Journal of the Formosan Medical Association最新文献_第2页

Comment on"High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C". 对“慢性丙型肝炎治疗后高正常和异常的丙氨酸转氨酶水平与肝癌风险增加有关”的评论。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-21 DOI: 10.1016/j.jfma.2025.06.030

Ruyin Jia, Guoshu Xu

引用次数: 0

Evaluating the effectiveness of adjuvant therapy on biochemical recurrence in prostate cancer patients with positive surgical margins after radical prostatectomy. 评价辅助治疗对前列腺癌根治性切缘阳性患者生化复发的疗效。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-21 DOI: 10.1016/j.jfma.2025.06.036

Hsiao-Chun Su, Ching-Chia Li, Wei-Ming Li, Hsin-Chih Yeh, Hung-Lung Ke, Wen-Jeng Wu, Tsu Ming Chien, Sheng-Chen Wen, Yen-Chun Wang, Hsiang-Ying Lee

{"title":"Evaluating the effectiveness of adjuvant therapy on biochemical recurrence in prostate cancer patients with positive surgical margins after radical prostatectomy.","authors":"Hsiao-Chun Su, Ching-Chia Li, Wei-Ming Li, Hsin-Chih Yeh, Hung-Lung Ke, Wen-Jeng Wu, Tsu Ming Chien, Sheng-Chen Wen, Yen-Chun Wang, Hsiang-Ying Lee","doi":"10.1016/j.jfma.2025.06.036","DOIUrl":"10.1016/j.jfma.2025.06.036","url":null,"abstract":"Background: This study investigates the correlations between positive surgical margins (PSMs) and biochemical recurrence (BCR) in patients undergoing radical prostatectomy (RP).Methods: A cohort of 111 patients who underwent RP between 2011 and 2020 was subjected to comprehensive analysis. Clinicopathological and laboratory data were collected to evaluate the influence of Gleason score (GS) and different PSM sites on BCR-free survival following RP. Various statistical analyses, including the Chi-square test, student's t-test, Cox regression models, and the Inverse Probability of Treatment Weighting (IPTW) model, were employed to examine the impact of these factors on patient outcomes.Results: The IPTW model revealed a consistent reduction in the risk of BCR among patients who received adjuvant therapy, irrespective of age, pre-biopsy prostate-specific antigen (PSA) levels, or the presence of lymphatic vascular invasion (LVI). Within the subgroup receiving adjuvant therapy, factors such as pathological GS≥8 (p<0.0001), pathological tumor stage (pT stage) beyond T3 (p<0.0001), presence of perineural invasion (PNI) (p<0.0001), utilization of a robotic-assisted radical prostatectomy (RaRP) surgical approach (p<0.0001), and involvement of apical or multifocal PSM sites (p=0.0042 and 0.0054) were identified as significantly associated with the observed protective effect of adjuvant therapy.Conclusions: This study underscores the importance of identifying apical PSMs, as their presence is associated with an elevated risk of BCR. Administering timely adjuvant therapy to patients with apical PSMs emerges as a potential strategy to improve outcomes. Nevertheless, further research is warranted to refine clinical decision-making and treatment approaches in light of these findings.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to the comment on "High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C". 回复关于“慢性丙型肝炎治疗后高正常和异常丙氨酸转氨酶水平与肝癌风险增加相关”的评论。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-21 DOI: 10.1016/j.jfma.2025.06.034

Yen-Chun Chen, Ming-Lung Yu

引用次数: 0

Enhancing thalassemia carrier detection: Advancing genetic screening strategies in prenatal care. 加强地中海贫血携带者检测：推进产前护理中的遗传筛查策略。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-20 DOI: 10.1016/j.jfma.2025.06.028

Han-Ying Chen, Yi-Lien Lin, Yi-Ning Su, Ti-Jia Yuan, Shin-Yu Lin, Chien-Nan Lee, Kuan-Heng Chen

