Journal of the Formosan Medical Association最新文献

Comment on 'Invasive fungal rhinosinusitis: experience from a 4-year case series of 49 adult patients at a tertiary hospital in Vietnam'. 对“侵袭性真菌性鼻窦炎：来自越南一家三级医院49名成年患者4年病例系列的经验”的评论。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-05 DOI: 10.1016/j.jfma.2026.09.001

Yiliang Huang, Luping Zhang

引用次数: 0

Comment on "Real-world outcomes after biologic-to-biologic switching to dupilumab in adult asthma: A retrospective single-center cohort study". 对“成人哮喘生物对生物转换为dupilumab后的真实结果：一项回顾性单中心队列研究”的评论。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-04 DOI: 10.1016/j.jfma.2026.09.002

Xiang Zhou, Xiangwen Gong

引用次数: 0

Prevalence and one-year transition of sarcopenic obesity in Taiwan - using new definition from Asia-Oceania sarcopenic obesity consensus. 台湾肌少性肥胖的患病率及一年的转变-使用亚洲-大洋洲肌少性肥胖共识的新定义。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-04 DOI: 10.1016/j.jfma.2026.08.056

Hsiang-Han Kao, Tsung-Po Chen, Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Chuan-Wei Yang, Wen-Yuan Lin, Cheng-Chieh Lin

{"title":"Prevalence and one-year transition of sarcopenic obesity in Taiwan - using new definition from Asia-Oceania sarcopenic obesity consensus.","authors":"Hsiang-Han Kao, Tsung-Po Chen, Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Chuan-Wei Yang, Wen-Yuan Lin, Cheng-Chieh Lin","doi":"10.1016/j.jfma.2026.08.056","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.08.056","url":null,"abstract":"Background: Sarcopenic obesity (SO) is a clinical and functional condition defined by the coexistence of obesity and sarcopenia. This study investigated the prevalence, incidence, and determinants of SO among Taiwanese older adults using the 2025 Asia-Oceania consensus.Methods: Data were analyzed from 1048 participants (aged≧65 years) in the Taichung Community Health Study for Elders (TCHS-E). Questionnaires with basic information were conducted. Participants were categorized into healthy, possible SO, and SO groups based on body mass index, waist circumference, body composition including muscle mass and body fat percentage by DXA/BIA, and physical function. Comparisons of baseline characteristics between sexes and across different sarcopenic obesity (SO) status transitions were performed using the Chi-square test. Logistic regression identified risk factors for 1-year status changes.Results: The baseline prevalence of SO was 2.0%, with women showing higher rates than men (2.6% vs. 1.5%, p < 0.001). The 1-year incidence of SO and possible SO was 1% and 3%, respectively. In fully adjusted models, hypertension (OR = 3.67, 95% CI: 1.26-10.66) and diabetes (OR = 4.01, 95% CI: 1.07-15.12) were independent predictors of SO deterioration. Conversely, regular exercise (OR = 0.46 in age/sex-adjusted models) and higher education were protective factors promoting improvement. Cognitive impairment also correlated with unfavorable SO trajectories.Conclusions: While the 1-year incidence of SO is relatively low, female sex, advanced age, and cardiometabolic comorbidities significantly increase deterioration risk, whereas exercise and education serve as protective factors, highlighting the need for tailored, multidimensional prevention strategies.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Rethinking endpoints, subgroup analyses, and time-varying treatment in AST-120 CKD research". 对“AST-120 CKD研究中重新思考终点、亚组分析和时变治疗”的回应。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-04 DOI: 10.1016/j.jfma.2026.08.050

Chin-Te Tseng, Fan-Yu Chen, Hsuan Lin, Chih-Ching Lin

引用次数: 0

Comment on "Healthcare service load as a structural barrier to end-of-life autonomy in Taiwan". 评“医疗服务负荷是台湾临终自主的结构性障碍”。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-03 DOI: 10.1016/j.jfma.2026.08.054

