Journal of Ultrasound in Medicine最新文献

{"title":"Visualization of the Fetal Corpus Callosum in Routine Second Trimester Screening Ultrasound Examinations.","authors":"Shehani Fernando, Ilona Lavender, Peter Coombs, Keith Van Haltren, Paul Lombardo, Melinda Goodyear, Daniel L Rolnik","doi":"10.1002/jum.16732","DOIUrl":"https://doi.org/10.1002/jum.16732","url":null,"abstract":"<p><strong>Objectives: </strong>The primary aim of this study was to determine the visualization rate of the corpus callosum (CC) in the mid-sagittal plane of ultrasound examinations performed between 18 and 22 weeks' gestation. The secondary aims were to compare this rate to that achieved 5 years earlier at the same center; assess the need for transvaginal ultrasound; identify fetal head positions most favorable for sagittal CC assessment; and evaluate the impact of maternal body mass index (BMI) and gestational age on CC visualization.</p><p><strong>Methods: </strong>A retrospective analysis of images from second trimester screening examinations of singleton pregnancies performed between January 2019 and June 2019 was undertaken. The mid-sagittal image of the CC was scored on a scale from 0 to 4, with one point assigned for the visualization of each anatomical part. A score of 4 indicated complete visualization, a score of 1 to 3 was considered partial visualization, and a score of 0 represented nonvisualization. The chi-squared test was used to compare the visualization rates to those achieved 5 years earlier and previously reported by our group.</p><p><strong>Results: </strong>A total of 999 second trimester screening examinations were included in the study. Complete CC visualization significantly improved from 71.3% at initial protocol implementation and training to 92.1% in the current study (P < .001). A transvaginal approach was required in 4.4% of cases. The craniocaudal fetal head position had the highest success rate (98.2%) for CC visualization. The odds of nonvisualization of the CC were 2.6 times higher before 20 weeks (7.4%) than at or after 20 weeks (3.0%) (odds ratio = 2.63, 95% confidence interval [1.20-5.76], P = .012). Higher maternal BMI (≥30.0 kg/m²) was associated with increased rates of nonvisualization in obesity classes I-III.</p><p><strong>Conclusion: </strong>Complete visualization of the CC in the mid-sagittal plane is achievable in routine second trimester morphology ultrasound examinations. Improvement in the quality of imaging is possible with a standardized protocol and training.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Variability in Liver Size Measurements Using Different View Angles in Ultrasound Imaging\".","authors":"Hideaki Ishida, Hiroko Naganuma","doi":"10.1002/jum.16738","DOIUrl":"https://doi.org/10.1002/jum.16738","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Adiposity in the First Trimester Pregnancy as a Predictor of Gestational Diabetes Mellitus: A Prospective Cohort Study.","authors":"Nattraporn Srisovanna, Noppasin Khwankaew, Ninlapa Pruksanusak, Natthicha Chainarong, Thitima Suntharasaj, Chitkasaem Suwanrath, Savitree Pranpanus, Chusana Petpichetchian, Manaphat Suksai","doi":"10.1002/jum.16735","DOIUrl":"https://doi.org/10.1002/jum.16735","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the predictive ability of first-trimester ultrasound measurements of maternal adiposity for predicting gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>Abdominal adiposity measurements by transabdominal ultrasound were performed, including subcutaneous fat thickness (SFT), visceral fat thickness (VFT), and preperitoneal fat thickness (PFT), measured at 3 specific regions: the umbilicus, suprapubic area, and anterior surface of the liver. Two additional values were calculated based on these measurements: total abdominal fat thickness (TAT), which was determined as the sum of SFT1 and VFT, and body fat index (BFI), which was calculated using the formula: BFI = PFT (mm) × SFT3 (mm)/maternal height (cm). Multiple logistic regression and receiver operating characteristic (ROC) analysis were used to evaluate the predictive ability.</p><p><strong>Results: </strong>A total of 330 pregnant women were enrolled with a prevalence of GDM of 23.0%. Multivariate logistic regression analysis showed that none of the fat parameters were significantly associated with GDM. However, for body mass index (BMI) ≥25 kg/m², only the BFI showed a statistically significant association with GDM (odds ratio [OR] 2.75 [1.54-4.92]), with an area under the ROC curve (AUC) of 0.677. In the subgroup with BMI < 23 kg/m², only SFT at the umbilicus was significantly associated with GDM (OR 3.21 [1.08-9.53]) using a cut-off value of ≥15.4 mm, with a sensitivity of 73.7%, a negative predictive value of 93.8%, and an AUC of 0.668.