Journal of Skin Cancer最新文献

{"title":"The Application of Differing Machine Learning Algorithms and Their Related Performance in Detecting Skin Cancers and Melanomas","authors":"Suboh Alkhushayni, Du’a Al-zaleq, Luwis Andradi, Patrick Flynn","doi":"10.1155/2022/2839162","DOIUrl":"https://doi.org/10.1155/2022/2839162","url":null,"abstract":"Skin cancer, and its less common form melanoma, is a disease affecting a wide variety of people. Since it is usually detected initially by visual inspection, it makes for a good candidate for the application of machine learning. With early detection being key to good outcomes, any method that can enhance the diagnostic accuracy of dermatologists and oncologists is of significant interest. When comparing different existing implementations of machine learning against public datasets and several we seek to create, we attempted to create a more accurate model that can be readily adapted to use in clinical settings. We tested combinations of models, including convolutional neural networks (CNNs), and various layers of data manipulation, such as the application of Gaussian functions and trimming of images to improve accuracy. We also created more traditional data models, including support vector classification, K-nearest neighbor, Naïve Bayes, random forest, and gradient boosting algorithms, and compared them to the CNN-based models we had created. Results had indicated that CNN-based algorithms significantly outperformed other data models we had created. Partial results of this work were presented at the CSET Presentations for Research Month at the Minnesota State University, Mankato.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"3 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76147655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Nanoscale Materials for Skin Cancer Therapy and Detection","authors":"Hamza Abu Owida","doi":"10.1155/2022/2961996","DOIUrl":"https://doi.org/10.1155/2022/2961996","url":null,"abstract":"Skin cancer has developed as one of the most common types of cancer in the world, with a significant impact on public health impact and the economy. Nanotechnology methods for cancer treatment are appealing since they allow for the effective transport of medicines and other biologically active substances to specific tissues while minimizing harmful consequences. It is one of the most significant fields of research for treating skin cancer. Various nanomaterials have been employed in skin cancer therapy. The current review will summarize numerous methods of treating and diagnosing skin cancer in the earliest stages. There are numerous skin cancer indicators available for the prompt diagnosis of this type of disease. Traditional approaches to skin cancer diagnosis are explored, as are their shortcomings. Electrochemical and optical biosensors for skin cancer diagnosis and management were also discussed. Finally, various difficulties concerning the cost and ease of use of innovative methods should be addressed and overcome.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"60 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75912911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases","authors":"Syeed Mehbub Ul Kadir, Mukti Rani Mitra, Riffat Rashid, Murtuza Nuruddin, Md. Kamrul Hassan Khan, G. Haider, M. Nessa","doi":"10.1155/2022/4075668","DOIUrl":"https://doi.org/10.1155/2022/4075668","url":null,"abstract":"Background Eyelid tumours are common in our ophthalmic practice. Malignancy cases account only for one-fourth of all eyelid tumours. The most aggressive eyelid malignancy is sebaceous gland carcinoma, but its occurrences are rare in western countries. We found sebaceous gland carcinoma is as common as basal cell carcinoma in our clinical practices. Hence, it is essential to build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. Aim To assess the relative frequency of eyelid malignancies in the Bangladesh population, state their clinical features and outcome of management strategies and build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. Methods This was a retrospective case series study of 332 patients in Bangladesh. This study analyzed all the recorded data of the histologically proven primary eyelid malignancies and followed them up for at least six months from 2014 to 2019 (6 years). All patients were managed by surgical excision with tumor-free margins verified on histopathology, either the frozen section or excision biopsy with 2–3 mm microscopic view of normal tissue followed by eyelid