Journal of the Formosan Medical Association最新文献

{"title":"Corrigendum to \"Comparing long and intermediate-length plates for metastatic bone disease of the proximal humerus: A retrospective analysis\" [J Formos Med Associat 124, 2025, 549-555].","authors":"Ching-Wei Lin, Hung-Kuan Yen, Chih-Chi Su, Young Lee, Chia-Che Lee, Wei-Hsin Lin, Olivier Q Groot","doi":"10.1016/j.jfma.2026.10.011","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.011","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and disease status as negative prognostic factors for 5-year survival in chondrosarcoma: A single-institution analysis.","authors":"Sung-Chuan Chao, Wei-Hsin Lin, Shing-Hwa Liu, Rong-Sen Yang","doi":"10.1016/j.jfma.2026.10.022","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.022","url":null,"abstract":"<p><strong>Background: </strong>While Western literature identifies age, histological grade, tumor characteristics, and metastasis as key prognostic factors for chondrosarcoma survival, data specifically focusing on the Taiwanese population remain sparse.</p><p><strong>Methods: </strong>This retrospective study included patients who were pathologically diagnosed with chondrosarcoma between January 1998 and July 2016. Clinical and demographic variables were collected, including sex, age, tumor characteristics (size, anatomical location, histological subtype, and pathological grade), treatment modalities (surgical approach and adjuvant therapies), and disease status within a five-year interval following diagnosis. Cox proportional hazards and logistic regression models were utilized to evaluate prognostic factors and to construct a predictive model.</p><p><strong>Results: </strong>Among 58 patients (mean age 47.4 ± 18.3 years; 5-year OS 77.6%), multivariate Cox regression showed that advanced age, progressive systemic disease (aHR 10.07, 95% CI: 1.49-68.00; p < 0.05), and primary metastatic disease (aHR 11.03, 95% CI: 1.62-75.20; p < 0.05) independently predicted worse survival. The multivariate logistic regression model demonstrated high discriminative ability (AUC = 0.954), supporting the use of the derived nomogram for individualized prognosis.</p><p><strong>Conclusion: </strong>This study identifies advanced age and unfavorable disease status as independent negative predictors of 5-year survival in chondrosarcoma. The developed prognostic model and nomogram demonstrated high predictive accuracy, providing a robust tool for clinical risk stratification and personalized management of this patient population.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide significance and rare-variant robustness in STEMI genetic associations.","authors":"Jianqi Qiao, Taotao Li, Xiaoyou Lin","doi":"10.1016/j.jfma.2026.10.017","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.017","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic stone angle in RIRS: from score discrimination to clinical interchangeability.","authors":"Maocan Cui, Tao Chen, Yizhe Yang, Minghong Xu","doi":"10.1016/j.jfma.2026.10.012","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.012","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding antiviral therapy in chronic hepatitis B: Evidence, uncertainties, and clinical considerations.","authors":"Yingying Yuan, Wei Li, Yingfang Yuan, Kai Zuo","doi":"10.1016/j.jfma.2026.10.016","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.016","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Impact of ALK rearrangement on survival in resected lung adenocarcinoma: A real-world analysis\": ALK ascertainment and the interpretation of a null result.","authors":"Guancheng Lai, Lin Jin","doi":"10.1016/j.jfma.2026.10.013","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.013","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parallel culprit-thrombus transcriptomic and genome-wide association analyses in ST-segment elevation myocardial infarction: An exploratory pilot study.","authors":"Jing-Xing Li, Wuh-Liang Hwu, Pei-Chun Hsu, Ting-Yuan Liu, Fuu-Jen Tsai, Kuan-Cheng Chang","doi":"10.1016/j.jfma.2026.10.010","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.010","url":null,"abstract":"<p><strong>Background: </strong>Direct molecular characterization of culprit coronary thrombi may provide insights into local mechanisms of ST-segment elevation myocardial infarction (STEMI) that are not captured by circulating blood. We investigated thrombus-associated transcriptomic patterns and their relationship with inherited genetic susceptibility.</p><p><strong>Methods: </strong>High-depth RNA sequencing was performed on paired aspirated culprit thrombi and peripheral blood from 10 patients with first-time STEMI. Differential expression was assessed using DESeq2, with exploratory signals defined by nominal P < 0.05 and absolute log₂ fold change ≥ 1.5. Benjamini-Hochberg correction was applied across 44,525 transcripts. Transcript-clinical associations and sensitivity analyses were also performed. In parallel, a genome-wide association study included 1787 patients with STEMI and 17,837 age- and sex-matched controls.