Journal of Skin Cancer最新文献

{"title":"Phytochemicals From <i>Houttuynia cordata</i> Thunb as Potential Inhibitors of BRAF, MEK, and ERK: Insights From Molecular Docking.","authors":"Mongkol Yanarojana, Salunya Tancharoen, Thamthiwat Nararatwanchai, Somchai Yanarojana","doi":"10.1155/jskc/2565084","DOIUrl":"10.1155/jskc/2565084","url":null,"abstract":"<p><p>This study utilized molecular docking techniques to investigate the potential of phytochemical compounds in <i>Houttuynia cordata</i> Thunb. extract as inhibitors of the oncogenic MAPK signaling pathway in melanoma. The docking results revealed that several phytochemical compounds exhibited favorable binding interactions with the BRAF^V600E, MEK, and ERK ATP-binding site. A total of 16 compounds have high affinity (binding energies < -9 kcal/mol) for BRAF^V600E, 13 compounds for MEK-1, 6 compounds for MEK-2, 18 compounds for ERK-1, and 10 compounds for ERK-2. Hesperidin exhibited the lowest binding energy to BRAF^V600E (-10.216 kcal/mol) and ERK-2 (-10.336 kcal/mol). Quercitrin has the lowest binding energy against MEK-1 (-9.963 kcal/mol), 3-hydroxy-β-sitost-5-en-7-one demonstrated the lowest binding energy to ERK-1 (-10.495 kcal/mol), and rutin was best against MEK-2 with a calculated binding energy value of -9.963 kcal/mol. The binding modes of these compounds are compared with the known inhibitors of the oncoprotein targets that showed similar interactions to key amino acid residues indicating their inhibitory potential and are suggested as promising candidates for melanoma treatment.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"2565084"},"PeriodicalIF":2.0,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12680463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Dermoscopic Characteristics in Cutaneous Squamous Cell Carcinoma: A Retrospective Analysis.","authors":"Jia-Li Zhang, Guan-Zhi Chen, Da Wang, Xiao-Ou Lu, Wei-Wei Fu, Chang-Qing Shi, Hong-Quan Chen","doi":"10.1155/jskc/9944605","DOIUrl":"10.1155/jskc/9944605","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the diagnostic efficacy of dermoscopy for cutaneous squamous cell carcinoma (cSCC).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on skin lesions diagnosed as cSCC via histopathology at the Department of Dermatology, Pingdu District, The Affiliated Hospital of Qingdao University, between January 2021 and August 2024 (case group). Lesions suspected of cSCC but ultimately diagnosed as other conditions served as the control group. The study compared disease progression and dermoscopic features between the two groups through chi-square test and logistic regression analysis, using histopathological results as the diagnostic reference standard.</p><p><strong>Results: </strong>The case group consisted of 41 lesions, while the control group comprised 18 lesions diagnosed with conditions including actinic keratosis, basal cell carcinoma, and keratoacanthoma. The clinical misdiagnosis rate was approximately 30.5%. Notably, a disease duration of less than 2 years (28/41, 68.29%), the presence of white circles (21/41, 51.22%) and blood spots (35/41, 85.37%), and a total of ≥ 5 dermoscopic features (19/41, 46.34%) were significantly more prevalent in the case group compared to the control group (both <i>p</i> < 0.05). Among these, a disease duration of less than 2 years, along with the presence of white circles and blood spots, demonstrated statistical significance in differentiating cSCC from other conditions (both <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>For patients with clinically suspected cSCC, a disease duration of less than 2 years and dermoscopic observation of white circles and blood spots provide substantial diagnostic value.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"9944605"},"PeriodicalIF":2.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12543451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Patterns in Mycosis Fungoides: A Cross-Sectional Study.","authors":"Fatemeh Mohaghegh, Mina Shayan, Parvin Rajabi, Farahnaz Fatemi Naeini, Zahra Nikyar","doi":"10.1155/jskc/9995443","DOIUrl":"10.1155/jskc/9995443","url":null,"abstract":"<p><strong>Introduction: </strong>Mycosis fungoides (MF) represents the most prevalent form of cutaneous lymphoma, characterized by diverse histopathological patterns. However, recent comprehensive studies systematically evaluating the spectrum of histopathological patterns and changes associated with MF in patients within Iran are notably lacking.