Factors Associated with Skin Cancers in People with Albinism in Togo.

IF 1.2 Q3 DERMATOLOGY

Journal of Skin Cancer Pub Date : 2021-12-23 eCollection Date: 2021-01-01 DOI:10.1155/2021/3433493

Abas Mouhari-Toure, Sefako Abla Akakpo, Julienne Noude Teclessou, Piham Gnossike, Saliou Adam, Garba Mahamadou, Panawé Kassang, Yvette Elegbede, Tchin Darre, Koussake Kombate, Palokinam Pitché, Bayaki Saka

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引用次数: 2

Abstract

Objective: The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo.

Method: This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021.

Results: During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years (p ≤ 0.001). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years (p ≤ 0.001) and the presence of actinic keratoses (p ≤ 0.001). In contrast, the presence of ephelides (p=0.018) was a protective factor.

Conclusion: This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.

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多哥白化病患者患皮肤癌的相关因素

目的:本研究的目的是确定与多哥白化病(PWA)患者皮肤癌相关的因素。方法:回顾性分析2019 - 2021年5次皮肤科会诊期间的PWA检查记录。结果:研究期间共观察到PWA 517例。其中64例(12.3%)出现了137例皮肤癌。性别比(M/F)为0.9。伴有皮肤癌的PWA患者的平均年龄为39.69±15.61岁，无皮肤癌的PWA患者的平均年龄为19.17±15.24岁(p≤0.001)。137例皮肤癌以基底细胞癌为主(45.9%)。这些皮肤癌主要位于头侧区域(77例;56.2%)，其次是上肢33例;24.1%)。在多因素分析中，PWA皮肤癌的危险因素是年龄大于39岁(p≤0.001)和存在光化性角化病(p≤0.001)。相反，黄芪的存在(p=0.018)是一个保护因素。结论:本研究证实高龄和光化性角化病是PWA皮肤癌的危险因素，与太阳辐射的累积作用有关。它的独创之处在于，它把球孢菌确定为一种保护因子。了解和考虑这些危险因素将有可能优化预防PWA皮肤癌的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Skin Cancer DERMATOLOGY-

CiteScore

2.30

自引率

18.20%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.