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Journal of The American Society of Nephrology最新文献

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ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation. 肾内炎症中肾脏驻留的自然杀伤 T 细胞和记忆 T 细胞上的 ATP 门控 P2X7 离子通道
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2024-12-09 DOI: 10.1681/ASN.0000000564
Marten Junge, Nastassia Liaukouskaya, Nicole Schwarz, Carolina Pinto-Espinoza, Alessa Z Schaffrath, Björn Rissiek, Christian F Krebs, Guido Rattay, Hans-Willi Mittrücker, Nicola M Tomas, Annette Nicke, Friedrich Haag, Tobias B Huber, Catherine Meyer-Schwesinger, Friedrich Koch-Nolte, Nicola Wanner
{"title":"ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation.","authors":"Marten Junge, Nastassia Liaukouskaya, Nicole Schwarz, Carolina Pinto-Espinoza, Alessa Z Schaffrath, Björn Rissiek, Christian F Krebs, Guido Rattay, Hans-Willi Mittrücker, Nicola M Tomas, Annette Nicke, Friedrich Haag, Tobias B Huber, Catherine Meyer-Schwesinger, Friedrich Koch-Nolte, Nicola Wanner","doi":"10.1681/ASN.0000000564","DOIUrl":"10.1681/ASN.0000000564","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"602-613"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune Tubulopathies. Tubulopathies自身免疫。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI: 10.1681/ASN.0000000628
Pascal Houillier, Caroline Prot-Bertoye
{"title":"Autoimmune Tubulopathies.","authors":"Pascal Houillier, Caroline Prot-Bertoye","doi":"10.1681/ASN.0000000628","DOIUrl":"10.1681/ASN.0000000628","url":null,"abstract":"<p><p>The renal tubule and collecting duct express a large number of proteins, all having putative immunoreactive motives. Therefore, all can be the target of pathogenic autoantibodies. However, autoimmune tubulopathies seem to be rare, and we hypothesize that they are underdiagnosed. This review summarizes the current knowledge on autoimmune tubulopathies. We elected to classify tubulopathies according to the segment that is targeted because this determines, at least in part, the phenotypic presentation. In the proximal tubule, autoantibodies can cause anti-brush border antibody disease, renal Fanconi syndrome, renal proximal tubular acidosis, or tubulointerstitial nephritis and uveitis syndrome. Autoantibodies targeting the thick ascending limb of the loop of Henle can cause either acquired Bartter syndrome or hypomagnesemia with hypercalciuria, whereas autoantibodies targeting the distal convoluted tubule can cause acquired Gitelman syndrome. Finally, renal distal tubular acidosis or nephrogenic diabetes insipidus can be caused by autoantibodies targeting the collecting duct. In most instances, the characterization of the autoantibodies remains incomplete and the pathogenesis of the disease obscure. We believe it is important to increase the awareness of physicians regarding autoantibody-mediated tubular diseases to have a better estimation of the prevalence and to improve the care to patients. A research effort to increase the understanding of the pathogenesis of autoantibodies-mediated tubular diseases is also hoped for.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"706-712"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syndrome of Inappropriate Antidiuresis. 抗利尿不当综合征。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2024-12-02 DOI: 10.1681/ASN.0000000588
Mitchell H Rosner, Helbert Rondon-Berrios, Richard H Sterns
{"title":"Syndrome of Inappropriate Antidiuresis.","authors":"Mitchell H Rosner, Helbert Rondon-Berrios, Richard H Sterns","doi":"10.1681/ASN.0000000588","DOIUrl":"10.1681/ASN.0000000588","url":null,"abstract":"<p><p>Syndrome of inappropriate antidiuresis (SIAD)-the most frequent cause of hypotonic hyponatremia-is mediated by nonosmotic release of arginine vasopressin, which promotes water retention by activating renal vasopressin type 2 (V2) receptors. There are numerous causes of SIAD, including malignancy, pulmonary and central nervous system diseases, and medications. Rare activating mutations of the V2 receptor can also cause SIAD. Determination of the etiology of SIAD is important because removal of the stimulus for inappropriate arginine vasopressin secretion offers the most effective therapy. Treatment of SIAD is guided by symptoms and their severity, as well as the level of plasma sodium. In the absence of severe symptoms, which require urgent intervention, many clinicians focus on fluid restriction as a first-line treatment. Second-line therapeutic options include loop diuretics and salt tablets, urea, and V2 receptor antagonists.</p>","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"713-722"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis of Organ Damage in Fabry Disease: The AGALopathy Pathogenetic Pathway.
