Journal of The American Society of Nephrology最新文献

{"title":"Authors' Reply: Pharmacokinetic Issue May Influence the Perceived Cardiac Risk Posed by Ondansetron in Patients Undergoing Chronic Hemodialysis.","authors":"Sherin Ismail, Michele Jonsson Funk, Jennifer E Flythe","doi":"10.1681/ASN.0000000000000386","DOIUrl":"10.1681/ASN.0000000000000386","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of Biologically Related Living Kidney Donation in the United States from 1988 to 2022.","authors":"Fawaz Al Ammary, Simeon Adeyemo, Krista L Lentine, Abimereki D Muzaale","doi":"10.1681/ASN.0000000000000424","DOIUrl":"10.1681/ASN.0000000000000424","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Reinforcements: Slowing Diabetic Kidney Disease with Multiple New Agents.","authors":"Robert L Thomas, Dena E Rifkin","doi":"10.1681/ASN.0000000000000458","DOIUrl":"10.1681/ASN.0000000000000458","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Legacy Effect of Intensive versus Standard BP Control on the Incidence of Needing Dialysis or Kidney Transplantation.","authors":"Nicholas M Pajewski, Srinivasan Beddhu, Adam P Bress, Tara I Chang, Glenn M Chertow, Alfred K Cheung, William C Cushman, Barry I Freedman, Tom Greene, Karen C Johnson, Byron C Jaeger, Manjula Kurella Tamura, Cora E Lewis, Mahboob Rahman, David M Reboussin, Michael V Rocco, Jeff D Williamson, Paul K Whelton, Jackson T Wright, Paul E Drawz, Joachim H Ix","doi":"10.1681/ASN.0000000000000459","DOIUrl":"10.1681/ASN.0000000000000459","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lysosomal-Associated Protein Transmembrane 5, Tubular Senescence, and Progression of CKD.","authors":"Xiaohan Liu, Ping Zhan, Yang Zhang, Huiying Jin, Youzhao Wang, Yujie Yang, Ziying Wang, Xiaojie Wang, Qianqian Xu, Junhui Zhen, Rong Sun, Jinpeng Sun, Min Liu, Fan Yi","doi":"10.1681/ASN.0000000000000446","DOIUrl":"10.1681/ASN.0000000000000446","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Ancestry versus Multi-Ancestry Polygenic Risk Scores for CKD in Black American Populations.","authors":"Alana C Jones, Amit Patki, Vinodh Srinivasasainagendra, Hemant K Tiwari, Nicole D Armstrong, Ninad S Chaudhary, Nita A Limdi, Bertha A Hidalgo, Brittney Davis, James J Cimino, Atlas Khan, Krzysztof Kiryluk, Leslie A Lange, Ethan M Lange, Donna K Arnett, Bessie A Young, Clarissa J Diamantidis, Nora Franceschini, Sylvia Wassertheil-Smoller, Stephen S Rich, Jerome I Rotter, Josyf C Mychaleckyj, Holly J Kramer, Yii-Der I Chen, Bruce M Psaty, Jennifer A Brody, Ian H de Boer, Nisha Bansal, Joshua C Bis, Marguerite R Irvin","doi":"10.1681/ASN.0000000000000437","DOIUrl":"10.1681/ASN.0000000000000437","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CKD Risk Stratification: The Emerging Role of Kidney Volume Imaging.","authors":"Fouad T Chebib, Neera K Dahl","doi":"10.1681/ASN.0000000000000455","DOIUrl":"10.1681/ASN.0000000000000455","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mTOR Signaling and Human Physiology Relevant to Kidney Disease.","authors":"Junna Yamaguchi, Guillaume Canaud","doi":"10.1681/ASN.0000000000000450","DOIUrl":"10.1681/ASN.0000000000000450","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selonsertib in Patients with Diabetic Kidney Disease: A Phase 2b Randomized Active Run-In Clinical Trial.","authors":"Hiddo J L Heerspink, Vlado Perkovic, Katherine R Tuttle, Pablo E Pergola, Kenneth W Mahaffey, Uptal D Patel, Julie H Ishida, Albert Kuo, Fang Chen, Robert Kustra, Vladimir Petrovic, Peter Rossing, Naoki Kashihara, Glenn M Chertow","doi":"10.1681/ASN.0000000000000444","DOIUrl":"https://doi.org/10.1681/ASN.0000000000000444","url":null,"abstract":"<p><strong>Background: </strong>Selonsertib is an apoptosis signal-regulating kinase 1 inhibitor that reduces inflammation, fibrosis, and apoptosis. The MOSAIC study evaluated whether selonsertib attenuated kidney function decline in patients with diabetic kidney disease.</p><p><strong>Methods: </strong>We conducted a phase 2b study in adults with type 2 diabetes and eGFR 20 to <60 ml/min/1.73 m2 with UACR 150 to 5000 mg/g on maximum tolerated dose of ACE inhibitor or ARB. To account for an acute selonsertib-related decrease in eGFRcr, patients entered a 4-week selonsertib run-in period to establish treatment-specific baseline eGFRcr. Patients were randomized 1:1 to selonsertib 18 mg or matching placebo once daily. We followed all participants up until the last randomized participant completed 48 weeks follow-up. The primary efficacy outcome was the difference in eGFRcr slopes from treatment-specific baselines to week 84, evaluated at a prespecified two-sided P = 0.30. We also evaluated kidney clinical events (eGFRcr ≥40% decline from pre-run-in baseline, kidney failure, or death due to kidney disease) and adverse events.</p><p><strong>Results: </strong>In total, 310 patients were randomized (selonsertib n=154, placebo n=156; 68% male, mean age 65 years, mean baseline eGFRcr 35 ml/min/1.73 m2). Mean difference between selonsertib and placebo eGFRcr slopes at week 84 was 1.20 ml/min/1.73 m2/year (95% CI, -0.41 to 2.81; P = 0.14). Kidney clinical events occurred in 17% (26/154) of patients randomized to selonsertib and 12% (19/156) of those randomized to placebo (difference 4.7%; 95% CI, -6.3% to 15.9%). The most common investigator-reported adverse event was acute kidney injury (selonsertib 11.0/100 and placebo 5.9/100 patient-years).</p><p><strong>Conclusions: </strong>Selonsertib attenuated the decline in eGFRcr over up to 84 weeks; however, it resulted in a numerically higher number of patients reaching a kidney clinical event and a numerically higher rate of investigator-reported acute kidney injury.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Urine pH-Ammonium Acid/Base Score and CKD Progression.","authors":"Samuel Levi Svendsen, Amalie Quist Rousing, Rasmus Kirkeskov Carlsen, Dinah Khatir, Danny Jensen, Nikita Misella Hansen, Louise Salomo, Henrik Birn, Niels Henrik Buus, Jens Leipziger, Mads Vaarby Sorensen, Peder Berg","doi":"10.1681/ASN.0000000000000447","DOIUrl":"10.1681/ASN.0000000000000447","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}