Journal of The American Society of Nephrology最新文献

{"title":"Tenascin C-Derived Peptide 6 Promotes De Novo Kidney Regeneration after Partial Nephrectomy in Axolotl.","authors":"Jianqing Liang, Liting Chen, Liuyan Xiao, Shihui Lin, Leilei Zhao, Xue Hong, Fan Fan Hou, Fujian Zhang, Youhua Liu","doi":"10.1681/ASN.0000001066","DOIUrl":"10.1681/ASN.0000001066","url":null,"abstract":"<p><strong>Key points: </strong>De novo nephron regeneration was achieved after partial nephrectomy in axolotls. Tenascin C induction peaked at 2-4 weeks postpartial nephrectomy and coincided with cell proliferation and extracellular matrix remodeling. Tenascin C-derived peptide 6, a tenascin C-derived matrikine, accelerated kidney regeneration by enhancing extracellular matrix remodeling and tenascin C expression.</p><p><strong>Background: </strong>Kidneys possess limited regenerative capacity. While renal tubules are capable of repair after injury, nephron loss resulting from renal mass ablation or disease is irreversible in mammals. In this study, we demonstrated de novo nephron regeneration after partial nephrectomy in axolotls, a model organism renowned for its remarkable regenerative ability.</p><p><strong>Methods: </strong>Kidney mass ablation was performed by using unilateral one-quarter partial nephrectomy in axolotls, and the regeneration process was assessed at multiple time points (0, 1, 2, 4, 8, 12, and 16 weeks) postsurgery.</p><p><strong>Results: </strong>We found that cells migrated into the wound sites and proliferated, beginning at 1 week postnephrectomy and nearly restoring the cell mass of the contralateral kidney by 4 weeks. Cell proliferation peaked between weeks 2 and 4 at the resected site and was accompanied by fibroblast activation, SOX9 expression, and induction of tenascin C. By 16 weeks after nephrectomy, new glomeruli had formed and renal tubules were de novo regenerated and functionally matured. Notably, tenascin C expression was transiently induced, peaking at 2-4 weeks postsurgery and rapidly declined as cell repopulation progressed. Knockdown of tenascin C expression reduced cell proliferation and impaired regenerative process. Conversely, administration of tenascin C-derived peptide 6 shifted tenascin C expression to an earlier stage and accelerated both new nephron formation and functional maturation.</p><p><strong>Conclusions: </strong>These studies demonstrate de novo nephron regeneration after partial nephrectomy in an animal model and identify tenascin C-derived peptide 6 as an accelerator of kidney regeneration in vivo .</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1936-1953"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply: Clarifying Crossover Interpretation and Volume-Signal Assessment in ASSIST.","authors":"Amy K Mottl, Hiddo J L Heerspink","doi":"10.1681/ASN.0000001142","DOIUrl":"10.1681/ASN.0000001142","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2081"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza Vaccination in Dialysis: New Technologies for a Vulnerable Population.","authors":"Caroline M Hsu, Dana C Miskulin","doi":"10.1681/ASN.0000001185","DOIUrl":"10.1681/ASN.0000001185","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1858-1860"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing Bias in Cluster Randomized Trials in Nephrology.","authors":"Jessica Kasza, Gabor Mihala, Agnès Caille, Rhys Bowden","doi":"10.1681/ASN.0000001189","DOIUrl":"10.1681/ASN.0000001189","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2055-2058"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney.","authors":"Kieran M Short, Giovane G Tortelote, Lynelle K Jones, Fabiola Diniz, Francesca Edgington-Giordano, Luise A Cullen-McEwen, Jan Schröder, Ashley Spencer, Andrew Keniry, Jose M Polo, John F Bertram, Marnie E Blewitt, Ian M Smyth, Samir S El-Dahr","doi":"10.1681/ASN.0000001053","DOIUrl":"10.1681/ASN.0000001053","url":null,"abstract":"<p><strong>Key points: </strong>Maternal low protein diet reduced kidney size and altered branching without changing ureteric tip number, with fewer nephrons at birth and adulthood. Nephron progenitor proliferation and commitment were impaired, pretubular aggregate formation decreased, consistent with a reduced nephron number.</p><p><strong>Background: </strong>Low nephron number has a direct effect on the development of hypertension and CKD later in life. Although intrauterine growth restriction caused by maternal low-protein diet (LPD) is believed to be a significant cause of reduced nephron endowment in impoverished communities, its influence on the cellular and molecular processes that drive nephron formation are poorly understood.</p><p><strong>Methods: </strong>We conducted a comprehensive characterization of the effect of LPD on kidney development using tomographic and confocal imaging to quantify changes in branching morphogenesis and the cellular and morphologic features of nephrogenic niches across development. These analyses were paired with single-cell RNA sequencing to dissect the transcriptional changes that LPD imposes during development of the kidneys to affect nephron number.</p><p><strong>Results: </strong>Single-cell analysis revealed differential expression across metabolic, cell cycle, epigenetic, and reciprocal inductive signaling pathways in most cell types, shifting cellular energy production and developmental trajectories. In nephron progenitor cells, LPD impeded commitment and differentiation toward pretubular aggregates and renal vesicles, accompanied by downregulated Wnt signaling. Confocal microscopy showed fewer pretubular aggregates and reduced progenitor proliferation, consistent with impaired commitment. Critically, nephron progenitor cell proliferation remained reduced through P0, whereas ureteric tip proliferation, although reduced earlier, had normalized by P0. Branching morphology also changed, with optical projection tomography showing shorter tip and tip-parent lengths, consistent with subtle patterning defects.</p><p><strong>Conclusions: </strong>This study demonstrates that gestational LPD reduced nephron endowment by impairing nephron progenitor cell commitment, with concurrent alterations in branching morphogenesis.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1895-1909"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining Causality in Gene Discovery: A Nephrologist's Perspective with Insights from ATP6V0A4.","authors":"Hadel Alsubaie, Krishna Gandhi, Mathieu Lemaire","doi":"10.1681/ASN.0000001104","DOIUrl":"10.1681/ASN.0000001104","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"2059-2061"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelin Receptor Antagonists in Patients with IgA Nephropathy Treated with Sodium-Glucose Cotransporter 2 Inhibitors.","authors":"Patrick H Nachman","doi":"10.1681/ASN.0000001198","DOIUrl":"10.1681/ASN.0000001198","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1861-1863"},"PeriodicalIF":9.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dialysis Access without Guesswork: A Digital Navigation Framework for Improved Access Technique.","authors":"Erin Moore, Jaime Haak, Paola Fernadez, Shannon Beardsley","doi":"10.1681/ASN.0000001267","DOIUrl":"https://doi.org/10.1681/ASN.0000001267","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dismissing the Chaperone in the Diabetic Kidney.","authors":"Sandeep K Mallipattu","doi":"10.1681/ASN.0000001237","DOIUrl":"https://doi.org/10.1681/ASN.0000001237","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modernizing Kidney Transplant Referral: Integrating eGFR with Kidney Failure Risk.","authors":"Amber B Paulus, Johanna Christensen, Nilang Patel, Scott Silvey, Dhiren Kumar, Rachel E Patzer, Navdeep Tangri, Gaurav Gupta","doi":"10.1681/ASN.0000001259","DOIUrl":"https://doi.org/10.1681/ASN.0000001259","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}