Guiping Huang, Yihua Yu

引用次数: 0

Emergency department-initiated Hospital-at-Home for older patients with acute infections: A propensity score matched cohort study. 急诊科发起的住院治疗老年急性感染患者：倾向评分匹配队列研究。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-02 DOI: 10.1016/j.jfma.2026.08.057

Chih-Hao Yang, Enoch Yi-No Kang, Shih-Chang Hsu, Sheng-Lun Hsu, Chin-Wang Hsu, I-Chen Huang

引用次数: 0

Clinical predictors of severe and fatal respiratory syncytial virus infection in adults and the elderly: A retrospective cohort study. 成人和老年人严重和致命呼吸道合胞病毒感染的临床预测因素：一项回顾性队列研究

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-09-01 DOI: 10.1016/j.jfma.2026.08.058

Yen-Chieh Chin, Li-Jie Lin, Shu-Yuan Ho, Yu-Tsung Huang, Ya-Li Hu, Chi-Tai Fang, Luan-Yin Chang

{"title":"Clinical predictors of severe and fatal respiratory syncytial virus infection in adults and the elderly: A retrospective cohort study.","authors":"Yen-Chieh Chin, Li-Jie Lin, Shu-Yuan Ho, Yu-Tsung Huang, Ya-Li Hu, Chi-Tai Fang, Luan-Yin Chang","doi":"10.1016/j.jfma.2026.08.058","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.08.058","url":null,"abstract":"Background: Respiratory syncytial virus (RSV) is increasingly recognized as a cause of severe respiratory illness in adults, especially the elderly and those with comorbidities. However, data on outcomes and risk factors for severe disease in this population remain limited.Methods: We retrospectively analyzed 123 adult patients diagnosed with RSV infection at a tertiary center in Taiwan from 2015 to 2023. Clinical characteristics, laboratory data, detection of other pathogens, clinical course and outcome were reviewed. Multivariable logistic regression identified risk factors for severe RSV infection, including ICU admission and 30-day mortality.Results: The mean age was 55.7 years; 50% were aged ≥60 years and 13% were ≥75 years. ICU admission occurred in 17%, with significant associations to viral coinfection and elevated C-reactive protein (CRP). Thirty-day mortality was 13%, and overall in-hospital mortality was 18%, all among patients with comorbidities. Independent predictors of 30-day mortality included late elderly (aOR 24.2, p = 0.03), high CRP > 11.5 mg/dL (aOR 16.4, p = 0.005) and thrombocytopenia < 34,103/μL (aOR 11.4, p = 0.01).Conclusion: Advanced age (≥75 years), high CRP, and severe thrombocytopenia are key predictors of mortality in adults RSV patients. These findings highlight the need for targeted prevention strategies, including vaccination, in high-risk populations.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External validation of prediction scores of positive random skin biopsy in suspected intravascular large B-cell lymphoma. 疑似血管内大b细胞淋巴瘤随机皮肤活检阳性预测评分的外部验证。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-08-31 DOI: 10.1016/j.jfma.2026.08.053

Yushi Segawa, Akinao Okamoto, Sayaka Sumiyoshi, Hiroko Watase, Mitsunaga Iwata, Akihiro Tomita, Teruhiko Terasawa

