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Toward Assessment of Tubular Function in Kidney Disease. 肾病肾小管功能的评价。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1681/ASN.0000000705
Sebastian B Beckmann, Madonna Salib, Robert A Fenton, Ewout J Hoorn
{"title":"Toward Assessment of Tubular Function in Kidney Disease.","authors":"Sebastian B Beckmann, Madonna Salib, Robert A Fenton, Ewout J Hoorn","doi":"10.1681/ASN.0000000705","DOIUrl":"10.1681/ASN.0000000705","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1201-1203"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection. 局灶黏附蛋白GIT2对Rac1的抑制及足细胞保护作用。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-28 DOI: 10.1681/ASN.0000000614
Naoyuki Shimada, Jun Matsuda, Kana Asano-Matsuda, Maho Tokuchi, Lamine Aoudjit, Agnieszka Masztalerz, Serge Lemay, Tomoko Takano, Yoshitaka Isaka
{"title":"Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection.","authors":"Naoyuki Shimada, Jun Matsuda, Kana Asano-Matsuda, Maho Tokuchi, Lamine Aoudjit, Agnieszka Masztalerz, Serge Lemay, Tomoko Takano, Yoshitaka Isaka","doi":"10.1681/ASN.0000000614","DOIUrl":"10.1681/ASN.0000000614","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1088-1104"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uremic Toxins, CKD, and Cognitive Dysfunction. 尿毒症毒素、慢性肾病和认知功能障碍。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-26 DOI: 10.1681/ASN.0000000675
Taylor D Andrews, Gregory S Day, Sarosh R Irani, Takahisa Kanekiyo, LaTonya J Hickson
{"title":"Uremic Toxins, CKD, and Cognitive Dysfunction.","authors":"Taylor D Andrews, Gregory S Day, Sarosh R Irani, Takahisa Kanekiyo, LaTonya J Hickson","doi":"10.1681/ASN.0000000675","DOIUrl":"10.1681/ASN.0000000675","url":null,"abstract":"<p><p>Cognitive impairment involves alterations to one's cognitive status that affects everyday life. Individuals with CKD, and particularly kidney failure, experience higher rates of cognitive impairment (20%-70%) compared with the general population. The highest prevalence is described in kidney failure such that dialysis-dependent patients have twice the prevalence of age-matched controls. In the past 5 years, the number of investigations examining the \"kidney-brain axis,\" mechanisms of CKD-related cognitive impairment, and potential therapeutics have exponentially increased. This review article summarizes recent literature on direct and indirect effects of CKD-associated cognitive impairment with emphasis on uremic toxins; brain injury mechanisms; overlap between CKD-associated cognitive impairment, Alzheimer's disease, and other neurodegenerative diseases. Reviewed therapeutic interventions include AST-120 (indoxyl sulfate absorbent), CH-223191 (aryl hydrocarbon receptor antagonist), triarylmethane-34 (Kca3.1-specific inhibitor), anakinra (IL-1R inhibitor), marimastat, exercise, supplements, and kidney transplantation. Special focus is placed on translational studies examining uremic toxin-associated pathogenic processes, including brain oxidative stress, neuroinflammation, and blood-brain barrier dysfunction through in vitro and in vivo models of CKD-associated brain injury. Finally, future research directions are suggested, including targeting of cellular senescence abundance with senotherapeutics and capitalizing on anti-inflammatory effects of regenerative, cell-based therapeutics ( e.g ., mesenchymal stem cells and extracellular vesicles), and use of aged murine models. Collectively, CKD-associated cognitive impairment represents a prevalent condition for which remaining knowledge gaps exist, and scientific advancements are needed to preserve cognitive function and improve the lives of individuals with CKD.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1208-1226"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics. 接触噻嗪类利尿剂前后血浆钠浓度的全基因组关联研究。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-01-31 DOI: 10.1681/ASN.0000000622
Niklas Worm Andersson, Xiaoping Wu, Frank Geller, Jan Wohlfahrt, Mads Melbye, Anders Hviid, Michael Schwinn, Christina Mikkelsen, Joseph Dowsett, Mie Topholm Bruun, Bitten Aagaard, Henrik Ullum, Christian Erikstrup, Daniel Fannar Gudbjartsson, Kári Stefánsson, Jonas Ghouse, Ole Birger Pedersen, Erik Sørensen, Sisse Rye Ostrowski, Henning Bundgaard, Marie Lund, Bjarke Feenstra
{"title":"Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics.","authors":"Niklas Worm Andersson, Xiaoping Wu, Frank Geller, Jan Wohlfahrt, Mads Melbye, Anders Hviid, Michael Schwinn, Christina Mikkelsen, Joseph Dowsett, Mie Topholm Bruun, Bitten Aagaard, Henrik Ullum, Christian Erikstrup, Daniel Fannar Gudbjartsson, Kári Stefánsson, Jonas Ghouse, Ole Birger Pedersen, Erik Sørensen, Sisse Rye Ostrowski, Henning Bundgaard, Marie Lund, Bjarke Feenstra","doi":"10.1681/ASN.0000000622","DOIUrl":"10.1681/ASN.0000000622","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1014-1027"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autopsy of a Hemodialysis Machine: Potential for Recycling at the End of the Life Cycle. 血液透析机的解剖：在生命周期结束时回收的潜力。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2024-12-13 DOI: 10.1681/ASN.0000000584
