Journal of the Formosan Medical Association最新文献

{"title":"Automated liver volumetry and hepatic steatosis quantification with magnetic resonance imaging proton density fat fraction","authors":"Yuan-Chen Chang ,&nbsp;Kuang-Chen Yen ,&nbsp;Po-Chin Liang ,&nbsp;Ming-Chih Ho ,&nbsp;Cheng-Maw Ho ,&nbsp;Chih-Yang Hsiao ,&nbsp;Chiu-Han Hsiao ,&nbsp;Chia-Hsun Lu ,&nbsp;Chih-Horng Wu","doi":"10.1016/j.jfma.2024.04.012","DOIUrl":"10.1016/j.jfma.2024.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Preoperative imaging evaluation of liver volume and hepatic steatosis for the donor affects transplantation outcomes. However, computed tomography (CT) for liver volumetry and magnetic resonance spectroscopy (MRS) for hepatic steatosis are time consuming. Therefore, we investigated the correlation of automated 3D-multi-echo-Dixon sequence magnetic resonance imaging (ME-Dixon MRI) and its derived proton density fat fraction (MRI-PDFF) with CT liver volumetry and MRS hepatic steatosis measurements in living liver donors.</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study was conducted from December 2017 to November 2022. We enrolled donors who received a dynamic CT scan and an MRI exam within 2 days. First, the CT volumetry was processed semiautomatically using commercial software, and ME-Dixon MRI volumetry was automatically measured using an embedded sequence. Next, the signal intensity of MRI-PDFF volumetric data was correlated with MRS as the gold standard.</div></div><div><h3>Results</h3><div>We included the 165 living donors. The total liver volume of ME-Dixon MRI was significantly correlated with CT (<em>r</em> = 0.913, <em>p</em> &lt; 0.001). The fat percentage measured using MRI-PDFF revealed a strong correlation between automatic segmental volume and MRS (<em>r</em> = 0.705, <em>p</em> &lt; 0.001). Furthermore, the hepatic steatosis group (MRS ≥5%) had a strong correlation than the non–hepatic steatosis group (MRS &lt;5%) in both volumetric (<em>r</em> = 0.906 vs. <em>r</em> = 0.887) and fat fraction analysis (<em>r</em> = 0.779 vs. <em>r</em> = 0.338).</div></div><div><h3>Conclusion</h3><div>Automated ME-Dixon MRI liver volumetry and MRI-PDFF were strongly correlated with CT liver volumetry and MRS hepatic steatosis measurements, especially in donors with hepatic steatosis.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 264-270"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases","authors":"Fai-Meng Sou ,&nbsp;Chien-Ning Hsu ,&nbsp;Yi-Chun Chiu ,&nbsp;Cheng-Kun Wu ,&nbsp;Lung-Sheng Lu ,&nbsp;Chung-Mou Kuo ,&nbsp;Shao-Ming Chiu ,&nbsp;Seng-Kee Chuah ,&nbsp;Yao-Hsu Yang ,&nbsp;Chih-Ming Liang","doi":"10.1016/j.jfma.2024.04.003","DOIUrl":"10.1016/j.jfma.2024.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Statins may reduce the risk of recurrent gallstone disease by decreasing bile cholesterol saturation and pathogenicity. However, limited studies have investigated this issue. This study aimed to assess whether statin doses and serum cholesterol levels were associated with a decreased risk of recurrent biliary stone diseases after the first event index, with a follow-up time of 15 years.</div></div><div><h3>Methods</h3><div>Based on the Chang Gung Research Database (CGRD) between January 1, 2001, and December 31, 2020, we enrolled 68,384 patients with the International Classification of Diseases, Ninth and Tenth Revision codes of choledocholithiasis. After exclusions, 32,696 patients were divided into non-statin (&lt;28 cDDD, cumulative defined daily doses) (n = 27,929) and statin (≥28 cDDD) (n = 4767) user groups for analysis. Serum cholesterol trajectories were estimated using group-based trajectory modeling (n = 8410).</div></div><div><h3>Results</h3><div>The statin users had higher Charlson Comorbidity Index (CCI) scores than the non-statin users. Time-dependent Cox regression analysis showed that statin use &gt;365 cDDD was associated with a significantly lower risk of recurrent biliary stones (adjusted hazard ratio [aHR] = 0.28, 95% CI, 0.24–0.34; p &lt; 00.0001), acute pancreatitis (aHR = 0.24, 95% CI, 0.17–0.32, p &lt; 00.0001), and cholangitis (aHR = 0.28, 95% CI, 0.25–0.32, p &lt; 00.0001). Cholecystectomy was also a protective factor for recurrent biliary stones (aHR = 0.41, 95% CI, 0.37–0.46; p &lt; 00.0001). The higher trajectory serum cholesterol group (Group 3) had a lower risk trend for recurrent biliary stones (aHR = 0.79, p = 0.0700) and a lower risk of cholangitis (aHR = 0.79, p = 0.0071).