Journal of the Formosan Medical Association最新文献_第10页

Comment on "PD-L1 expression and immune profiling cannot predict osimertinib efficacy in lung cancer with EGFR T790 M mutation: A translational study". 评论“PD-L1表达和免疫谱不能预测奥西替尼对EGFR t790m突变肺癌的疗效：一项翻译研究”。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-19 DOI: 10.1016/j.jfma.2025.04.019

Shengjing Zhou, Chengyan He

引用次数: 0

Risk of colon polyps and colorectal cancer in primary biliary cholangitis, a population-based retrospective cohort study in Taiwan. 原发性胆管炎患者结肠息肉和结直肠癌的风险：台湾一项以人群为基础的回顾性队列研究。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-18 DOI: 10.1016/j.jfma.2025.04.007

Pei-Tzu Chen, Wu-Chien Chien, Chi-Hsiang Chung, Peng-Jen Chen, Tien-Yu Huang, Hsuan-Wei Chen

{"title":"Risk of colon polyps and colorectal cancer in primary biliary cholangitis, a population-based retrospective cohort study in Taiwan.","authors":"Pei-Tzu Chen, Wu-Chien Chien, Chi-Hsiang Chung, Peng-Jen Chen, Tien-Yu Huang, Hsuan-Wei Chen","doi":"10.1016/j.jfma.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.04.007","url":null,"abstract":"Background & aims: Bile acids are carcinogens causing mutations leading to colorectal cancer (CRC). Higher total bile acid concentrations in the serum of patients with primary biliary cholangitis (PBC), compared to healthy controls, have been reported in previous studies. However, the association between PBC and the risk for CRC remains controversial. We investigated the association between PBC and the development of colonic polyps leading to CRC overall in this study.Methods: The study enrolled 1,936,512 individuals from the Longitudinal Health Insurance Database spanning 2000 to 2017 for cohort analysis. Individuals assigned to ICD-9-CM and ICD-10-CM codes representing PBC were incorporated. A 1:4 control cohort was randomly selected. After adjusting for CRC risk factors using Cox regression analysis, we calculated the hazard ratios for developing colon polyps and CRC in PBC patients compared to the general population.Results: Within the study cohort, consisting of 2024 individuals meeting the inclusion criteria, 199 patients developed colon polyps or CRC. In contrast, among the 8096 individuals in the comparison cohort, 650 cases of colon polyps or CRC were observed during the 17-year-follow-up period. According to Cox regression analysis, the adjusted hazard ratio indicated that the risk was 1.678 times higher in the PBC group compared to the comparison group.Conclusions: This population-based retrospective cohort study identified a 1.68-fold increased risk of colon polyps and CRC in patients with PBC, suggesting a potential association with colonic neoplasia. Further research is warranted to evaluate the role of endoscopic surveillance in patients with PBC.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting maternal age and child health: A nationwide birth cohort study in Taiwan. 重新检视母亲年龄与儿童健康：台湾一项全国性出生队列研究。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-18 DOI: 10.1016/j.jfma.2025.04.018

Yi-Yu Su, Chi-Jen Chen, Mei-Huei Chen, Ching-Chun Lin, Wu-Shiun Hsieh, Hsi Chang, Chin-Kan Chan, Wan-Ling Ho, Mu-Ming Chien, Pau-Chung Chen

