Journal of The American Society of Nephrology最新文献

{"title":"Proximal Tubule Cells Contribute to the Thin Descending Limb of the Loop of Henle during Mouse Kidney Development.","authors":"Eunah Chung, Fariba Nosrati, Mike Adam, Andrew Potter, Mohammed Sayed, Christopher Ahn, Benjamin D Humphreys, Hee-Woong Lim, Yueh-Chiang Hu, S Steven Potter, Joo-Seop Park","doi":"10.1681/ASN.0000000721","DOIUrl":"10.1681/ASN.0000000721","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1928-1938"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Split Developmental Origin of the Loop of Henle.","authors":"Jamie A Davies","doi":"10.1681/ASN.0000000827","DOIUrl":"10.1681/ASN.0000000827","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1894-1896"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Complexity of Clinical Outcomes with HIF-PH Inhibitor for Anemia Management.","authors":"Navdeep Tangri","doi":"10.1681/ASN.0000000850","DOIUrl":"10.1681/ASN.0000000850","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1897-1898"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Kidney Disease with Sickle Cell Disease.","authors":"Momen Abbasi, Anand Srivastava, Santosh L Saraf","doi":"10.1681/ASN.0000000804","DOIUrl":"10.1681/ASN.0000000804","url":null,"abstract":"<p><p>Sickle cell disease is the most common inherited blood cell disorder in the United States. Vaso-occlusion and hemolysis are hallmark features of sickle cell disease that may lead to kidney damage through endothelial dysfunction and oxidative and inflammatory stress. Manifestations of sickle cell disease-related kidney disease include hyperfiltration that occurs early in the disease course followed by albuminuria and a progressive decline in eGFR. Patients with sickle cell disease have a faster rate of eGFR decline and the development of CKD is associated with higher morbidity and early mortality. The assessment of kidney function is challenged by the transition from the hyperfiltration phase to reduced eGFR and by tubular creatinine secretion, which may lead to overestimation of the true GFR. Cystatin C-based and race-free estimating GFR equations reduce the overestimation but require further validation. Complications of kidney dysfunction include hyperkalemia and metabolic acidosis that occur at higher eGFR thresholds compared with the general population. Coinheritance of genetic variants, such as APOL1 G1 and G2 kidney risk variants, may help identify patients with sickle cell disease at higher risk for CKD and guide treatment and screening strategies. Therapeutic approaches targeting the sickle cell disease pathophysiology, such as hydroxyurea, chronic red blood cell transfusions, and hematopoietic stem cell transplantation, have demonstrated some kidney protective effects, but larger studies with longer follow-up are needed. Novel agents, including endothelin receptor antagonists, pyruvate kinase activators, and APOL1 inhibitors, are currently under investigation. Kidney-protective therapies such as renin-angiotensin-aldosterone system inhibitors and sodium-glucose cotransporter 2 inhibitors offer promise but require prospective validation in sickle cell disease cohorts. Kidney transplantation is associated with better survival and should not be withheld based solely on sickle cell disease diagnosis. Early identification, individualized management, and ongoing research are essential to improve kidney outcomes and reduce mortality in this high-risk population.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2041-2054"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.","authors":"Joanne B Cole, Emma H Dahlström, Damian Fermin, Yogesh Gupta, Claire Hill, Laura J Smyth, Hongbo Liu, Raymond J Kreienkamp, Marcus G Pezzolesi, Jing Jing Cao, Erkka Valo, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Eoin P Brennan, Darrell Andrews, Ciarán Kennedy, Harvest F Gu, Lars Stechemesser, Raimund Weitgasser, Jelizaveta Sokolovska, Lina Radzeviciene, Rasa Verkauskiene, Nicolae M Panduru, Peter Rossing, Tarunveer S Ahluwalia, Gianpaolo Zerbini, Michel Marre, Samy Hadjadj, Tina Costacou, Rachel G Miller, Barbara E Klein, Kristine E Lee, Janet K Snell-Bergeon, Maria Luiza Caramori, Michael Mauer, Kerstin Brismar, Petter Bjornstad, Amy J McKnight, Gareth McKay, Viji Nair, Rany M Salem, Per-Henrik Groop, Catherine Godson, Katalin Susztak, Matthias Kretzler, Alexander P Maxwell, Andrzej Krolewski, Andrew Paterson, Niina Sandholm-Lafferre, Jose C Florez, Joel N Hirschhorn","doi":"10.1681/ASN.0000000718","DOIUrl":"10.1681/ASN.0000000718","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1939-1953"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Blood Flow and Cognition in CKD: A Physiological Paradox.","authors":"Aditi Gupta, Swati R Levendovszky","doi":"10.1681/ASN.0000000784","DOIUrl":"10.1681/ASN.0000000784","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2058-2060"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer Support for Hemodialysis Patients: Moving from Effectiveness to Implementation.","authors":"Flor Alvarado, Rasheeda K Hall","doi":"10.1681/ASN.0000000839","DOIUrl":"10.1681/ASN.0000000839","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1899-1901"},"PeriodicalIF":9.