</div></div><div><h3>Conclusion</h3><div>This study supports the potential benefits of statin use and the role of cholecystectomy in reducing the risk of recurrent biliary stone diseases.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 246-252"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The crucial role of centrioles in tooth growth and development","authors":"Shan-Li Pei ,&nbsp;Rung-Shu Chen ,&nbsp;Min-Huey Chen","doi":"10.1016/j.jfma.2024.04.014","DOIUrl":"10.1016/j.jfma.2024.04.014","url":null,"abstract":"<div><h3>Background</h3><div>Tooth development hinged on reciprocal interactions between enamel and dentin, shaping tooth structures. Centrioles influenced cellular direction, critical for stem cell differentiation. Aberrant centrioles contributed to conditions like Huntington's disease and cancers. Centriole-related gene mutations, like Pericentrin and Centrosomal P4.1-associated protein (CPAP), led to tooth abnormalities, microcephaly. Our study explored the role of centrioles in ameloblasts during molar growth, shedding light on tooth development mechanisms.</div></div><div><h3>Methods</h3><div>Tissue sections underwent immunofluorescence and hematoxylin and eosin staining to observe centriole changes in C57BL/6 mouse molars (1,3,5,7, and 9 days). Emphasis was placed on comparing centrioles in enamel and ameloblasts between Nestin-Cremediated Cpap conditional knockout in p53-deficient mice (Cpap(-/-) mice) and normal mice on the ninth day.</div></div><div><h3>Results</h3><div>In mouse molar tissue, ameloblasts and enamel underwent notable changes during the 1-9 days after birth. Centrioles in ameloblasts exhibited dynamic temporal localization, migrating away from cell nuclei towards enamel generation. Correlation between enamel thickness and centriole quantity suggested a relationship. Comparative analysis of normal and Cpap (-/-) mice on the ninth day revealed differences in enamel thickness, ameloblast elongation, and centriole distribution, highlighting the impact of CPAP deficiency on tooth development.</div></div><div><h3>Conclusion</h3><div>This study affirmed the positive contribution of ciliated centrioles in ameloblasts to enamel growth during the secretory phase. Increased centrioles correlated with enhanced enamel formation. Conversely, CPAP loss disrupted centriole organization, impacting ameloblast morphology and functionality, resembling enamel hypoplasia observed in microcephaly patients. Further research is essential to unravel molecular mechanisms and potential interactions with odontoblast centrioles.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 271-277"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the optimal lower blood pressure boundary during endovascular thrombectomy in patients with large vessel occlusion","authors":"Yu-Ming Chang ,&nbsp;Chun-Min Wang ,&nbsp;Kang-Po Lee ,&nbsp;Po-Chun Shen ,&nbsp;Po-Yu Lin ,&nbsp;Chi-Hung Liu ,&nbsp;Sheng-Hsiang Lin ,&nbsp;Chih-Hung Chen ,&nbsp;Meng-Tsang Hsieh ,&nbsp;Pi-Shan Sung","doi":"10.1016/j.jfma.2024.05.003","DOIUrl":"10.1016/j.jfma.2024.05.003","url":null,"abstract":"<div><h3>Background</h3><div>Current guidelines advocate for maintaining BP level below 180/105 mmHg during EVT, determining the safe lower boundary remains primarily consensus-driven by experts. This study aims to delve into the correlation between various targets of lower boundary for systolic and diastolic BP (SBP and DBP) during EVT and 3-month functional outcomes.</div></div><div><h3>Methods</h3><div>A cohort study was conducted across two EVT-capable centers, enrolling patients with large artery occlusion undergoing EVT within 8 h of stroke onset. Mean BP values during EVT were meticulously recorded, and logistic regression models were utilized to evaluate the correlation between outcomes and diverse lower boundary targets for SBP and DBP. Additionally, logistic regression models investigated the relationship between periprocedural BP variability and subsequent outcomes.