Journal of the National Medical Association最新文献

{"title":"Suicide-related mortality in cardiovascular disease in the United States from 1999 to 2019","authors":"Kenyon Agrons ,&nbsp;Vijay Nambi ,&nbsp;Ramiro Salas ,&nbsp;Abdul Mannan Khan Minhas","doi":"10.1016/j.jnma.2024.07.001","DOIUrl":"10.1016/j.jnma.2024.07.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Research has shown chronic diseases can be associated with suicide but there is limited data on suicide in cardiovascular disease (CVD). Given the substantial psychosocial, financial, quality of life, and health impact of CVD, we aimed to study suicide-related mortality in CVD.</p></div><div><h3>Methods</h3><p>We used Center for Disease Control Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) to access Multiple Cause of Death data from 1999 to 2019. Suicide and CVD related deaths in patients ≥ 25 years were identified. Proportionate suicide-related mortality (PSrM) was calculated as suicide-related deaths (listed with CVD) divided by all CVD-related deaths (irrespective of suicide) and reported as PSrM per 100,000 CVD-related deaths. Joinpoint regression was used to examine trend changes using annual percentage change (APC) overall and by sex, race/ethnicity, disease subtype, and age.</p></div><div><h3>Results</h3><p>Overall, PSrM in CVD increased from 62.8 in 1999 to 90.5 in 2019. The PSrM increased from 1999 to 2002 with an associated APC of 6.2 (95 % CI, 0.0 to 12.7), remained stable from 2002 to 2005, increased from 2005 to 2013 with an APC of 4.8 (95 % CI, 3.4 to 6.3), and decreased from 2013 to 2019 with an APC of -2.1 (95 % CI, -3.6 to -0.5). Among racial/ethnic groups, PSrM was highest in non-hispanic (NH) White (103.8), then Hispanic or Latino (63.6), and then NH Black or African American individuals (29.2). PSrM was highest in the 25–39 years age group (858), then 40–54 years (382.8), 55–69 years (146.2), 70–84 years (55.9), and then 85+ (17). PSrM initially increased in men with APC (3.1 until 2013), women (4.1 until 2014), NH White individuals (3.9 until 2013), Hispanic or Latino (3.5 until 2014), ages 40–54 years (2.9 until 2013), 55–69 years (6.0 until 2013), then stabilized or decreased. AAMR increased in NH Black or AA individuals APC (1.0) and 25–39 years APC (1.4) from 1999 to 2019.</p></div><div><h3>Conclusion</h3><p>PSrM in CVD peaked in the early 2010s, with varying differences across sex, racial/ethnic, and age groups. Further research is needed to understand disparities and develop preventive strategies.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Pages 378-389"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between Live Births and CVD among African American Women in Jackson Heart Study","authors":"Elizabeth A.K. Jones MPH,&nbsp;Dr. Keith Norris MD, PhD,&nbsp;Dr. Brenda Jenkins PhD,&nbsp;Dr. Clifton Addison PhD,&nbsp;Dr. Marinelle Payton MD, PhD, MS, MPH","doi":"10.1016/j.jnma.2024.07.021","DOIUrl":"10.1016/j.jnma.2024.07.021","url":null,"abstract":"<div><h3>Background</h3><p>Previous studies have reported mixed results on the relationship between live births and cardiovascular disease among African American females, with few controlling for an inclusive list of major cardiovascular disease (CVD) risk factors and/or including a large population of African American female participants.</p></div><div><h3>Methods</h3><p>Data was from 3367 African American women, 21 and older, in the Jackson Heart Study. Myocardial Infraction (MI), Self-reported history of cardiac procedures, Coronary Heart Disease Status/History, Self-reported history of Carotid Angioplasty, Cardiovascular Disease history, and Heart Failure History were obtained from 2000 to 2004 interviews. Live births were self-reported. Chi-square test indicated a significant association between live births and the presence of CVD (p =.000). Logistic regression estimated the relationship between live births and cardiovascular events, adjusting for major cardiovascular risk factors.</p></div><div><h3>Results</h3><p>After adjusting for hypertension status, current smoking status, cholesterol status, diabetes status, family history of heart diseases (mother), family history of heart disease (father), age, frequency of alcohol use in the past 12 months, and the average number of drinks per week in the past 12 months, there was no longer a significant relationship between live births and the risk of CVD (AOR 1.012, 95% CI, 1.009-1.015, p=.895).</p></div><div><h3>Conclusion</h3><p>The unadjusted significant relationship between live births and CVD events disappeared after adjusting for major CVD risk factors, which suggests that an association between live births and CVD is indirect and based on the distribution of CVD risk factors.