Journal of Skin Cancer最新文献_第3页

Factors Associated with Skin Cancers in People with Albinism in Togo. 多哥白化病患者患皮肤癌的相关因素

IF 1.1

Journal of Skin Cancer Pub Date : 2021-12-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3433493

Abas Mouhari-Toure, Sefako Abla Akakpo, Julienne Noude Teclessou, Piham Gnossike, Saliou Adam, Garba Mahamadou, Panawé Kassang, Yvette Elegbede, Tchin Darre, Koussake Kombate, Palokinam Pitché, Bayaki Saka

{"title":"Factors Associated with Skin Cancers in People with Albinism in Togo.","authors":"Abas Mouhari-Toure, Sefako Abla Akakpo, Julienne Noude Teclessou, Piham Gnossike, Saliou Adam, Garba Mahamadou, Panawé Kassang, Yvette Elegbede, Tchin Darre, Koussake Kombate, Palokinam Pitché, Bayaki Saka","doi":"10.1155/2021/3433493","DOIUrl":"https://doi.org/10.1155/2021/3433493","url":null,"abstract":"Objective: The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo.Method: This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021.Results: During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years (p ≤ 0.001). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years (p ≤ 0.001) and the presence of actinic keratoses (p ≤ 0.001). In contrast, the presence of ephelides (p=0.018) was a protective factor.Conclusion: This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Use of Intraoperative Frozen Section in the Surgical Management of Patients with Nonmelanoma Skin Cancer. 术中冷冻切片在非黑色素瘤皮肤癌患者手术治疗中的应用。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-11-01 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4944570

LiAnn Loh, Priya Tiwari, Jingtzer Lee, O-Wern Low, Vigneswaran Nallathamby, Hanjing Lee, Jane Lim, Thiam Chye Lim, Yan Lin Yap

{"title":"Use of Intraoperative Frozen Section in the Surgical Management of Patients with Nonmelanoma Skin Cancer.","authors":"LiAnn Loh, Priya Tiwari, Jingtzer Lee, O-Wern Low, Vigneswaran Nallathamby, Hanjing Lee, Jane Lim, Thiam Chye Lim, Yan Lin Yap","doi":"10.1155/2021/4944570","DOIUrl":"https://doi.org/10.1155/2021/4944570","url":null,"abstract":"Background: Intraoperative frozen section (IFS) is often utilised in the surgical treatment of nonmelanocytic skin cancer (NMSC) in sensitive facial regions when Mohs micrographic surgery (MMS) is not available.Objective: To compare the outcome of NMSC patients with excision performed with and without IFS.Materials and methods: A retrospective, single-centre study was performed on all patients who had undergone resection of NMSC with and without IFS control at the National University Hospital (NUH) from 2010 to 2015.Results: 116 patients were recruited, of which 86 had IFS and 30 did not. The complete excision rate of patients with IFS was higher at 87.2% (p=0.0194), need for secondary operation was lower at 1.2% (p=0.005), and need for postsurgery radiotherapy or chemotherapy was lower at 1.2% (p=0.001). The average duration of surgery in patients who underwent IFS was 95.4 minutes compared to 70.1 minutes in cases which did not undergo IFS.Conclusion: Our study showed an increased complete excision rate and reduced need for secondary surgeries and adjuvant therapy in patients with IFS. However, a longer operative duration was required. Use of IFS may be useful in patients with NMSC lesions in sensitive regions requiring complex reconstruction after tumour excision.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A. 黑色素瘤中的 MDM4 同工酶表达支持 MDM4-A 的致癌作用。

IF 1.2

Journal of Skin Cancer Pub Date : 2021-10-16 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3087579

Abdullah Alatawi, SoonJye Kho, Michael P Markey

引用次数: 0

Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review. 白斑病的诊断与治疗：临床表现与综合评述》（Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review）。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-07-24 eCollection Date: 2021-01-01 DOI: 10.1155/2021/7178305

