Histopathological Characteristics of Cutaneous Melanoma in Isfahan, Iran, from 2013 to 2018.

IF 1.2 Q3 DERMATOLOGY

Journal of Skin Cancer Pub Date : 2022-09-19 eCollection Date: 2022-01-01 DOI:10.1155/2022/4490648

Zahra Malakoutikhah, Fatemeh Mohaghegh, Siavash Karimi, Parvin Rajabi, Elham T Tabatabaei

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Abstract

Objectives: To investigate the histopathological characteristics of cutaneous melanoma in Isfahan from 2013 to 2018, according to histopathological subtype, lesions location, Clark level, and Breslow thickness.

Methods: A descriptive, retrospective study in reports of Alzahra Hospital and Dr. Rajabi Pathology Laboratory in Isfahan.

Results: In total, 45 patients were included in this study. The most prevalent histopathological subtype was acral lentiginous melanoma (48.89%), followed by lentigo maligna melanoma (17.78%), nodular melanoma (11.11%), and superficial spreading melanoma (8.89%). Most malignant lesions were on the foot and toes (31.1%) and face (24.4%). Tumor invasion level was mainly at Clark level IV (42.2%). Furthermore, the mean depth of tumor penetration (Breslow thickness) was 3.87 ± 3.35.

Conclusions: Our study revealed the characteristics of melanoma in the Iranian population. Our results showed a similar trend with previous studies in the Asian population. Further investigations are needed to elucidate the role of ethnic and environmental risk factors for developing melanoma in different populations.

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2013 - 2018年伊朗伊斯法罕地区皮肤黑色素瘤的组织病理学特征

目的:根据组织病理学亚型、病变部位、Clark水平、Breslow厚度，探讨2013 - 2018年伊斯法罕地区皮肤黑色素瘤的组织病理学特征。方法:对伊斯法罕Alzahra医院和Dr. Rajabi病理实验室的报告进行描述性、回顾性研究。结果:本研究共纳入45例患者。最常见的组织病理学亚型为肢端小晶状体黑色素瘤(48.89%)，其次为小晶状体恶性黑色素瘤(17.78%)、结节性黑色素瘤(11.11%)和浅表扩散性黑色素瘤(8.89%)。恶性病变以足、趾部(31.1%)和面部(24.4%)居多。肿瘤侵袭程度主要为Clark IV级(42.2%)。肿瘤平均穿透深度(Breslow厚度)为3.87±3.35。结论:我们的研究揭示了伊朗人群中黑色素瘤的特征。我们的研究结果与之前对亚洲人群的研究显示出类似的趋势。需要进一步的调查来阐明种族和环境风险因素在不同人群中发生黑色素瘤的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Skin Cancer DERMATOLOGY-

CiteScore

2.30

自引率

18.20%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.