Carole Bonnet, Massimo Torreggiani, Lavinia Bianco, Frédéric Amiard, Zeyad Elsalhy, Ajla Grozdanic, Hana Grozdanic, Anastasia Vladimira Sizov, Makrem Kayel, Michaël Saulnier, Gaëlle Vayssieres, Hafedh Fessi, Nicolas Delorme, Giorgina Barbara Piccoli
{"title":"Autopsy of a Hemodialysis Machine: Potential for Recycling at the End of the Life Cycle.","authors":"Carole Bonnet, Massimo Torreggiani, Lavinia Bianco, Frédéric Amiard, Zeyad Elsalhy, Ajla Grozdanic, Hana Grozdanic, Anastasia Vladimira Sizov, Makrem Kayel, Michaël Saulnier, Gaëlle Vayssieres, Hafedh Fessi, Nicolas Delorme, Giorgina Barbara Piccoli","doi":"10.1681/ASN.0000000584","DOIUrl":"10.1681/ASN.0000000584","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1126-1137"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Labor and Delivery Outcomes in Australian Mothers after Kidney Transplantation. 澳大利亚母亲肾移植后的分娩和分娩结局。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2024-11-25 DOI: 10.1681/ASN.0000000559
Nishanta Tangirala, Erandi Hewawasam, Christopher E Davies, Amanda Poprzeczny, Elizabeth Sullivan, Stephen P McDonald, Shilpanjali Jesudason
{"title":"Labor and Delivery Outcomes in Australian Mothers after Kidney Transplantation.","authors":"Nishanta Tangirala, Erandi Hewawasam, Christopher E Davies, Amanda Poprzeczny, Elizabeth Sullivan, Stephen P McDonald, Shilpanjali Jesudason","doi":"10.1681/ASN.0000000559","DOIUrl":"10.1681/ASN.0000000559","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1152-1163"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between CKD and Kidney Stones: A Reliable Relationship? CKD与肾结石的关系：可靠的关系？
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1681/ASN.0000000678
Guanghao Zheng, Tao Zeng
{"title":"Association between CKD and Kidney Stones: A Reliable Relationship?","authors":"Guanghao Zheng, Tao Zeng","doi":"10.1681/ASN.0000000678","DOIUrl":"10.1681/ASN.0000000678","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1227-1228"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of the Cystic Phenotype Associated with Monoallelic ALG8 and ALG9 Pathogenic Variants. 与单等位基因ALG8和ALG9致病变异相关的囊性表型特征
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.1681/ASN.0000000613
Tabinda Jawaid, Doaa E Elbarougy, Sravanthi Lavu, Guillaume Buia, Sarah R Senum, Eric Olinger, Hana Yang, Shannon K McDonnell, Joshua T Bublitz, Jun Ma, Marie-Pierre Audrézet, Charles D Madsen, Rachel S Schauer, Tracy A Baker, Adriana V Gregory, Sarah E Orr, Miguel Barroso-Gil, Ruxandra Neatu, Giancarlo Joli, Neera K Dahl, Timothy L Kline, Valentine Gillion, Karin Dahan, Francois Jouret, Ronald D Perrone, Theodore I Steinman, Dorien J M Peters, Berenice Y Gitomer, Terry J Watnick, Eliecer Coto, Fouad T Chebib, Marie C Hogan, Janet E Olson, Nicholas B Larson, Elisabet Ars, Jan Halbritter, Nathalie Demoulin, Vicente E Torres, John A Sayer, Emilie Cornec-Le Gall, Peter C Harris
{"title":"Characterization of the Cystic Phenotype Associated with Monoallelic ALG8 and ALG9 Pathogenic Variants.","authors":"Tabinda Jawaid, Doaa E Elbarougy, Sravanthi Lavu, Guillaume Buia, Sarah R Senum, Eric Olinger, Hana Yang, Shannon K McDonnell, Joshua T Bublitz, Jun Ma, Marie-Pierre Audrézet, Charles D Madsen, Rachel S Schauer, Tracy A Baker, Adriana V Gregory, Sarah E Orr, Miguel Barroso-Gil, Ruxandra Neatu, Giancarlo Joli, Neera K Dahl, Timothy L Kline, Valentine Gillion, Karin Dahan, Francois Jouret, Ronald D Perrone, Theodore I Steinman, Dorien J M Peters, Berenice Y Gitomer, Terry J Watnick, Eliecer Coto, Fouad T Chebib, Marie C Hogan, Janet E Olson, Nicholas B Larson, Elisabet Ars, Jan Halbritter, Nathalie Demoulin, Vicente E Torres, John A Sayer, Emilie Cornec-Le Gall, Peter C Harris","doi":"10.1681/ASN.0000000613","DOIUrl":"10.1681/ASN.0000000613","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1056-1071"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of Increased Medicare Advantage Enrollment for Access to Kidney Transplant Waitlisting. 增加医疗保险优势登记对获得肾移植等候名单的影响。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI: 10.1681/ASN.0000000667
Joel T Adler, Arnold E Kuk, Kelsey M Drewry, Kevin H Nguyen, Adam S Wilk
{"title":"Implications of Increased Medicare Advantage Enrollment for Access to Kidney Transplant Waitlisting.","authors":"Joel T Adler, Arnold E Kuk, Kelsey M Drewry, Kevin H Nguyen, Adam S Wilk","doi":"10.1681/ASN.0000000667","DOIUrl":"10.1681/ASN.0000000667","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1173-1175"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Association between CKD and Kidney Stones: A Reliable Relationship? 作者回复：CKD与肾结石的关联：可靠的关系？
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1681/ASN.0000000679
Le-Ting Zhou, Muthuvel Jayachandran, Nicholas B Larson, John C Lieske
{"title":"Authors' Reply: Association between CKD and Kidney Stones: A Reliable Relationship?","authors":"Le-Ting Zhou, Muthuvel Jayachandran, Nicholas B Larson, John C Lieske","doi":"10.1681/ASN.0000000679","DOIUrl":"10.1681/ASN.0000000679","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"1229"},"PeriodicalIF":10.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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