Piyu Parth Naik

{"title":"Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review.","authors":"Piyu Parth Naik","doi":"10.1155/2021/7178305","DOIUrl":"10.1155/2021/7178305","url":null,"abstract":"Lentigo maligna (LM), also known as Hutchinson's melanotic freckle, is a form of in situ melanoma characterized by the proliferation of atypical melanocytes along the basal epidermis in sun-damaged skin. If left untreated, LM will progress to lentigo maligna melanoma (LMM), a form of invasive melanoma with the same prognosis as other forms of invasive melanoma. LM is more common in the elderly, with a peak occurrence between the ages of 65 and 80 years. LM, however, is rarely present on the trunk and extremities. The diagnosis of LM, confirmed by histopathological and biopsy examination, is based on clinical and dermoscopic features. It typically begins as a tan-brown macule or patch, but it can progress to a variegated pigmentation with dark black color or even amelanotic characteristics. The risk factors involved in the LM development include a history of sunburns, lighter skin types, advanced age, history of nonmelanoma skin cancers, and tendency to form solar lentigines. This article explains the clinical presentation of LM, also reviews the available information on the diagnosis and management of LM, and discusses the potential of such information in facilitating the future prospective.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Antibiotics and Other Drugs with Clinical Outcomes in Metastatic Melanoma Patients Treated with Immunotherapy. 抗生素和其他药物与免疫治疗转移性黑色素瘤患者临床结果的关系

IF 1.1

Journal of Skin Cancer Pub Date : 2021-07-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9120162

Manish D Angrish, Arun Agha, Rossanna C Pezo

{"title":"Association of Antibiotics and Other Drugs with Clinical Outcomes in Metastatic Melanoma Patients Treated with Immunotherapy.","authors":"Manish D Angrish, Arun Agha, Rossanna C Pezo","doi":"10.1155/2021/9120162","DOIUrl":"https://doi.org/10.1155/2021/9120162","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) targeting the programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have improved survival in many advanced cancers including advanced melanoma, renal cell, urothelial, and non-small-cell lung cancers. However, not all patients respond, and immune-related adverse events (irAEs) are common. Commensal gut bacteria may serve as an immunoregulatory link-mediating ICI response and toxicity. Recent studies have shown that a lack of bacterial diversity, known as gut dysbiosis, can have an adverse impact on patients' response to ICIs and predispose to the development of irAEs. Data were collected from 167 patients with metastatic melanoma who received antibiotics within 30 days prior to and/or after initiation of ICI and patients who received NSAIDs, statins, steroids, or proton-pump inhibitors (PPI) within 30 days prior to ICI initiation. The primary outcome was time-to-discontinuation (TTD) of ICI therapy, measured from the date of ICI initiation to the last treatment date. The secondary outcome of interest was toxicity, with incidence of irAEs graded as per the Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. Here, we demonstrate that individuals who received antibiotics had a significantly shorter time-to-discontinuation (TTD) of the ICI therapy as opposed those who were not administered antibiotics. Consistent with results from previous research, we propose that antibiotics have a negative effect on a patient's response to ICI therapy, most likely due to the result of gut dysbiosis, and should be critically assessed in terms of their use in patients undergoing ICI treatment.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39273455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Determinants of Sailors' Protective Behaviors in Fishing Spots against the Risks of Sunlight and Skin Cancer: A Qualitative Study in Iran. 在伊朗的一项定性研究中，水手在渔点对阳光和皮肤癌风险的保护行为的决定因素。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-07-17 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9954946

Ali Asadian, Mojtaba Fattahi Ardakani, Ahmad Sotoudeh, Moradali Zareipour, Ehsan Movahed

{"title":"Determinants of Sailors' Protective Behaviors in Fishing Spots against the Risks of Sunlight and Skin Cancer: A Qualitative Study in Iran.","authors":"Ali Asadian, Mojtaba Fattahi Ardakani, Ahmad Sotoudeh, Moradali Zareipour, Ehsan Movahed","doi":"10.1155/2021/9954946","DOIUrl":"https://doi.org/10.1155/2021/9954946","url":null,"abstract":"Introduction: The growing rate of nonmelanoma skin cancer (NMSC) and melanoma has been a great challenge for global health system. The present research aims to determine sailors' protective behaviors against the risks of sunlight and skin cancer in Iran.Materials and methods: The present research was qualitative in type, and its data were collected from August to December 2019. To this aim, 23 participants were recruited with whom semistructured interviews were held. The data collection continued until data saturation, and the interviews were coded in MAXQDA 10. Conventional content analysis was used to analyze the qualitative data.Results: Analysis of sailors' perceptions and experiences revealed 7 categories: protective behaviors, hard personal and familial conditions, social interactions, poor social support, feeling of satisfaction, self-care, and fear.Conclusion: Sailors are prone to skin cancer due to their specific work conditions. Perceptions and determinants of skin cancer and protective behaviors against sunlight were identified among sailors. Promotion of protective behaviors and beliefs that impeded preventive behaviors are among issues that require special attention.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39258624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retrospective Analysis of Rechallenge with Ipilimumab in Patients with Metastatic Melanoma. 转移性黑色素瘤患者伊匹单抗再挑战的回顾性分析。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-07-05 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5531864