</p><p><strong>Conclusions: </strong>Both BFI and SFT at the umbilical region demonstrate moderate discriminatory predictive performance for this condition across BMI-stratified subgroups.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of an Aggressiveness Diagnostic Model for Basal Cell Carcinoma Using Multimodal Ultrasound Features.","authors":"Ming-Chu Feng, Jian-Feng Liang, Yan-Xuan Chen, Jun-Ming Lu, Jing Wang","doi":"10.1002/jum.16734","DOIUrl":"https://doi.org/10.1002/jum.16734","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a nomogram-based diagnostic model to assess basal cell carcinoma (BCC) aggressiveness by integrating clinical data and multimodal ultrasound imaging features, thereby establishing an evidence-based framework for clinical decision-making.</p><p><strong>Methods: </strong>A retrospective analysis of 120 pathologically confirmed BCC lesions (January 2017-December 2024) was conducted. Lesions were classified as high-risk BCCs (n = 30) or low-risk BCCs (n = 90) based on histopathology. Clinical and multimodal ultrasound features acquired using a 5- to 18-MHz linear array transducer were compared between groups. Logistic regression identified predictors of aggressiveness, and a nomogram was subsequently developed and validated.</p><p><strong>Results: </strong>Univariate analysis identified morphological configuration, infiltration level (IL), intralesional echoic pattern (IEP), distribution of hyperechoic foci, maximum infiltration depth (MID), and average elastic Young's modulus (Eave) as factors significantly associated with BCC aggressiveness (p < .05). Multivariate logistic regression analysis revealed that IL (p = .047), IEP (p = .020), MID (p = .047), and Eave (p = .023) were independent predictors of high-risk BCC. Receiver operating characteristic curve analysis demonstrated that the nomogram model exhibited robust predictive performance, with a concordance index (C-index) of 0.921 (95% confidence interval: 0.860-0.981).</p><p><strong>Conclusion: </strong>The multimodal ultrasound-based nomogram effectively predicts BCC aggressiveness, offering a noninvasive tool for clinical assessment and treatment planning.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Ovarian Stiffness in Women With Polycystic Ovary Syndrome: A Tertiary Center Shear Wave Elastography Study.","authors":"Muradiye Yildirim, Sumeyya Duran Kaymak, Neval Cayonu Kahraman, Belgin Savran Ucok, Yaprak Engin-Ustun","doi":"10.1002/jum.16731","DOIUrl":"https://doi.org/10.1002/jum.16731","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate ovarian stiffness in polycystic ovary syndrome (PCOS) patients with and without metabolic syndrome (MetS) using acoustic pulse imaging.</p><p><strong>Methods: </strong>This case-control study was conducted in a tertiary center PCOS outpatient clinic. A total of 105 participants, 51 PCOS patients (20 MetS and 31 non-MetS) and 54 healthy women between the ages of 20 and 35 years, were included in the study. Laboratory and sonographic assessments were performed in the early follicular phase. The shear wave elastography (SWE) technique was used to measure ovarian tissue stiffness transvaginally.</p><p><strong>Results: </strong>Age and body mass index were found to be similar between PCOS and control groups. Mean SWE values were found to be 13.61 ± 2.2 kPa and 8.82 ± 1.62 kPa, in the PCOS and control groups, respectively; P < 0.001. The intraobserver intraclass correlation coefficient value for the mean SWE measurement (kPa) was found to be 0.811 (good reliability agreement). Using receiver operating curve analysis, an optimized cut-off point of SWE_mean 10.58 kPa was determined. Similar SWE values were found in PCOS subgroups with clinical and/or biochemical hyperandrogenism. In PCOS patients with and without MetS, SWE was 15.68 ± 1.36 kPa and 12.28 ± 1.50 kPa, respectively (P < 0.001). A moderate positive correlation was found with waist circumference, triglyceride and insulin resistance parameters, and a weak correlation was found with systolic and diastolic blood pressure.</p><p><strong>Conclusion: </strong>Ovulatory dysfunction and the fibroinflammatory environment in PCOS lead to quantitatively measurable changes in ovarian tissue elasticity. MetS exacerbates these changes. Ovarian elasticity values were found to be associated with clinical and laboratory markers.