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Journal of The American Society of Nephrology最新文献

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Labor and Delivery Outcomes in Australian Mothers after Kidney Transplantation. 澳大利亚母亲肾移植后的分娩和分娩结局。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2024-11-25 DOI: 10.1681/ASN.0000000559
Nishanta Tangirala, Erandi Hewawasam, Christopher E Davies, Amanda Poprzeczny, Elizabeth Sullivan, Stephen P McDonald, Shilpanjali Jesudason
{"title":"Labor and Delivery Outcomes in Australian Mothers after Kidney Transplantation.","authors":"Nishanta Tangirala, Erandi Hewawasam, Christopher E Davies, Amanda Poprzeczny, Elizabeth Sullivan, Stephen P McDonald, Shilpanjali Jesudason","doi":"10.1681/ASN.0000000559","DOIUrl":"10.1681/ASN.0000000559","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1152-1163"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between CKD and Kidney Stones: A Reliable Relationship? CKD与肾结石的关系：可靠的关系？
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1681/ASN.0000000678
Guanghao Zheng, Tao Zeng
{"title":"Association between CKD and Kidney Stones: A Reliable Relationship?","authors":"Guanghao Zheng, Tao Zeng","doi":"10.1681/ASN.0000000678","DOIUrl":"10.1681/ASN.0000000678","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1227-1228"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of the Cystic Phenotype Associated with Monoallelic ALG8 and ALG9 Pathogenic Variants. 与单等位基因ALG8和ALG9致病变异相关的囊性表型特征
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.1681/ASN.0000000613
Tabinda Jawaid, Doaa E Elbarougy, Sravanthi Lavu, Guillaume Buia, Sarah R Senum, Eric Olinger, Hana Yang, Shannon K McDonnell, Joshua T Bublitz, Jun Ma, Marie-Pierre Audrézet, Charles D Madsen, Rachel S Schauer, Tracy A Baker, Adriana V Gregory, Sarah E Orr, Miguel Barroso-Gil, Ruxandra Neatu, Giancarlo Joli, Neera K Dahl, Timothy L Kline, Valentine Gillion, Karin Dahan, Francois Jouret, Ronald D Perrone, Theodore I Steinman, Dorien J M Peters, Berenice Y Gitomer, Terry J Watnick, Eliecer Coto, Fouad T Chebib, Marie C Hogan, Janet E Olson, Nicholas B Larson, Elisabet Ars, Jan Halbritter, Nathalie Demoulin, Vicente E Torres, John A Sayer, Emilie Cornec-Le Gall, Peter C Harris
{"title":"Characterization of the Cystic Phenotype Associated with Monoallelic ALG8 and ALG9 Pathogenic Variants.","authors":"Tabinda Jawaid, Doaa E Elbarougy, Sravanthi Lavu, Guillaume Buia, Sarah R Senum, Eric Olinger, Hana Yang, Shannon K McDonnell, Joshua T Bublitz, Jun Ma, Marie-Pierre Audrézet, Charles D Madsen, Rachel S Schauer, Tracy A Baker, Adriana V Gregory, Sarah E Orr, Miguel Barroso-Gil, Ruxandra Neatu, Giancarlo Joli, Neera K Dahl, Timothy L Kline, Valentine Gillion, Karin Dahan, Francois Jouret, Ronald D Perrone, Theodore I Steinman, Dorien J M Peters, Berenice Y Gitomer, Terry J Watnick, Eliecer Coto, Fouad T Chebib, Marie C Hogan, Janet E Olson, Nicholas B Larson, Elisabet Ars, Jan Halbritter, Nathalie Demoulin, Vicente E Torres, John A Sayer, Emilie Cornec-Le Gall, Peter C Harris","doi":"10.1681/ASN.0000000613","DOIUrl":"10.1681/ASN.0000000613","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1056-1071"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotype-Based Molecular Mechanisms in Alport Syndrome. 基于基因型的Alport综合征分子机制。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.1681/ASN.0000000647
Emine Bilge Caparali, Vanessa De Gregorio, Moumita Barua
{"title":"Genotype-Based Molecular Mechanisms in Alport Syndrome.","authors":"Emine Bilge Caparali, Vanessa De Gregorio, Moumita Barua","doi":"10.1681/ASN.0000000647","DOIUrl":"10.1681/ASN.0000000647","url":null,"abstract":"<p><p>Alport syndrome is an inherited disorder characterized by kidney disease, sensorineural hearing loss, and ocular abnormalities. Alport syndrome is caused by pathogenic variants in COL4A3 , COL4A4 , or COL4A5 , which encode the α 3, α 4, and α 5 chains of type 4 collagen that forms a heterotrimer expressed in the glomerular basement membrane. Knowledge of its genetic basis has informed the development of different models in dogs, mice, and rats that reflect its autosomal and X-linked inheritance patterns as well as different mutation types, including protein-truncating and missense variants. A key difference between these two types is the synthesis of α 3 α 4 α 5(IV), which is not made in autosomal Alport syndrome (two pathogenic variants in trans or biallelic) or male patients with X-linked Alport syndrome due to protein-truncating variants. By contrast, α 3 α 4 α 5(IV) is synthesized in Alport syndrome because of missense variants. For missense variants, in vitro studies suggest that these cause impaired type 4 collagen trafficking and endoplasmic reticulum stress. For protein-truncating variants, knockout models suggest that persistence of an immature α 1 α 1 α 2(IV) network is associated with biomechanical strain, which activates endothelin-A receptors leading to mesangial filopodia formation. Moreover, studies suggest that activation of collagen receptors, integrins and discoidin domain receptor 1, play a role in disease propagation. In this review, we provide an overview of how these genotype-phenotype mechanisms are key for a precision medicine-based approach in the future.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1176-1183"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of Increased Medicare Advantage Enrollment for Access to Kidney Transplant Waitlisting. 增加医疗保险优势登记对获得肾移植等候名单的影响。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI: 10.1681/ASN.0000000667