{"title":"Revisiting maternal age and child health: A nationwide birth cohort study in Taiwan.","authors":"Yi-Yu Su, Chi-Jen Chen, Mei-Huei Chen, Ching-Chun Lin, Wu-Shiun Hsieh, Hsi Chang, Chin-Kan Chan, Wan-Ling Ho, Mu-Ming Chien, Pau-Chung Chen","doi":"10.1016/j.jfma.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.04.018","url":null,"abstract":"Background: Delayed childbearing is a growing trend globally, with Taiwan experiencing one of the steepest increases in maternal age. Advanced maternal age affects offspring health, including birth outcomes and long-term morbidity. However, its impact in Taiwan remains underexplored. This study investigates these effects using a nationwide birth cohort.Methods: This retrospective cohort study utilized data from Taiwan's National Health Insurance Research Database (NHIRD), covering infants born from January 1, 2004, to December 31, 2014. The cohort included 2,068,672 infants, categorized into six maternal age groups: <20, 20-24, 25-29, 30-34, 35-40, and ≥40 years. Principal outcomes were stillbirth, mortality, preterm birth, congenital anomalies, neurodevelopmental outcomes, and atopic diseases. Multivariate logistic regression models adjusted for covariates to assess associations between maternal age and health outcomes.Results: Among the 2,068,672 infants, stillbirth and mortality rates were highest in infants born to mothers <20 years, decreased with increasing maternal age, then rose again for mothers ≥30 years, showing a reverse J-shaped pattern. Similar trends were noted for preterm birth, congenital anomalies, and neurodevelopmental outcomes. Atopic diseases followed a nonlinear trend, peaking at maternal age 25-34 years.Conclusion: Maternal age significantly impacts child health, with risks associated with both younger and older maternal ages. These findings are crucial for regions experiencing delayed childbearing. Further research is needed to explore underlying mechanisms and establish causality.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter "Comment to: The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases". 对“评论：血清胆固醇轨迹、他汀类药物剂量与胆结石疾病复发风险之间的关系”信函的回应。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-17 DOI: 10.1016/j.jfma.2025.04.012

Chih-Ming Liang

引用次数: 0

Comment on "A bibliometric analysis of primary health care publication trends in the Asia-Pacific region from 2011 to 2023". 对“2011年至2023年亚太地区初级卫生保健出版物趋势的文献计量分析”的评论。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-17 DOI: 10.1016/j.jfma.2025.04.015

Deng Ting, Liu Ping, Li Jierong, Gu Xiaomei

引用次数: 0

Controlling nutritional status score as a survival prognosticator in patients with head and neck cancer. 控制营养状况评分作为头颈癌患者的生存预后指标。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-16 DOI: 10.1016/j.jfma.2025.04.017

Ming-Hsien Tsai, Chao-Hui Yang, Yao-Te Tsai, Yu-Tsai Lin, Chun-Yuan Chao, Hui-Ching Chuang, Tai-Lin Huang, Hui Lu, Wen-Ling Tsai, Chih-Yen Chien, Fu-Min Fang

{"title":"Controlling nutritional status score as a survival prognosticator in patients with head and neck cancer.","authors":"Ming-Hsien Tsai, Chao-Hui Yang, Yao-Te Tsai, Yu-Tsai Lin, Chun-Yuan Chao, Hui-Ching Chuang, Tai-Lin Huang, Hui Lu, Wen-Ling Tsai, Chih-Yen Chien, Fu-Min Fang","doi":"10.1016/j.jfma.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.04.017","url":null,"abstract":"Purpose: This study aimed to evaluate the prognostic significance of the preoperative Controlling Nutritional Status (CONUT) score in head and neck squamous cell carcinoma (HNSCC).Methods: Patients with HNSCC who underwent radical surgery between 2008 and 2017 were retrospectively analyzed and randomly divided into training and validation cohorts by 3:1 ratio. The CONUT score, based on serum albumin, total cholesterol, and lymphocyte count measured within 1 week before surgery, was used. Univariate and multivariate Cox regression identified survival-related variables, forming the basis for predictive models developed in the training cohort and validated in the validation cohort.Results: A total of 636 patients were enrolled in this study, including 477 patients in the training cohort and 159 patients in validation cohort. A CONUT cutoff value of 2 effectively stratified patients into two distinct prognostic groups with significant survival differences in both the training and validation cohorts. In the multivariate Cox model, a high CONUT score emerged as an independent negative prognosticator of overall survival (OS) and cancer specific survival (CSS) in both training and validation cohorts. The CONUT score-based nomograms accurately predicted OS (concordance index: 0.778 in training cohort and 0.709 in validation cohort) and CSS (concordance index: 0.830 in training cohort and 0.778 in validation cohort).Conclusion: The preoperative CONUT score is a useful prognostic marker for surgically treated HNSCC, enhancing nomogram-based risk models to identify high-risk patients and guide treatment decisions effectively.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concerns and opportunities in combining TORS and OPR for managing inflammation and oxidative stress in OSA. 联合tor和OPR治疗OSA患者炎症和氧化应激的关注和机遇。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-15 DOI: 10.1016/j.jfma.2025.04.010