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errors Between Reported Equations and an Excel Calculator for Computing Cardiac Biometry and z-Scores Between 18 and 34 Weeks of Gestation.","authors":"Greggory R DeVore","doi":"10.1002/jum.16730","DOIUrl":"https://doi.org/10.1002/jum.16730","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Ultrasound Assessment of Correlation Between Intraventricular Hemorrhage Severity and Cerebrospinal Fluid Volume in Preterm Infants.","authors":"Belinda Chan, Dan York, Alison Ford, Susie Gleason, Ivah Floyd, Sasha Gordon, Yogen Singh","doi":"10.1002/jum.16727","DOIUrl":"https://doi.org/10.1002/jum.16727","url":null,"abstract":"<p><strong>Objectives: </strong>Intraventricular hemorrhage (IVH) affects >15% of preterm infants. Severe IVH disrupts cerebrospinal fluid (CSF) flow dynamics, causing post-hemorrhagic ventricular dilation (PHVD) and further brain injury. Although lumbar puncture (LP) may reduce CSF volume and intracranial pressure, its effectiveness depends on brain-to-spine CSF flow dynamics and spinal CSF volume, which remain underexplored. This study correlates IVH severity with spinal CSF volume of preterm infants using spinal ultrasound (SUS).</p><p><strong>Methods: </strong>This prospective study enrolled infants (<33 weeks gestational age [GA]) with head ultrasounds (HUS) done at 7-15 days of life. SUS was performed within 2 days of HUS and repeated if another HUS was done. Exclusion criteria were congenital, chromosomal, or spinal anomalies. Using SUS clips, an automated algorithm calculating the proportion of anechoic CSF area within the spinal canal at the L3-L4 intervertebral space, termed the CSF-to-Spinal Canal Index (CSCI) was developed. Clinical data and IVH grades were analyzed.</p><p><strong>Results: </strong>Twenty-five infants (mean GA: 28 ± 3 weeks) were enrolled, with 46 SUS studies performed. We found no correlation between IVH grade and CSCI (R² = 0.13, P = .57). The CSCI did not correlate with birth GA, birth weight, corrected GA, current weight, day of life, and previous 24-hour weight change at the time of SUS. The CSCI decreased after each LP in 4 infants with PHVD. Four infants needed surgical CSF diversion.</p><p><strong>Conclusions: </strong>SUS is a non-invasive method to estimate spinal CSF volume. The lack of correlation with IVH severity suggests multifactorial mechanisms besides previously proposed CSF outflow obstruction. Further research is necessary to understand the pathophysiology of PHVD.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Prenatal Pipeline for Three-Dimensional Hemodynamic Modeling of the Fetal Aorta.","authors":"Joanne Sarsam, Angela Desmond, Mehrdad Roustaei, Gary Satou, Yalda Afshar","doi":"10.1002/jum.16721","DOIUrl":"https://doi.org/10.1002/jum.16721","url":null,"abstract":"<p><strong>Objective: </strong>Congenital heart disease (CHD) is the most common birth defect and the leading cause of infant death from congenital anomalies. Limitations in standard-of-care fetal echocardiography lack hemodynamic insight. Cardiovascular computational modeling methods have been developed to simulate patient-specific morphology and hemodynamics, but are limited in applications for fetal diagnosis, as existing pipelines depend upon 3D CMR imaging data. There is no existing workflow for converting 2D echocardiograms into models of the fetal aorta. We aim to develop a methodology to create pulsatile 3D-aortic models from standard-of-care 2D echocardiograms to supplement fetal imaging with noninvasive predictions of hemodynamics in CHD diagnosis.</p><p><strong>Methods: </strong>Utilizing 2D fetal echocardiograms, edge detection algorithms are applied to delineate vessel boundaries. Cross-sectional diameters along the aortic arch and branch centerlines were segmented, integrated into 3D geometric models, and reconstructed using SimVascular. Patient-specific simulations were developed for three false-positive coarctation of the aorta (CoA) fetuses and 3 true positive CoA fetuses (postnatally confirmed), using echocardiogram and Doppler source data.</p><p><strong>Results: </strong>We propose a modeling methodology and set of boundary conditions that generate physiologically reasonable and cross-validated quantifications of fetal hemodynamics. Noninvasive predictions of fetal aortic pressures, flow streamlines, and vessel displacement offer insight into real-time hemodynamics and the stress of abnormal morphology on flow directions in the prenatal aorta.