectal Malformation.","authors":"Takahiro Hosokawa, Yumiko Sato, Yutaka Tanami, Kyoichi Deie, Hiroshi Kawashima, Eiji Oguma","doi":"10.1002/jum.16724","DOIUrl":"https://doi.org/10.1002/jum.16724","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the incidence of presacral masses in patients with anorectal malformations (ARMs) and evaluate the diagnostic performance of ultrasound to detect presacral masses during the neonatal period.</p><p><strong>Methods: </strong>Pediatric patients with ARM underwent ultrasonography during the neonatal period, and their magnetic resonance imaging (MRI) results were reviewed. The presence or absence of a presacral mass was assessed employing ultrasonography and compared with MRI results using the Clopper-Pearson method. The type of ARM (low/not-low) and the presence or absence of sacral anomalies were compared between patients with and without a presacral mass using Fisher's exact test.</p><p><strong>Results: </strong>The incidence of presacral masses in our study cohort was 4.6% (5/109). Ultrasound diagnostic performance for detecting presacral masses had an accuracy of 98.2% (95% confidence interval (CI): 93.5-99.8), sensitivity of 60% (95% CI: 14.7-94.7), specificity of 100% (95% CI: 96.5-100), positive predictive value of 100% (95% CI: 29.3-100), and negative predictive value of 98.1% (95% CI: 93.4-99.8). ARM type and presence or absence of sacral anomalies were significantly different between the presacral mass and without presacral mass groups (low/not-low = 5/0 vs 47/57, P = .022; and presence/absence of sacral anomalies = 3/2 vs 18/86, respectively, P = .048).</p><p><strong>Conclusions: </strong>The incidence of presacral masses in pediatric patients with ARM was low (5%). Although the positive predictive value was reliable, ultrasonography performed during the neonatal period was not sensitive. Therefore, sonographers should pay attention when evaluating patients with low-type ARMs accompanying sacral anomalies to avoid overlooking them.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Testicular Trauma Diagnosis: Insights From CEUS and Biomarker Analysis in Animal Models and Future Directions.","authors":"Jingdan Cheng, Xiaohui Wu, Chengqiang Jin","doi":"10.1002/jum.16719","DOIUrl":"https://doi.org/10.1002/jum.16719","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Ultrasound Guidance Provide Pain Relief During Intrauterine Contraceptive Device Insertion? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Jan Bosteels, William Spratt, Ben W Mol","doi":"10.1002/jum.16720","DOIUrl":"https://doi.org/10.1002/jum.16720","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Comments on \"The Effect of Backscatter Anisotropy in Assessing Hepatic Steatosis Using Hepatorenal Index\".","authors":"Jonathan M Rubin, Oliver Kripfgans, Jing Gao","doi":"10.1002/jum.16717","DOIUrl":"https://doi.org/10.1002/jum.16717","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explore the Effect of Low-Intensity Focused Ultrasound on Pain Relief in Patients With Diabetic Peripheral Neuropathy: A Pilot Randomized Trial.","authors":"Xiaoru Zhang, Yan Wang, Wei Peng, Zhiping Liu, Limei Liu, Xinbin Han, Chenghai Li, Faqi Li, Qian Ge","doi":"10.1002/jum.16716","DOIUrl":"https://doi.org/10.1002/jum.16716","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the efficacy of low-intensity focused ultrasound (LIFU) in alleviating pain in patients with painful diabetic peripheral neuropathy (PDPN).</p><p><strong>Methods: </strong>Between November 2022 and January 2024, a total of 50 participants diagnosed with PDPN were randomly assigned to either LIFU therapy or placebo therapy. Pain levels were assessed using the numeric pain rating scale (NRS), while neuropathic symptoms and signs were evaluated using the neuropathy symptom score (NSS) and neuropathy deficit score (NDS), respectively. Motor and sensory nerve conduction velocities were measured via electromyography (EMG).</p><p><strong>Results: </strong>After 7 days of treatment, both groups exhibited a reduction in NRS compared to baseline; however, the LIFU group demonstrated significantly lower NRS scores than the placebo group (3.96 ± 1.07 versus 2.76 ± 1.79, P < .05). Additionally, significant improvements in neuropathic symptoms, as measured by NSS, were observed in the LIFU group post-treatment. Notably, LIFU therapy did not alter the conduction velocities or amplitudes of the bilateral peroneal, tibial, and sural nerves.