A A Formozo, J R Gomes, R A Schmerling, A C Buzaid

{"title":"Retrospective Analysis of Rechallenge with Ipilimumab in Patients with Metastatic Melanoma.","authors":"A A Formozo, J R Gomes, R A Schmerling, A C Buzaid","doi":"10.1155/2021/5531864","DOIUrl":"https://doi.org/10.1155/2021/5531864","url":null,"abstract":"Background: Checkpoint inhibitors are effective in the treatment of several types of cancer, either being used separately or in combination. Ipilimumab pioneered the treatment of metastatic melanoma, and nowadays, it has been used more frequently in combination with anti-PD-1. Since the development of anti-PD1 for melanoma, rechallenge with ipilimumab has not been considered, although its use was considered in early trials.Cases: In this study, we analyzed 22 patients with metastatic melanoma who had benefited from the first treatment with ipilimumab, but eventually had progressive disease. They received ipilimumab at the same dose as the first treatment. Most of the patients received the second course after six months or more from the first treatment with ipilimumab. The median progression-free survival (mPFS) of the treatment with ipilimumab was 8.9 months, and the median progression-free survival of the second course was 6.3 months.Conclusion: There are limited data on rechallenge with ipilimumab addressing progression-free survival (PFS). In our analysis, twenty-two patients treated with a second course of ipilimumab were analyzed and most of them had a significant benefit. Despite the current alternatives for salvage therapies, rechallenging with ipilimumab might be an alternative to be considered in patients who had initial benefit.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39203009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Vitamin D and Vitamin D Analogs as Adjuncts to Field Therapy Treatments for Actinic Keratoses: Current Research and Future Approaches. 维生素D和维生素D类似物作为光化性角化病现场治疗的辅助药物:目前的研究和未来的方法。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-06-19 eCollection Date: 2021-01-01 DOI: 10.1155/2021/9920558

Zafer Sattouf, Steven J Repas, Jeffrey B Travers, Craig A Rohan

{"title":"Vitamin D and Vitamin D Analogs as Adjuncts to Field Therapy Treatments for Actinic Keratoses: Current Research and Future Approaches.","authors":"Zafer Sattouf, Steven J Repas, Jeffrey B Travers, Craig A Rohan","doi":"10.1155/2021/9920558","DOIUrl":"https://doi.org/10.1155/2021/9920558","url":null,"abstract":"Actinic keratoses (AK), also known as solar keratoses, are precancerous hyperkeratotic papules caused by long-term exposure to ultraviolet radiation. Management of AK prior to progression to cutaneous malignancy represents an important window of intervention. This is important on a population level, given the high incidence, morbidity, financial costs, and the low but measurable risk of mortality from cutaneous neoplasia. Treatments for AK have been refined for many years with significant progress over the past decade. Those recent advancements lead to questions about current treatment paradigms and the role of harnessing the immune system in field therapies. Recent studies suggest a key interplay between vitamin D and cancer immunity; in particular, the systemic and/or topical vitamin D analogs can augment field therapies used for severe actinic damage. In this review, we will examine the literature supporting the use of vitamin D-directed therapies to improve field therapy approaches. An enhanced understanding of these recent concepts with a focus on mechanisms is important in the optimized management of AK. These mechanisms will be critical in guiding whether selected populations, including those with immunosuppression, heritable cancer syndromes, and other risk factors for skin cancer, can benefit from these new concepts with vitamin D analogs and whether the approaches will be as effective in these populations as in immunocompetent patients.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39220539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Effect of Alpha and Hydrocortisone Ointments on Prevention of Acute Skin Complications Due to Radiotherapy in Breast Cancer Patients. α软膏与氢化可的松软膏预防乳腺癌放疗急性皮肤并发症的疗效比较。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-06-16 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5575688