</p><p><strong>Results: </strong>Although 708 transcripts met the nominal exploratory criteria, none remained significant after transcriptome-wide correction. The nominal signals converged on biologically relevant processes, including extracellular matrix remodeling, inflammatory and chemokine signaling, lipid and apolipoprotein regulation, angiogenesis, and metalloprotease activity. These patterns likely reflected both local thrombus biology and differences in cellular composition between thrombi and peripheral blood. Clinical correlations and differences according to prior coronary artery disease were not robust after multiplicity correction or sensitivity analysis. Genome-wide association analysis identified rs74755602 at the MASTL locus (odds ratio, 2.08; 95% confidence interval, 1.65-2.63; P = 7.85 × 10^-10), but MASTL showed no corresponding differential expression.</p><p><strong>Conclusion: </strong>Paired thrombus-blood profiling revealed coherent but exploratory transcriptomic patterns related to thrombosis, inflammation, and vascular remodeling. The independent MASTL association lacked transcriptomic concordance, supporting cautious interpretation and further functional validation.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Diagnostic dilemmas and transitional care pathways\": Recent admissions as a sentinel indicator to compliment clinical practice.","authors":"Guo-Shou Wang, Tai-Yin Wu, Chih-Hung Wang, Chien-Hua Huang","doi":"10.1016/j.jfma.2026.10.006","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.006","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating machine learning and classical statistics in sarcopenia screening for community-dwelling older women.","authors":"Jiun Hsu, Hsun-Mao Cheng, Yi-Ju Chen, Hui-Chi Hsieh, Ai-Tzu Li, Jou-Wei Lin","doi":"10.1016/j.jfma.2026.10.007","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.007","url":null,"abstract":"<p><strong>Background: </strong>Machine learning (ML) is increasingly used for sarcopenia screening, but its added value over conventional models remains uncertain when datasets are moderately sized and predictors are few. We compared logistic regression (LR) with five ML algorithms in older women.</p><p><strong>Methods: </strong>We analyzed 433 community-dwelling women aged ≥65 years. Sarcopenia was defined as handgrip strength <18 kg and bioelectrical impedance-derived appendicular skeletal muscle mass index <5.7 kg/m². LR, XGBoost, random forest, a CART decision tree, support vector machine (SVM), and multilayer perceptron (MLP) were evaluated using stratified five-fold cross-validation and pooled out-of-fold predictions. Analyses included a full nine-predictor set and a previously identified set comprising age, height, and calf circumference. A sensitivity analysis used nested cross-validation for hyperparameter selection.</p><p><strong>Results: </strong>Mean age was 76.2 ± 7.0 years, and 105 women (24.2%) had sarcopenia. In the primary nine-predictor analysis, LR and XGBoost achieved areas under the receiver operating characteristic curve (AUROCs) of 0.845 and 0.838, respectively, followed by random forest at 0.832. SVM, CART, and MLP showed lower discrimination. The three-predictor LR model achieved an AUROC of 0.852. With nested tuning, full-model AUROCs were numerically similar for LR (0.835), SVM (0.843), and MLP (0.840); corresponding three-predictor AUROCs were 0.865, 0.850, and 0.852.</p><p><strong>Conclusion: </strong>LR remained competitive with the evaluated ML models, and the previously identified three-predictor model showed good discrimination. Relative performance depended on model configuration and training procedures. Independent external validation is required before clinical implementation.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental adverse impact of pathological factors in head and neck cancer with extranodal extension.","authors":"Min-Ju Chien, Kai-Shan Yang, Hui-Ching Chuang, Chih-Yen Chien, Fu-Min Fang, Ming-Huei Chou, Ming-Hsien Tsai","doi":"10.1016/j.jfma.2026.10.008","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.10.008","url":null,"abstract":"<p><strong>Purpose: </strong>Pathological extranodal extension (pENE) is a well-established adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate multiple adverse pathological features and to demonstrate their cumulative impacts on prognosis among patients with pENE-positive HNSCC.</p><p><strong>Methods: </strong>A cohort of 281 patients with pENE-positive HNSCC that underwent upfront surgery followed by adjuvant chemoradiotherapy between 2008 and 2016 was retrospectively analyzed with Cox proportional hazards models being employed to identify factors associated with overall survival (OS) and disease-free survival (DFS).</p><p><strong>Results: </strong>The 5-year OS and DFS rates in this cohort were 45.7% and 41.5% respectively. Positive surgical margins, poor tumor differentiation and positive metastatic lymph nodes over 3 (>3) were all independently associated with inferior OS and DFS. Patients were stratified into groups based on the number of these adverse pathological \"P\" factors (0, 1 or 2). When stratified by the number of these \"P\" factors, the 5-year OS rates were 55% for patients with none, 37.5% for one, and 6.7% for two factors (p < 0.001). A similar trend was observed for 5-year DFS (50.5%, 34.5% and 0.0% respectively; p < 0.001). The 2-factor group was small (n = 15), resulting in substantial statistical uncertainty.</p><p><strong>Conclusion: </strong>Among patients with pENE-positive HNSCC, the accumulation of adverse pathological \"P\" factors was associated with incrementally poorer survival outcomes despite standard adjuvant chemoradiotherapy. These findings suggest that cumulative pathological risk factors might help identify patients at particularly high risk, although validation in larger independent cohorts is warranted.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}