reconstruction. Computer-based statistical software SPSS was used for the analysis, and an appropriate test of significance (chi-square) was used for the statistical analysis. Results Sebaceous gland carcinoma (SGC) was the highest in occurrence, at 42%, followed by 38% basal cell carcinoma (BCC), 18% squamous cell carcinoma (SqCC), and 02% malignant melanoma (MM). The mean age at presentation of SGC, BCC, SqCC, and MM were 57.41 years, 62.56 years, 64.73 years, and 59.28 years, respectively. Female (59%) was slightly more preponderance over the male (41%) for SGC than other malignancies. Pigmentation was associated with malignant melanoma (100%) and BCC (81%). Statistically, a significant difference was found between eyelid malignancies, including location, size, pigmentation, recurrence, and invasiveness. The recurrence rate was low lower in the patients who underwent frozen section biopsy (3%) for margin clearance than those who underwent excision biopsy (21.5%) in the follow-up time. Conjunctival map biopsy (8%) was performed as an essential tool for excluding the pagetoid spread of SGC. A new reconstruction method named triangular-shaped musculocutaneous tail flap was performed in 33 (11%) patients to reconstruct the moderate eyelid defect following local resection. Conclusion Sebaceous gland carcinoma (SGC) was the highest occurrence found to be the highest occurrence among all eyelid malignancies in Bangladesh. SGC is more aggressive and the recurrence rate was higher than BCC and SqCC.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"30 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83361248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV-Induced Skin Cancer Knowledge, Sun Exposure, and Tanning Behavior among University Students: Investigation of an Opportunity Sample of German University Students.","authors":"Marc Rocholl,&nbsp;Julia Hannappel,&nbsp;Michaela Ludewig,&nbsp;Swen Malte John","doi":"10.1155/2021/5558694","DOIUrl":"10.1155/2021/5558694","url":null,"abstract":"<p><p>Ultraviolet radiation (UVR) is the most important risk factor for developing skin cancer. University students can be considered as a particularly high-risk group for long- and short-term adverse effects of UVR due to intensive solar UVR exposure and high rates of sunburn. While validated questionnaires for assessing solar UVR exposure and sun protection behavior are available in German, a questionnaire for assessing the level of knowledge about this topic is still missing. We conducted a literature search for cross-sectional studies assessing skin cancer and sun protection knowledge among university students in Medline (via PubMed) and analyzed existing questionnaires and topics contained therein. We chose to translate the \"Skin Cancer and Sun Knowledge Scale\" referring to the TRAPD method into the German language and pilot-tested the translation with an opportunity sample of German students. The literature search revealed 36 eligible studies. Four major topics were identified within the studies: knowledge on skin cancer, risk factors, UVR, and sun protection measures. One hundred and seven German university students (86.0% female) with a mean age of 26.25 years (SD ± 4.58; range: 19-46) participated in our pilot study. The internal reliability of the scale was KR-20 = 0.624. We discovered an improvable level of knowledge in terms of skin cancer among the study population. Statistical analyses revealed no significant associations between the level of knowledge and UVR exposure or tanning behavior, respectively. The skin cancer and sun protection knowledge of German university students should be examined thoroughly. While the psychometric properties of the SCSK require further thorough investigation, first empirical experiences indicate the suitability of the tool to assess the level of knowledge regarding skin cancer and sun protection.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"5558694"},"PeriodicalIF":1.1,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39802845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Skin Cancers in People with Albinism in Togo.","authors":"Abas Mouhari-Toure,&nbsp;Sefako Abla Akakpo,&nbsp;Julienne Noude Teclessou,&nbsp;Piham Gnossike,&nbsp;Saliou Adam,&nbsp;Garba Mahamadou,&nbsp;Panawé Kassang,&nbsp;Yvette Elegbede,&nbsp;Tchin Darre,&nbsp;Koussake Kombate,&nbsp;Palokinam Pitché,&nbsp;Bayaki Saka","doi":"10.1155/2021/3433493","DOIUrl":"https://doi.org/10.1155/2021/3433493","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo.