Journal of the Formosan Medical Association最新文献_第2页

Authorship statement 作者声明

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-29 DOI: 10.1016/S0929-6646(25)00131-7

引用次数: 0

Prevalence and factors associated with informal advance care planning discussion and do-not-resuscitate directives in patients at geriatric clinics. 老年门诊患者非正式的预先护理计划讨论和不复苏指示的患病率和相关因素。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-28 DOI: 10.1016/j.jfma.2025.03.024

Yu-Tai Lo, Sheng-Yu Fan, Chung-Yi Li, Deng-Chi Yang, Chi-Chang Huang, Mei-Hua Chen

{"title":"Prevalence and factors associated with informal advance care planning discussion and do-not-resuscitate directives in patients at geriatric clinics.","authors":"Yu-Tai Lo, Sheng-Yu Fan, Chung-Yi Li, Deng-Chi Yang, Chi-Chang Huang, Mei-Hua Chen","doi":"10.1016/j.jfma.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.024","url":null,"abstract":"Background: Advance care planning (ACP) discussions and do-not-resuscitate (DNR) directives are essential for ensuring quality end-of-life care, especially for older adults with multiple comorbidities. This study aimed to investigate the prevalence and associated factors of informal ACP discussions and DNR directives among geriatric outpatients in Taiwan.Methods: A cross-sectional study was conducted among 276 Taiwanese geriatric outpatients aged 65 years and older. Data on demographics, comorbidities, functional status, informal ACP discussions, and DNR directives were collected. Multinomial logistic regression was used to analyze the association between independent variables and dependent variables (ACP discussion experience and DNR directives).Results: While 92.1 % of participants reported having informal ACP discussions, only 8.3 % had completed DNR directives. Compared to those who only discussed ACP (reference group), individuals with a one-point higher Cumulative Illness Rating Scale for Geriatrics score were significantly more likely to have both discussed ACP and completed DNR directives (odds ratio [OR] = 1.14, 95 % confidence interval [CI]: 1.01-1.29, p = .035). Conversely, individuals with junior high school education or higher (OR = 0.25, 95 % CI: 0.08-0.84, p = .025) and those dependent on others for activities of daily living (ADL dependence; OR = 0.24, 95 % CI: 0.07-0.86, p = .029) were significantly less likely to have neither informally discussed ACP nor completed DNR directives.Conclusion: While Taiwanese older outpatients often informally discussed ACP, the completion of DNR directives was less common. The link between higher geriatric comorbidity and DNR directives highlights the need for proactive, tailored interventions in this population.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe SARS-CoV-2 alpha variant convalescent patients exhibit worse T cell immune response than those with mild severity disease. 重症SARS-CoV-2 α变异恢复期患者的T细胞免疫反应较轻重症患者差。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-27 DOI: 10.1016/j.jfma.2025.03.009

Chih-Yao Hsu, Chun-Hsiang Chiu, Te-Yu Lin, Feng-Yee Chang

{"title":"Severe SARS-CoV-2 alpha variant convalescent patients exhibit worse T cell immune response than those with mild severity disease.","authors":"Chih-Yao Hsu, Chun-Hsiang Chiu, Te-Yu Lin, Feng-Yee Chang","doi":"10.1016/j.jfma.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.009","url":null,"abstract":"Objectives: This study aimed to assess T cell phenotype and the role of cellular immunity against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in alpha variant coronavirus disease 2019 (COVID-19) convalescent patients.Methods: Thirty-two confirmed SARS-CoV-2 infected patients and ten healthy controls were enrolled. T cell subsets in peripheral blood were classified and quantified using flow cytometry. Additionally, T cell immune responses against SARS-CoV-2 spike peptide pools were assessed. Flow cytometry data were analyzed using Cytobank software. Other analyses involved Student's t-test or chi-square test.Results: CD127 expression on T helper cells and cytotoxic T cells was lower in the severe disease group than that in the mild disease group. Severe COVID-19 convalescents with SARS-CoV-2 alpha variant exhibited poorer T cell immune responses than those with mild disease upon spike peptide pools stimulation with SARS-CoV-2 wild type, alpha, or omicron variants.Conclusions: COVID-19 convalescents showed T helper and cytotoxic T cells with lower CD127 expression in the severe disease group than those in the mild disease group. Severe COVID-19 convalescents infected with the alpha variant exhibited poorer T cell immune responses against the SARS-CoV-2 wild type, alpha, or omicron variants. Our study provides insights into the differences in T cell phenotypes and immune responses during the contraction phase following SARS-CoV-2 infection across varying disease severities. These findings offer valuable perspectives for advancing future research on SARS-CoV-2 T cell-related immune responses.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment to: The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases. 评论：血清胆固醇轨迹、他汀类药物剂量与胆结石疾病复发风险之间的关系。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-27 DOI: 10.1016/j.jfma.2025.03.023

Edy Kornelius

引用次数: 0

Reassessing LDL-C thresholds: Toward tailored lipid management. 重新评估LDL-C阈值：面向量身定制的脂质管理。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-25 DOI: 10.1016/j.jfma.2025.03.019

