Journal of Ultrasound in Medicine最新文献

{"title":"Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment.","authors":"Mallory Brayer, Vesna Zderic, Aleksandar Jeremic","doi":"10.1002/jum.16712","DOIUrl":"https://doi.org/10.1002/jum.16712","url":null,"abstract":"<p><strong>Objectives: </strong>Type 2 diabetes is partially caused by insufficient pancreatic β cell insulin secretion. Previous studies show therapeutic ultrasound (TUS) evokes insulin secretion from β cells as a potential treatment for type 2 diabetes; however, how β cells sense TUS and the broad effects of this treatment on cells remain unknown. Here, we identified mechanosensitive channels (MSC) expressed by β cells and TUS-mediated gene downregulation and reactive oxygen species (ROS) formation.</p><p><strong>Methods: </strong>For all experiments, 1 W/cm² intensity and 800 kHz frequency TUS were continuously applied for 5 minutes with a 100% duty cycle. RNA and protein isolation of human pancreatic islets and the rat insulinoma INS 832/13 cell line were used for rtqPCR and western blot, respectively, to determine MSC expression. INS cells treated with MSC agonists and/or antagonists during TUS were visualized via fluorescent microscopy to track ROS formation. Using the same treatments, rtPCR analysis of INS insulin and IAPP encoding insulin and islet amyloid polypeptide (IAPP), respectively, was performed. TUS treatments were replicated in rats from which pancreatic sections were collected for immunohistochemistry analysis.</p><p><strong>Results: </strong>We found the expression of TRPV2, TRPV5, and piezo1 in human islets and INS cells. TUS increased ROS formation in INS cells compared to sham-treated controls (P < .0001); however, modulation of MSC mitigated this effect (P < .001). TUS decreased the expression of the genes insulin and IAPP in INS cells compared to sham-treated controls (P < .001 and P < .01, respectively); however, complete MSC inhibition reversed this effect (P < .01 and P < .05, respectively). In our rat model, pancreatic and duodenal homeobox 1 (PDX1) expression was decreased by TUS compared to sham-treated controls (*P < .05); however, TUS did not decrease insulin or IAPP levels (P > .05).</p><p><strong>Conclusion: </strong>We report the expression of TRPV2, TRPV5, and piezo1 in human and rodent pancreatic β cells that are implicated in both TUS-mediated ROS formation and the downregulation of essential β cell genes.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on ABUS Applicability for Rural Women With Low Health Resources in China-Large-Scale Population, Non-Opportunistic Screening.","authors":"Meili Niu, Jie Zheng, Xiaoyang Feng, Huijiao Yan, Mengmeng Jia, Shuzhen Qi, Youlin Qiao, Fanghui Zhao, Xiangxian Feng, Zhifang Li","doi":"10.1002/jum.16708","DOIUrl":"https://doi.org/10.1002/jum.16708","url":null,"abstract":"<p><strong>Objectives: </strong>Comparing the screening performance of different breast cancer screening methods and exploring the applicability of automated breast ultrasonography (ABUS) in rural areas with low health resources in China.</p><p><strong>Methods: </strong>Women aged 35-64 underwent hand-held ultrasonography (HHUS) and ABUS in Zezhou County, Jincheng City, Shanxi Province, China from 2018 to 2021. Additionally, women aged 45-69 were also screened with mammography (MG). We compared the 3 methods' cancer detection rates, diagnostic accuracy, and overall screening performance, stratified by age groups and breast density. The chi-square test was used to analyze indicators such as sensitivity, specificity, and referral rate.</p><p><strong>Results: </strong>The mean age of the 9100 women studied was 45 ± 6.42 years, and 25 cases of breast cancer were identified (2.72‰). The proportion of dense breasts is higher among women aged 45-64 years (67.52%). Compared to the non-dense breast group, the detection rate of breast cancer by MG is significantly reduced in the dense breast group (3.42‰ versus 1.97‰). The diagnostic accuracy rate of ABUS and HHUS for lesions is higher than that of MG (P < .05). The kappa coefficient indicates moderate agreement in diagnostic results between HHUS and ABUS. However, the agreement between HHUS/ABUS and MG is poor. There were no statistical differences in sensitivity and specificity among the 3 screening methods. The referral rate and NNR for ultrasound were lower than those for MG (P < .05), but there were no statistically significant differences between ABUS and HHUS.