</p><p><strong>Method: </strong>This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021.</p><p><strong>Results: </strong>During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years (<i>p</i> ≤ 0.001). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years (<i>p</i> ≤ 0.001) and the presence of actinic keratoses (<i>p</i> ≤ 0.001). In contrast, the presence of ephelides (<i>p</i>=0.018) was a protective factor.</p><p><strong>Conclusion: </strong>This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"3433493"},"PeriodicalIF":1.1,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Intraoperative Frozen Section in the Surgical Management of Patients with Nonmelanoma Skin Cancer.","authors":"LiAnn Loh,&nbsp;Priya Tiwari,&nbsp;Jingtzer Lee,&nbsp;O-Wern Low,&nbsp;Vigneswaran Nallathamby,&nbsp;Hanjing Lee,&nbsp;Jane Lim,&nbsp;Thiam Chye Lim,&nbsp;Yan Lin Yap","doi":"10.1155/2021/4944570","DOIUrl":"https://doi.org/10.1155/2021/4944570","url":null,"abstract":"<p><strong>Background: </strong>Intraoperative frozen section (IFS) is often utilised in the surgical treatment of nonmelanocytic skin cancer (NMSC) in sensitive facial regions when Mohs micrographic surgery (MMS) is not available.</p><p><strong>Objective: </strong>To compare the outcome of NMSC patients with excision performed with and without IFS.</p><p><strong>Materials and methods: </strong>A retrospective, single-centre study was performed on all patients who had undergone resection of NMSC with and without IFS control at the National University Hospital (NUH) from 2010 to 2015.</p><p><strong>Results: </strong>116 patients were recruited, of which 86 had IFS and 30 did not. The complete excision rate of patients with IFS was higher at 87.2% (<i>p</i>=0.0194), need for secondary operation was lower at 1.2% (<i>p</i>=0.005), and need for postsurgery radiotherapy or chemotherapy was lower at 1.2% (<i>p</i>=0.001). The average duration of surgery in patients who underwent IFS was 95.4 minutes compared to 70.1 minutes in cases which did not undergo IFS.</p><p><strong>Conclusion: </strong>Our study showed an increased complete excision rate and reduced need for secondary surgeries and adjuvant therapy in patients with IFS. However, a longer operative duration was required. Use of IFS may be useful in patients with NMSC lesions in sensitive regions requiring complex reconstruction after tumour excision.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"4944570"},"PeriodicalIF":1.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A.","authors":"Abdullah Alatawi, SoonJye Kho, Michael P Markey","doi":"10.1155/2021/3087579","DOIUrl":"10.1155/2021/3087579","url":null,"abstract":"<p><p>The p53 tumor suppressor integrates upstream signals such as DNA damage and active oncogenes to initiate cell cycle arrest or apoptosis. This response is critical to halting inappropriate growth signals. As such, p53 activity is lost in cancer. In melanoma, however, the p53 gene is intact in a reported 94% of human cases. Rather than direct mutation, p53 is held inactive through interaction with inhibitory proteins. Here, we examine the expression of the two primary inhibitors of p53, MDM2 and MDM4, in genomic databases and biopsy specimens. We find that MDM4 is frequently overexpressed. Moreover, changes in splicing of MDM4 occur frequently and early in melanomagenesis. These changes in splicing must be considered in the design of therapeutic inhibitors of the MDM2/4 proteins for melanoma.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"3087579"},"PeriodicalIF":1.2,"publicationDate":"2021-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39569599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review.","authors":"Piyu Parth Naik","doi":"10.1155/2021/7178305","DOIUrl":"10.1155/2021/7178305","url":null,"abstract":"<p><p>Lentigo maligna (LM), also known as Hutchinson's melanotic freckle, is a form of in situ melanoma characterized by the proliferation of atypical melanocytes along the basal epidermis in sun-damaged skin. If left untreated, LM will progress to lentigo maligna melanoma (LMM), a form of invasive melanoma with the same prognosis as other forms of invasive melanoma. LM is more common in the elderly, with a peak occurrence between the ages of 65 and 80 years. LM, however, is rarely present on the trunk and extremities. The diagnosis of LM, confirmed by histopathological and biopsy examination, is based on clinical and dermoscopic features. It typically begins as a tan-brown macule or patch, but it can progress to a variegated pigmentation with dark black color or even amelanotic characteristics. The risk factors involved in the LM development include a history of sunburns, lighter skin types, advanced age, history of nonmelanoma skin cancers, and tendency to form solar lentigines. This article explains the clinical presentation of LM, also reviews the available information on the diagnosis and management of LM, and discusses the potential of such information in facilitating the future prospective.