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 419"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Diabetes Mellitus Prevalence and Correlates in North West, Nigeria","authors":"Ashiru Argungu Ladan MBBS, MPH, FWACS,&nbsp;Oche Mansur Oche,&nbsp;Kahinde Joseph Awosan,&nbsp;Aisha Nana Adamu,&nbsp;Umar Augie Ibrahim,&nbsp;Asma'u Husna Ibrahim,&nbsp;Bashir Hashim,&nbsp;Ja'afarAliyu Musa","doi":"10.1016/j.jnma.2024.07.071","DOIUrl":"10.1016/j.jnma.2024.07.071","url":null,"abstract":"<div><h3>Introduction</h3><p>Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. It is a condition in which women without previously diagnosed diabetes mellitus exhibit high blood glucose levels during pregnancy. Hyperglycemia in pregnancy results in both maternal and fetal complications. The prevalence is rising worldwide. The study aimed to determine the prevalence of GDM and its correlates among women attending ANC at FMC Birnin Kebbi.</p></div><div><h3>Methodology</h3><p>A cross sectional study was carried out among 130 women attending ANC at FMC, Birnin Kebbi. An interviewer administered semi-structured questionnaire was used to obtain the biodata and other relevant information which were imputed into an SPSS computer statistical software version 20 and analyzed.</p></div><div><h3>Results</h3><p>The mean age of study participants was 27.4±4.5 years. Awareness of DM was high (90%), while that of GDM was low 41%. The major sources of information were friends/ neighbors (35%). However, only 35.2% had overall good knowledge for GDM. The prevalence of GDM and DM in pregnancy was 10% and 3.8% respectively. The major risk factors for GDM identified were; age, obesity and family of type 2 DM. The common complications identified associated from GDM/DM were; polyhydramnios, intrauterine fetal death and increase risk of Caesarean section.</p></div><div><h3>Conclusion</h3><p>From the study the prevalence of GDM is increasing with general poor knowledge of the condition. Hence, more public enlightenment programs are needed to improve the level of awareness among the populace and regular screening in all health facilities among the ANC patients.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 442"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Early Detection and Management of Prenatal Substance Use Disorder","authors":"Tiffany A. Lacroix BS,&nbsp;Jillian Cherry MBA, BSN, RNC-OB, C-EFM,&nbsp;Meryl Grimaldi MD, FACOG","doi":"10.1016/j.jnma.2024.07.075","DOIUrl":"10.1016/j.jnma.2024.07.075","url":null,"abstract":"<div><h3>Introduction</h3><p>Substance use disorder (SUD) in pregnancy poses undesirable effects on both mother and child. ACOG recommends universal screening at the initial prenatal visit using validated screening tools to identify prenatal substance and alcohol use. There are various barriers to early detection. However, providers have a unique chance to screen and identify high-risk patients during the prenatal period. Timely intervention can prevent continued substance use and improve maternal-fetal outcomes. This study aims to improve St. Barnabas Hospital's (SBH) approach to identification and management of patients with SUD by implementing the 4P screening tool into the EMR.</p></div><div><h3>Methods</h3><p>A retrospective chart review of SBH prenatal patients was conducted after the 4P screening tool was added to the EMR. Patient charts with a positive screen were reviewed for documentation of a brief intervention and plan of safe care. 50 unscreened patient charts were reviewed for documentation of other positive screening tools related to drugs and alcohol.</p></div><div><h3>Results</h3><p>314 prenatal patients were seen between 1/1/2024 and 2/29/2024. Of the 162 prenatal patients seen in January, 41% were screened and 2% resulted in a positive screen with a documented brief intervention. Of the 152 prenatal patients seen in February, 52% were screened with no positive results. Among the 50 charts reviewed without a 4P screen, three patients self-reported active nicotine use during pregnancy.</p></div><div><h3>Conclusion</h3><p>Implementing the 4P screening tool into the EMR may improve documentation of SUD in pregnancy. Tracking screening rates and interventions can be vital in enhancing SUD detection.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 444"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior segment manifestations in patients with HLA-B27 associated uveitis","authors":"Sherin Lajevardi BS, MS","doi":"10.1016/j.jnma.2024.07.077","DOIUrl":"10.1016/j.jnma.2024.07.077","url":null,"abstract":"<div><h3>Purpose</h3><p>Posterior segment involvement in patients with HLA-B27 associated uveitis is a relatively uncommon condition, with a prevalence of 17.4 to 23.1%. This retrospective cohort study investigated the prevalence and characterized the posterior segment involvement in eyes with HLA-B27 associated uveitis. We also aimed to assess the patient characteristics which are associated with posterior segment involvement.