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI: 10.1681/ASN.0000000625
Paula Rozenfeld, Sandro Feriozzi
{"title":"Pathogenesis of Organ Damage in Fabry Disease: The AGALopathy Pathogenetic Pathway.","authors":"Paula Rozenfeld, Sandro Feriozzi","doi":"10.1681/ASN.0000000625","DOIUrl":"10.1681/ASN.0000000625","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"539-540"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postnatal Development of the Mammalian Kidney.
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 DOI: 10.1681/ASN.0000000695
Richard Willliam Naylor
{"title":"Postnatal Development of the Mammalian Kidney.","authors":"Richard Willliam Naylor","doi":"10.1681/ASN.0000000695","DOIUrl":"https://doi.org/10.1681/ASN.0000000695","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resident T Cells and Intrarenal Inflammation.
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.1681/ASN.0000000662
Rachel M B Bell, Laura Denby
{"title":"Resident T Cells and Intrarenal Inflammation.","authors":"Rachel M B Bell, Laura Denby","doi":"10.1681/ASN.0000000662","DOIUrl":"10.1681/ASN.0000000662","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"536-538"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Simulation to Optimize the Design of Adaptive Clinical Trials.
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2024-10-31 DOI: 10.1681/ASN.0000000565
Cal H Robinson, Rulan S Parekh, Brian H Cuthbertson, Eddy Fan, Yongdong Ouyang, Anna Heath
{"title":"Using Simulation to Optimize the Design of Adaptive Clinical Trials.","authors":"Cal H Robinson, Rulan S Parekh, Brian H Cuthbertson, Eddy Fan, Yongdong Ouyang, Anna Heath","doi":"10.1681/ASN.0000000565","DOIUrl":"10.1681/ASN.0000000565","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":"36 4","pages":"723-725"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Competing Risk Models Should Be Considered When Estimating Kidney Allograft Failure.
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI: 10.1681/ASN.0000000630
Agathe Truchot, Marc Raynaud, Alexandre Loupy
{"title":"Authors' Reply: Competing Risk Models Should Be Considered When Estimating Kidney Allograft Failure.","authors":"Agathe Truchot, Marc Raynaud, Alexandre Loupy","doi":"10.1681/ASN.0000000630","DOIUrl":"10.1681/ASN.0000000630","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"749"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Unlocking the Potential of SC0062: A New Horizon in IgA Nephropathy Treatment?
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2025-02-26 DOI: 10.1681/ASN.0000000657
Jianghua Chen, Hiddo J L Heerspink
{"title":"Authors' Reply: Unlocking the Potential of SC0062: A New Horizon in IgA Nephropathy Treatment?","authors":"Jianghua Chen, Hiddo J L Heerspink","doi":"10.1681/ASN.0000000657","DOIUrl":"10.1681/ASN.0000000657","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"746"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Despair to Promise: The Dawn of Novel Treatment in IgA Nephropathy. 从绝望到希望：IgA 肾病新疗法的曙光。
IF 10.3 1区 医学
Journal of The American Society of Nephrology Pub Date : 2025-04-01 Epub Date: 2024-10-26 DOI: 10.1681/ASN.0000000551
Sydney C W Tang, Girish N Nadkarni
{"title":"From Despair to Promise: The Dawn of Novel Treatment in IgA Nephropathy.","authors":"Sydney C W Tang, Girish N Nadkarni","doi":"10.1681/ASN.0000000551","DOIUrl":"10.1681/ASN.0000000551","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":" ","pages":"541-543"},"PeriodicalIF":10.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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