</p><p><strong>Method: </strong>This cross-sectional descriptive study analyzed 64 skin biopsy slides diagnosed with MF, archived from 2013 to 2023 at Al-Zahra Hospital and a private dermatopathology laboratory in Isfahan, Iran. Inclusion criteria included all slides with complete demographic data and a confirmed MF diagnosis. Patterns and finding of these slides were analyzed according to age, gender, and biopsy site. Data analysis was performed using SPSS Version 26.0, with significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>The study included 31 females and 33 males, with a mean age of 44.64 ± 14.91 years. The most common biopsy site was the trunk (45.31%). The predominant histopathologic patterns observed were psoriasiform (33 cases), lichenoid (14 cases), and spongiotic (10 cases), with universal epidermotropism across all slides. Parakeratosis and cytological atypia were found in 37 and 31 cases, respectively. Notably, eosinophils were more frequent in males (<i>p</i>=0.016), and cytological atypia were significantly more common in males than females (<i>p</i>=0.044). Mild dermal infiltrate was the most prevalent, particularly in the 35-42 and 43-56 age groups, with a significant age-related variation (<i>p</i>=0.041).</p><p><strong>Conclusion: </strong>This study reveals that psoriasiform, lichenoid, and spongiotic patterns are the most common in MF, with epidermotropism present in all cases. Age and gender significantly influence certain features, but overall, histopathological patterns showed no significant variation by biopsy location or age group.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"9995443"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanoma Disparities in Hispanic Populations: Socioeconomic Challenges and Cultural Barriers.","authors":"Tarek Zieneldien, Sophia Ma, Janice Kim, Bernard A Cohen","doi":"10.1155/jskc/3133773","DOIUrl":"10.1155/jskc/3133773","url":null,"abstract":"<p><p>Hispanic and Latino melanoma patients face significant disparities in patient outcomes and survival rates due to challenges in melanoma care, including later-stage diagnoses, disproportionate financial burdens, and cultural differences. Healthcare insurance status is an important contributing factor to these disparities, with uninsured Hispanic patients being more likely to delay seeking medical attention and face higher out-of-pocket costs. Socioeconomic factors, including lower income levels, limited education, and occupations that may increase UV exposure exacerbate these disparities. Additional factors such as inadequate patient education, language barriers, and inadequate health education campaigns also limit melanoma awareness, prevention, and healthcare access in Hispanic populations. Consequently, there is an urgent need for culturally tailored interventions, such as community-based, targeted health campaigns and enhanced, culturally sensitive provider training to better address these disparities and improve melanoma outcomes in Hispanic and Latino populations.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"3133773"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticotropin-Releasing Hormone in Melanoma and Nonmelanoma Skin Cancer.","authors":"Marcel Mueller, Susanne Melchers, Iris Mueller, Jochen Utikal, Julia Krug, Astrid Schmieder","doi":"10.1155/jskc/9788886","DOIUrl":"10.1155/jskc/9788886","url":null,"abstract":"<p><p><b>Background:</b> Corticotropin-releasing hormone (CRH) regulates immunological and cellular processes. Recently, CRH is expressed in skin cancers, where its expression appears to correlate with the degree of malignancy. <b>Objective:</b> This study correlates CRH expression in melanoma metastases with patient survival and compares the intensity of CRH expression in melanoma to that in less aggressive skin cancer entities. <b>Methods:</b> Tissue microarrays with cores from 94 melanomas and 40 melanocytic nevi and 51 slides from 41 basal cell carcinomas (BCCs) and 10 squamous cell carcinomas (SCCs) were immunohistochemically stained for CRH. The intensity of