Journal of the Formosan Medical Association最新文献

{"title":"Comment on \"Prevalent and incident hepatitis C virus infections among participants in a pre-exposure prophylaxis program in Taiwan\".","authors":"Rui Xia, Yun Wang, Huizhen Ma","doi":"10.1016/j.jfma.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.012","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of persistence of advanced therapies among patients with inflammatory bowel disease in Taiwan.","authors":"Horng-Yih Chiu, Chia-Jung Kuo, Ming-Wei Lai, Ren-Chin Wu, Chien-Ming Chen, Cheng-Tang Chiu, Yu-Bin Pan, Cheng-Hsun Chiu, Puo-Hsien Le","doi":"10.1016/j.jfma.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.014","url":null,"abstract":"<p><strong>Background/aims: </strong>The prevalence of inflammatory bowel disease (IBD) is rising in Asia. Advanced therapies, defined as biologics and small-molecule drug used for IBD treatment, have improved outcomes for moderate to severe IBD, making treatment selection critical. This is the first study in Taiwan comparing real-world persistence rates of advanced therapies in IBD patients in Taiwan.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 511 IBD patients from Linkou Chang Gung Memorial Hospital between October 2017 and January 2024. The five therapies evaluated were infliximab (IFX), adalimumab (ADA), vedolizumab (VDZ), ustekinumab (UST), and tofacitinib (TOF). Persistence within 52 weeks was assessed for biologic-naïve and biologic-experienced IBD patients.</p><p><strong>Results: </strong>Of the 511 patients, 210 had ulcerative colitis (UC) and 301 had Crohn's disease (CD). UST showed the highest 52-week persistence in CD (91.08 %), followed by ADA (81.94 %), IFX (73.76 %), and VDZ (64.35 %), with a statistically significant difference (p < 0.001). In UC, UST also had the highest persistence rate (78.95 %), though this did not reach statistical significance (p = 0.083). IFX had the highest discontinuation rate due to side effects (5.9 %) CONCLUSIONS: UST showed superior 52-week persistence in CD patients, though it also had the highest rate of dose escalation. IFX had the highest rate of discontinuation due to side effects.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights and lessons from recent conflicts: A narrative review from the military medicine perspective.","authors":"Shih-Hung Tsai, Wen-I Liao, Ching-Tsung Peng, Zuei-How Young, Chih-Yuan Lin, Yu-Juei Hsu, Chien-Sung Tsai","doi":"10.1016/j.jfma.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.006","url":null,"abstract":"<p><p>The article provides insights and lessons learned from recent conflicts, further elaborating on crucial issues in medical preparedness and medical planning from the perspective of military medicine. It highlights the unique challenges due to its geographical and political situation, predicting scenarios that involve urban casualties and evacuation difficulties. This article describes the evolving nature of warfare, noting the increased frequency of urban combat and the use of advanced weaponry like drones and thermobaric explosives, necessitating enhanced protective equipment and medical protocols to address the new injury patterns. The need for improved civilian-military coordination, advanced medical training, strategic stockpiling of medical supplies, and the blood supply chain is emphasized. The role of Forward Resuscitation and Surgical Detachment is highlighted as crucial for providing urgent surgical care in forward areas. Furthermore, this article emphasizes the importance of realistic medical and operational planning, incorporating simulations and war gaming to estimate medical supply needs. It advocates for the inclusion of advanced airway management kits, burn wound management supplies, and effective pain management protocols in medical stockpiles. The review concludes with a need for continuous training and strategic allocation of medical resources to ensure optimal operational effectiveness and resilience in the face of potential conflicts.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor Regarding \"Assessing the link between post-treatment ALT and HCC risk in chronic hepatitis C\".","authors":"Yen-Chun Chen, Ming-Lung Yu","doi":"10.1016/j.jfma.2025.09.007","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.007","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with the need for colonoscopic hemostasis for acute lower gastrointestinal bleeding.","authors":"Hao-Che Chang, Li-Chun Chang, Wei-Chih Liao, Hsiu-Po Wang, Han-Mo Chiu, Ming-Shiang Wu, Ping-Huei Tseng","doi":"10.1016/j.jfma.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.009","url":null,"abstract":"<p><strong>Background and purpose: </strong>Colonoscopy is an essential diagnostic and therapeutic tool for lower gastrointestinal bleeding (LGIB), with colonoscopic hemostasis needed in a subset of patients. We aim to identify risk factors associated with colonoscopic hemostasis requirement in acute LGIB patients.