Journal of The American Society of Nephrology最新文献

{"title":"Hypercalcemia's Hidden Regulator: Calcium-Sensing Receptor and the Kidney's Secret Weapon.","authors":"Jessica Paola Bahena-López,Gerardo Gamba","doi":"10.1681/asn.0000000725","DOIUrl":"https://doi.org/10.1681/asn.0000000725","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"42 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-Based Guidance for Strategies for Blood Transfusion with CKD and Myocardial Infarction.","authors":"Michelle M Y Wong,Charles A Herzog","doi":"10.1681/asn.0000000736","DOIUrl":"https://doi.org/10.1681/asn.0000000736","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Vadadustat for the Treatment of CKD-Related Anemia within and outside the United States.","authors":"Glenn M Chertow,Kai-Uwe Eckardt,Mark J Sarnak,Wolfgang C Winkelmayer,Rajiv Agarwal,Todd Minga,Wenli Luo,Steven K Burke","doi":"10.1681/asn.0000000708","DOIUrl":"https://doi.org/10.1681/asn.0000000708","url":null,"abstract":"BACKGROUNDVadadustat's global clinical program was comprised of four noninferiority trials comparing vadadustat and darbepoetin alfa for CKD-related anemia: two in dialysis-dependent (DD)-CKD and two in non-dialysis-dependent (NDD)-CKD. While vadadustat met prespecified noninferiority criteria for hematological efficacy globally, it did not meet noninferiority criteria for cardiovascular safety in the NDD-CKD trials. The trials considered regional differences in treatment practices, including hemoglobin targets within (10-11 g/dL) and outside the US (10-12 g/dL).METHODSTo examine region-specific outcomes, we performed prespecified analyses for US and non-US patient subgroups from the vadadustat global program. The primary safety end point was first occurrence of MACE (death from any cause, or nonfatal myocardial infarction or stroke). The primary efficacy end point was change in hemoglobin from baseline to average values during weeks 24-36.RESULTS4084/7399 (55%) randomized patients were enrolled in the US. In pooled analyses of all US patients, MACE risk was similar among vadadustat-treated and darbepoetin alfa-treated patients (hazard ratio [HR] 1.03; 95% CI 0.90-1.17). HRs were similar for US patients with DD-CKD (HR 1.00; 95% CI 0.84-1.18) and NDD-CKD (HR 1.06; 95% CI 0.87-1.29). In pooled analyses of non-US patients, MACE risk was numerically higher among vadadustat-treated patients (HR 1.12; 95% CI 0.94-1.33); the higher risk was primarily attributed to the NDD-CKD subgroup (HR 1.29; 95% CI 1.03-1.60). In the non-US DD-CKD subgroup, MACE risk was similar among vadadustat-treated and darbepoetin alfa-treated patients (HR 0.88; 95% CI 0.67-1.17). Changes in hemoglobin were similar among treatment groups in all regions, as were rates of treatment-emergent and serious adverse events.CONCLUSIONSIn patients with DD-CKD, safety (vis-à-vis MACE) and efficacy (vis-à-vis change in hemoglobin) of vadadustat and darbepoetin alfa were similar when stratified by region (US versus non-US). In US patients with NDD-CKD, safety and efficacy of vadadustat and darbepoetin alfa were similar.","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"32 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetazolamide and Renal Hemodynamics: Interplay between Tubuloglomerular Feedback and Renin-Angiotensin-Aldosterone System Adaptation.","authors":"Hiroki Ito, Takefumi Mori","doi":"10.1681/ASN.0000000731","DOIUrl":"10.1681/ASN.0000000731","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1450-1451"},"PeriodicalIF":10.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply: Acetazolamide and Renal Hemodynamics: Interplay between Tubuloglomerular Feedback and Renin-Angiotensin-Aldosterone System Adaptation.","authors":"Charles Ginsberg,Jeremy Pettus,Joachim H Ix","doi":"10.1681/asn.0000000732","DOIUrl":"https://doi.org/10.1681/asn.0000000732","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"3 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply: Concerns about Hospitalization on Cystatin C- and Creatinine-Based eGFR.","authors":"Ian E McCoy,Chi-Yuan Hsu","doi":"10.1681/asn.0000000741","DOIUrl":"https://doi.org/10.1681/asn.0000000741","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"39 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Neuromedin U Promotes Type 2 Innate Immunity and Renoprotection in Acute Kidney Injury.","authors":"Sara Trindade-Correia,Vasco Correia,Filipe Delgado,Marta Baptista,Inês Amendoeira Cabral,Tânia Carvalho,Luana Macedo,Margarida Nunes,Pedro Z Andrade,Filipa Cardoso,Julie Chesné,David F Braga Malta,Covadonga Pañeda,Henrique Veiga-Fernandes,Vânia Cardoso","doi":"10.1681/asn.0000000747","DOIUrl":"https://doi.org/10.1681/asn.0000000747","url":null,"abstract":"BACKGROUNDAcute kidney injury (AKI) is a severe condition leading to the sudden loss of kidney function. Activation of type 2 innate lymphoid cells (ILC2s) by neuromedin U (NMU) is highly selective and