Yu-Chung Hsiao, Tzu-Yang Chen, Fang-Ju Lin, Chau-Chung Wu

引用次数: 0

Disability level as a key predictor of mortality in patients with oral cancer: A hospital-based retrospective study in Taiwan. 残障程度是口腔癌患者死亡率的关键预测因子：台湾一项以医院为基础的回顾性研究。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-24 DOI: 10.1016/j.jfma.2025.03.018

Chih-Chin Lai, Jing-Rong Jhuang, Kuo-Liong Chien, Chun-Nan Chen, Jiu-Jenq Lin, Hsin-Hui Peng, Shin-Liang Pan

{"title":"Disability level as a key predictor of mortality in patients with oral cancer: A hospital-based retrospective study in Taiwan.","authors":"Chih-Chin Lai, Jing-Rong Jhuang, Kuo-Liong Chien, Chun-Nan Chen, Jiu-Jenq Lin, Hsin-Hui Peng, Shin-Liang Pan","doi":"10.1016/j.jfma.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.018","url":null,"abstract":"Background: This study investigated the demographics, comorbidities, and mortality rates of patients diagnosed with oral cancer, guided by a hypothesis that disability level would emerge as an independent predictor of adverse outcomes alongside age and comorbidities.Methods: Socio-demographic and medical information for patients treated for oral cancer at National Taiwan University Hospital (NTUH) from 2012 to 2018 was collected, along with their mortality data from NTUH's integrated medical database. Disability levels were measured using WHODAS 2.0, dividing patients into severe (WHODAS score ≥60, n = 197) and non-severe disability (WHODAS score ≤59, n = 228) groups. The primary outcome was overall survival probability. Propensity-score matching balanced baseline characteristics, and Cox proportional-hazard models analyzed the impact of various covariates on mortality rates.Results: A total of 425 patients diagnosed with oral cancer were enrolled in the study, with a mean age of 55.1 years (standard deviation, 9.8). The majority (95 %) were men. Over the 6.75-year data-collection window, 94 of them (22.1 %) died. The severely disabled group exhibited significantly poorer survival (p = 0.02), and univariate analyses identified WHODAS scores of 60 or higher as an independent prognostic factor among patients with oral cancer (hazard ratio = 1.59, 95 % confidence interval = [1.05-2.40]).Conclusion: WHODAS 2.0 scores of 60 or higher indicate severe to extreme disability, which often correlates with poorer overall health and reduced ability to manage oral cancer and its treatments. This significant impairment is likely to be a contributory factor in higher mortality rates amongst this patient group.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK inhibitors combined with bisphosphonates treatment for chronic diffuse sclerosing osteomyelitis of mandible: A 4-year follow-up. JAK抑制剂联合双膦酸盐治疗下颌骨慢性弥漫性硬化性骨髓炎：4年随访

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-22 DOI: 10.1016/j.jfma.2025.02.032

Mu Wang, Weihua Han, Ge Kong, Shang-Zhu Zhang, Wen Zhang

引用次数: 0

Telemedicine service facilitates but does not yet replace standard care in hospitalized patients in quarantine. 远程医疗服务有助于但尚未取代隔离住院患者的标准护理。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-21 DOI: 10.1016/j.jfma.2025.03.015

Tung-Hung Su, Jia-Horng Kao

引用次数: 0

Comment on "A comparative analysis of MMR immunohistochemistry panels: Evaluating the utility of four-protein versus two-protein panels in endometrial cancer patients". 关于 "MMR 免疫组化样本的比较分析：评估子宫内膜癌患者中四种蛋白与两种蛋白的效用"。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-20 DOI: 10.1016/j.jfma.2025.03.013

Sisi Zhou

引用次数: 0

Polymorphisms in the calcium voltage-gated channel subunit Alpha1 D (CACNA1D) gene are associated with spontaneous preterm birth in Taiwanese women. 钙电压门控通道亚基α 1D （CACNA1D）基因多态性与台湾女性自发性早产有关。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-03-19 DOI: 10.1016/j.jfma.2025.03.010

Tzu-Yang Chang, Tzu-Hsiang Kao, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen

{"title":"Polymorphisms in the calcium voltage-gated channel subunit Alpha1 D (CACNA1D) gene are associated with spontaneous preterm birth in Taiwanese women.","authors":"Tzu-Yang Chang, Tzu-Hsiang Kao, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen","doi":"10.1016/j.jfma.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.03.010","url":null,"abstract":"Purpose: Calcium signaling is essential for immune function, myometrial contractions, and hormone secretion, all of which contribute to preterm birth. In this study, we investigated the associations of 3 single-nucleotide polymorphisms (SNPs) in CACNA1D gene, which encodes the Cav1.3 calcium channel, with the risk of spontaneous preterm birth (sPTB).Methods: A hospital-based case-control study was conducted with 112 women of sPTB and 1120 term control women. Three CACNA1D SNPs (rs9810888 T/G, rs1045958 C/T, and rs881883 G/A) were genotyped.Results: The T/G genotype of the CACNA1D rs9810888 SNP was associated with a reduced risk of sPTB (odds ratio: 0.61, 95 % confidence interval: 0.41-0.91, P = 0.01, Pc = 0.03). However, no significant associations were observed for the other 2 SNPs. Haplotype analysis revealed no significant differences between the case and control groups.Conclusion: Our findings suggest that the intronic rs9810888 T/G variant of CACNA1D gene protects against sPTB in Taiwanese women.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0