</p></div><div><h3>Methods</h3><p>Medical records of 65 patients (130 eyes) with HLA-B27 associated uveitis, from two university uveitis clinics (United States and Turkey) were reviewed. Posterior segment findings were identified based on medical records and optical imaging including color fundus photography, fluorescein angiography and optical coherence tomography. Findings identified were vitreous haze, vasculitis, optic disc leakage and macular edema. Clinical course of anterior uveitis was described as acute, recurrent, or chronic according to the standardization of uveitis nomenclature (SUN) classification. Recurrent uveitis was defined as repeated episodes separated by periods of inactivity without treatment ≥ 3 months in duration, and chronic uveitis was persistence or relapse of symptoms within 3 months after discontinuation of treatment. Patients who had significant systemic and ocular comorbidities were excluded from the study. Data was collected using REDCap and analyzed using Stata ver. 16.1.</p></div><div><h3>Results</h3><p>Forty-four patients were included from US while 21 patients were included from Turkey. The mean age at presentation was 41 ± 15.1 years with a majority being male [42 (65%)] and non-Hispanic Caucasian [34 (53%)]. Overall, 26 patients (36 eyes) demonstrated posterior segment findings; 15 (34%) belonged to US while 11 (52.4%) patients belonged to Turkey. Among eyes with posterior segment involvement, most common findings were peripheral vasculitis and vitreous haze [13 (36.11%) each] followed by macular edema and disc leakage [6 (16.67%) each]. Patients with chronic uveitis (5/7) presented with more posterior segment involvement in US while patients with recurrent uveitis (5/6) presented with more posterior segment findings in Turkish cohort.</p></div><div><h3>Conclusions</h3><p>Posterior ocular findings can be seen in up to 40% of patients with HLA-B27-associated uveitis. Patients with chronic or recurrent uveitis are more likely to have posterior segment involvement and therefore should warrant more comprehensive evaluation for posterior disease.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 445"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Patient Perspectives on Novel Radiation Dermatitis Intervention: Single-Center Experience","authors":"Phylicia Gawu DO,&nbsp;Oluwatomiwa Awobayiku BS,&nbsp;Alekhya Mitta MD,&nbsp;Christina Henson MD","doi":"10.1016/j.jnma.2024.07.101","DOIUrl":"10.1016/j.jnma.2024.07.101","url":null,"abstract":"<div><h3>Introduction</h3><p>Radiation dermatitis presents challenges in radiotherapy, with conventional treatments often falling short in severe cases. Silverlon, a recent innovation, shows promise in managing this condition. This study aims to explore patient perspectives on Silverlon's effectiveness in radiation dermatitis management.</p></div><div><h3>Methods</h3><p>Eleven patients undergoing breast or head and neck radiation participated, with two excluded for protocol non-compliance. Patients used Silverlon at various treatment stages and completed surveys on ease of use, compliance, concurrent use with emollients, skin effects, and pain relief.</p></div><div><h3>Results</h3><p>Seven patients with complete data were included in the final analysis: five underwent head and neck radiation, while two underwent breast radiotherapy. Treatment fractionation schemes ranged from 15 – 33 with all patients beginning use of Silverlon after CTCAE grade 1 dermatitis. Patients were surveyed after a week of use. All patients were protocol compliant but ease of use, varied, with four head and neck patients experiencing difficulties, due to product displacement. Adverse effects, including rash exacerbation and allergic reactions, were reported by two patients. However, some patients noted benefits such as a cooling effect and aid in wound healing, with two patients reporting pain relief.</p></div><div><h3>Conclusion</h3><p>Overall, breast cancer patients viewed Silverlon more favorably, likely due to its compatibility with bra attachment. This preliminary data suggests Silverlon's efficacy, especially in breast cancer cases, warranting further investigation through a proof of concept trial. Silverlon shows promise in managing radiation dermatitis, particularly in breast cancer patients, with potential for further refinement and= clinical application.