Journal of the Formosan Medical Association最新文献

Highlights.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1016/j.jfma.2025.03.014

Jia-Horng Kao

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Liver injury in non-severe COVID-19 with various pandemic phases: A real-world study.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-31 DOI: 10.1016/j.jfma.2025.03.026

Jirayuth Winyupakorn, Chunlanee Sangketchon, Watcharaporn Devakul Na Ayutthaya, Supatsri Sethasine

{"title":"Liver injury in non-severe COVID-19 with various pandemic phases: A real-world study.","authors":"Jirayuth Winyupakorn, Chunlanee Sangketchon, Watcharaporn Devakul Na Ayutthaya, Supatsri Sethasine","doi":"10.1016/j.jfma.2025.03.026","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.026","url":null,"abstract":"Background: COVID-19 severity affects liver damage. The utilization of various anti-COVID-19 drugs in non-severe cases related to liver impairment in the short term seemed intriguing.Objectives: To assess the dynamic course of liver injury in mild to moderate COVID-19 patients within 10 days of admission and identify risk variables, including medication linkage.Methods: This prospective cohort study of 300 newly diagnosed mild to moderate COVID-19 cases between September 2021 and October 2022. Tertiary center hospitel, field hospital, or cohort ward admissions were made. Patient demographics and treatment were recorded. The drug, liver injury (LI) dynamics, and clinical course were evaluated.Results: Hospitel/field hospital (188) and cohort wards (112) had 300 individuals. One hundred fifteen participants had liver damage. Favipiravir (45 %), remdesivir (17.4 %), molnupiravir (11.3 %), Andrographis paniculata (ADG) (8.7 %), and favipiravir plus ivermectin (7.7 %) were given to most LI group (n = 104). The baseline AST/ALT levels of 68 (65.4 %) treated patients were abnormal. Favipiravir, remdesivir, and favipiravir + ivermectin increased mean AST/ALT in participants with normal baseline AST/ALT (p = 0.001, 0.003, and 0.016, respectively), but not molnupiravir or Andrographis paniculata. Transaminase levels climbed in untreated patients independent of baseline. The ground-glass imaging pattern was linked to mild LI. Most subjects had transaminase declines after 10 days. Preexisting liver disease did not increase the likelihood of in-hospital LI.Conclusion: In the real world, a less-than-critical level of liver damage was reported in mild to moderate COVID-19 that allows clinicians to administer a variety of standard medications during short periods of hospital stay.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impact of the COVID-19 pandemic on the utilization of healthcare.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-29 DOI: 10.1016/j.jfma.2025.03.020

Chung-Liang Shih, Oliver Liu, You-Jun Lin

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Guide for Authors

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-29 DOI: 10.1016/S0929-6646(25)00129-9

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Copyright transfer statement

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-29 DOI: 10.1016/S0929-6646(25)00132-9

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Checklist

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-29 DOI: 10.1016/S0929-6646(25)00130-5

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Authorship statement

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-29 DOI: 10.1016/S0929-6646(25)00131-7

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Prevalence and factors associated with informal advance care planning discussion and do-not-resuscitate directives in patients at geriatric clinics.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-28 DOI: 10.1016/j.jfma.2025.03.024

Yu-Tai Lo, Sheng-Yu Fan, Chung-Yi Li, Deng-Chi Yang, Chi-Chang Huang, Mei-Hua Chen

{"title":"Prevalence and factors associated with informal advance care planning discussion and do-not-resuscitate directives in patients at geriatric clinics.","authors":"Yu-Tai Lo, Sheng-Yu Fan, Chung-Yi Li, Deng-Chi Yang, Chi-Chang Huang, Mei-Hua Chen","doi":"10.1016/j.jfma.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.024","url":null,"abstract":"Background: Advance care planning (ACP) discussions and do-not-resuscitate (DNR) directives are essential for ensuring quality end-of-life care, especially for older adults with multiple comorbidities. This study aimed to investigate the prevalence and associated factors of informal ACP discussions and DNR directives among geriatric outpatients in Taiwan.Methods: A cross-sectional study was conducted among 276 Taiwanese geriatric outpatients aged 65 years and older. Data on demographics, comorbidities, functional status, informal ACP discussions, and DNR directives were collected. Multinomial logistic regression was used to analyze the association between independent variables and dependent variables (ACP discussion experience and DNR directives).Results: While 92.1 % of participants reported having informal ACP discussions, only 8.3 % had completed DNR directives. Compared to those who only discussed ACP (reference group), individuals with a one-point higher Cumulative Illness Rating Scale for Geriatrics score were significantly more likely to have both discussed ACP and completed DNR directives (odds ratio [OR] = 1.14, 95 % confidence interval [CI]: 1.01-1.29, p = .035). Conversely, individuals with junior high school education or higher (OR = 0.25, 95 % CI: 0.08-0.84, p = .025) and those dependent on others for activities of daily living (ADL dependence; OR = 0.24, 95 % CI: 0.07-0.86, p = .029) were significantly less likely to have neither informally discussed ACP nor completed DNR directives.Conclusion: While Taiwanese older outpatients often informally discussed ACP, the completion of DNR directives was less common. The link between higher geriatric comorbidity and DNR directives highlights the need for proactive, tailored interventions in this population.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Severe SARS-CoV-2 alpha variant convalescent patients exhibit worse T cell immune response than those with mild severity disease.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-27 DOI: 10.1016/j.jfma.2025.03.009

Chih-Yao Hsu, Chun-Hsiang Chiu, Te-Yu Lin, Feng-Yee Chang

{"title":"Severe SARS-CoV-2 alpha variant convalescent patients exhibit worse T cell immune response than those with mild severity disease.","authors":"Chih-Yao Hsu, Chun-Hsiang Chiu, Te-Yu Lin, Feng-Yee Chang","doi":"10.1016/j.jfma.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.009","url":null,"abstract":"Objectives: This study aimed to assess T cell phenotype and the role of cellular immunity against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in alpha variant coronavirus disease 2019 (COVID-19) convalescent patients.Methods: Thirty-two confirmed SARS-CoV-2 infected patients and ten healthy controls were enrolled. T cell subsets in peripheral blood were classified and quantified using flow cytometry. Additionally, T cell immune responses against SARS-CoV-2 spike peptide pools were assessed. Flow cytometry data were analyzed using Cytobank software. Other analyses involved Student's t-test or chi-square test.Results: CD127 expression on T helper cells and cytotoxic T cells was lower in the severe disease group than that in the mild disease group. Severe COVID-19 convalescents with SARS-CoV-2 alpha variant exhibited poorer T cell immune responses than those with mild disease upon spike peptide pools stimulation with SARS-CoV-2 wild type, alpha, or omicron variants.Conclusions: COVID-19 convalescents showed T helper and cytotoxic T cells with lower CD127 expression in the severe disease group than those in the mild disease group. Severe COVID-19 convalescents infected with the alpha variant exhibited poorer T cell immune responses against the SARS-CoV-2 wild type, alpha, or omicron variants. Our study provides insights into the differences in T cell phenotypes and immune responses during the contraction phase following SARS-CoV-2 infection across varying disease severities. These findings offer valuable perspectives for advancing future research on SARS-CoV-2 T cell-related immune responses.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comment to: The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-27 DOI: 10.1016/j.jfma.2025.03.023

Edy Kornelius

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