</p><p><strong>Conclusions: </strong>LIFU therapy was effective in reducing pain and improving neuropathic symptoms in patients with mild-to-moderate PDPN. Future studies should further investigate the long-term effectiveness and sustainability of this novel therapeutic approach across diverse patient populations.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Molecular Imaging With VEGFR2-Targeted Microbubbles to Evaluate Intrauterine Adhesion After Endometrial Injury and Monitor the Therapeutic Effects.","authors":"Likang Hou, Zhili Guo, Shun Liu, Xiaowen Liang, Meng Du, Zhiyi Chen","doi":"10.1002/jum.16710","DOIUrl":"https://doi.org/10.1002/jum.16710","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the severity of intrauterine adhesion (IUA) after endometrial injury via ultrasound molecular imaging (USMI) of vascular endothelial growth factor receptor 2 (VEGFR2) expression on the uterine endothelium.</p><p><strong>Methods: </strong>MB_VEGFR2 was constructed via \"biotin-avidin-biotin\" bridging technology. A rat IUA animal model was constructed via chemical injury. Fourteen days after the model was constructed, MB_Con and MB_VEGFR2 contrast agents were injected into the standard group and the model group of rats, and simultaneous ultrasound molecular imaging was carried out and ultrasound molecular imaging was performed and the changes in ultrasound signals in vivo were normalized to differential targeted enhancement (dTE). In addition, immunohistochemistry was used to detect the expression levels of VEGFR2 and α-SMA in the uterine tissues of the rats in both groups.</p><p><strong>Results: </strong>Targeted-VEGFR2 microbubble (MB_VEGFR2) was successfully constructed, the average particle size of the targeted VEGFR2 microbubble contrast agent was 2309.6 ± 234.3 nm, with the average zeta potential -16.9 ± 0.15 mV and the dispersity coefficient less than 0.4. In addition, its essential performance and biosafety were examined, which revealed that the MB_VEGFR2 contrast agent had an appropriate size, stable imaging performance, good target adhesion, and good biocompatibility. In vivo, ultrasound imaging results revealed that after the injection of the targeted MB_VEGFR2, the contrast ultrasound signal intensity of uterine tissues in the model group (62.5 ± 17.9 dB) was higher than in the normal group (33.5 ± 12.5 dB), and the difference was statistically significant (P < .05). The immunohistochemistry results revealed that the expression of VEGFR2 and α-SMA in the uterine tissue of the model group was greater than that in the standard group (P < .05), further indicating that the signal intensity of the MB_VEGFR2 contrast agent can reflect the expression level of VEGFR2 molecules.</p><p><strong>Conclusions: </strong>Ultrasound molecular imaging based on MB_VEGFR2 can be used to evaluate the expression level of VEGFR2 in uterine vascular endothelial cells. This provides a potential approach for the early diagnosis and treatment monitoring of intrauterine adhesions after endometrial injury.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Triangle Method\" for Evaluating the Morphological Characteristics of the Aortic Arch in Healthy Mid-to-Late Pregnancy Fetuses.","authors":"Pan Yang, Shi Zeng, Ganqiong Xu, Yushan Liu, Yang Yang","doi":"10.1002/jum.16711","DOIUrl":"https://doi.org/10.1002/jum.16711","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to apply the 2-dimensional grayscale ultrasound \"triangle method\" to evaluate the morphology of the aortic arch in healthy mid-to-late pregnancy fetuses.</p><p><strong>Methods: </strong>A total of 317 healthy singleton fetuses at 20-38⁺⁶ weeks of gestation were assessed. Using the long-axis view of the aortic arch, the \"triangle method\" was employed to measure the aortic arch length (sum of the 2 sides of a triangle), width, height, and angle. The aortic arch tortuosity (length/width) and height-to-width ratio were calculated. Healthy reference values for these morphological parameters were established, and their relationship to gestational age (GA) and cardiac valve annuli was explored.</p><p><strong>Results: </strong>The length, width, and height of the aortic arch in healthy mid-to-late pregnancy fetuses increased significantly with GA (P < .05). Instead, no significant correlation was observed between GA or cardiac valve annuli and the aortic arch angle, tortuosity, or height-to-width ratio (P > .05), whose corresponding reference values were 69.2 ± 6.1°, 1.7 ± 0.1, and 0.7 ± 0.1, respectively.</p><p><strong>Conclusions: </strong>The aortic arch angle, tortuosity, and height-to-width ratio in healthy mid-to-late pregnancy fetuses remain relatively stable during development.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}