Journal of the Formosan Medical Association最新文献

{"title":"Response to \"Handgrip strength is probably not a predictor of mortality in patients with cardiovascular disease\".","authors":"Zhengjie Qin, Guoming Li","doi":"10.1016/j.jfma.2025.02.033","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.02.033","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and perinatal outcomes of mothers with inflammatory bowel disease in Taiwan: A national database analysis.","authors":"Chi-Nien Chen, Hsin-Yun Wu, Meng-Tzu Weng, Chiuan-Bo Huang, Chien-Chih Tung, Shu-Chen Wei, Po-Nien Tsao","doi":"10.1016/j.jfma.2025.02.034","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.02.034","url":null,"abstract":"<p><strong>Background: </strong>Pregnant women with inflammatory bowel disease frequently experience suboptimal perinatal outcomes. One Taiwanese study conducted from 2001 to 2003 revealed higher risks of preterm birth and low birth weight in infants born to mothers with ulcerative colitis. With the advancement in disease management, we aim to investigate the pregnancy and perinatal outcomes of Taiwanese mothers with inflammatory bowel disease between 2004 and 2018.</p><p><strong>Methods: </strong>We integrated data from Taiwan's Maternal and Child Health Database, Birth Reporting Database, National Health Insurance Database, and Catastrophic Illness Registry from 2004 to 2018. Mothers with inflammatory bowel disease were identified using International Classification of Diseases codes and the Catastrophic Illness Registry and matched 1:10 with healthy pregnant women based on the year of childbirth and maternal age. Statistical analyses involved chi-squared tests and conditional logistic regression models.</p><p><strong>Results: </strong>A total of 3,059,647 births were recorded, of which 146 were born to mothers with IBD (126 to those with ulcerative colitis and 20 to those with Crohn's disease). We observed no significant differences in stillbirths, preterm births, cesarean deliveries, low birth weights, small- or large-for-gestational-age newborns, or Apgar scores between the mothers with inflammatory bowel disease and the controls. Hypertensive disorders of pregnancy were less prevalent in the inflammatory bowel disease group (4.1% vs 13.6%; P = 0.001). Subgroup analysis revealed consistent outcomes in both ulcerative colitis and Crohn's disease, across socioeconomic status, and disease duration.</p><p><strong>Conclusions: </strong>Pregnancy and perinatal outcomes are comparable in Taiwanese women with inflammatory bowel disease and matched healthy counterparts. While no statistically significant differences were observed, the limited statistical power for certain outcomes warrants cautious interpretation. These findings highlight the need for further investigation in larger cohorts or pooled datasets to explore small but potentially clinically meaningful differences.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved survival with adding-on strategy after failure of nanoliposomal irinotecan plus 5-fluorouracil and leucovorin in metastatic pancreatic adenocarcinoma.","authors":"Shih-Hung Yang, Chien-Jui Huang, Sz-Chi Chiu, Hsiang-Fong Kao, Li-Chun Lu, Yan-Shen Shan, Sung-Hsin Kuo, Kun-Huei Yeh","doi":"10.1016/j.jfma.2025.02.035","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.02.035","url":null,"abstract":"<p><strong>Background: </strong>Nanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (FL) is indicated after progression on gemcitabine-based therapy in patients with metastatic pancreatic ductal adenocarcinoma (PDAC). However, salvage therapy after nal-IRI/FL failure remains to be established.</p><p><strong>Methods: </strong>This study included 260 consecutive patients who initiated nal-IRI/FL therapy reimbursed by the National Health Insurance of Taiwan between January 2019 and March 2023. All patients were stratified into three groups (adding-on, regimen-shifting, and supportive) according to their strategy for nal-IRI/FL treatment. The prognostic factors were identified using univariate and multivariate analyses. Propensity score matching (PSM) was used to compare the median overall survival (OS) between the adding-on oxaliplatin or nab-paclitaxel and regimen-shifting groups following treatment failure with nal-IRI/FL.</p><p><strong>Results: </strong>The median OS after the initiation of nal-IRI/FL was 7.8 (95% confidence interval [CI], 5.2-10.5) months and 6.1 (95% CI, 5.3-6.9) months for the adding-on oxaliplatin or nab-paclitaxel and regimen-shifting groups, respectively (P = 0.035). An Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-1, no peritoneal metastasis before nal-IRI/FL, and the addition of oxaliplatin or nab-paclitaxel were significant independent prognostic factors for OS after nal-IRI/FL initiation. After PSM, the median OS after adding-on oxaliplatin/nab-paclitaxel or shifting regimens following the treatment failure of nal-IRI/FL were 4.1 (95% CI, 3.5-4.7) months and 3.1 (95% CI, 1.7-4.5) months, respectively (P = 0.039).