{"title":"External validation of prediction scores of positive random skin biopsy in suspected intravascular large B-cell lymphoma.","authors":"Yushi Segawa, Akinao Okamoto, Sayaka Sumiyoshi, Hiroko Watase, Mitsunaga Iwata, Akihiro Tomita, Teruhiko Terasawa","doi":"10.1016/j.jfma.2026.08.053","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.08.053","url":null,"abstract":"Background: Intravascular large B-cell lymphoma (IVLBCL), a rare but increasingly recognized aggressive extranodal B-cell lymphoma, often presents with diagnostically challenging manifestations. Three prediction scores-the Kameda, Okayama, and St. Marianna scores-have recently been proposed to guide the use of random skin biopsy (RSB) for diagnosing IVLBCL, but none have undergone external validation.Methods: We retrospectively included 86 consecutive patients aged ≥15 years with suspected IVLBCL who underwent RSB between May 2013 and June 2024. The outcome of interest was a positive RSB for IVLBCL lesions. We evaluated the 2-risk-group classification measures and the 3-risk-group model performance.Results: Fourteen patients (16%) had a positive RSB. Although the St. Marianna score had the best 3-risk-group model performance, both the Okayama and St. Marianna scores achieved 100% sensitivity and negative predictive value in the 2-risk-group classification. The Kameda score rarely stratified patients as high risk, resulting in limited predictive performance. In settings where missed diagnoses are considered more harmful than unnecessary biopsies, the 2-risk-group classification and the 3-risk-group model of each score performed similarly.Conclusion: The St. Marianna score or Okayama scores may help reducing unnecessary biopsies without missing IVLBCL diagnoses in settings similar to our cohort. These results should be validated locally before routine clinical use.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights. 高光。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-08-31 DOI: 10.1016/j.jfma.2026.08.055

Jia-Horng Kao

引用次数: 0

Clonal hematopoiesis and atherosclerotic cardiovascular disease: Clinical implications, biological mechanisms, and emerging therapeutic strategies. 克隆造血和动脉粥样硬化性心血管疾病：临床意义、生物学机制和新兴治疗策略。

IF 2.8 3区医学

Journal of the Formosan Medical Association Pub Date : 2026-08-31 DOI: 10.1016/j.jfma.2026.08.052

Chi-Yuan Yao, Yen-Chun Chen, Bing-Ru Tsai, Jeng-Wei Chen, Chih-Yang Chan, Wen-Jone Chen, Lian-Yu Lin, Wen-Chien Chou, Yi-Lwun Ho, Li-Tan Yang

{"title":"Clonal hematopoiesis and atherosclerotic cardiovascular disease: Clinical implications, biological mechanisms, and emerging therapeutic strategies.","authors":"Chi-Yuan Yao, Yen-Chun Chen, Bing-Ru Tsai, Jeng-Wei Chen, Chih-Yang Chan, Wen-Jone Chen, Lian-Yu Lin, Wen-Chien Chou, Yi-Lwun Ho, Li-Tan Yang","doi":"10.1016/j.jfma.2026.08.052","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.08.052","url":null,"abstract":"Clonal hematopoiesis (CH), defined by the age-related expansion of hematopoietic stem cells harboring somatic driver mutations, has emerged as a novel and clinically relevant contributor to atherosclerotic cardiovascular disease (ASCVD). Once considered primarily a precursor to hematologic malignancy, CH is now recognized as a systemic pro-inflammatory state linking somatic evolution to cardiovascular pathology. Epidemiological studies consistently demonstrate that CH is independently associated with increased risks of coronary artery disease, heart failure, aortic stenosis, and cardiovascular mortality. Mechanistically, CH-associated mutations-most commonly in DNMT3A, TET2, and ASXL1-reprogram immune cells toward a pro-inflammatory phenotype, characterized by activation of the NLRP3 inflammasome and increased cytokine production, thereby promoting endothelial dysfunction, atherogenesis, and adverse cardiac remodeling. These insights have catalyzed the development of targeted therapeutic strategies, particularly anti-inflammatory interventions, as well as approaches aimed at modulating clonal expansion and leveraging cardiometabolic agents. Clinically, incorporation of CH genotype and clonal burden into risk assessment may refine cardiovascular risk stratification and guide personalized prevention strategies. In this review, we summarize current evidence on the biological mechanisms linking CH to ASCVD, its clinical implications across cardiovascular phenotypes, and emerging therapeutic approaches. Collectively, CH represents a paradigm shift toward inflammation-driven precision cardiology.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0