Journal of the Formosan Medical Association最新文献_第2页

DAB2 binds to LASP1 to participate in migration and invasion of non-small cell lung cancer through TGF-β/Smad pathway. DAB2通过TGF-β/Smad途径与LASP1结合参与非小细胞肺癌的迁移和侵袭。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-27 DOI: 10.1016/j.jfma.2025.05.019

Qing Li, Saili Zeng, Hui Long, Yunwu He, Rongfang Tu, Yonglin Li, Xianfei Liu, Qiao Xiao, Xing He, Zhenhua He

{"title":"DAB2 binds to LASP1 to participate in migration and invasion of non-small cell lung cancer through TGF-β/Smad pathway.","authors":"Qing Li, Saili Zeng, Hui Long, Yunwu He, Rongfang Tu, Yonglin Li, Xianfei Liu, Qiao Xiao, Xing He, Zhenhua He","doi":"10.1016/j.jfma.2025.05.019","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.05.019","url":null,"abstract":"Background: Disabled homolog 2 (DAB2) and LIM and Src homology 3 region (SH3) domain protein 1 (LASP1) have been shown to play a role in the course of non-small cell lung cancer (NSCLC). However, the specific regulatory mechanism remains to be elucidated. The aim of this work was to investigate the role and interaction between DAB2 and LASP1 in the development of NSCLC.Methods: The western blot assay was conducted to analyze protein levels. Immunohistochemical (IHC) staining assay was employed to evaluate the expressions of DAB2 and LASP1. The cell proliferation was examined using colony formation assay. Co-immunoprecipitation (Co-IP) assay was applied to analyze the binding relationship between DAB2 and LASP1. Cell counting kit-8 (CCK-8) assay was utilized for detection of cell viability. The invasion and migration properties of A549 cells were detected by using the transwell assay.Results: DAB2 was lowly expressed while LASP1 was highly expressed in NSCLC tissues and cells compared with non-tumor tissues and normal lung cells, and there was interaction between DAB2 and LASP1. Overexpression of DAB2 served as a tumor suppressor to suppress the proliferation, migration as well as invasion of NSCLC cells. LASP1 knockdown restrained NSCLC cell migration and invasion through suppressing TGF-β/Smad pathway. Moreover, the biological behavior induced by DAB2 overexpression were reversed after oe-LASP1 transfection, and DAB2 and LASP1 were involved in the process of NSCLC through TGF-β/Smad pathway.Conclusion: DAB2 could bind to LASP1 to participate in NSCLC development, involving the regulatory mechanism of TGF-β/Smad pathway.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic and novel approaches for evaluation of indeterminate biliary strictures. 评估不确定胆道狭窄的内镜和新方法。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-27 DOI: 10.1016/j.jfma.2025.05.036

Tung-Yen Lin, Chieh-Chang Chen, Yu-Ting Kuo, Wei-Chih Liao

{"title":"Endoscopic and novel approaches for evaluation of indeterminate biliary strictures.","authors":"Tung-Yen Lin, Chieh-Chang Chen, Yu-Ting Kuo, Wei-Chih Liao","doi":"10.1016/j.jfma.2025.05.036","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.05.036","url":null,"abstract":"Indeterminate biliary strictures are defined as strictures which evade definitive diagnosis after endoscopic retrograde cholangiopancreatography (ERCP)-assisted sampling with brush cytology and/or forceps biopsy and pose significant clinical challenges. While most indeterminate biliary strictures are attributed to malignancies, up to one-third are benign strictures. False-negative and false-positive diagnoses lead to delayed or inappropriate treatment with untoward clinical consequences. Peroral cholangioscopy (POC) and single-operator cholangioscopy (SOC) have demonstrated superior diagnostic accuracy over traditional ERCP-based techniques through enhanced visualization and targeted biopsy. Endoscopic ultrasound (EUS)-guided tissue sampling also achieves superior sensitivity and diagnostic accuracy compared with ERCP-based tissue sampling. The 2025 ESGE guideline proposes an algorithm for optimizing the utilization of ERCP-based and EUS-guided tissue sampling and cholangioscopy with consideration of the stricture location. Furthermore, molecular diagnostic tools such as fluorescence in situ hybridization (FISH) and next-generation sequencing (NGS) enable the detection of chromosomal and genetic alterations commonly associated with biliary malignancies, thereby enhancing the sensitivity for malignancy. This review summarizes recent advances in the diagnostic work-up of indeterminate biliary strictures and emerging diagnostic strategies and modalities.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author reply to letter to the editor "Arsenic exposure and trend of incidence in urinary cancer from 1979 to 2019: A nationwide population-based study". 作者回复《1979 - 2019年尿路癌砷暴露与发病率趋势：一项基于全国人群的研究》

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-27 DOI: 10.1016/j.jfma.2025.05.035

Yi-Sheng Tai

引用次数: 0

Reply to "comment on risk of colon polyps and colorectal cancer in primary biliary cholangitis, a population-based retrospective cohort study in taiwan". 回复“台湾原发性胆管炎患者发生结肠息肉及结直肠癌风险之回顾性研究”。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-27 DOI: 10.1016/j.jfma.2025.05.030

Pei-Tzu Chen, Hsuan-Wei Chen

引用次数: 0

Far-infrared therapy improves cardiovascular and infectious outcomes in peritoneal dialysis patients. 远红外治疗改善腹膜透析患者的心血管和感染结局。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-26 DOI: 10.1016/j.jfma.2025.05.028