</p><p><strong>Conclusion: </strong>Addition of oxaliplatin or nab-paclitaxel to nal-IRI/FL was significantly associated with a better OS than regimen shifting after progression on nal-IRI/FL in patients with metastatic PDAC.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of primary health care publication trends in the Asia-Pacific region from 2011 to 2023.","authors":"Chun-Feng Huang, Brian Bih-Jeng Chang, I-Hsuan Hwang, Yu-Chun Chen, Shinn-Jang Hwang","doi":"10.1016/j.jfma.2025.02.028","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.02.028","url":null,"abstract":"<p><strong>Background: </strong>Emphasis on primary health care (PHC) is the most efficient and economical approach to achieving universal health coverage, and should serve as its foundation. The aim of the study is to examine academic publications from 2011 to 2023 in the Asia-Pacific region (APR) using the Web of Science (WoS) subject category of PHC.</p><p><strong>Methods: </strong>Academic papers in the WoS PHC category published in the APR from 2011 to 2023 were retrieved and analyzed, including papers published in the Science Citation Index-Expanded and the Social Science Citation Index.</p><p><strong>Results: </strong>A total of 5172 papers were published in the WoS PHC category from APR onwards. The annual number of publications and their citations increased from 2011 to 2023. Australia led PHC publications in the APR with 3918 publications (75.75% of APR regional output). New Zealand had the highest number of citations per paper (14.54) and the highest mean impact factor (3.25 ± 1.70). Publications in the WoS PHC category also covered a wide range of topics, including Medicine General Internal (70.86%), Health Care Sciences Services (18.10%), Health Policy Services (17.67%), and Public Environmental Occupational Health (17.67%), demonstrating the breadth of PHC research.</p><p><strong>Conclusion: </strong>The annual number of publications and their citations in the WoS PHC category from the APR increased from 2011 to 2023. Australia and New Zealand have a significant presence in the PHC publications in the APR.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definition, prevalence, and economic impacts of hypertension on the elderly population.","authors":"Cheng-Wei Lien, Yi-Hsuan Lee, Chia-Wen Lu, Yu-Ching Chang, Yi-Syuan Lin, Hao-Min Cheng, Michael Yu-Chih Chen, Long-Teng Lee, Cheng-Kuo Huang, Yen-Hung Lin, Chih-Fan Yeh, Shao-Yi Cheng","doi":"10.1016/j.jfma.2025.02.020","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.02.020","url":null,"abstract":"<p><p>Arterial hypertension is the most important modifiable risk factor for cardiovascular disease and a leading cause of death. The incidence of hypertension increases with age, with a lifetime risk of more than 90% for elderly individuals. With the growth in the absolute numbers and proportion of the elderly population worldwide, the economic impact and burden on healthcare systems due to elderly hypertension continue to rise. However, inconsistencies in the definition of elderly hypertension in different guidelines and the controversial results of various clinical trials underscore the importance of determining the consensus of management for elderly hypertension. Therefore, to clarify the current situation, this article discusses the definition, prevalence, and economic impacts of elderly hypertension.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediated model of PTSD between ADHD symptoms and alcohol abuse in a population of college students in Taiwan","authors":"Kunhua Lee ,&nbsp;Hong Wang Fung","doi":"10.1016/j.jfma.2024.08.008","DOIUrl":"10.1016/j.jfma.2024.08.008","url":null,"abstract":"<div><h3>Purpose</h3><div>Impulsivity, inattention, childhood trauma, PTSD, and depressive symptoms were the high-risk factors of alcohol abuse in ADHD symptoms. There is a lack of a comprehensive framework of trauma and PTSD in ADHD symptoms with alcohol abuse to explain why ADHD college students become problematic alcohol drinking.</div></div><div><h3>Method</h3><div>521 college students were recruited from online platforms (e.g., Facebook, LINE, or Google) after informed consent (females, 67.9%, n = 354; averaged age = 20.34, S.D. = 1.98). All of them completed the questionnaires, which included symptoms of ADHD, inattention and impulsivity, depressive symptoms, childhood trauma, PTSD symptoms, and problematic alcohol drinking. One-way ANOVA and path analysis were applied to examine the significance of eight paths.</div></div><div><h3>Results</h3><div>Our results supported the mediating effects of childhood trauma and PTSD symptoms in ADHD symptoms with problematic alcohol drinking.</div></div><div><h3>Discussion</h3><div>The effect of complex PTSD between impulsivity and problematic alcohol drinking is still unclear. In addition to impulsivity and inattention to ADHD symptoms with problematic alcohol drinking, the impact of hyperactivity also needs to be considered.</div></div><div><h3>Conclusion</h3><div>Effective treatment for ADHD symptoms with alcohol abuse could focus on self-control training and emotional regulation in the future.