Mansour Rezaei, Ahmad Khoshay, Nasrin Amirifard, Ali Goli, Alireza Abdi

{"title":"Comparison of the Effect of Alpha and Hydrocortisone Ointments on Prevention of Acute Skin Complications Due to Radiotherapy in Breast Cancer Patients.","authors":"Mansour Rezaei, Ahmad Khoshay, Nasrin Amirifard, Ali Goli, Alireza Abdi","doi":"10.1155/2021/5575688","DOIUrl":"https://doi.org/10.1155/2021/5575688","url":null,"abstract":"Background: Radiotherapy in breast cancer patients is associated with acute and delayed side effects. This study aimed to compare the effect of alpha and hydrocortisone 1% (H1%) ointments on prevention of acute skin complications due to radiotherapy in breast cancer patients.Methods: This clinical trial was conducted on 86 patients with breast cancer in the radiotherapy center of Imam Reza Hospital of Kermanshah, Iran. Using the records, the patients were selected and randomly divided into alpha and H1% groups after obtaining informed consent. The severity of dermatitis, complications, and patient complaints during treatment were evaluated weekly for up to 6 weeks by RTOG criteria. Data were analyzed using SPSS-16 software.Results: At the end of the third, fourth, fifth, and sixth weeks, 10 (11.7%), 25 (29.1%), 53 (61.6%), and 28 (32.6%) patients had skin complications, respectively. In weeks 5 and 6 in the H1 group, the incidence of complications was higher (P = 0.001). The frequency of pain and burning complaints at the end of the third, fourth, fifth, and sixth weeks was 15 (17.4%), 37 (43.0%), 52 (60.5%), and 1(1.2%), respectively. Pain and burning intensity in the fourth and fifth weeks in the H1 group was lower than alpha (P = 0010). Complaints of skin itching at the end of the third, fourth, and fifth weeks were 16 (18.6%), 25 (29.1%), and 28 (32.6), respectively. This complication was lower in the H1% group during these weeks (P < 0.05).Conclusion: Alpha ointment is more effective than H1% in relieving pain and burning, preventing complications except itching. It seems using an alpha ointment or combining it with H1% is an appropriate strategy to reduce the rate of injuries and skin complications of radiotherapy.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39081948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Keratinocyte Skin Cancers in General Surgery: The Impact of Anaesthesia, Trainee Supervision, and Choice of Reconstruction. 角化细胞皮肤癌在普通外科:麻醉的影响，学员的监督，和选择重建。

IF 1.1

Journal of Skin Cancer Pub Date : 2021-04-13 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5537273

William McSweeney, Matthew Leaning, Darius Dastouri

{"title":"Keratinocyte Skin Cancers in General Surgery: The Impact of Anaesthesia, Trainee Supervision, and Choice of Reconstruction.","authors":"William McSweeney, Matthew Leaning, Darius Dastouri","doi":"10.1155/2021/5537273","DOIUrl":"https://doi.org/10.1155/2021/5537273","url":null,"abstract":"Background: Keratinocyte skin cancers are common in Australia, incurring disproportionately high health expenditure in comparison with mortality. General surgeons often excise these lesions as day-surgery. Balancing individual complexities of these cancers with trainee supervision and health expenditure is key to deliver efficacious care and maintain day-surgery volume for patients during a pandemic.Methods: A retrospective, cross-sectional study was performed, examining 414 procedures from January 2019 to December 2020. Pathology was reviewed, and benign lesions excluded. Complete excision was based on 5 mm margins for squamous cell carcinoma (SCC), 0.5 mm microscopic margins for low-risk basal cell carcinoma (BCC) subtypes, and 3 mm for high-risk. Results of trainee-performed local anesthetic (LA) excision and general anesthetic (GA) excision (consultant scrubbed) were compared.Results: 288 excisions were reviewed for completeness, location, and reconstruction modality. 69% were BCC (199), and 31% were SCC (89). These were excised under GA (72.5%) and LA (27.5%). 25.6% of BCC excisions were \"close,\" and 22.6% were \"positive\" under GA, whilst 31% were \"close\" and 15.5% were \"positive\" under LA. 52.8% of SCC excisions were \"close,\" and 7.8% were \"positive\" under GA, compared with 42.8% \"close\" and 9.5% \"positive\" under LA. Complex reconstruction (skin graft, flap) was more common under GA (38% SCC and 36.1% BCC), but occurred at a modest rate under LA (22% BCC and 28.5% SCC).Conclusions: The results confirm that comparable margins and reconstruction options are achievable when excising keratinocyte cancers under LA by surgical trainees. This is fundamental in cost and timesaving, as well as reducing risk of aerosolisation of virus during GA, in a pandemic.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38954424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0