Journal of the Formosan Medical Association最新文献

{"title":"Response to comment on \"Psychological well-being of individuals with Parkinson's disease and their caregivers: A one-year follow-up study of patient-caregiver dyads\".","authors":"Yu Lee, Liang-Jen Wang","doi":"10.1016/j.jfma.2025.10.008","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.008","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian perspective reveals potential benefits of fluid restriction in heart failure.","authors":"Pei-Chun Lai, Yen-Ta Huang","doi":"10.1016/j.jfma.2025.10.017","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.017","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights.","authors":"Jia-Horng Kao","doi":"10.1016/j.jfma.2025.10.013","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.013","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Broadening the perspective on mpox: addressing inequities, surveillance gaps, and long-term challenges\".","authors":"Chun-Yuan Chen, Yin-Chien Lin, Chi-Tai Fang","doi":"10.1016/j.jfma.2025.10.011","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.011","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid detection and prevalence of the AGT deletion/insertion mutation underlying autosomal recessive renal tubular dysgenesis.","authors":"Min-Hua Tseng, Martin Konrad, Wen-Lang Fan, Tai-Wei Wu, Jhao-Jhuang Ding, Jeng-Daw Tsai, Tsung-Chieh Yao, Shih-Hua Lin","doi":"10.1016/j.jfma.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.001","url":null,"abstract":"<p><strong>Background: </strong>A homozygous deletion/insertion (del/ins) mutation (NM_000029.3: c.1365_c.1777delinsTTGCCTTGC) in the AGT gene responsible for autosomal recessive renal tubular dysgenesis (ARRTD) is frequently reported in Taiwan. Rapid and accurate detection of this peculiar mutation is crucial for genetic counseling and knowledge of the allele frequency in the population may help to better characterize the a priori risk for ARRTD.</p><p><strong>Methods: </strong>Using a TaqMan probe-based real-time polymerase chain reaction, we designed a mutation detection plate for the c.1365_c.1777delinsTTGCCTTGC mutation of the AGT gene, with Sanger sequencing as the reference standard. The allelic frequency of heterozygous AGT mutation was determined in 5000 healthy subjects. Demographic data and serum AGT, angiotensin I (AgI), and AgII concentrations were collected in 2 affected patients, 20 carriers, and 9 normal subjects.</p><p><strong>Results: </strong>The designed detection plate, thoroughly validated by direct sequencing, showed perfect sensitivity and specificity in genetically-diagnosed patients, carriers, and healthy subjects. The overall allelic frequency of positive AGT heterozygosity was 1 % (50/5000). There was a significantly higher serum AGT concentration in heterozygous AGT carriers than wild-type subjects despite no difference in blood pressure.</p><p><strong>Conclusion: </strong>This del/ins mutation in AGT can be rapidly and accurately identified by this allele-specific mutation plate. Due to its high prevalence in the Taiwanese population, it is likely that ARRTD may be more common in Taiwan than previously thought.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on \"Right ventricular pacing burden and progression of renal failure in chronic kidney disease patients with permanent pacemakers\".","authors":"Chih-Hen Yu, Ju-Yi Chen, Junne-Ming Sung","doi":"10.1016/j.jfma.2025.10.014","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.014","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The RElationship of Advanced Education and ADherence (ReAHEAD) on antithrombotic in younger patients with non-valvular atrial fibrillation in Taiwan.","authors":"Chih-Sheng Chu, Cheng-Ting Tsai, Chun-Yao Huang, Cheng-Hung Li, Han-Lin Tsai, Yen-Bin Liu, Ju-Chi Liu, Huai-Ren Chang, Wei-Shiang Lin, Tze-Fan Chao, Tien-Ping Tsao, Jhih-Yuan Shih, Jun-Ted Chong, Shih-Chung Huang, Chih-Cheng Wu, Cheng-Sheng Lin, Chun-Che Shih, Cheng-I Cheng, Ting-Hsing Chao, Cheng-Hung Chiang, Chi-Hung Huang, Chen-Yu Chien, Wei-Yu Lei, Keng-Ru Lin, Pao-Hsien Chu, Tsung-Hsien Lin","doi":"10.1016/j.jfma.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.002","url":null,"abstract":"<p><strong>Background: </strong>The prevalence and incidence of non-valvular atrial fibrillation (NVAF) in Taiwan increase with age. Low adherence to oral anticoagulants heightens stroke risk. This study evaluated whether advanced educational intervention could enhance dabigatran adherence in Taiwanese patients with NVAF.</p><p><strong>Methods: </strong>This multicenter clinical trial in Taiwan enrolled 873 patients aged 20-74 years and newly diagnosed with NVAF. Patients were randomized to receive advanced educational intervention or standard care only. Dabigatran adherence at 12 months was evaluated using the Morisky Medication Adherence Scale (MMAS-8), along with the proportion of subjects reporting \"never/rarely forgetting to take dabigatran\" at 3, 6, and 9 months, dabigatran discontinuation rate, and the safety outcomes in both groups.</p><p><strong>Results: </strong>Both groups reached the maximum MMAS-8 median score at all visits, showing no significant differences. Adverse event rates were 3.9 % (17/441) in the standard care group, including four stroke and thromboembolic events, versus 4.2 % (18/432) in the advanced educational intervention group, with one stroke and thromboembolic event. Subgroup analysis of patients with initial MMAS-8 scores below 8 points showed a significant difference at sixth month (6 vs. 7, P = 0.011). Over 3, 6, 9, and 12 months, MMAS-8 scores improved in both groups, with the advanced educational intervention group achieving a perfect adherence by 12 months (routine group: 6, 6, 7, 7; advanced group: 6, 7, 7, 8).</p><p><strong>Conclusion: </strong>Advanced educational intervention significantly improved dabigatran adherence in younger patients with low initial adherence, demonstrating its potential in managing NVAF in Taiwan.</p><p><strong>Trial registration number: </strong>NCT04532528.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Utilization of home-based traditional Chinese medicine in a homebound population under the integrated home-based medical care program in Taiwan\".","authors":"Xue Li, Yue Tan, Baoying Zhang","doi":"10.1016/j.jfma.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.006","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Border inspection of imported medicines and medical devices in Taiwan.","authors":"Yueh-Hao Pai, Tsung-Hsi Wu, Wei-Chih Cheng","doi":"10.1016/j.jfma.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.007","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response letter to the comment on \"Utilization of home-based traditional Chinese medicine in a homebound population under the Integrated Home-Based Medical Care program in Taiwan\".","authors":"Wen-Chiung Chang, Yi-Chang Su","doi":"10.1016/j.jfma.2025.10.010","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.10.010","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}