Journal of the Formosan Medical Association最新文献

{"title":"Response to comment on \"Clinical predictors of severe and fatal respiratory syncytial virus infection in adults and the elderly: A retrospective cohort study\".","authors":"Yen-Chieh Chin, Ya-Li Hu, Luan-Yin Chang","doi":"10.1016/j.jfma.2026.09.039","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.039","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Metabolic score for insulin resistance is associated with myopia in adolescents: A cross-sectional study with a complementary independent cohort\".","authors":"Lili Wu","doi":"10.1016/j.jfma.2026.09.043","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.043","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Taiwan consensus and management guidelines for gastric cancer.","authors":"Chih-Chieh Yen, I-Chen Wu, Cheng-Chan Yu, Ming-Huang Chen, Nai-Jung Chiang, Wen-Liang Fang, Kuo-Hsing Chen, Chieh-Chang Chen, Tzu-Chan Hong, Yen-Cheng Chen, Ming-Wun Wong, De-Chuan Chan, I-Shu Chen, Yen-Yang Chen, Yueh-Wei Liu, Jiann-Ming Wu, Wen-Chi Chou, Chan-Keng Yang, Jun-Te Hsu, Ta-Sen Yeh, Li-Yuan Bai, Yi-Fang Chang, Yao-Yu Hsieh, Cheng-Ming Peng, Jaw-Yuan Wang, Hui-Hua Hsiao, Li-Tzong Chen, Kun-Ming Rau, Chia-Jui Yen, Jen-Shi Chen, Yan-Shen Shan","doi":"10.1016/j.jfma.2026.09.041","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.041","url":null,"abstract":"<p><p>Gastric cancer (GC) remains a significant health burden in Taiwan, where current international guidelines may not fully align with local clinical realities. This expert consensus presents the 2025 Taiwan Consensus and Management Guidelines for Gastric Cancer, developed by a multidisciplinary taskforce from 17 medical institutions, including experts in oncology, gastroenterology, surgery, and pathology. Using a modified Delphi process and evidence-based literature review, 23 key clinical questions were identified and addressed. Recommendations encompass screening strategies, indications for endoscopic resection, perioperative treatment for locally advanced disease, biomarker-guided therapy, and palliative care. This consensus integrates both global evidence and local practice patterns, aiming to support individualized and practical decision-making for GC management in Taiwan.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline striatal dopamine transporter availability and exercise-related body-composition changes: Response to Xiao.","authors":"Muhammad Abdullah, Shih-Hsien Lin, Li-Chung Huang, Nan-Tsing Chiu, Yen Kuang Yang","doi":"10.1016/j.jfma.2026.09.038","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.038","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudomotor dysfunction is associated with loss of residual renal function in patients undergoing peritoneal dialysis.","authors":"Liang-Te Chiu, Yu-Li Lin, Chih-Hsien Wang, Chii-Min Hwu, Hung-Hsiang Liou, Bang-Gee Hsu","doi":"10.1016/j.jfma.2026.09.031","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.031","url":null,"abstract":"<p><strong>Purpose: </strong>Uremic neuropathy is common in dialysis patients. We investigated the association between electrochemical skin conductance (ESC), a measure of sudomotor function, and residual renal function (RRF) in patients undergoing peritoneal dialysis (PD), accounting for dialysis vintage, and examined relationships with clinical neuropathy scores.</p><p><strong>Methods: </strong>This cross-sectional study included 86 PD patients assessed by Sudoscan and the Michigan Neuropathy Screening Instrument (MNSI), with comparison to matched stage 4-5 chronic kidney disease (CKD) patients. Absence of RRF was defined as urine output <100 mL/day or creatinine clearance <1 mL/min. Multivariable regression and moderated mediation analyses were performed.</p><p><strong>Results: </strong>Hands and feet ESC decreased, while pathological ESC prevalence increased, across stage 4-5 CKD, PD with RRF, and PD without RRF (P for trend <0.001). Residual renal creatinine clearance (CCr) was independently associated with both hands and feet ESC. When CCr and dialysis vintage were entered simultaneously, CCr remained associated with feet ESC but not significantly with hands ESC. Absence of RRF was associated with pathological hands (OR 4.56, P = 0.014) and feet ESC (OR 3.70, P = 0.024). Conditional indirect associations through CCr were observed among patients without diabetes, with significant moderated mediation for feet ESC only. ESC correlated inversely with MNSI-P scores for hands (r = -0.33, P = 0.002) and feet (r = -0.31, P = 0.005).</p><p><strong>Conclusion: </strong>Lower RRF was associated with worse sudomotor function in PD patients, particularly for feet ESC after accounting for dialysis vintage. ESC also correlated with objective neuropathy scores. Prospective studies are needed to clarify temporal relationships.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The third-year results of denosumab sequential therapy trial: An extension of a randomized clinical trial.","authors":"Hung-Kuan Yen, Ming-Hung Chiang, Shan-Lun Tsao, Jen-Hao Liu, Tzu-Hao Tseng, Ta-Chun Lin, Chia-Che Lee, Chih-Chien Hung, Chuan-Ching Huang, Shau-Huai Fu, Chen-Yu Wang","doi":"10.1016/j.jfma.2026.09.029","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.029","url":null,"abstract":"<p><strong>Background/purpose: </strong>Denosumab effectively increases bone mineral density (BMD) and reduces fracture risk in osteoporosis patients. Denosumab discontinuation is related with rebound bone loss and increased fracture risk. Zoledronate has been proposed as sequential therapy to mitigate this effect. We investigated the efficacy of an alternating regimen of denosumab and zoledronate on BMD and bone turnover markers (BTMs) over three years.