Journal of the Formosan Medical Association最新文献

{"title":"Assessing the link between post-treatment ALT and HCC risk in chronic hepatitis C.","authors":"Weiyi Jiang, Ye Li, YongSheng Wang, Tingsu Zhang","doi":"10.1016/j.jfma.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.004","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Controlling nutritional status score as a survival prognosticator in patients with head and neck cancer\".","authors":"Xiaocen Wang","doi":"10.1016/j.jfma.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.09.002","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of chromatin remodeling genes predicts clinical outcomes in acute myeloid leukemia.","authors":"Lanxiang Liu, Li Wang, Hongbin Zhang, Lin Liu, Xinyu Yan","doi":"10.1016/j.jfma.2025.08.045","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.045","url":null,"abstract":"<p><strong>Background: </strong>Acute myeloid leukemia (AML) is a malignancy of the blood system. The commonly altered regions in the genome of AML encompass a multitude of gene modifications associated with epigenetic regulation. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) as an overall indicator has yet to be assessed in AML.</p><p><strong>Methods: </strong>Univariate Cox regression analysis was performed for CRRGs. Following unsupervised clustering analysis, the differentially expressed genes (DEGs) and immune cells between chromatin remodeling related subtypes in TCGA-AML were measured. Univariate Cox analysis and Least Absolute Shrinkage and Selection Operator (LASSO) analysis were used to screen prognostic biomarkers for AML, and a risk model was subsequently constructed. Gene set variation analysis (GSVA) analysis and tumor mutation burden (TMB) analysis was conducted in different risk groups. Using Tumor Immune Dysfunction and Exclusion (TIDE) score to assess patients' differences in sensitivity to immunotherapy. Additionally, the construction and verification of the nomogram were carried out. The expression of biomarkers in healthy and AML patients was analyzed by Quantitative Real-time Polymerase Chain Reaction (RT-qPCR).</p><p><strong>Results: </strong>A total of 106 prognostic CRRGs were identified. Between the two clusters, 3995 genes, activated CD4 memory T cells and activated Dendritic cells were differentially expressed. A total of 6 prognostic biomarkers were identified (ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1I), and a risk model was generated based on these biomarkers. The high-risk group exhibited higher TIDE scores. Moreover, 29 drugs showed lower IC50 values in high-risk group. We also found that risk score was an independent prognostic factor for AML. RT-qPCR results showed significant differences in expression of ARF6, KDM5B and CHD5 between healthy and AML patients.</p><p><strong>Conclusion: </strong>We identified six biomarkers, namely ARF6, ASF1B, CHD5, FLNA, KDM5B, and SPI1, thereby establishing a theoretical foundation for clinical diagnosis of AML.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Impact of completely histological remission on reducing flare-ups in moderate-to-severe, biologics-experienced ulcerative colitis patients with endoscopic remission.","authors":"Tirayut Veerasathian, Schawanya K Rattanapitoon, Thawatchai Eaksanti, Nathkapach K Rattanapitoon","doi":"10.1016/j.jfma.2025.08.043","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.043","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Clinical characteristics and predictive models of plastic bronchitis caused by mycoplasma pneumoniae pneumonia in children\": Clinical characteristics and predictive models of plastic bronchitis.","authors":"Fenfang Song, Wenlong Yue, Fenle Song","doi":"10.1016/j.jfma.2025.08.044","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.044","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C virus microelimination among men who have sex with men in Taiwan: Our progress, achievements, and remaining challenges.","authors":"Miao-Hui Huang, Guan-Jhou Chen, Chien-Ching Hung","doi":"10.1016/j.jfma.2025.08.039","DOIUrl":"10.1016/j.jfma.2025.08.039","url":null,"abstract":"<p><p>Since 2010, high-risk sexual contact has become a major route of hepatitis C virus (HCV) transmission in Taiwan, particularly among men who have sex with men (MSM). With the rollout of direct-acting antivirals (DAAs) and the implementation of national strategies such as mass screening and reflex viral load testing to improve detection of HCV viremia, Taiwan has made substantial progress toward HCV elimination. Among MSM living with HIV, the prevalence, incidence, and reinfection rates of HCV have significantly declined following the implementation of the HCV elimination program. This success has been largely attributed to the integration of HCV care into routine HIV services, resulting in high rates of HCV screening, confirmation of viremia, and treatment uptake. In contrast, the HCV epidemiology among HIV-negative MSM remains poorly characterized, and those not engaged in pre-exposure prophylaxis (PrEP) programs may have limited access to testing and treatment. As Taiwan has achieved the goals of HCV elimination in the general population, sustained efforts are needed to timely diagnose sexually transmitted HCV infection, monitor reinfection, and expand unlimited access to DAAs to sustain elimination efforts beyond 2025.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Safety and efficacy of early varenicline prescription in hospitalized patients with acute myocardial infarction: East Asian population.","authors":"Luo Biao, Wang Jie, Wu Xiaohan, Deng Lvyu","doi":"10.1016/j.jfma.2025.08.042","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.042","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broadening the perspective on mpox: Addressing inequities, surveillance gaps, and long-term challenges.","authors":"Amitabh Tripathi, Udaya Pratap Singh","doi":"10.1016/j.jfma.2025.08.041","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.041","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Comparison of the clinicoradiological features and outcomes of lymphoepithelioma-like cholangiocarcinoma and conventional intrahepatic cholangiocarcinoma: A propensity score matching analysis\".","authors":"Shashank Dokania, Parth Aphale, Himanshu Shekhar","doi":"10.1016/j.jfma.2025.08.046","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.046","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Far infrared therapy improves the vascular function of lower extremities in hemodialysis patients.","authors":"Wei-Hao Lee, Hung-Hsiang Liou, Chung-Kuan Wu","doi":"10.1016/j.jfma.2025.08.033","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.08.033","url":null,"abstract":"<p><strong>Background: </strong>Hemodialysis (HD) patients commonly experience peripheral vascular dysfunction due to multiple risk factors for stenosis. Far infrared radiation (FIR) causes vasodilation and enhances the circulation of vascular access. The effect of FIR on the peripheral vascular system remains uncertain.</p><p><strong>Methods: </strong>The study enrolled 28 chronic HD patients from a medical center in 2022. These patients received FIR therapy on both feet for 40 min during each HD session for one year. Ankle-brachial index (ABI), pulse volume record (PVR), skin perfusion pressure (SPP), peripheral vascular sonography (PVS), and maximal venous outflow/segmental venous capacitance were analyzed using paired t-tests and Wilcoxon signed-rank tests to assess changes before and after FIR therapy.</p><p><strong>Results: </strong>FIR significantly reduced the proportion of HD patients with an ABI <0.9 from 7.1 % to 3.6 %. FIR significantly decreased the proportion from 32.1 % to 17.9 % of those with right anterior tibial stenosis on PVS, and the proportion from 53.6 % to 32.1 % of those with arterial stenosis by PVR over the left thigh, especially in those with DM. FIR significantly augmented left plantar SPP of HD patients (from 80.04 mmHg to 94.14 mmHg) and those without DM (from 73.00 mmHg to 95.86 mmHg). FIR significantly reduced the ratio of HD patients with abnormal venous return during respiration in the left common femoral vein (CFV) from 25.9 % to 3.7 %, and of those without DM from 28.6 % to 0 % on bilateral CFV.</p><p><strong>Conclusion: </strong>FIR therapy was associated with improvements in arterial stenosis, skin perfusion, and venous return in the lower extremities.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}