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"7178305"},"PeriodicalIF":1.1,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Antibiotics and Other Drugs with Clinical Outcomes in Metastatic Melanoma Patients Treated with Immunotherapy.","authors":"Manish D Angrish,&nbsp;Arun Agha,&nbsp;Rossanna C Pezo","doi":"10.1155/2021/9120162","DOIUrl":"https://doi.org/10.1155/2021/9120162","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) targeting the programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have improved survival in many advanced cancers including advanced melanoma, renal cell, urothelial, and non-small-cell lung cancers. However, not all patients respond, and immune-related adverse events (irAEs) are common. Commensal gut bacteria may serve as an immunoregulatory link-mediating ICI response and toxicity. Recent studies have shown that a lack of bacterial diversity, known as gut dysbiosis, can have an adverse impact on patients' response to ICIs and predispose to the development of irAEs. Data were collected from 167 patients with metastatic melanoma who received antibiotics within 30 days prior to and/or after initiation of ICI and patients who received NSAIDs, statins, steroids, or proton-pump inhibitors (PPI) within 30 days prior to ICI initiation. The primary outcome was time-to-discontinuation (TTD) of ICI therapy, measured from the date of ICI initiation to the last treatment date. The secondary outcome of interest was toxicity, with incidence of irAEs graded as per the Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. Here, we demonstrate that individuals who received antibiotics had a significantly shorter time-to-discontinuation (TTD) of the ICI therapy as opposed those who were not administered antibiotics. Consistent with results from previous research, we propose that antibiotics have a negative effect on a patient's response to ICI therapy, most likely due to the result of gut dysbiosis, and should be critically assessed in terms of their use in patients undergoing ICI treatment.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"9120162"},"PeriodicalIF":1.1,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39273455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Sailors' Protective Behaviors in Fishing Spots against the Risks of Sunlight and Skin Cancer: A Qualitative Study in Iran.","authors":"Ali Asadian,&nbsp;Mojtaba Fattahi Ardakani,&nbsp;Ahmad Sotoudeh,&nbsp;Moradali Zareipour,&nbsp;Ehsan Movahed","doi":"10.1155/2021/9954946","DOIUrl":"https://doi.org/10.1155/2021/9954946","url":null,"abstract":"<p><strong>Introduction: </strong>The growing rate of nonmelanoma skin cancer (NMSC) and melanoma has been a great challenge for global health system. The present research aims to determine sailors' protective behaviors against the risks of sunlight and skin cancer in Iran.</p><p><strong>Materials and methods: </strong>The present research was qualitative in type, and its data were collected from August to December 2019. To this aim, 23 participants were recruited with whom semistructured interviews were held. The data collection continued until data saturation, and the interviews were coded in MAXQDA 10. Conventional content analysis was used to analyze the qualitative data.</p><p><strong>Results: </strong>Analysis of sailors' perceptions and experiences revealed 7 categories: protective behaviors, hard personal and familial conditions, social interactions, poor social support, feeling of satisfaction, self-care, and fear.</p><p><strong>Conclusion: </strong>Sailors are prone to skin cancer due to their specific work conditions. Perceptions and determinants of skin cancer and protective behaviors against sunlight were identified among sailors. Promotion of protective behaviors and beliefs that impeded preventive behaviors are among issues that require special attention.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2021 ","pages":"9954946"},"PeriodicalIF":1.1,"publicationDate":"2021-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39258624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}