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commemorating the National Institute of Diabetes and Digestive and Kidney Diseases' Advances in Kidney Health: 75 Years of Discovery and Impact.","authors":"Connie M Rhee,Michael Allon,Rajnish Mehrotra","doi":"10.1681/asn.0000000898","DOIUrl":"https://doi.org/10.1681/asn.0000000898","url":null,"abstract":"This year commemorates the 75th anniversary of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), one of the 27 institutes and centers of the National Institutes of Health. A core mission of the NIDDK has been the advancement and support of biomedical research across a diverse spectrum of disciplines, including endocrine and metabolic diseases, digestive and nutritional disorders, obesity, urologic and benign hematologic conditions, and, notably, kidney diseases, which has been a major focus of the institute's strategic priorities. Through the years, the NIDDK has heavily invested in biomedical infrastructure, foundational studies, and cross-cutting basic science, clinical investigation, epidemiology, and health services research, which have fundamentally shaped the detection, management, and prevention of kidney diseases worldwide. Furthermore, the NIDDK has had a longstanding commitment to promoting workforce development, advancing equal access to kidney health care, and forging collaborative partnerships with academic centers, federal agencies, professional societies, patient advocacy organizations, community groups, and industry stakeholders toward the shared goal of improving kidney disease outcomes. In this review published across the three American Society of Nephrology journals, we celebrate the landmark achievements and profound effect of the NIDDK in improving the health and well-being of people living with kidney diseases.","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Chemokines and the Continuing Challenge of Noninvasive Kidney Allograft Surveillance.","authors":"Syed Ali Husain,Krista L Lentine","doi":"10.1681/asn.0000000872","DOIUrl":"https://doi.org/10.1681/asn.0000000872","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bmpr2 Drives Aberrant Activation and Injury of Glomerular Endothelial Cells in Lupus Nephritis.","authors":"Jianbo Qing,Jiejun Wen,Xiao Wang,Yiting Zhao,Xiaoyun Shen,Xinyu Huang,Ruipeng Wei,Xinni Wang,Minchao Kang,Linnan Bai,Lei Zhou,Xiaodong Wang,Qiang Tong,Junnan Wu","doi":"10.1681/asn.0000000856","DOIUrl":"https://doi.org/10.1681/asn.0000000856","url":null,"abstract":"BACKGROUNDLupus nephritis, a severe complication of systemic lupus erythematosus, is closely associated with the abnormal activation of glomerular endothelial cells. Despite its significance, the core mechanisms underlying glomerular endothelial cell activation remain elusive.METHODSWe performed single-nucleus RNA sequencing (snRNA-seq) on kidney tissues from lupus nephritis patients and mouse models to investigate transcriptional alterations in glomerular endothelial cells, and validated our findings in two lupus nephritis models: pristane-induced lupus nephritis and MRL/lpr mice. Genetically modified mice and cultured cells were employed to further validate the key discoveries. Additionally, a panel of cytokine stimulations was used to elucidate the underlying causes of glomerular endothelial cell injury in lupus nephritis.RESULTSBmpr2 was identified as a critical regulator, showing significant upregulation in glomerular endothelial cells from both lupus nephritis patients and mouse models. Elevated Bmpr2 expression correlated with enhanced glomerular endothelial cell proliferation, migration, and increased expression of adhesion molecules (Vcam1, Icam1). BMPR2 activated SMAD-dependent pathways, leading to the upregulation of downstream targets ID1 and ID3, thereby promoting glomerular endothelial cell hyperactivation. Bmpr2 overexpression amplified glomerular endothelial cell proliferation and migration, whereas inhibition of ID signaling by DMH2 or endothelial-specific Bmpr2 knockout attenuated these effects. Moreover, targeting BMPR2 signaling reduced the infiltration of CD86+ macrophages into lupus nephritis kidneys. Co-culture experiments confirmed that Bmpr2-activated glomerular endothelial cells promoted macrophage differentiation into an inflammatory phenotype. Complement component C5a was identified as a critical upstream inducer of Bmpr2 in glomerular endothelial cells, and inhibition of C5a signaling with the C5aR1 antagonist PMX-53 effectively suppressed Bmpr2 upregulation.CONCLUSIONSThese findings highlight BMPR2 as a key regulator of glomerular endothelial cell injury and macrophage-mediated inflammation in lupus nephritis. Targeting BMPR2 or its upstream activators, such as C5a, effectively treated and improved lupus nephritis.","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}