Yingxue Hu, Qinghui Yang, Pingwei Ni, Xiao Liu

引用次数: 0

Comment on "Impact of pre-Omicron COVID-19 vaccine boosters on the risk of Omicron variant infections: A systematic review and meta-regression". 对“预Omicron COVID-19疫苗增强剂对Omicron变异感染风险的影响：一项系统综述和元回归”的评论。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-14 DOI: 10.1016/j.jfma.2025.04.008

Venkata Dileep Kumar Veldi, Renu Sah

引用次数: 0

Long-term outcomes of functional endoscopic sinus surgery with selective vidian neurectomy for chronic rhinosinusitis with nasal polyps combined with allergic rhinitis and asthma. 功能性内窥镜鼻窦手术联合选择性维甸神经切除术治疗慢性鼻窦炎合并鼻息肉合并变应性鼻炎和哮喘的远期疗效。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-12 DOI: 10.1016/j.jfma.2025.04.005

Chengxun Jin, Yunmeng Wang, Wenjia Wang, Tingyue Zheng, Jingpu Yang

{"title":"Long-term outcomes of functional endoscopic sinus surgery with selective vidian neurectomy for chronic rhinosinusitis with nasal polyps combined with allergic rhinitis and asthma.","authors":"Chengxun Jin, Yunmeng Wang, Wenjia Wang, Tingyue Zheng, Jingpu Yang","doi":"10.1016/j.jfma.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.04.005","url":null,"abstract":"Background: Patients with allergic rhinitis (AR), chronic rhinosinusitis (CRS) with nasal polyps (ARwCRSwNP), and asthma often exhibit high recurrence rates after functional endoscopic sinus surgery (FESS), sometimes requiring revision surgery. This study evaluated the long-term outcomes of combining FESS with selective vidian neurectomy in patients with ARwCRSwNP and asthma.Methods: Fifty-six ARwCRSwNP patients, including 27 with asthma, were divided into two groups: one received FESS with selective vidian neurectomy (group A), and the other underwent FESS alone (group B or control). Disease severity, control, and outcomes were evaluated using the Visual Analog Scale (VAS), the 22-item Sino-Nasal Outcome Test (SNOT-22), and the Lund-Kennedy score for nasal endoscopy. To assess factors influencing disease severity and treatment outcomes, we recorded allergy assessments (for mites, mold, and pollens), preoperative blood eosinophilia, and tissue eosinophil levels from histopathological examination following endoscopic surgery.Results: After three years, patients from both groups showed significant improvements in symptoms and quality of life compared to the preoperative period (p < 0.01). CRS patients with high tissue eosinophilic inflammation exhibited reduced disease control compared to those with controlled or partly controlled disease (p < 0.05). Patients in group A had better outcomes for nasal itching and sneezing compared to group B. While overall CRS control was similar between the two groups, group A demonstrated better CRS control among asthma patients (p < 0.05).Conclusion: Combining FESS with selective vidian neurectomy effectively improves nasal symptoms in ARwCRSwNP patients and represents a beneficial treatment option for those with comorbid asthma.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on: "Severe SARS-CoV-2 alpha variant convalescent patients exhibit worse T cell immune response than those with mild severity disease". 评论：“重症SARS-CoV-2 α变异恢复期患者的T细胞免疫反应较轻重症患者差”。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-11 DOI: 10.1016/j.jfma.2025.04.003

Shubham Kumar, Rachana Mehta, Ranjana Sah, Amogh Verma

引用次数: 0