CRH expression in melanoma metastases was stratified by sex and correlated with patient survival. Furthermore, proliferation and apoptosis were assessed in CRH-stimulated A431 cells using enzyme-linked immunosorbent assays and an apoptosis detection kit. <b>Results:</b> The intensity of CRH expression was higher in primary melanomas than in melanocytic nevi. Higher CRH expression was also found in melanoma metastases from women compared to men. However, higher CRH expression was correlated with reduced overall survival only in men. Compared to melanoma, BCCs and SCCs showed weaker CRH expression, which was in line with the finding that in vitro, CRH stimulation of the A431 cells reduced their proliferative activity. <b>Conclusion:</b> CRH does not necessarily correlate with the degree of malignancy, as semimalignant cancers such as BCC show higher levels of CRH expression than SCCs. In melanoma, CRH expression in metastases may be an important prognostic factor for overall survival in men, which needs further evaluation.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"9788886"},"PeriodicalIF":0.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Trends, Clinical Impact, and Geographical Variations of Nonmelanoma Skin Cancers: A Twelve-Year Study in Messina, Italy.","authors":"Gabriele Delia, Fabiana Battaglia, Pasqualina Laganà, Giovanni Genovese, Cristina Genovese, Giuseppe Trimarchi, Roberta Giuffrida, Francesco Stagno d'Alcontres","doi":"10.1155/jskc/1823281","DOIUrl":"10.1155/jskc/1823281","url":null,"abstract":"<p><p>The incidence of nonmelanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), is increasing globally, driven by factors such as chronic UV exposure, climate change, and aging populations. This comprehensive retrospective cohort study examined 1252 patients treated for NMSCs at the Plastic Surgery Unit of the University of Messina, Italy, from 2012 to 2023. The study aimed to assess demographic characteristics, histological types, lesion attributes, recurrence rates, and geographical variations in NMSC incidence. Beyond confirming global epidemiological trends, this study highlights clinically relevant factors influencing tumor presentation, including environmental risk exposure, lesion recurrence, and histological aggressiveness. Data were collected on patient demographics, tumor location, histological subtype, lesion diameter, presence of ulceration, recurrence, and differentiation grade. Statistical analysis was conducted using R software (Version 4.2.0). Findings demonstrated that patients residing in coastal areas had a significantly higher incidence of NMSCs, reinforcing the role of exposure and environmental pollutants in carcinogenesis. These findings align with global trends and highlight the urgent need for early diagnosis, targeted dermatological surveillance, and public health interventions to mitigate the rising burden of NMSCs. The study underscores the necessity of enhanced sun protection awareness, integration of dermatological screenings in primary care settings, and improved treatment protocols to reduce recurrence and morbidity.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"1823281"},"PeriodicalIF":1.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamous Cell Carcinoma: A Clinical and Histopathological Review of a South African Tertiary Dermatology Unit.","authors":"Ahmed Dadoo, Bianca Tod, Johann Schneider, Willem Visser","doi":"10.1155/jskc/8884436","DOIUrl":"10.1155/jskc/8884436","url":null,"abstract":"<p><p><b>Background:</b> Cutaneous squamous cell carcinoma (CSCC) is the second most prevalent form of skin cancer globally. However, its incidence is rising relative to basal cell carcinoma (BCC) in countries such as Australia and the United States. In South Africa, where the population is exposed to numerous CSCC risk factors, including high ultraviolet radiation levels and a high burden of immunosuppression, there remains a notable paucity of scientific literature characterising the disease within this context. <b>Aims:</b> To describe the clinical, histopathological and risk profile characteristics of CSCC in a South African cohort to identify patterns that can inform local clinical practice and guide future research priorities. <b>Methods:</b> A retrospective data analysis