Journal of The American Society of Nephrology最新文献

{"title":"Angiopoietin-2 and Progressive Kidney Disease.","authors":"Marie Jeansson","doi":"10.1681/ASN.0000001207","DOIUrl":"10.1681/ASN.0000001207","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2085-2087"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Effects on Cystatin C and the Interpretation of Kidney Function: Imperfect but Informative.","authors":"Erin F Barreto, Victoria L Williams","doi":"10.1681/ASN.0000001229","DOIUrl":"10.1681/ASN.0000001229","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2094-2096"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: A Report from the 34th Acute Disease Quality Initiative (ADQI) Consensus Conference.","authors":"Shruti Gupta, Roberta Fenoglio, Naoka Murakami, Elad Sharon, Sandra M Herrmann, Biruh T Workeneh, Dario Roccatello, Jack A Blau, Marlies Ostermann, Claudio Ronco, Amanda DeMauro Renaghan, Mitchell H Rosner, David E Leaf","doi":"10.1681/ASN.0000001232","DOIUrl":"10.1681/ASN.0000001232","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with immune-related adverse events, including ICI-associated AKI (ICI-AKI). ICI-AKI presents diagnostic and management challenges and can influence decisions regarding immunosuppression and ICI rechallenge, with important implications for both kidney and cancer outcomes. An international, multidisciplinary panel convened at the 34th Acute Disease Quality Initiative (ADQI) consensus conference in September 2024. Systematic literature searches of PubMed were conducted to identify studies on the epidemiology, mechanisms, diagnosis, management, rechallenge, and outcomes of ICI-AKI. The meeting followed the established ADQI process and used a modified Delphi method to achieve consensus. Evidence was reviewed and appraised by workgroups, and consensus statements were developed through structured discussion and voting. Observational data suggest that AKI occurs in up to 20% of patients receiving ICIs, with ICI-AKI accounting for approximately 2%-5% of cases. Acute tubulointerstitial nephritis is the most common lesion, observed in 80%-90% of biopsies, although glomerular diseases are increasingly recognized. No clinical features reliably distinguish ICI-AKI from other causes of AKI, and kidney biopsy remains the diagnostic gold standard. Emerging urinary, circulating, and imaging biomarkers show promise but are not yet ready for routine clinical use. Early glucocorticoid initiation (within 3 days of ICI-AKI diagnosis versus >3 days after diagnosis) is associated with higher rates of kidney recovery, although optimal dosing and duration remain uncertain. Recurrent ICI-AKI occurs in fewer than 20% of patients undergoing ICI rechallenge. Management of high-risk populations, including kidney transplant recipients and patients with autoimmune disease or advanced CKD, requires individualized, multidisciplinary decision making. ICI-AKI is an important and potentially reversible complication of cancer immunotherapy; these consensus statements provide a framework for diagnosis and management, support cautious ICI rechallenge in selected patients, and identify priorities for future research.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2329-2344"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD.","authors":"Jianmin Chen, Julius E Keswich, Fausto Chiazza, Amie J Moyes, Thomas Gobbetti, Gareth S D Purvis, Daniela C F Salvatori, Nimesh S A Patel, Mauro Perretti, Adrian J Hobbs, Massimo Collino, Muhammad M Yaqoob, Christoph Thiemermann","doi":"10.1681/ASN.0000001186","DOIUrl":"10.1681/ASN.0000001186","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2355-2359"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of Serum Bicarbonate as a Criterion for Metabolic Acidosis in CKD: Implications for Clinical Trials.","authors":"Nabil William Sweis, Bhupinder Singh, Daniel Batlle","doi":"10.1681/ASN.0000001181","DOIUrl":"10.1681/ASN.0000001181","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2275-2277"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension Management in Pregnancy and Postpartum.","authors":"Line Malha, Phyllis August","doi":"10.1681/ASN.0000001236","DOIUrl":"10.1681/ASN.0000001236","url":null,"abstract":"<p><p>Hypertensive disorders of pregnancy affect approximately 9% of pregnancies in the United States and are a leading cause of maternal morbidity and mortality. For nephrologists, these conditions sit at a critical intersection: CKD is among the strongest risk factors of preeclampsia, and pregnancy itself can unmask previously unrecognized kidney disease. The physiologic demands of gestation stress renal and vascular reserve in ways that make the pregnant and immediately postpartum patient particularly vulnerable. Preeclampsia, driven by placental release of antiangiogenic factors and widespread maternal endothelial dysfunction, produces acute cardiorenal injury that does not entirely resolve with delivery. Postpartum hypertension peaks between days 3 and 6 after delivery and is under-recognized, yet this period carries the greatest risk of preventable maternal death, with cardiovascular causes accounting for more than one third of pregnancy-related deaths. Beyond the acute phase, women with hypertensive pregnancies face accelerated trajectories toward chronic hypertension, CKD, and overall cardiometabolic risks that compound with each affected pregnancy. The postpartum visit represents a critical and underutilized opportunity to identify women who warrant nephrology evaluation, initiate renoprotective therapy, and interrupt a long-term cardiorenal disease course. Nephrologists are well positioned to recognize cardiorenal sequelae of hypertensive pregnancy and ensure that the postpartum period is not a missed opportunity for intervention. This review addresses the diagnosis, pathophysiology, and management of hypertensive disorders across the full peripartum continuum, with particular attention to the role of nephrologists in recognizing kidney disease that pregnancy has brought to light and in ensuring that delivery is not treated as a clinical end point.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2306-2318"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normalization Benchmarking for nCounter Diagnostics Requires Deployment- and Biology-Aware Evaluation.","authors":"Dina Zielinski","doi":"10.1681/ASN.0000001206","DOIUrl":"10.1681/ASN.0000001206","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2346-2347"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The (Mis)interpretation of Hazard Ratios in Clinical Trials.","authors":"Amarnath Marthi, Amy K Mottl, Paul N Zivich","doi":"10.1681/ASN.0000001182","DOIUrl":"10.1681/ASN.0000001182","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2319-2321"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Risk Strata and Proteomic Prediction of Atrial Fibrillation in CKD.","authors":"Yuru Yang, Yixuan Ma, Yushen Yang","doi":"10.1681/ASN.0000001193","DOIUrl":"10.1681/ASN.0000001193","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2350"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting Donor-Derived Cell-Free DNA: From Performance to Decision.","authors":"Amandine Meudec, Olivier Aubert","doi":"10.1681/ASN.0000001240","DOIUrl":"10.1681/ASN.0000001240","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2100-2102"},"PeriodicalIF":9.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}