Journal of the Formosan Medical Association最新文献_第2页

Reassessing LDL-C thresholds: Toward tailored lipid management.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-25 DOI: 10.1016/j.jfma.2025.03.019

Yu-Chung Hsiao, Tzu-Yang Chen, Fang-Ju Lin, Chau-Chung Wu

引用次数: 0

Disability level as a key predictor of mortality in patients with oral cancer: A hospital-based retrospective study in Taiwan.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-24 DOI: 10.1016/j.jfma.2025.03.018

Chih-Chin Lai, Jing-Rong Jhuang, Kuo-Liong Chien, Chun-Nan Chen, Jiu-Jenq Lin, Hsin-Hui Peng, Shin-Liang Pan

{"title":"Disability level as a key predictor of mortality in patients with oral cancer: A hospital-based retrospective study in Taiwan.","authors":"Chih-Chin Lai, Jing-Rong Jhuang, Kuo-Liong Chien, Chun-Nan Chen, Jiu-Jenq Lin, Hsin-Hui Peng, Shin-Liang Pan","doi":"10.1016/j.jfma.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.018","url":null,"abstract":"Background: This study investigated the demographics, comorbidities, and mortality rates of patients diagnosed with oral cancer, guided by a hypothesis that disability level would emerge as an independent predictor of adverse outcomes alongside age and comorbidities.Methods: Socio-demographic and medical information for patients treated for oral cancer at National Taiwan University Hospital (NTUH) from 2012 to 2018 was collected, along with their mortality data from NTUH's integrated medical database. Disability levels were measured using WHODAS 2.0, dividing patients into severe (WHODAS score ≥60, n = 197) and non-severe disability (WHODAS score ≤59, n = 228) groups. The primary outcome was overall survival probability. Propensity-score matching balanced baseline characteristics, and Cox proportional-hazard models analyzed the impact of various covariates on mortality rates.Results: A total of 425 patients diagnosed with oral cancer were enrolled in the study, with a mean age of 55.1 years (standard deviation, 9.8). The majority (95 %) were men. Over the 6.75-year data-collection window, 94 of them (22.1 %) died. The severely disabled group exhibited significantly poorer survival (p = 0.02), and univariate analyses identified WHODAS scores of 60 or higher as an independent prognostic factor among patients with oral cancer (hazard ratio = 1.59, 95 % confidence interval = [1.05-2.40]).Conclusion: WHODAS 2.0 scores of 60 or higher indicate severe to extreme disability, which often correlates with poorer overall health and reduced ability to manage oral cancer and its treatments. This significant impairment is likely to be a contributory factor in higher mortality rates amongst this patient group.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK inhibitors combined with bisphosphonates treatment for chronic diffuse sclerosing osteomyelitis of mandible: A 4-year follow-up.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-22 DOI: 10.1016/j.jfma.2025.02.032

Mu Wang, Weihua Han, Ge Kong, Shang-Zhu Zhang, Wen Zhang

引用次数: 0

Telemedicine service facilitates but does not yet replace standard care in hospitalized patients in quarantine.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-21 DOI: 10.1016/j.jfma.2025.03.015

Tung-Hung Su, Jia-Horng Kao

引用次数: 0

Comment on "A comparative analysis of MMR immunohistochemistry panels: Evaluating the utility of four-protein versus two-protein panels in endometrial cancer patients". 关于 "MMR 免疫组化样本的比较分析：评估子宫内膜癌患者中四种蛋白与两种蛋白的效用"。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-20 DOI: 10.1016/j.jfma.2025.03.013

Sisi Zhou

引用次数: 0

Polymorphisms in the calcium voltage-gated channel subunit Alpha1 D (CACNA1D) gene are associated with spontaneous preterm birth in Taiwanese women.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-19 DOI: 10.1016/j.jfma.2025.03.010

Tzu-Yang Chang, Tzu-Hsiang Kao, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen

{"title":"Polymorphisms in the calcium voltage-gated channel subunit Alpha1 D (CACNA1D) gene are associated with spontaneous preterm birth in Taiwanese women.","authors":"Tzu-Yang Chang, Tzu-Hsiang Kao, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen","doi":"10.1016/j.jfma.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.010","url":null,"abstract":"Purpose: Calcium signaling is essential for immune function, myometrial contractions, and hormone secretion, all of which contribute to preterm birth. In this study, we investigated the associations of 3 single-nucleotide polymorphisms (SNPs) in CACNA1D gene, which encodes the Cav1.3 calcium channel, with the risk of spontaneous preterm birth (sPTB).Methods: A hospital-based case-control study was conducted with 112 women of sPTB and 1120 term control women. Three CACNA1D SNPs (rs9810888 T/G, rs1045958 C/T, and rs881883 G/A) were genotyped.Results: The T/G genotype of the CACNA1D rs9810888 SNP was associated with a reduced risk of sPTB (odds ratio: 0.61, 95 % confidence interval: 0.41-0.91, P = 0.01, Pc = 0.03). However, no significant associations were observed for the other 2 SNPs. Haplotype analysis revealed no significant differences between the case and control groups.Conclusion: Our findings suggest that the intronic rs9810888 T/G variant of CACNA1D gene protects against sPTB in Taiwanese women.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to comments on "A comparative analysis of MMR immunohistochemistry panels: Evaluating the utility of four-protein versus two-protein panels in endometrial cancer patients". 对 "MMR 免疫组化样本的比较分析：评估子宫内膜癌患者中四种蛋白和两种蛋白的效用"。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-17 DOI: 10.1016/j.jfma.2025.03.012

Hao Lin, Yu-Sheng Huang

引用次数: 0

Reply to comments on "the association of temporalis muscle thickness with post-stroke dysphagia based on swallowing kinematic analysis".