</p><p><strong>Conclusions: </strong>Among women with denser breasts, ultrasound has a higher diagnostic accuracy rate compared to MG, and it avoids unnecessary biopsies. Compared to HHUS, ABUS can diagnose malignant tumors more objectively and standardized.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ovarian Endometriotic Cyst on the Efficacy of High Intensity Focused Ultrasound for Adenomyosis.","authors":"Jinfeng Lin, Zhiyun Yang, Tao Tan, Lu Wang, Zhibo Xiao, Jinyun Chen","doi":"10.1002/jum.16714","DOIUrl":"https://doi.org/10.1002/jum.16714","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effect of ovarian endometriotic cysts on the efficacy of high intensity focused ultrasound (HIFU) in patients with adenomyosis.</p><p><strong>Methods: </strong>Based on magnetic resonance imaging (MRI) findings, patients were categorized into three groups according to the presence and type of adnexal cyst signal: group A (with endometriotic cyst signal), group B (with simple cyst signal), and group C (without cyst signal). The non-perfused volume ratio (NPVR), postoperative dysmenorrhea scores, and long-term recurrence of HIFU were compared among groups.</p><p><strong>Results: </strong>A total of 396 patients were enrolled, comprising group A (77 cases), group B (134 cases), and group C (185 cases), and the NPVR were 41.83, 44.99, and 50.79%, respectively (P = .021). The postoperative dysmenorrhea scores were 3 (2, 5), 2 (1, 4), and 2 (1, 4) (P = .012), while the pregnancy rates were 20.00%, 27.27%, and 43.59%, respectively (P = .072). Cumulative recurrence rates for patients with endometriotic cysts at 1, 2, 3, 5, and 10 years were 45.60, 56.10, 57.90, 61.90, and 67.30%, respectively (log-rank P < .001). Endometriotic cysts were significantly associated with higher dysmenorrhea scores and represented an independent risk factor for postoperative pregnancy (OR = 0.338, 95% CI: 0.129-0.886, P = .027) and long-term recurrence (HR = 1.865, 95% CI: 1.275-2.728, P = .001).</p><p><strong>Conclusions: </strong>The signal of endometriotic cyst on MRI exhibits a negative correlation with the efficacy of HIFU in patients with adenomyosis. Preoperative MRI assessment of adnexal cyst signal in patients facilitates the development of a more tailored and comprehensive treatment plan for individuals suffering from adenomyosis.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Quantitative Lung Ultrasound and Successful Extubation in Infants.","authors":"Yan-Mei Xie, Cai-Man Yan, Xiang Zhao, Yuan-Yuan Zhao, Jian-Ru Peng, Xiao-Mei Liu, Li Huang, Hai-Ran Ma","doi":"10.1002/jum.16715","DOIUrl":"https://doi.org/10.1002/jum.16715","url":null,"abstract":"<p><strong>Objectives: </strong>The aim is to evaluate the value of lung ultrasound (LUS) in the weaning of neonates from ventilators.</p><p><strong>Methods: </strong>This prospective observational study included hospitalized neonates who underwent invasive ventilation (excluding neonates ineligible for enrollment, eg, neonates with nonrespiratory conditions requiring mechanical ventilation). All the included neonates underwent LUS using a palm-sized ultrasound machine. After extubation, the neonates were divided into success and failure groups. Additionally, the neonates were divided into 2 groups according to gestational age (GA, <28 weeks and ≥28 weeks). Data on the main LUS signs and scores half an hour before and 2 hours after extubation were collected, and ultrasound scores were compared.</p><p><strong>Results: </strong>When LUS scores before and after extubation were used to predict weaning failure, the sensitivities were 83.3 and 94.6% (95% CI, 0.823-0.986; P < .05), and the specificities were 83.3 and 97.3% (95% CI, 0.819-0.995; P < .05), respectively. After grouping, for the <28-week group, the sensitivity was 84.6% both before and after extubation, and the specificities were 77.8 and 88.9%, respectively (before extubation: 95% CI, 0.653-1.013; P < .001; after extubation: 95% CI, 0.652-1.023; P < .001). In the ≥28-week group, the sensitivity was 80.0% both before and after extubation, and the specificities were 96.9 and 98.5%, respectively (before extubation: 95% CI, 0.724-1.051; P < .001; after extubation: 95% CI, 0.777-1.051; P < .001).</p><p><strong>Conclusions: </strong>LUS can predict weaning failure in neonates with different respiratory diseases on the basis of LUS scores, with or without differences in GA. The use of palm-sized handheld portable ultrasound machines for LUS is feasible.