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 284-289"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Checklist","authors":"","doi":"10.1016/S0929-6646(25)00086-5","DOIUrl":"10.1016/S0929-6646(25)00086-5","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Page e9"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and validation of traditional Chinese version of the pediatric eating assessment Tool-10","authors":"Sz-Ting Wang ,&nbsp;Kun-Tai Kang ,&nbsp;Wen-Chin Weng ,&nbsp;Pin-Hung Lu ,&nbsp;Chi-Fen Chang ,&nbsp;Yuh-Yu Lin ,&nbsp;Yu-Chen Lee ,&nbsp;Chen-Yu Chen ,&nbsp;Jing-Chun Song ,&nbsp;Wei-Chung Hsu","doi":"10.1016/j.jfma.2024.04.010","DOIUrl":"10.1016/j.jfma.2024.04.010","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>The Pediatric Eating Assessment Tool-10 (Pedi-EAT-10) is a caregiver-administrated subjective questionnaire for evaluating swallowing and feeding disorders among children. This study translated the Pedi-EAT-10 into Traditional Chinese and tested the translated version's reliability and validity.</div></div><div><h3>Methods</h3><div>Pedi-EAT-10 was translated into Traditional Chinese by experts and finalized after discussion and testing. A total of 168 participants, consisting of 32 children with dysphagia from a tertiary medical center and 136 healthy controls from its Children Care Center for Employees, were recruited. All participants were assessed by an otolaryngologist and speech-language pathologist. The reliability, validity, and efficacy of the translated Pedi-EAT-10 were analyzed to ensure it could be used to identify pediatric dysphagia and feeding problems.</div></div><div><h3>Results</h3><div>The Traditional Chinese version of the Pedi-EAT-10 had significant clinical discriminative validity between the dysphagia group and the control group (total score = 9.6 vs. 2.6, <em>P</em> &lt; 0.001), acceptable test–retest reliability (intraclass correlation = 0.63), and excellent internal consistency (Cronbach's α = 0.91 for the entire cohort). The overall performance of the test for distinguishing children with dysphagia from normal controls was acceptable, and the area under the curve was 74.8% (sensitivity = 71.9%; specificity = 69.9%). The optimal cutoff score was ≥3 on the Youdex index.</div></div><div><h3>Conclusion</h3><div>The Traditional Chinese version of the Pedi-EAT-10 has fair reliability and validity and can be quickly and easily completed by caregivers. The translated Ped-EAT-10 can be used as a first-line tool for assessing the need for further referral and instrumental examination.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 258-263"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes and predictors in patients with acute on chronic liver failure in Southern Taiwan","authors":"Pao-Yuan Huang ,&nbsp;Yu-Cheng Lin ,&nbsp;Chih-Chi Wang ,&nbsp;Chien-Hung Chen","doi":"10.1016/j.jfma.2024.08.034","DOIUrl":"10.1016/j.jfma.2024.08.034","url":null,"abstract":"<div><h3>Background/aims</h3><div>The study is to analyze the clinical characteristics and identify prognostic factors as well as evaluate predictive models in patients with acute-on-chronic liver failure (ACLF) from Southern Taiwan.</div></div><div><h3>Methods</h3><div>The cohort study was conducted using the Chang Gung Research Database. We included patients with ACLF based on the definition provided by the Asian-Pacific Association for the Study of the Liver ACLF Research Consortium (AARC).</div></div><div><h3>Results</h3><div>A total of 231 patients diagnosed with ACLF were included in this study, out of which 26 patients underwent liver transplantation (LT). The primary cause of ACLF was acute exacerbation of hepatitis B virus (HBV) in 68.4% of cases and followed by severe alcoholic hepatitis (20.8%). Among LT-free patients, the 28-day mortality rate was observed to be 31%. Older age, higher INR and ammonia levels, and the presence of severe hepatic encephalopathy on 3–6 days of treatment were independent predictors of 28-day mortality. The CLIF-C ACLF and COSSH-ACLF scores, evaluated on 3–6 days, demonstrated the highest predictive performance for 28-day mortality. The optimal cut-off values for the CLIF-C ACLF and COSSH-ACLF scores were determined to be 47 and 6.3, respectively. Patients with CLIF-C ACLF score &gt;63 or COSSH-ACLF score &gt;8.1 experienced 100% mortality by day 28.</div></div><div><h3>Conclusion</h3><div>The CLIF-C ACLF and COSSH-ACLF scores, evaluated within one week after treatment, exhibit strong predictive capabilities for short-term mortality in ACLF patients. These models are valuable tools for guiding timely decision-making, including the consideration of liver transplantation or withdrawal from treatment.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 234-240"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142212288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns regarding the study on vitamin D consumption and gallstones","authors":"Lihua Yang,&nbsp;Chenghua Zhou,&nbsp;Cailing Qin,&nbsp;Yuan Huang","doi":"10.1016/j.jfma.2024.09.031","DOIUrl":"10.1016/j.jfma.2024.09.031","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 291-293"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}