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 456"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesteatoma: Conventional patient-focused versus AI-generated resources","authors":"Samantha N Little B.S., M.S., MPH","doi":"10.1016/j.jnma.2024.07.084","DOIUrl":"10.1016/j.jnma.2024.07.084","url":null,"abstract":"<div><h3>Introduction</h3><p>A diagnosis of cholesteatoma necessitates a collaborative effort between otolaryngologists and patients for effective treatment. While physicians play a central role in providing medical education, patients often seek additional information from external sources to enhance the comprehension of their diagnosis. This study compared patient-focused cholesteatoma literature from established sources to ChatGPT-generated material. Emphasizing health literacy's crucial influence on patient health outcomes, it evaluates both sources' accuracy, readability, understandability, and actionability to highlight potential differences in these frequently accessed resources.</p></div><div><h3>Methods</h3><p>A quantitative assessment was conducted by calculating the Patient Education Materials Assessment Tool (PEMAT) score, DISCERN score, Flesch-Kincaid Grade Level (FKGL), and Flesch Reading Ease Score (FRES) for each website and ChatGPT response. Raters determined accuracy by quantifying the number of errors in each resource.</p></div><div><h3>Results</h3><p>The patient-focused content was associated with better understandability compared to ChatGPT responses with a mean PEMAT-U score of 80.2 ± 10.6 and 60.0 ± 3.72 (P &lt; .001), respectively. There was a significant difference in readability and quality demonstrated by average FKGL (P &lt; .001), FRES (P &lt; .001), and DISCERN scores in the individual ChatGPT responses (P &lt; .001). There was no significant difference with regard to DISCERN combined responses (p = 0.224) or PEMAT-A scores (p = 0.567). An average of 2.6 ± 1.1 errors were found in the combined ChatGPT responses.</p></div><div><h3>Conclusion</h3><p>Patient-focused content from established sources on cholesteatoma was easier to read, more understandable, and more accurate when compared to responses from ChatGPT. k T Nickles, B.S.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 448"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathology Activity Booths Used to Promote Colon Health","authors":"Ange Maxime TCHOUTANG BS,&nbsp;MacDonald BIN Eric,&nbsp;Severin Donald Kamdem,&nbsp;Marie Chrisitne NKUNO,&nbsp;NGUM Lesly NGUM,&nbsp;Arnauld Tepa,&nbsp;Palmer MASUMBE NETONGO","doi":"10.1016/j.jnma.2024.07.085","DOIUrl":"10.1016/j.jnma.2024.07.085","url":null,"abstract":"<div><h3>Introduction</h3><p>Malaria and Typhoid fever are significant diseases in many parts of the world, especially in the tropics and fever is a common sign. Prominent markers for early diagnosis and better comprehension of this pathological association and immunity are vital to reduce mortality, drug resistance and for clinical purposes. We sought to explore the profile of severity, oxidative stress, and inflammatory markers during malaria and typhoid fever co-infection.</p></div><div><h3>Methods</h3><p>From a cross-sectional study, 81 malaria and/or typhoid fever-positive patients from 288 fever patients were selected. Malaria was diagnosed using a Rapid diagnostic test and microscopy while typhoid fever was diagnosed using a Rapid typhoid test and Widal. Severity, stress level and inflammatory responses were evaluated by hematological analysis using full blood count, erythropoietin, cortisol, IL-10, IL-4 and IFN-γ through ELISA, superoxide dismutase and Catalase activities by spectrophotometer. Data were analyzed using SPPS 26 and PRISM 9 software.</p></div><div><h3>Results</h3><p>Co-infected patients present significant alterations of red blood cell lines such as thrombocytopenia and anemia. We founded also a significant increase of stress marker cortisol, IFN-γ and IFN-γ/IL-10 ratio compared to other groups, a decrease in anti-oxidant activities and an alteration of erythropoietin production. The levels of IL-10 and IL-4 were higher during mono-infections.</p></div><div><h3>Conclusion</h3><p>Co-infected subjects show changes in hematological parameters. The presence of malaria and typhoid fever results in a significant increase in stress, alterations in erythropoietin production, anti-oxidants and TH1- cytokine dominance. These findings allow for better management by the clinicians of these infections in the tropics.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 448"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Efficacy of Inflammatory Indices for Hyperuricemia: NHANES Analysis 2017-2020","authors":"Chutawat Kookanok MD,&nbsp;Methavee Poochanasri MD,&nbsp;Tulaton Sodsri MD,&nbsp;Nicha Wareesawetsuwan MD,&nbsp;Vitchapong Prasitsumrit MD,&nbsp;Tatchaya Kanthajan MD,&nbsp;Vichayut Chayapinun MD,&nbsp;Sethapong Lertsakulbunlue MD,&nbsp;Nisha Wanichwecharungruang MD,&nbsp;Voramol Rochanaroon MD,&nbsp;Narathorn Kulthamrongsri MD,&nbsp;Wanprapit Noree MD,&nbsp;Adivitch Sripusanapan MD,&nbsp;Kamonluk Rodsom MD,&nbsp;Napat Suriyathumrongkul MD,&nbsp;Natee Deepan MD,&nbsp;Ekamol Tantisattamo MD, MPH","doi":"10.1016/j.jnma.2024.07.059","DOIUrl":"10.1016/j.jnma.2024.07.059","url":null,"abstract":"<div><h3>Purpose</h3><p>Hyperuricemia is a widespread health issue globally, with serum uric acid (SUA) implicated in inflammation and various chronic diseases. Our study seeks to assess the correlation between established inflammatory markers and SUA, aiming to define their relationship and predictive efficacy.