Fan-Yu Chen, Ann Charis Tan, Szu-Yuan Li, Chih-Yu Yang, Kuo-Hua Lee, Ming-Tsun Tsai, Hsuan Lin, Chyong-Mei Chen, Chih-Ching Lin

{"title":"Far-infrared therapy improves cardiovascular and infectious outcomes in peritoneal dialysis patients.","authors":"Fan-Yu Chen, Ann Charis Tan, Szu-Yuan Li, Chih-Yu Yang, Kuo-Hua Lee, Ming-Tsun Tsai, Hsuan Lin, Chyong-Mei Chen, Chih-Ching Lin","doi":"10.1016/j.jfma.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.05.028","url":null,"abstract":"Introduction: While far-infrared (FIR) therapy has improved the treatment of various diseases, its effects on peritoneal dialysis (PD) remain understudied. The study aims to investigate the impact of FIR therapy on the cardiovascular and infectious outcomes in PD patients.Methods: A prospective observational study was conducted for six months, comparing a group receiving FIR therapy (n = 49) with a control group (n = 50). The primary outcome is defined as the composite outcome of three-point major adverse cardiovascular events (3P-MACE), coronary artery disease (CAD), congestive heart failure (CHF), or PD-related infection. The secondary outcomes are: (1) 3P-MACE; (2) 3P-MACE, CAD, or CHF; (3) PD-related infection.Results: The FIR group consistently exhibited lower incidence rates for primary and secondary outcomes. The primary outcome occurred in six patients (12.2 %) in the FIR group and 15 patients (30 %) in the control group, with incidence rates of 0.26 vs. 0.75 events per patient-year, respectively (p = 0.03). The secondary outcomes for the FIR and control groups were: (1) 3P-MACE occurred in zero patients and four patients (8 %), respectively; (2) composite outcome of 3P-MACE, CAD, or CHF occurred in two patients (4.1 %) and six patients (12 %), respectively; (3) PD-related infection occurred in six patients (12.2 %) and 12 patients (24 %), respectively. Furthermore, FIR therapy significantly reduced hospitalizations for the primary outcome (HR = 0.22; 95 % CI = 0.07-0.71; p = 0.01) and demonstrated better survival rate at six months (85.7 % vs. 67.9 %, respectively).Conclusion: This study suggests that FIR therapy shows promise in reducing hospitalizations associated with cardiovascular and infectious outcomes in PD patients.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's reply: Post-operative oropharyngeal rehabilitation suppress oxidative stress and inflammation in obstructive sleep apnea patients with transoral robotic surgery. 作者回复：经口机器人手术的阻塞性睡眠呼吸暂停患者术后口咽康复可抑制氧化应激和炎症。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-24 DOI: 10.1016/j.jfma.2025.05.027

Yi-Ju Lai, Kun-Ling Tsai, Ching-Hsia Hung, Cheng-Yu Lin

引用次数: 0

BGMP: a comprehensive database of human blood group gene mutations and phenotypes. BGMP：人类血型基因突变和表型的综合数据库。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-24 DOI: 10.1016/j.jfma.2025.05.029

Chengyan Gao, Wenqian Yu, Can Lou, Hang Lei, Shenglin Huang, Xuefeng Wang, Jiaming Li, Xiaohong Cai

{"title":"BGMP: a comprehensive database of human blood group gene mutations and phenotypes.","authors":"Chengyan Gao, Wenqian Yu, Can Lou, Hang Lei, Shenglin Huang, Xuefeng Wang, Jiaming Li, Xiaohong Cai","doi":"10.1016/j.jfma.2025.05.029","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.05.029","url":null,"abstract":"The BGMP Database (http://bloodgmp.org) serves as a centralized genomic resource for the comprehensive characterization of human blood group systems. Developed to address critical gaps in existing repositories, this platform advances precision in transfusion medicine and compatibility research by integrating classical blood group data with understudied antigen systems, including human neutrophil antigen (HNA), platelet antigens (including human platelet antigens (HPA) and CD36 variants), and immunoglobulin (Ig) allotypes. BGMP consolidates curated data encompassing 47 erythrocyte blood group systems (54 related genes) with phenotype-frequency correlations, 5 human neutrophil antigen (HNA) systems with 25 characterized epitopes, 41 HPA across 7 glycoprotein targets, CD36 deficiency variants (99 mutation profiles), and 3 immunoglobulin allotype systems with 70 serum protein polymorphisms. The database provides tools for allele variant mapping and data visualization. A dedicated submission portal enables researchers to contribute novel allele sequences or population frequency data, which undergo dual validation through automated pipeline checks and manual curation prior to integration. The current release (Version 1.0, 2025) aggregates 2785 annotated variants across all blood group systems, providing a comprehensive resource that supports clinical transfusion practices and advances blood compatibility research.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on "Arsenic exposure and trend of incidence in urinary cancer from 1979 to 2019: A nationwide population-based study". 《1979 - 2019年尿路癌人群砷暴露与发病趋势研究》

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-24 DOI: 10.1016/j.jfma.2025.05.034

Yanna Le, Qingyun Xu

引用次数: 0

Comment on Social determinants of health that impact the time to diagnosis and treatment of infertility in Taiwan. 评论影响台湾不孕症诊断和治疗时间的健康社会决定因素。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-05-23 DOI: 10.1016/j.jfma.2025.05.026

Cao Shanshan, Hu Xueliang

引用次数: 0

Bridging international guidelines on gastroparesis with clinical practice in Taiwan. 衔接国际胃轻瘫指南与台湾临床实践。