</p><p><strong>Conclusions: </strong>We present a clinically useful pipeline for generating simulations of flow in the fetal aorta that capture fluid-structure interactions and generate noninvasive predictions of diagnostic hemodynamic indicators that could not previously be captured prenatally. This pipeline integrates into clinical diagnosis and offers insight into patient-specific physiology beyond a visualization of cardiac morphology alone, offering the potential to enhance the diagnostic precision of CHDs.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a Predictive Model for the Efficacy of High-Intensity Focused Ultrasound in the Treatment of Uterine Fibroids.","authors":"Huiqing Li, Yanlei Gao, Xiaoyan Zhang, Weili Hou, Yaru Ma, Rui Shi, Peng Ren","doi":"10.1002/jum.16718","DOIUrl":"https://doi.org/10.1002/jum.16718","url":null,"abstract":"<p><strong>Objectives: </strong>High-intensity focused ultrasound (HIFU) has demonstrated efficacy as a non-invasive treatment for uterine fibroids, though individual variability exists. This study aims to develop a risk scoring model using clinical and biochemical features to predict HIFU treatment outcomes.</p><p><strong>Methods: </strong>This study collected clinical data from patients receiving HIFU treatment, including demographic characteristics, clinical symptoms, treatment information, and biochemical indicators. A risk scoring model was constructed using the random forest analysis method, and its performance was evaluated. Meanwhile, the impact of risk models and other factors on the efficacy of HIFU was evaluated. Furthermore, the interrelationships between the risk model and other factors were explored through interaction analysis. Finally, a nomogram was developed to evaluate its clinical utility.</p><p><strong>Results: </strong>The risk model, 4 or more treatments, age, and tumor necrosis factor levels were identified as independent influencing factors, with the risk model demonstrating the best performance (area under the curve (AUC) = 0.693). Interaction analysis revealed a significant synergistic effect between the risk model and receiving 4 or more treatments. The nomogram analysis indicated that lower risk scores and fewer treatment sessions were associated with better HIFU treatment outcomes. The receiver operating characteristic curves and calibration curves in both the training and validation sets demonstrated good performance of the nomogram.</p><p><strong>Conclusions: </strong>This study successfully constructed a risk scoring model based on clinical features and biochemical indicators, which can effectively predict the efficacy of HIFU treatment for uterine fibroids. There is a significant interaction between the risk model and 4 or more treatments. The constructed nomogram provides strong support for individualized treatment.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Findings of Bile Duct Involvement in Pediatric Langerhans Cell Histiocytosis.","authors":"Jiachao Wang, Xin Wei, Yu Wang, Yanxiu Hu, Xiaoman Wang","doi":"10.1002/jum.16723","DOIUrl":"https://doi.org/10.1002/jum.16723","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the ultrasound findings of bile duct involvement in pediatric Langerhans cell histiocytosis (LCH).</p><p><strong>Methods: </strong>We retrospectively analyzed 42 patients diagnosed with pediatric LCH by pathology at our hospital from December 2016 to December 2023. All patients had comprehensive clinical data and ultrasound findings indicating biliary abnormalities. This study analyzed intrahepatic and extrahepatic bile duct dilation, the extent of bile duct wall thickening, and surrounding abnormal echoes.</p><p><strong>Results: </strong>Among the 42 children, ultrasonography showed intrahepatic and extrahepatic bile duct dilation in 27 cases (64%), bile duct wall thickening in 21 cases (50%), hypoechoic areas along the intrahepatic bile ducts in 16 cases (38%), and thickening of the Glisson's capsule with decreased echogenicity around the bile ducts in 8 cases (19%).</p><p><strong>Conclusion: </strong>Ultrasonography revealing varying degrees of bile duct dilatation or stenosis, thickened bile duct walls, and abnormal echo patterns along the bile duct in the liver in pediatric patients with cholangitis should raise suspicion for LCH.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}