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonography of the Thenar Motor Branch of the Median Nerve: A Pictorial Review.","authors":"Márcio Luís Duarte, Ocacir de Souza Reis Soares, Jean-Louis Brasseur","doi":"10.1002/jum.16705","DOIUrl":"https://doi.org/10.1002/jum.16705","url":null,"abstract":"<p><p>The thenar motor branch (TMB) of the median nerve exhibits significant anatomical variability, making it particularly vulnerable to iatrogenic injury during procedures such as carpal tunnel surgery. Understanding the diverse courses and origins of the TMB is critical for minimizing surgical complications. Such knowledge not only aids in preoperative planning but also enhances the accuracy of nerve conduction tests, contributing to improved postoperative outcomes. The ability to visualize and assess the TMB using imaging modalities like ultrasound represents a significant advancement in diagnostic and surgical preparation. Ultrasound is an accessible, cost-effective, and dynamic imaging technique that allows for real-time evaluation of neural structures. It provides detailed visualization of the TMB and its anatomical variations, offering valuable information that can guide surgical approaches and reduce the risk of injury to this vital branch. This article aims to provide a comprehensive overview of the anatomy, anatomical variants, and clinical significance of the TMB, with a particular focus on its assessment via ultrasound. Using high-resolution imaging, we demonstrate the application of ultrasound to identify the TMB in various configurations. Notably, the Lanz classification of the TMB is illustrated with ultrasound images, some of which, to our knowledge, are being presented for the first time. By integrating anatomical knowledge with advanced imaging techniques, this work emphasizes the importance of precise TMB evaluation, paving the way for safer surgical practices and enhanced patient outcomes.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The State of the Journal of Ultrasound in Medicine in 2024.","authors":"Richard G Barr","doi":"10.1002/jum.16707","DOIUrl":"https://doi.org/10.1002/jum.16707","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Contrast-Enhanced Ultrasonography Results, Vascular Endothelial Cell Damage, and Oxidative Stress Indicators in Rabbit Models With Varying Degrees of Testicular Injury.","authors":"Yaxi Zhao, Haifei Wang, Gaofeng Su, Yanbin Zhu","doi":"10.1002/jum.16704","DOIUrl":"https://doi.org/10.1002/jum.16704","url":null,"abstract":"<p><strong>Objective: </strong>It is difficult to quickly assess the degree of testicular injury in patients with blunt testicular trauma, and accurate and rapid assessment of the degree of injury is related to clinical decision-making and treatment outcomes. This study explored the sonographic characteristics of patients with different degrees of blunt testicular trauma via contrast-enhanced ultrasound (CEUS), as well as biomarkers of oxidative stress and vascular endothelial cell injury, to further evaluate the diagnostic value of these parameters in blunt testicular trauma.</p><p><strong>Method: </strong>New Zealand male rabbits were used to establish blunt testicular trauma models of different degrees, including contusion, hematoma, rupture, and control models. Routine ultrasound and CEUS were performed immediately, 2, 4, and 6 h after modeling, and pathological examination was used to confirm the modeling results further. The levels of von Willebrand factor (vWF), endothelin-1 (ET-1), reactive oxygen species (ROS), and nitric oxide (NO) in the serum were analyzed.</p><p><strong>Results: </strong>According to the CEUS results, the arrival time (AT) (F = 35.159, P < .001), time to peak intensity (TTP) (F = 122.434; P < .001), and area under the curve (AUC) (F = 47.444; P < .001) of the time-intensity curves showed significant differences among the groups. There was no significant difference between Hematoma Trauma (HT) (F = 0.178; P = .91) and Peak Intensity (PI) (F = 0.172; P = .92). For biomarkers, there were significant differences in vWF (F = 40.61; P < .001), ROS (F = 106.3; P < .001), NO (F = 79.3; P < .001), and ET-1 (F = 61.94; P < .001) levels among the groups.</p><p><strong>Conclusions: </strong>For blunt testicular trauma, the AT, TTP, and AUC indices of CEUS can more accurately distinguish the degree of testicular injury. Oxidative stress and endothelial cell damage may also be used as biomarkers for evaluating the degree of testicular injury.