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Journal of The American Society of Nephrology最新文献

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Megalin: A Sidekick or Nemesis of the Kidney? 美加净：肾脏的助手还是克星？
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-11-15 DOI: 10.1681/ASN.0000000572
Kalyani Kulkarni, Tahir Hussain
{"title":"Megalin: A Sidekick or Nemesis of the Kidney?","authors":"Kalyani Kulkarni, Tahir Hussain","doi":"10.1681/ASN.0000000572","DOIUrl":"10.1681/ASN.0000000572","url":null,"abstract":"<p><p>Megalin is an endocytic receptor in the proximal tubules that reabsorbs filtered proteins in the kidneys. Recycling of megalin after endocytosis and its expression on the apical plasma membrane of the proximal tubule are critical for its function. The expression of megalin in the kidney undergoes dynamic changes under physiologic and pathophysiologic conditions. Receptors and various effector signaling components regulate megalin expression and, potentially, function. Genetic manipulation and rare mutations in megalin suggest that a lack of or deficiency in megalin expression/function promotes tubular proteinuria and albuminuria. However, the role of megalin in kidney diseases associated with obesity, diabetes, hypertension, and nephrotoxicity remains unclear. To address these questions, animal and human studies have indicated megalin as a protective, injurious, and potentially urinary marker of nephropathy. This article reviews the literature on the regulation of megalin expression and the role of megalin in the pathophysiology of the kidney under experimental and clinical conditions. Moreover, this review articulates the need for studies that can clarify whether megalin can serve as a therapeutic target, in one way or the other, to treat kidney disease.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"293-300"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Effects of Zibotentan and Dapagliflozin on Fluid Retention in Patients with CKD: Need More Evidence. 作者回复：齐波特坦和达格列净对慢性肾病患者体液潴留的影响：需要更多证据。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-11-15 DOI: 10.1681/ASN.0000000553
Hiddo J L Heerspink, Johannes David Smeijer
{"title":"Authors' Reply: Effects of Zibotentan and Dapagliflozin on Fluid Retention in Patients with CKD: Need More Evidence.","authors":"Hiddo J L Heerspink, Johannes David Smeijer","doi":"10.1681/ASN.0000000553","DOIUrl":"10.1681/ASN.0000000553","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"324"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Understanding of Cardiovascular Risk in CKD.
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.1681/ASN.0000000606
Vikas S Sridhar, Ayodele Odutayo
{"title":"Advancing Understanding of Cardiovascular Risk in CKD.","authors":"Vikas S Sridhar, Ayodele Odutayo","doi":"10.1681/ASN.0000000606","DOIUrl":"10.1681/ASN.0000000606","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"36 2","pages":"171-173"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Numerical Flow Simulations of the Shear Stress Forces Arising in Filtration Slits during Glomerular Filtration in Rat Kidney. 大鼠肾小球滤过过程中滤过狭缝中产生的剪切应力力的数值流动模拟
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-09-30 DOI: 10.1681/ASN.0000000513
Alexander Fuhrmann, Balazs Pritz, Karlhans Endlich, Wilhelm Kriz
{"title":"Numerical Flow Simulations of the Shear Stress Forces Arising in Filtration Slits during Glomerular Filtration in Rat Kidney.","authors":"Alexander Fuhrmann, Balazs Pritz, Karlhans Endlich, Wilhelm Kriz","doi":"10.1681/ASN.0000000513","DOIUrl":"10.1681/ASN.0000000513","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"219-230"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Prescriptions in Type 2 Diabetes by Kidney and Cardiovascular Disease. 胰高血糖素样肽-1受体激动剂和钠-葡萄糖共转运蛋白2抑制剂在2型糖尿病肾脏和心血管疾病中的应用
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1681/ASN.0000000585
Sneha S Mehta, Aditya L Surapaneni, Krutika Pandit, Yunwen Xu, Leora Horwitz, Saul Blecker, Matthew F Blum, Alexander R Chang, Jung-Im Shin, Morgan E Grams
{"title":"Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Prescriptions in Type 2 Diabetes by Kidney and Cardiovascular Disease.","authors":"Sneha S Mehta, Aditya L Surapaneni, Krutika Pandit, Yunwen Xu, Leora Horwitz, Saul Blecker, Matthew F Blum, Alexander R Chang, Jung-Im Shin, Morgan E Grams","doi":"10.1681/ASN.0000000585","DOIUrl":"10.1681/ASN.0000000585","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"290-292"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xenotransplantation: The Future Is Here. 异种移植：未来就在这里。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-11-14 DOI: 10.1681/ASN.0000000581
Leonardo V Riella
{"title":"Xenotransplantation: The Future Is Here.","authors":"Leonardo V Riella","doi":"10.1681/ASN.0000000581","DOIUrl":"10.1681/ASN.0000000581","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"305-307"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using VNtyper from Whole Exome Sequencing Data to Detect Pathogenic Variants in the MUC1 Gene. 利用全外显子组测序数据中的 VNtyper 检测 MUC1 基因中的致病性变异。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-12-09 DOI: 10.1681/ASN.0000000574
Hassan Saei, Cécile Masson, Vincent Morinière, Jessica Kachmar, Laurence Heidet, Olivier Gribouval, Corinne Antignac, Guillaume Dorval
{"title":"Using VNtyper from Whole Exome Sequencing Data to Detect Pathogenic Variants in the MUC1 Gene.","authors":"Hassan Saei, Cécile Masson, Vincent Morinière, Jessica Kachmar, Laurence Heidet, Olivier Gribouval, Corinne Antignac, Guillaume Dorval","doi":"10.1681/ASN.0000000574","DOIUrl":"10.1681/ASN.0000000574","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"327-328"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Podocyte-Mediated Protection from Kidney Injury. 足细胞介导的肾损伤保护。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2024-12-27 DOI: 10.1681/ASN.0000000594
Sanna Lehtonen, Seppo Meri
{"title":"Podocyte-Mediated Protection from Kidney Injury.","authors":"Sanna Lehtonen, Seppo Meri","doi":"10.1681/ASN.0000000594","DOIUrl":"10.1681/ASN.0000000594","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"166-168"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotype-Phenotype Correlations with TRPC6-Associated Podocytopathy. 基因型-表型与trpc6相关足细胞病的相关性。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.1681/ASN.0000000598
Jing Miao, Ladan Zand
{"title":"Genotype-Phenotype Correlations with TRPC6-Associated Podocytopathy.","authors":"Jing Miao, Ladan Zand","doi":"10.1681/ASN.0000000598","DOIUrl":"10.1681/ASN.0000000598","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"177-180"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovations in Targeting the V2 Receptor. 靶向V2受体的创新。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.1681/ASN.0000000601
Francesco Trepiccione, Anna Iervolino
{"title":"Innovations in Targeting the V2 Receptor.","authors":"Francesco Trepiccione, Anna Iervolino","doi":"10.1681/ASN.0000000601","DOIUrl":"10.1681/ASN.0000000601","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"163-165"},"PeriodicalIF":10.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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