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-15 DOI: 10.1016/j.jfma.2025.03.011

Kuan-Yu Chen, Meng-Ting Lin

引用次数: 0

Post-operative oropharyngeal rehabilitation suppress oxidative stress and inflammation in obstructive sleep apnea patients with transoral robotic surgery.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-14 DOI: 10.1016/j.jfma.2025.03.004

Yi-Ju Lai, Chung-Yi Li, Kun-Ling Tsai, Ching-Hsia Hung, Cheng-Yu Lin

{"title":"Post-operative oropharyngeal rehabilitation suppress oxidative stress and inflammation in obstructive sleep apnea patients with transoral robotic surgery.","authors":"Yi-Ju Lai, Chung-Yi Li, Kun-Ling Tsai, Ching-Hsia Hung, Cheng-Yu Lin","doi":"10.1016/j.jfma.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.004","url":null,"abstract":"Purpose: To demonstrate the effects of postoperative oropharyngeal rehabilitation on inflammatory mediators and antioxidant capacity in adults with obstructive sleep apnea.Methods: This quasi-experimental study enrolled participants without blinding between January 2020 and December 2022. Patients with obstructive sleep apnea were divided into a conservative treatment group (n = 17), surgery group (n = 23), or surgery combined with oropharyngeal rehabilitation (surgery + rehabilitation) group (n = 19). Polysomnography data and the concentration of inflammatory mediators and antioxidant capacity were determined at baseline, after 6 weeks of treatment, and after 18 weeks of treatment.Results: Posttreatment percent changes in the apnea-hypopnea index in rapid eye movement sleep were positively correlated with that of IL-6 (0.641, 95% CI: 0.598 to 0.685; P < 0.001). Compared with the patients in the control group, those in the surgery + rehabilitation group had significantly reduced posttreatment percent changes in IL-6 (-77.273, 95% CI: -144.580 to -9.966; P = 0.024). In addition, the concentrations of IL-6 (-3.423, 95% CI: -6.638 to -0.207; P = 0.037) and matrix metallopeptidase-9 (-20.517, 95% CI: -40.584 to -0.450; P = 0.045) significantly decreased in the surgery + rehabilitation group. The total antioxidant capacity significantly improved in the surgery + rehabilitation group compared with in the surgery-only group (0.034, 95% CI: 0.005 to 0.063; P = 0.020).Conclusion: The results reveal that postoperative oropharyngeal rehabilitation can reduce the serum levels of inflammatory mediators and increase antioxidant capacity. The combined treatment is more effective than surgery-only or conservative treatment.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language and motor plasticity in toddlerhood and early preschool as predictors of intelligence in late preschool.

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-14 DOI: 10.1016/j.jfma.2025.03.005

Chang Chen, Yu-Ju Lin, Hsin-Hui Lu, Jao-Shwann Liang, Huey-Ling Chiang

{"title":"Language and motor plasticity in toddlerhood and early preschool as predictors of intelligence in late preschool.","authors":"Chang Chen, Yu-Ju Lin, Hsin-Hui Lu, Jao-Shwann Liang, Huey-Ling Chiang","doi":"10.1016/j.jfma.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.005","url":null,"abstract":"Background: Early language and motor development may influence cognitive function in a cascading manner later in life. This study aimed to explore the impact of language and motor plasticity during toddlerhood and early preschool years on intelligence in late preschool, with an additional consideration of the influence of ASD and ADHD diagnoses.Methods: We retrospectively collected medical chart from 423 children aged 2-5 years (316 boys and 107 girls; mean age at Time 1: 3.49 ± 0.98 years), who participated in an early intervention program at a medical center in Northern Taiwan. Language and motor development along with demographic information were assessed during the initial evaluation (Time 1). These assessments were repeated, and intelligence was measured at the follow-up (Time 2). A generalized linear model was used for the data analysis.Results: Receptive language developmental change was the strongest predictor of lower intelligence quotient (IQ) scores, followed by gross, expressive language, and fine motor developmental changes (all p < 0.01). Children with catch-up receptive or expressive language or gross or fine motor development had better IQ outcomes than those with persistent delay (all p < 0.001). There were no ASD-by-developmental type or ADHD-by-developmental type interactions predicting IQ.Conclusions: Better plasticity in language and motor abilities during toddlerhood and early pre-school years was associated with better intelligence in the late pre-school years. The importance of early and effective interventions for language and motor development has been highlighted.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0