处理严重的B型主动脉夹层并发症

IF 2.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Kouomegne Simo MD, MHS, Salim Aziz MD
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引用次数: 0

摘要

复发性主动脉夹层(AD)由于其严重并发症和死亡率的高风险,在医学和外科治疗方面都面临着巨大的挑战。特别是B型AD,需要仔细的血流动力学控制和程序性干预,以防止危及生命的后遗症。本病例强调了处理严重B型AD患者、复发性夹层和多种术后并发症的复杂性。方法1例49岁女性,高血压、高脂血症和心房颤动未得到控制,以突然发作的胸痛放射至背部和肩部。计算机断层血管造影(CTA)显示Stanford B型AD伴胸壁内血肿,从胸降主动脉延伸至主动脉分叉。最初的治疗包括胸血管内主动脉修复(TEVAR)。然而,她随后出现了严重的并发症,包括主动脉-食管瘘、纵隔炎、新的假性动脉瘤和上一次修复远端的第二次AD。采用多学科方法对患者进行治疗,包括抗冲动治疗、多种血管内和开放手术干预以及重症监护支持。尽管进行了大量的医疗和手术治疗,包括分阶段开放修复、内脏去分支和体外膜氧合(ECMO)启动,但患者仍经历了进行性恶化。持续的假腔灌注、难治性血流动力学不稳定和多器官衰竭最终导致心脏骤停和死亡。结论本病例强调了复发性B型AD的高危性和现有治疗策略的局限性。多种程序的需要突出了实现长期稳定的挑战。多学科方法是必要的,但需要进一步研究最佳管理策略和新的治疗选择,以改善这种复杂病例的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Managing Severe Type B Aortic Dissection Complications

Introduction

Recurrent aortic dissection (AD) presents significant challenges in both medical and surgical management due to its high risk of severe complications and mortality. Type B AD, in particular, requires careful hemodynamic control and procedural interventions to prevent life-threatening sequelae. This case highlights the complexity of managing a patient with severe Type B AD, recurrent dissections, and multiple post-procedural complications.

Methods

A 49-year-old woman with uncontrolled hypertension, hyperlipidemia, and atrial fibrillation presented with sudden onset of chest pain radiating to the back and shoulders. Computed tomography angiography (CTA) revealed Stanford Type B AD with an intramural hematoma extending from the descending thoracic aorta to the aortic bifurcation. Initial management included thoracic endovascular aortic repair (TEVAR). However, she subsequently developed severe complications, including an aorto-esophageal fistula, mediastinitis, new pseudoaneurysms, and a second AD distal to the previous repair. A multidisciplinary approach was employed to manage her condition, incorporating anti-impulse therapy, multiple endovascular and open surgical interventions, and critical care support.

Results

Despite extensive medical and surgical efforts—including staged open repair, visceral debranching, and extracorporeal membrane oxygenation (ECMO) initiation—the patient experienced progressive deterioration. Persistent false lumen perfusion, refractory hemodynamic instability, and multi-organ failure ultimately led to cardiac arrest and death.

Conclusion

This case underscores the high-risk nature of recurrent Type B AD and the limitations of current treatment strategies. The need for multiple procedures highlights the challenges in achieving long-term stability. A multidisciplinary approach is essential, but further research into optimal management strategies and novel therapeutic options is needed to improve outcomes in such complex cases.
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来源期刊
CiteScore
4.80
自引率
3.00%
发文量
139
审稿时长
98 days
期刊介绍: Journal of the National Medical Association, the official journal of the National Medical Association, is a peer-reviewed publication whose purpose is to address medical care disparities of persons of African descent. The Journal of the National Medical Association is focused on specialized clinical research activities related to the health problems of African Americans and other minority groups. Special emphasis is placed on the application of medical science to improve the healthcare of underserved populations both in the United States and abroad. The Journal has the following objectives: (1) to expand the base of original peer-reviewed literature and the quality of that research on the topic of minority health; (2) to provide greater dissemination of this research; (3) to offer appropriate and timely recognition of the significant contributions of physicians who serve these populations; and (4) to promote engagement by member and non-member physicians in the overall goals and objectives of the National Medical Association.
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