of patients seen at Tygerberg Academic Hospital between 1 September 2019 and 31 August 2020 was conducted. Demographic and clinical data were extracted from medical records. Two study evaluators used predetermined criteria to review the histopathological features in skin biopsies. Risk stratification of lesions followed the guidelines of the National Comprehensive Cancer Network. <b>Results:</b> Over one year, 113 CSCCs were diagnosed in 83 patients. Participants were primarily Fitzpatrick skin phototype I (65.1%) and male (60.2%), with a median age of 73 years and a male-to-female ratio of 1.51:1. The BCC-to-CSCC incidence ratio was 1.71:1. Most lesions had been present for over 6 months (87.6%) and were located on the head and neck (59.3%). Punch biopsies diagnosed 62.8% of lesions. Histologically, 63.7% were well differentiated, and 40.7% were invasive. Conventional CSCCs comprised 75.2% of lesions; 5.3% were the high-risk acantholytic subtype. A high recurrence risk was found in 77.0% of lesions. <b>Conclusion:</b> This study highlights the heterogeneous nature of CSCC in South Africa and underscores the need for prospective, context-specific research to enhance prevention, early detection and management efforts nationwide.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"8884436"},"PeriodicalIF":1.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Features of Nevus Sebaceous and Superimposed Skin Tumors.","authors":"Paridokht Karimian, Naz Zargar Javaheri, Kaveh Gharaei Nejad, Hojat Eftekhari, Elahe Rafiei, Rana Rafiei","doi":"10.1155/jskc/3828133","DOIUrl":"10.1155/jskc/3828133","url":null,"abstract":"<p><p><b>Introduction:</b> Nevus sebaceous (NS) is a rare congenital hamartoma that may cause some concerns for parents. Benign skin tumors can develop in NS, although malignant transformations have occasionally been documented. This study aimed to investigate the histopathological characteristics of NS lesions in relation to sex, age, location, type, and any associated superimposed tumors. <b>Methods:</b> This retrospective cross-sectional study was conducted on the histopathologic reports of 60 patients with NS who were referred to our center between 2010 and 2022. Information, including sex, age, location of the lesion, and histopathological features of the NS lesion, was recorded. <b>Results:</b> The mean age of the patients was 24.52 ± 12.19 years, and 65.0% of the patients (39 cases) were men. Most of the lesions were observed on the scalp and face. Benign and malignant neoplasms were observed in 5% and 10% of patients, respectively. All the cases of malignant tumors (six cases) were identified as basal cell carcinoma, and three cases were benign tumors of syringocystadenoma papilliferum. Demodex infestation and apocrine gland dilatation were observed in 56.7% and 23.3% of patients, respectively. Benign neoplasms were significantly more frequent in women (<i>p</i>=0.039). In addition, malignant neoplasms were significantly more prevalent among patients aged ≥ 25 years (<i>p</i>=0.001). The frequencies of acanthosis and focal parakeratosis were higher in the scalp, and sebaceous hyperplasia was more common in the face (<i>p</i> < 0.05). <b>Conclusion:</b> Our study revealed that malignant tumors were more common than benign lesions in patients with NS. Benign neoplasms were more frequent in women. Malignant neoplasms were detected in patients aged more than 25 years.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"3828133"},"PeriodicalIF":1.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons for Outdoor Tanning in Adults: Q Methodology Identifies Three Types of Tanners.","authors":"Ciara Bergmann, Tobias Konkel, Tatiana Görig, Esma Dursun, Katharina Diehl","doi":"10.1155/jskc/5592331","DOIUrl":"10.1155/jskc/5592331","url":null,"abstract":"<p><p><b>Background:</b> Ultraviolet (UV) radiation from the sun is a major risk factor for skin cancers. Nonetheless, many individuals in western countries tan outdoors. This study aimed to identify types of tanners and their reasons for outdoor tanning based on a Q methodology study. <b>Methods:</b> A heterogeneous sample of 25 participants aged 19-61 years was recruited and interviewed using the Q sort method. The participants ranked 37 reasons for outdoor tanning