Joel T Adler, Arnold E Kuk, Kelsey M Drewry, Kevin H Nguyen, Adam S Wilk
{"title":"Implications of Increased Medicare Advantage Enrollment for Access to Kidney Transplant Waitlisting.","authors":"Joel T Adler, Arnold E Kuk, Kelsey M Drewry, Kevin H Nguyen, Adam S Wilk","doi":"10.1681/ASN.0000000667","DOIUrl":"10.1681/ASN.0000000667","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1173-1175"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Trial End Points for Childhood CKD. 儿童CKD的临床试验终点。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-03-14 DOI: 10.1681/ASN.0000000701
Louise Oni, Jennifer McKenzie, Svenja Seide, William E Smoyer, Howard Trachtman
{"title":"Clinical Trial End Points for Childhood CKD.","authors":"Louise Oni, Jennifer McKenzie, Svenja Seide, William E Smoyer, Howard Trachtman","doi":"10.1681/ASN.0000000701","DOIUrl":"10.1681/ASN.0000000701","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1204-1207"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Association between CKD and Kidney Stones: A Reliable Relationship? 作者回复：CKD与肾结石的关联：可靠的关系？
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1681/ASN.0000000679
Le-Ting Zhou, Muthuvel Jayachandran, Nicholas B Larson, John C Lieske
{"title":"Authors' Reply: Association between CKD and Kidney Stones: A Reliable Relationship?","authors":"Le-Ting Zhou, Muthuvel Jayachandran, Nicholas B Larson, John C Lieske","doi":"10.1681/ASN.0000000679","DOIUrl":"10.1681/ASN.0000000679","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1229"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Autoimmune Tubulopathies. 纠正：自身免疫性小管病。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1681/ASN.0000000723
Pascal Houillier, Caroline Prot-Bertoye
{"title":"Correction: Autoimmune Tubulopathies.","authors":"Pascal Houillier, Caroline Prot-Bertoye","doi":"10.1681/ASN.0000000723","DOIUrl":"10.1681/ASN.0000000723","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1233"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Questions and Caveats in Antigen-Defined Membranous Nephropathy. 抗原定义膜性肾病的问题和注意事项。
IF 9.4 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-05-27 DOI: 10.1681/ASN.0000000769
Nicole K Andeen, Vanderlene L Kung, Rupali S Avasare, Sean Barbour, Megan Griffith, Mei Lin Z Bissonnette, Candice Roufosse
{"title":"Questions and Caveats in Antigen-Defined Membranous Nephropathy.","authors":"Nicole K Andeen, Vanderlene L Kung, Rupali S Avasare, Sean Barbour, Megan Griffith, Mei Lin Z Bissonnette, Candice Roufosse","doi":"10.1681/ASN.0000000769","DOIUrl":"10.1681/ASN.0000000769","url":null,"abstract":"<p><p>Remarkable progress has been made in the discovery of autoantigens in membranous nephropathy. With increasing testing for membranous antigens in daily practice, it is important to consider the varying strength of associations between certain antigens and underlying conditions. This review explores questions and caveats that arise when assessing results of membranous antigen testing. Specifically, we will discuss: ( 1 ) discrepancy between tissue antigen and clinical scenario, focusing on phospholipase A2 receptor; ( 2 ) one antigen≠one clinical condition, i.e ., the heterogeneity of membranous antigens seen in one clinical condition (such as in sarcoidosis), and conversely, heterogeneity of conditions associated with one antigen (such as for neural epidermal growth factor-like 1); ( 3 ) rare presence of multiple membranous-associated antigens in tissue or blood (such as with antiprotocadherin 7); and ( 4 ) lupus membranous nephritis-related antigens and their influence on diagnosis or treatment.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1639-1651"},"PeriodicalIF":9.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternative Splicing in Mechanically Stretched Podocytes as a Model of Glomerular Hypertension. 机械拉伸足细胞的选择性剪接作为肾小球高血压的模型。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-05-26 DOI: 10.1681/ASN.0000000706
Francescapaola Mattias, Olga Tsoy, Elke Hammer, Alexander Gress, Stefan Simm, Chit Tong Lio, Sabine Ameling, Kerstin Amann, Leonie Dreher, Ulrich Wenzel, Tim Kacprowski, Markus List, Olga Kalinina, Karlhans Endlich, Jan Baumbach, Uwe Völker, Nicole Endlich, Felix Kliewe
{"title":"Alternative Splicing in Mechanically Stretched Podocytes as a Model of Glomerular Hypertension.","authors":"Francescapaola Mattias, Olga Tsoy, Elke Hammer, Alexander Gress, Stefan Simm, Chit Tong Lio, Sabine Ameling, Kerstin Amann, Leonie Dreher, Ulrich Wenzel, Tim Kacprowski, Markus List, Olga Kalinina, Karlhans Endlich, Jan Baumbach, Uwe Völker, Nicole Endlich, Felix Kliewe","doi":"10.1681/ASN.0000000706","DOIUrl":"10.1681/ASN.0000000706","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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