</p><p><strong>Methods: </strong>This one-year extension of a multicenter, open-label randomized controlled trial included postmenopausal women and men aged ≥50 who had been receiving biannual denosumab for at least two years but less than three years. In the original trial, participants were assigned to either a control group that received denosumab for two years or an intervention group that received zoledronate in the first year followed by a switch back to denosumab in the second year. In this extension study, both groups received denosumab in the third year.</p><p><strong>Results: </strong>At 36 months, no statistically significant between-group differences in BMD changes were observed during the extension period. However, the intervention group exhibited lower levels of BTMs (CTX and P1NP), indicating a reduction in bone resorption activity. There was no significant difference in fracture rates between groups.</p><p><strong>Conclusion: </strong>These findings suggest that an alternating regimen of denosumab and zoledronate may be a viable strategy for managing osteoporosis, effectively mitigating the rebound effect while maintaining BMD gains. The observed benefits of reduced BTMs in the intervention group highlight the long-lasting therapeutic effects of zoledronate. Further research is necessary to confirm these results and determine this approach's long-term safety and cost-effectiveness.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT03868033; registered March 7, 2019.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Arsenic exposure and trend of incidence in urinary cancer from 1979 to 2019: A nationwide population-based study\".","authors":"Hongquan Liu, Youwei Chi, Qian Li, Jitao Wu","doi":"10.1016/j.jfma.2026.09.033","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.033","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining meaningful neuropsychological changes following epilepsy surgery for Chinese-speaking patients in Taiwan.","authors":"Yi-Jiun Lu, Sanford Pc Hsu, Chun-Fu Lin, Chien-Chen Chou, Wei-Han Wang, Hsiang-Yu Yu","doi":"10.1016/j.jfma.2026.09.027","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.027","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop reliable change index (RCI) and standardized regression-based (SRB) change scores for Chinese versions of the neuropsychological tests to provide an empirical standard for evaluating meaningful cognitive changes after epilepsy surgery for patients with temporal lobe epilepsy (TLE).</p><p><strong>Methods: </strong>Thirty-one non-operated patients with TLE were assessed twice (6-month interval) by using the Wechsler Adult Intelligence Scale-III (WAIS-III) and the subtests of the Wechsler Memory Scale-III (WMS-III) to compute RCI with the correction of practice effect and SRB equations. The predictor variables for the SRB models included the demographic variables (age, gender, education), clinical variables (age of seizure onset, seizure duration), and baseline performance. These standards were then applied to sixty patients who underwent selective amygdalohippocampectomy (SAH).</p><p><strong>Results: </strong>Test-retest reliability was acceptable while the individual subtest variability was noted (r = 0.51 to 0.94). Baseline performance was the primary predictor in each SRB equation, accounting for 31.4% to 88.4% of the variance. Among the SAH cohort, 80.0%-100.0% remained cognitively stable across different tests. However, the patients in left SAH group exhibited a significant decline in verbal memory (20.0-23.3%), working memory and executive control (6.7-30.0%). Conversely, more than 10% of the right SAH group showed deterioration in visual memory and processing speed.</p><p><strong>Conclusion: </strong>This study developed and demonstrated the clinical applicability of disease-specific, population-specific RCI and SRB indices for Traditional Chinese-speaking patients with TLE. These indices provide a standardized framework for accounting for practice effects, regression to the mean, and test-retest variability when interpreting meaningful cognitive changes following epilepsy surgery.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Adipose stem-cell-derived microvesicles ameliorate long-term bladder ischemia-induced bladder underactivity\".","authors":"Hongquan Liu, Hao Wang, Jie Gao, Jitao Wu","doi":"10.1016/j.jfma.2026.09.035","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.035","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on \"Impact of computed tomography noise and region of interest sizes on the characterization of homogeneous renal mass: a proof-of-concept study\".","authors":"Yao-Ting Lee, Chung-Ming Chen, Jeff S Chueh, Po-Ting Chen","doi":"10.1016/j.jfma.2026.09.030","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.09.030","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}