according to their subjectively perceived importance in a predetermined grid. Data were analyzed using an inverted factor analysis technique developed specifically for Q methodology. The transcripts of the postsort interviews were used to better understand the quantitative findings. <b>Results:</b> Three groups (factors) of tanners were identified based on 22 of the 25 participants. While enhancement of attractiveness was a major reason for outdoor tanning in the middle-aged group, the youngest and the oldest groups had a stronger focus on relaxation, well-being, and mental health. All three groups stated that vitamin D production was an important factor for tanning outdoors. <b>Discussion:</b> These findings suggest that people may have different reasons for exposing themselves to harmful UV radiation, but that there is a pattern most participants in our study could be assigned to. Especially the finding that all groups tanned outdoors to meet their vitamin D needs seems to be a starting point for future research and skin cancer prevention.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"5592331"},"PeriodicalIF":1.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Skin Cancer Knowledge, Attitudes, and Preventive Practices Among Healthcare Professionals and the General Population in Pakistan: Insights for Healthcare Interventions and Policy Development.","authors":"Adeel Aslam, Shazia Jamshed, Asma Ghulam Mustafa, Suresh Shanmugham, Abubakar Wazir, Ali Hussnain, Maha Amjad, Hafiz Muhammad Bilal, Zahra Moslemifard Khaledi","doi":"10.1155/jskc/3035274","DOIUrl":"10.1155/jskc/3035274","url":null,"abstract":"<p><p><b>Background:</b> Skin cancer is a major global health issue that can be life-threatening. The current study explores the knowledge, attitudes, and practices of healthcare professionals and the general population regarding skin cancer. <b>Method:</b> A cross-sectional study was conducted between January and June 2023 in Lahore, the second-largest city in Pakistan. A total of 407 respondents from the general population and 230 healthcare professionals were recruited using a convenient and snowball sampling technique, respectively. Data were collected using questionnaires and statistical analysis, including chi-square tests, and bivariate logistic regression was performed using SPSS Version 20. <b>Result:</b> In the overall population, 46.4% identified as male, 45.0% as female, and 8.6% chose not to disclose their gender. Significantly differing levels of skin cancer knowledge were observed between genders, with males reporting a higher knowledge (36.4%, crude odds ratio = 1.413, <i>p</i> < 0.001) compared to females (32.9%). In addition, females displayed a more positive attitude (crude odds ratio = 1.874, <i>p</i> < 0.001) and practice (crude odds ratio = 1.401, <i>p</i> < 0.05) toward skin cancer prevention. Furthermore, younger age groups exhibited greater knowledge, attitudes, and practices regarding skin cancer. Education and employment status also have a direct influence on skin cancer knowledge and practices. Moreover, in the current study, healthcare professionals comprised 61.3% physicians, 16.5% nurses, and 22.2% pharmacists. Among these, 37.3% of physicians, 11.3% of nurses, and 12.6% of pharmacists demonstrated the ability to identify common signs and symptoms of skin cancer in a patient (<i>p</i> < 0.001). Furthermore, 44% of physicians regarded regular skin cancer screenings as \"very important\" (<i>p</i> < 0.01). In addition, 27.4% of physicians and 8.7% of pharmacists exhibited a positive attitude toward regular screening of at-risk patients (<i>p</i> < 0.05). <b>Conclusion:</b> The current study highlights gender and age disparities in skin cancer knowledge and prevention among the general population, emphasizing the need for targeted public health interventions to enhance knowledge and proactive practices. In addition, among healthcare professionals, it reveals variations in knowledge levels, emphasizing the importance of tailored education initiatives to promote consistent skin cancer prevention and management practices within the healthcare community.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2025 ","pages":"3035274"},"PeriodicalIF":1.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}