{"title":"Enhancing thalassemia carrier detection: Advancing genetic screening strategies in prenatal care.","authors":"Han-Ying Chen, Yi-Lien Lin, Yi-Ning Su, Ti-Jia Yuan, Shin-Yu Lin, Chien-Nan Lee, Kuan-Heng Chen","doi":"10.1016/j.jfma.2025.06.028","DOIUrl":"10.1016/j.jfma.2025.06.028","url":null,"abstract":"The carrier rates of alpha- and beta-thalassemia are notably high in certain regions. Current screening methods using traditional mean corpuscular volume (MCV) measurements can prevent the birth of severe cases of thalassemia, but often miss carriers of mild forms, potentially leading to hemoglobin H disease or thalassemia in their offspring. This study aimed to demonstrate that genetic carrier screening using next-generation sequencing (NGS) enhances the detection of silent thalassemia carriers and explores its clinical feasibility for large-scale population screening to illustrate the prevalence and spectrum of thalassemia in Taiwan. This retrospective study was conducted in Taiwan between April 1, 2019 and August 30, 2022. Of 1901 screened patients, 174 thalassemia carriers were identified, indicating a carrier rate of 9.2 %. The prevalence of alpha-thalassemia, beta-thalassemia, and combined alpha- and beta-thalassemia was 7.8 %, 1.3 %, and 0.1 %, respectively. Specifically, 84.5 %, 13.8 %, and 1.1 % of the patients had alpha-thalassemia, beta-thalassemia, and both types of thalassemia, respectively. These carrier rates were higher than those reported in previous studies. Among alpha-thalassemia carriers, the SEA (Southeast Asian) type was the most prevalent at 52.7 %, followed by the right-end deletion type (-α3.7) at 30.4 %. Using the MCV cut-off method would have missed 33.8 % and 12.5 % of alpha- and beta-thalassemia carriers, respectively. Screening for thalassemia carriers based solely on MCV leads to a high rate of misdiagnosis. To our knowledge, this study is the first to apply NGS to analyze the distribution of thalassemia in Taiwan, offering a valuable foundation for screening, prevention, and treatment strategies.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four decades of the RET gene: From discovery to tumor-agnostic therapy. RET基因的四十年：从发现到肿瘤治疗。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-20 DOI: 10.1016/j.jfma.2025.06.033

Masahide Takahashi

{"title":"Four decades of the RET gene: From discovery to tumor-agnostic therapy.","authors":"Masahide Takahashi","doi":"10.1016/j.jfma.2025.06.033","DOIUrl":"10.1016/j.jfma.2025.06.033","url":null,"abstract":"The physiological and disease-related roles of the Rearranged during Transfection (RET) gene have been extensively studied since its discovery four decades ago. RET encodes a receptor tyrosine kinase whose ligands are members of the glial cell line-derived neurotrophic factor (GDNF) family. Unlike other receptor tyrosine kinase ligands, GDNF family ligands (GFLs) do not bind to RET directly; instead, RET requires GDNF family receptor αs (GFRαs) as coreceptors for their binding. The resulting GFL/GFRα/RET ternary complex plays physiologically crucial roles in developing some organ systems. RET alterations cause various human cancers and developmental disorders. Gene rearrangements occur in 5-20 % of papillary thyroid carcinoma, 1-2 % of non-small cell lung carcinoma, and <1 % of other solid cancers. Germline and somatic RET point mutations have been detected in almost all multiple endocrine neoplasia type 2 families and 40-70 % of sporadic medullary thyroid carcinoma. Moreover, RET loss-of-function mutations or deletions cause Hirschsprung's disease. Selective RET kinase inhibitors have recently shown remarkable progress for the treatment of advanced non-small cell lung and thyroid cancers. As RET alterations occur across multiple tumor types, RET inhibitor development is enabling a new paradigm of tumor-agnostic therapies. This review highlights clinical efficacy of selective RET inhibitors.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response letter to "Comment on Social determinants of health that impact the time to diagnosis and treatment of infertility in Taiwan". 对“关于影响台湾不孕症诊断和治疗时间的健康社会决定因素的评论”的答复函。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-19 DOI: 10.1016/j.jfma.2025.06.026