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Neuromodulation (Low-Intensity Focused Ultrasound) to Treat Knee Osteoarthritis Pain: A Randomized, Observer- and Participant-Masked, Sham-Controlled, Human-Subjects Pilot Study.","authors":"Brian M Ilfeld, Khoa N Cao, Ruben Branson, Philip Bloom","doi":"10.1002/jum.16706","DOIUrl":"https://doi.org/10.1002/jum.16706","url":null,"abstract":"<p><p>Low-intensity focused ultrasound is a non-invasive neuromodulation technique that delivers mechanical forces to a deep location within the body through acoustic pressure waves without affecting tissue between the transducer and focal target. Preliminary studies involving healthy volunteers suggest focused ultrasound reversibly prevents action potential formation similar to a local anesthetic nerve block, but the modality has not been used in patients with existing pain. The current randomized pilot study was undertaken to 1) determine the feasibility and optimize the protocol for a subsequent definitive clinical trial; and 2) monitor for related complications of focused ultrasound when treating knee osteoarthritis pain.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraobserver Reliability of Two-Dimensional Ultrasound Measurements of the Linea Alba in Parous Women During Different Abdominopelvic Exercises.","authors":"Claudia Espinoza-Bravo, Montserrat Rejano-Campo, Fernando Domínguez-Navarro, Bernadette de Gasquet, Laura Fuentes-Aparicio","doi":"10.1002/jum.16697","DOIUrl":"https://doi.org/10.1002/jum.16697","url":null,"abstract":"<p><strong>Objective: </strong>To assess the intraobserver reliability of Diastasis Recti Abdominis (DRA) measurement by ultrasonography during four specific abdominopelvic exercises, evaluating interrecti distance, Linea Alba (LA) thickness, and distortion index in parous women.</p><p><strong>Methods: </strong>Fifty-four parous women were assessed using ultrasound imaging for the LA. Four exercises were evaluated: crunch, abdominal drawing-in maneuver, pelvic floor muscle contraction, and one exercise based on the de Gasquet Method. Each exercise was performed three times. The ultrasound probe was placed 3 cm above and 2 cm below the umbilicus. Interrecti distance (IRD), distortion index, and LA thickness were measured and analyzed using ImageJ software by independent researchers. Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC) with a 95% confidence interval.</p><p><strong>Results: </strong>ICC values for the IRD ranged from 0.84 to 0.99 for the four exercises. The distortion index showed moderate to high reliability (ICC: 0.77-0.98), while LA thickness also demonstrated moderate to high reliability (ICC: 0.75-0.98).</p><p><strong>Conclusion: </strong>The results demonstrate the reliability of ultrasound in measuring key parameters, including LA thickness, distortion, and IRD in women with DRA during various exercises. As a non-invasive tool, it supports evidence-based interventions in postpartum recovery and clinical practice.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Fetal Heart Morphology and Function in Fetuses With Right Ventricular Outflow Obstruction by Fetal Heart Quantitative Technique.","authors":"Chenke Pan, Jinjing Li, Lijian Huang, Bin Ying, Xin Wang, Bowen Zhao","doi":"10.1002/jum.16693","DOIUrl":"https://doi.org/10.1002/jum.16693","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the clinical utility of the fetal heart quantification (Fetal HQ) technique in the assessment of morphological and functional changes in fetuses with right ventricular outflow obstruction (RVOTO).</p><p><strong>Methods: </strong>This study included 53 fetuses with RVOTO and 30 age-matched normal controls. The RVOTO fetuses were divided into 2 groups based on the occurrence of other cardiovascular malformations: the simple pulmonary stenosis (PS group) and the conotruncal defects (CTD group). Size, shape, and contractility parameters of the fetal heart in 4-chamber view (4CV), left ventricle, and right ventricle (LV and RV) detected by fetal HQ.</p><p><strong>Results: </strong>Fetuses with RVOTO exhibited an increased 4CV-width, with normal 4CV-Length. The end-diastolic diameter (ED) of the LV segments 1-22 was significantly greater in RVOTO fetuses. The sphericity index (SI) of the LV 24-segment was significantly smaller in the CTD and PS groups. Global longitudinal strain (GLS) and fractional area change (FAC) of the LV and RV were reduced in RVOTO fetuses.</p><p><strong>Conclusion: </strong>Our results suggested that the characteristic changes in the morphology and function of the RVOTO fetal heart could be detected early by the HQ technique, which has clinical utility in analyzing the morphology of the RVOTO fetal heart in a quantitative manner.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}