</div></div><div><h3>Results</h3><div>Among the 201 patients included, having a SBP higher than 130 or 140 mmHg showed an independent association with increased good functional outcomes at 3 months (adjusted odds ratio, aOR 2.80, 95% Cis, 1.26–6.39 for 140 mmHg; aOR 2.34, 95% Cis, 1.03–5.56 for 130 mmHg). Additionally, an SBP exceeding 130 mmHg was correlated with decreased 3-month mortality (aOR, 0.24, 95% CI 0.07–0.74). No significant relationship was observed between DBP and functional outcomes. Patients with higher periprocedural SBP coefficient variance exhibited a decreased rate of good functional outcomes at 3 months (aOR, 0.42, 95% CI, 0.18–0.96).</div></div><div><h3>Conclusion</h3><div>A SBP range above 130–140 mmHg could potentially serve as a safe lower boundary during EVT, while minimizing BP fluctuations may correlate with improved post-EVT functional outcomes.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 278-283"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment to: Colchicine to prevent cardiovascular death after an acute myocardial infarction.","authors":"Edy Kornelius","doi":"10.1016/j.jfma.2025.02.030","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.02.030","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for previously published articles","authors":"","doi":"10.1016/j.jfma.2025.01.004","DOIUrl":"10.1016/j.jfma.2025.01.004","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Page 300"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S0929-6646(25)00085-3","DOIUrl":"10.1016/S0929-6646(25)00085-3","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages e1-e8"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion safety concerns during the COVID-19 pandemic in Taiwan: Altered by evolving control strategies","authors":"Yun-Yuan Chen ,&nbsp;Min-Hui Yang ,&nbsp;Jou-Zhen Lai ,&nbsp;Jen-Wei Chen ,&nbsp;Yun-Long Wang ,&nbsp;Cheng-Shen Hung ,&nbsp;Chang-Der Kow ,&nbsp;Chi-Ling Lin ,&nbsp;Sheng-Mou Hou ,&nbsp;Ho-Sheng Wu ,&nbsp;Sheng-Tang Wei","doi":"10.1016/j.jfma.2024.09.003","DOIUrl":"10.1016/j.jfma.2024.09.003","url":null,"abstract":"<div><h3>Background</h3><div>In 2022, the SARS-CoV-2 Omicron surge affected 8.8 million people in Taiwan. This study delves into how the transition from containment to mitigation strategies in COVID-19 control has altered concerns regarding transfusion safety.</div></div><div><h3>Methods</h3><div>Blood donations during 2020–2022 in Taiwan were included. Donation details and post-donation information (PDI) were retrieved to assess donation fluctuations and incidences of various PDI. The main effects of PDI reporting were assessed using chi-square test and logistic regression. Additionally, from April to August 2022, we collected disease information from COVID-19 donors, and tested their repository specimens for SARS-CoV-2 RNA and antibodies.</div></div><div><h3>Results</h3><div>Before 2022, when containment measures were in place, only 8 blood donors with COVID-19 reported PDI. However, by mid-2021, there was a significant decrease in blood donations. In 2022, with mitigation strategies implemented, a total of 3483 donations reported COVID-19 PDI. The incidence of all cause PDI increased from 10.5 per 10,000 donations in 2020–2021 to 29.9 per 10,000 in 2022, with nearly 70% of PDI being related to COVID-19. Female donors reported more PDI events. Additionally, the incidence significantly decreased with age. A total of 1148 repository specimens from COVID-19 donor were tested, revealing no detection of SARS-CoV-2 RNA. The seroprevalence rates of anti-nucleocapsid(N) and anti-spike(S) antibodies were 0.61% and 98.4%, respectively.</div></div><div><h3>Conclusion</h3><div>Transfusion safety concerns in Taiwan progressed alongside the evolution of control strategies, with a one-year delay following the pandemic started. The absence of RNAemia among COVID-19 donors indicates that precautionary measures were commensurate with the risk.