</p></div><div><h3>Method</h3><p>In our analysis, we studied 9,450 adults aged 18 years and older from NHANES 2017-2018, defining hyperuricemia as SUA levels of 7 mg/dL for males and 6 mg/dL for females. We evaluated key inflammatory indices, including the Systemic Inflammation Response Index (SIRI), serum ferritin, and hs-CRP, using linear regression and ROC analysis. Additionally, we adjusted the linear regression model to predict inflammatory indices, considering factors such as age, race, lifestyle habits, and medical history (hypertension, diabetes and arthritis), as well as intake of anti-inflammatory nutrients including zinc, vitamin C, D, and selenium.</p></div><div><h3>Result</h3><p>In the adjusted model, SUA increased by 0.044 (95% CI: 0.028-0.060) and 0.003 (95% CI: 0.003-0.004) per unit increase in hs- CRP and ferritin, respectively, and by 0.160 (95% CI: 0.065-0.255) per unit increase in SIRI. In male population hs-CRP, showing an increased degree of correlation to 0.051 (95% CI: 0.009-0.251). The predictive ability of hsCRP and ferritin for hyperuricemia is evident especially for female, with the ideal cut-off points for prediction being 2.785 (AUC=0.653, Sensitivity=61.7%, Specificity=39.0%) and 75.35 (AUC=0.647, Sensitivity=61.0%, Specificity=39.4%), respectively.</p></div><div><h3>Conclusion</h3><p>A strong positive relationship between inflammatory markers and SUA was evident, with gender serving as a modifying influence. SIRI, determined solely through CBC analysis, might be utilized in predicting SUA.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Pages 436-437"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Patterns of Supplement Use among Plasma Cell Disorder Patients","authors":"Eliana M. Schach BA,&nbsp;Yan Leyfman MD,&nbsp;Andriy Derkach PhD,&nbsp;Francesca Castro MS, RD, CDN,&nbsp;Jorge Arturo Hurtado Martínez MD,&nbsp;Ana M. Sahagun Sanchez Aldana MD,&nbsp;Patricia Alejandra Flores Pérez MD,&nbsp;Maria Malik BA,&nbsp;Jennifer M. Ahlstrom,&nbsp;Jay R Hydren PhD,&nbsp;Saad Z. Usmani MD, MBA, FRCP, FASCO,&nbsp;Jun J. Mao MD, MSCE,&nbsp;Susan Chimonas PhD","doi":"10.1016/j.jnma.2024.07.060","DOIUrl":"10.1016/j.jnma.2024.07.060","url":null,"abstract":"<div><h3>Purpose</h3><p>Individuals diagnosed with plasma cell disorders (PCDs) have a significant interest to incorporate supplements to enhance their health. This survey investigates perceptions, habits, and awareness related to vitamin D, omega-3 fatty acids, turmeric/curcumin, and probiotics.</p></div><div><h3>Methods</h3><p>Between September 2023 and January 2024, 480 survey responses were gathered through HealthTree Cure Hub. Summary statistics were employed to assess the deidentified survey responses.</p></div><div><h3>Results</h3><p>The study population was predominantly female (58%), aged 65+ (61%), at least college educated (67%), and from the US (90%). While white participants formed the majority (78%), minorities including African Americans, Hispanics, and American Indian or Alaska Natives comprised 9% of the respondents. Prior to diagnosis, 71% used supplements, with a notable 46% increase post-diagnosis, reaching 95% usage. Patients primarily obtained supplement information from online medical media (45%) or from healthcare providers (oncologists 46%, primary care physicians 34%). Motivations for supplement use were immune system support (70%), preventing nutritional deficiencies (54%), and slowing cancer progression (38%). Notably, 63% of patients discussed supplements with their physicians, with a strong preference for oncologist recommendations (74%). An overwhelming 91% of patients expressed interest in further research on supplement risks and benefits.</p></div><div><h3>Conclusion</h3><p>This survey highlights the growing demand for further investigation into supplements, as supplement usage increased post-diagnosis and there was a notable preference for oncologist recommendations. Addressing healthcare disparities necessitates diverse participant inclusion in future research endeavors, despite recruitment challenges. Enhanced outreach and enrollment strategies are crucial as research in this area progresses.</p></div>","PeriodicalId":17369,"journal":{"name":"Journal of the National Medical Association","volume":"116 4","pages":"Page 437"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}