</p><p><strong>Methods: </strong>This retrospective study examined consecutive patients who underwent colonoscopy for acute LGIB at a single tertiary hospital between November 2020 and May 2023. Clinical and laboratory profiles were compared between acute LGIB patients who did and did not require colonoscopic hemostasis. Risk factors for hemostasis were determined using regression analysis.</p><p><strong>Results: </strong>The study cohort included 409 acute LGIB patients. The most common cause of acute LGIB among the 212 patients with overt bleeding was inflammatory lesions (n = 120; 56.60 %), followed by neoplastic (n = 38; 17.92 %) and vascular lesions (n = 26; 12.26 %). Hypotension was significantly more common among patients with overt bleeding than those without (11.32 % vs. 1.52 %; P = 0.0001). Patients who required colonoscopic hemostasis (n = 53) had a significantly lower hemoglobin level (9.3 vs. 10.0 g/dL; P = 0.039), higher rate of red blood cell transfusion (52.83 % vs. 36.52 %; P = 0.023), and more significant hypotension (18.87 % vs. 4.78 %; P = 0.0001) compared to those who did not. Significant hypotension was an independent risk factor for colonoscopic hemostasis (adjusted odds ratio, 3.64; 95 % confidence interval, 1.43-9.30; P = 0.007).</p><p><strong>Conclusions: </strong>Acute LGIB patients with significant hypotension are at higher risk of requiring colonoscopic hemostasis and may benefit from early colonoscopic evaluation.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the link between post-treatment ALT and HCC risk in chronic hepatitis C.","authors":"Weiyi Jiang, Ye Li, YongSheng Wang, Tingsu Zhang","doi":"10.1016/j.jfma.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.004","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Controlling nutritional status score as a survival prognosticator in patients with head and neck cancer\".","authors":"Xiaocen Wang","doi":"10.1016/j.jfma.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.002","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of chromatin remodeling genes predicts clinical outcomes in acute myeloid leukemia.","authors":"Lanxiang Liu, Li Wang, Hongbin Zhang, Lin Liu, Xinyu Yan","doi":"10.1016/j.jfma.2025.08.045","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.045","url":null,"abstract":"<p><strong>Background: </strong>Acute myeloid leukemia (AML) is a malignancy of the blood system. The commonly altered regions in the genome of AML encompass a multitude of gene modifications associated with epigenetic regulation. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) as an overall indicator has yet to be assessed in AML.</p><p><strong>Methods: </strong>Univariate Cox regression analysis was performed for CRRGs. Following unsupervised clustering analysis, the differentially expressed genes (DEGs) and immune cells between chromatin remodeling related subtypes in TCGA-AML were measured. Univariate Cox analysis and Least Absolute Shrinkage and Selection Operator (LASSO) analysis were used to screen prognostic biomarkers for AML, and a risk model was subsequently constructed. Gene set variation analysis (GSVA) analysis and tumor mutation burden (TMB) analysis was conducted in different risk groups. Using Tumor Immune Dysfunction and Exclusion (TIDE) score to assess patients' differences in sensitivity to immunotherapy. Additionally, the construction and verification of the nomogram were carried out. The expression of biomarkers in healthy and AML patients was analyzed by Quantitative Real-time Polymerase Chain Reaction (RT-qPCR).</p><p><strong>Results: </strong>A total of 106 prognostic CRRGs were identified. Between the two clusters, 3995 genes, activated CD4 memory T cells and activated Dendritic cells were differentially expressed. A total of 6 prognostic biomarkers were identified (ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1I), and a risk model was generated based on these biomarkers. The high-risk group exhibited higher TIDE scores. Moreover, 29 drugs showed lower IC50 values in high-risk group. We also found that risk score was an independent prognostic factor for AML. RT-qPCR results showed significant differences in expression of ARF6, KDM5B and CHD5 between healthy and AML patients.</p><p><strong>Conclusion: </strong>We identified six biomarkers, namely ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1, thereby establishing a theoretical foundation for clinical diagnosis of AML.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Impact of completely histological remission on reducing flare-ups in moderate-to-severe, biologics-experienced ulcerative colitis patients with endoscopic remission.","authors":"Tirayut Veerasathian, Schawanya K Rattanapitoon, Thawatchai Eaksanti, Nathkapach K Rattanapitoon","doi":"10.1016/j.jfma.2025.08.043","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.043","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Clinical characteristics and predictive models of plastic bronchitis caused by mycoplasma pneumoniae pneumonia in children\": Clinical characteristics and predictive models of plastic bronchitis.","authors":"Fenfang Song, Wenlong Yue, Fenle Song","doi":"10.1016/j.jfma.2025.08.044","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.044","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}