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 218-226"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019","authors":"Mu-Ming Chien ,&nbsp;Mei-Hwei Chang ,&nbsp;Kai-Chi Chang ,&nbsp;Yen-Hsuan Ni ,&nbsp;Jia-Feng Wu","doi":"10.1016/j.jfma.2024.04.006","DOIUrl":"10.1016/j.jfma.2024.04.006","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of <em>Clostridium difficile</em> infection (CDI) is increasing around the world, and patients with inflammatory bowel disease (IBD) have a higher risk of obtaining CDI. The data on the incidence rate of CDI in the Asian pediatric IBD population was lacking.</div></div><div><h3>Methods</h3><div>We retrospectively collected data from a tertiary medical center in Taipei, Taiwan. All patients aged 1–18 years old who visited the outpatient department or were admitted to our hospital between 2006 and 2019 were included. CDI was defined as positive stool <em>C. difficile toxin</em> or <em>C. difficile</em> culture results with appropriate antibiotic use within the range of 7 days prior or 14 days after the result.</div></div><div><h3>Results</h3><div>We compared the average annual incidence of CDI before and after 2013. The average incidence of community-acquired CDI (CA-CDI) increased from 0.063 to 0.564 cases per 1,000 visits, with a rate ratio (RR) of 8.82 (95% CI 5.74-14.38). In patients with IBD, the rate increased from 26.738 to 278.873 cases per 1,000 visits (RR=10.12, 95% CI: 4.57-29.02). The average incidence rate increased from 0.685 to 1.874 cases per 1,000 admissions in pediatric general patients (RR = 2.72, 95% CI 1.82-4.20) and from 14.706 to 62.500 cases per 1,000 admissions in pediatric IBD patients (RR = 3.77, 95% CI 0.71-93.53).</div></div><div><h3>Conclusion</h3><div>Both CA-CDI and healthcare facility-onset CDI (HO-CDI) were increasing substantially in the pediatric population over the past decade in Taiwan. Compared to the general pediatric population, pediatric IBD patients had a much higher incidence of CDI.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 253-257"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of shared decision-making in Taiwanese patients with atrial fibrillation eligible for novel oral anticoagulant therapy","authors":"Yen-Wen Wu ,&nbsp;Tsung-Hsien Lin ,&nbsp;Yuan-Po Yang ,&nbsp;Wei-Tsung Wu ,&nbsp;Chung-Ming Tu ,&nbsp;Hung-Kain Huang ,&nbsp;Chun-Yuan Chu ,&nbsp;Chi-Cheng Huang ,&nbsp;Szu-Chi Chien ,&nbsp;Shih-Jie Jhuo ,&nbsp;Ching-Pei Chen","doi":"10.1016/j.jfma.2024.08.036","DOIUrl":"10.1016/j.jfma.2024.08.036","url":null,"abstract":"<div><h3>Background/Purpose</h3><div>Shared decision-making (SDM) promotes patient awareness about medical conditions and treatments, facilitating patient involvement in care decisions. This two-stage multicenter study evaluated impacts of SDM in Taiwanese adults with atrial fibrillation (AF) eligible for novel oral anticoagulant (NOAC) therapy.</div></div><div><h3>Methods</h3><div>Participants were NOAC-naïve (part I) or dabigatran-experienced (part II). During Stage I, part I participants (n = 124) completed a semi-structured survey (understanding evaluation sections only) before and after viewing SDM materials on stroke prevention for AF. Surveys collected data on anxiety about AF, confidence in healthcare professionals, usefulness of the SDM materials, and perception of different NOACs. During Stage II, part I participants after being prescribed NOACs, and part II participants completed another survey to compare impacts of SDM.</div></div><div><h3>Results</h3><div>During Stage I, dabigatran was the preferred NOAC after viewing the SDM materials among 90% of part I participants. During Stage II, both part I (n = 87) and part II participants (n = 104) completed another survey. Fewer part I participants were anxious about AF (<em>p</em> &lt; 0.01), and more had confidence in healthcare professionals (<em>p</em> &lt; 0.01) after viewing SDM materials than before. Most part I participants (≥90%) rated the SDM materials as “very helpful”. In Stage II, participants viewing SDM before initiating dabigatran had lower anxiety (part I, 43%; part II, 53%; <em>p</em> &lt; 0.01) and a higher trust (part I, 92%; part II, 84%; <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>In conclusion, SDM reduced anxiety and improved trust in healthcare professionals among NOAC-naïve participants with AF.</div></div>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":"124 3","pages":"Pages 227-233"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}