key in controlling mucosal tissue repair and homeostasis. Renal ILC2s are associated with renoprotective effects in AKI. Here, we explored the therapeutic potential of an engineered NMU analogue (LIMM102) in a preclinical model of renal ischemia-reperfusion injury (IRI)-induced AKI.METHODSLIMM102 was administered prophylactically to wild-type (WT) mice subjected to IRI-induced AKI and to sham-operated controls. Survival, glomerular filtration rate (GFR), kidney function biomarkers, histopathological analysis, and immune cell infiltration were assessed to determine LIMM102 treatment efficacy. Moreover, to interrogate the molecular selectivity of LIMM102, NMUR1-deficient mice (Nmur1-/-) were used to formally test the need of NMUR1 signalling for the beneficial effects of LIMM102.RESULTSLIMM102-treated IRI animals presented reduced mortality rates when compared to their untreated IRI counterparts. Notably, LIMM102-treated animals displayed higher GFR, lower levels of kidney function biomarkers, and lower severity of kidney lesions, which associated with renal ILC2-activated phenotypes. Importantly, LIMM102 therapeutic effects relied entirely on NMUR1 signalling, as LIMM102 administration produced no beneficial effect on AKI outcome in Nmur1 deficient animals.CONCLUSIONSLIMM102 exerted its renal therapeutic action by improving kidney function in IRI-induced AKI via NMUR1, which was associated with the presence of activated ILC2s in the kidney.","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"92 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns about Hospitalization on Cystatin C- and Creatinine-Based eGFR.","authors":"Shiwei Yang,Xianhai Zhao,Linghua Wang,Guang Zhang","doi":"10.1681/asn.0000000740","DOIUrl":"https://doi.org/10.1681/asn.0000000740","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis.","authors":"Yannick Binois,David Buob,Marie-Sophie Meuleman,Idris Boudhabhay,Pierre Isnard,Marion Rabant,Viviane Gnemmi,Laurent Daniel,Isabelle Brocheriou,Clement Gosset,Marie Frimat,Thomas Quémeneur,Rafik Mesbah,Noemie Jourde-Chiche,Olivier Moranne,Pierre Housset,Emmanuel Esteve,Alexis Mathian,Sebastien Rivière,Aurélie Hummel,Luc Mouthon,Benjamin Chaigne,Anne Lyse Langlois,Eric Thervet,Olivier Aubert,Lubka Roumenina,Sophie Chauvet,Alexandre Karras,Jean-Paul Duong-Van-Huyen","doi":"10.1681/asn.0000000720","DOIUrl":"https://doi.org/10.1681/asn.0000000720","url":null,"abstract":"BACKGROUNDScleroderma renal crisis is a severe complication of systemic sclerosis that is associated with higher morbidity and mortality. However, limited data are currently available regarding the factors affecting renal outcome during scleroderma renal crisis. The objective of this study is to describe renal histopathology in scleroderma renal crisis and to evaluate its association with kidney failure.METHODSWe performed a French multicenter retrospective study that included 65 patients who underwent a kidney biopsy in the context of scleroderma renal crisis, between 2006 and 2020. Non-supervised hierarchical cluster analysis was used to identify histologic patterns. Cox model was performed to estimate the hazard ratios associated with histologic parameters for kidney failure, defined as the need for long-term dialysis therapy of or eGFR <15 ml/min/1.73m2 at last follow-up. Multiplexed sequential Immunofluorescence and proximity ligation assay was used in kidney biopsies to analyze complement system activation.RESULTSRenal pathology in scleroderma renal crisis was more heterogeneous than expected, with 3 histological patterns of kidney injury identified by cluster analysis. Multivariable analysis showed that together with creatinine at presentation, acute arteriolar thrombotic microangiopathy and onion skinning in small arteries were independently associated with the risk of kidney failure. Multiplex immunofluorescence identified fractions from the complement classical pathway in arterioles and arteries in scleroderma renal crisis, while proximity ligation experiments confirmed the in situ activation of classical pathway C3 convertase. Complement terminal pathway fraction C5b-9 was localized in injured arteries.CONCLUSIONSThis study shows that the clinical definition of scleroderma renal crisis encompasses heterogeneity in the patterns of kidney injury. Acute arteriolar thrombotic microangiopathy and onion skinning were associated with kidney failure. Complement system was activated in these injured vessels.","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"26 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profibrotic Mucosal-Associated Invariant T Cells Were Polarized to Produce IL-17 in Peritoneal Fibrosis: A New Kid on the Block?","authors":"Jing Liu,Simon Davies,Jing O Wu","doi":"10.1681/asn.0000000733","DOIUrl":"https://doi.org/10.1681/asn.0000000733","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"48 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}