Wei-An Chen, Mei-Jou Chen

引用次数: 0

Comment on "Diagnostic value and fracture healing-preventing effect of upregulated microRNA-4534 in patients with osteoporotic fractures". 对“microRNA-4534上调在骨质疏松性骨折患者中的诊断价值及预防骨折愈合作用”的评论。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-19 DOI: 10.1016/j.jfma.2025.06.031

Zhe Yang, Zhongwei Jia

引用次数: 0

Comment on Awareness and willingness towards Mpox vaccination among men who have sex with men seeking HIV-related services. 评论寻求艾滋病毒相关服务的男男性行为者对m痘疫苗接种的认识和意愿。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-18 DOI: 10.1016/j.jfma.2025.06.027

Mingwei Tan, Yifeng Wang

引用次数: 0

Comparison of dosimetry models to predict outcome for radioembolization in patients with intermediate to advanced hepatocellular carcinoma. 预测中晚期肝细胞癌放射栓塞预后的剂量学模型的比较。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-18 DOI: 10.1016/j.jfma.2025.06.024

Hui-Chi Liu, Po-Chin Liang, Yung-Hsuan Yang, Shan-Yu Lin, Yu-Uen Hsu, Chih-Horng Wu

{"title":"Comparison of dosimetry models to predict outcome for radioembolization in patients with intermediate to advanced hepatocellular carcinoma.","authors":"Hui-Chi Liu, Po-Chin Liang, Yung-Hsuan Yang, Shan-Yu Lin, Yu-Uen Hsu, Chih-Horng Wu","doi":"10.1016/j.jfma.2025.06.024","DOIUrl":"10.1016/j.jfma.2025.06.024","url":null,"abstract":"Background: Yttrium-90 (Y90) radioembolization is an effective locoregional therapy for hepatocellular carcinoma (HCC). However, the radiation dose determines the result of Y-90. This study aimed to compare the outcomes of two dosimetry methods of Y-90 resin microspheres (the body surface area model [BSA] and the partition model [PM]) and determine the radiation dose to predict prognosis.Methods: A retrospective cohort study was conducted in a single tertiary medical center in Taiwan. Between May 2016 to September 2019, 89 patients with intermediate to advanced HCCs were treated with Y90 resin microspheres and followed up for at least six months. Clinical data, laboratory profiles, dosimetric parameters, tumor response, and prognosis were collected and compared between BSA and PM. Univariate and multivariate survival analyses were performed to investigate whether the dosimetric model impacts prognosis.Results: The median overall survival (OS) was 15.8 months. The PM had significantly better OS than the BSA model (27.8 vs. 10.8 months, p = 0.011). The disease control rate in the seventh month was 40.9 % in PM and 31.1 % in BSA. There was no difference in the non-tumor and tumor doses between the two dosimetric groups. The independent prognostic factors are dosimetric method and total tumor volume scale (TTVS). Subgroup analysis for each dosimetry model showed improved OS in patients who received tumor doses over 125Gy (p = 0.040 for PM; p = 0.037 for BSA). CONC: lusion: Y-90 radioembolization using the PM and tumor volume are associated with OS in patients with intermediate to advanced HCC.","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Dexmedetomidine infusion on blood loss in orthognathic surgery: A retrospective study on its efficacy. 评论：右美托咪定输注对正颌手术失血量的疗效回顾性研究。

IF 2.6 3区医学

Journal of the Formosan Medical Association Pub Date : 2025-06-16 DOI: 10.1016/j.jfma.2025.06.023

Luyi Yu, Yuebing Li

引用次数: 0