Journal of Skin Cancer最新文献_第10页

Gene expression differences predict treatment outcome of merkel cell carcinoma patients. 基因表达差异预测默克尔细胞癌患者的治疗结果。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-01-30 DOI: 10.1155/2014/596459

Loren Masterson, Bryan J Thibodeau, Laura E Fortier, Timothy J Geddes, Barbara L Pruetz, Rajwant Malhotra, Richard Keidan, George D Wilson

{"title":"Gene expression differences predict treatment outcome of merkel cell carcinoma patients.","authors":"Loren Masterson, Bryan J Thibodeau, Laura E Fortier, Timothy J Geddes, Barbara L Pruetz, Rajwant Malhotra, Richard Keidan, George D Wilson","doi":"10.1155/2014/596459","DOIUrl":"https://doi.org/10.1155/2014/596459","url":null,"abstract":"Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical. This study aimed to identify biomarkers with prognostic significance. While sixty-two patients were identified who were treated for MCC at our institution, only seventeen patients had adequate formalin-fixed paraffin-embedded archival tissue and followup to be included in the study. Patients were stratified into good, moderate, or poor prognosis. Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays. Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis. Immunohistochemistry further established that keratin 20 was overexpressed in the poor prognosis tumors. In addition, novel genes of interest such as phospholipase A2 group X, kinesin family member 3A, tumor protein D52, mucin 1, and KIT were upregulated in specimens from patients with poor prognosis. Our pilot study identified several gene expression differences which could be used in the future as prognostic biomarkers in MCC patients. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"596459"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/596459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32179811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The pink rim sign: location of pink as an indicator of melanoma in dermoscopic images. 粉红色边缘标志:在皮肤镜图像中，粉红色作为黑色素瘤的指示。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-03 DOI: 10.1155/2014/719740

Ryan K Rader, Katie S Payne, Uday Guntupalli, Harold S Rabinovitz, Maggie C Oliviero, Rhett J Drugge, Joseph J Malters, William V Stoecker

{"title":"The pink rim sign: location of pink as an indicator of melanoma in dermoscopic images.","authors":"Ryan K Rader, Katie S Payne, Uday Guntupalli, Harold S Rabinovitz, Maggie C Oliviero, Rhett J Drugge, Joseph J Malters, William V Stoecker","doi":"10.1155/2014/719740","DOIUrl":"https://doi.org/10.1155/2014/719740","url":null,"abstract":"Background. In dermoscopic images, multiple shades of pink have been described in melanoma without specifying location of these areas within the lesion. Objective. The purpose of this study was to determine the statistics for the presence of centrally and peripherally located pink melanoma and benign melanocytic lesions. Methods. Three observers, untrained in dermoscopy, each retrospectively analyzed 1290 dermoscopic images (296 melanomas (170 in situ and 126 invasive), 994 benign melanocytic nevi) and assessed the presence of any shade of pink in the center and periphery of the lesion. Results. Pink was located in the peripheral region in 14.5% of melanomas and 6.3% of benign melanocytic lesions, yielding an odds ratio of 2.51 (95% CI: 1.7-3.8, P < 0.0001). Central pink was located in 12.8% of melanomas and 21.8% of benign lesions, yielding an odds ratio of 0.462 (95% CI: 0.67, P = 0.204). Pink in melanoma in situ tended to be present throughout the lesion (68% of pink lesions). Pink in invasive melanoma was present in 17% of cases, often presenting as a pink rim. Conclusions. The presence of pink in the periphery or rim of a dermoscopic melanocytic lesion image provides an indication of malignancy. We offer the \"pink rim sign\" as a clue to the dermoscopic diagnosis of invasive melanoma. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"719740"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/719740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32184641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Validity and stability of the decisional balance for sun protection inventory. 防晒产品库存决策平衡的有效性和稳定性。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-12-07 DOI: 10.1155/2014/190541

Hui-Qing Yin, Joseph S Rossi, Colleen A Redding, Andrea L Paiva, Steven F Babbin, Wayne F Velicer

引用次数: 4

Melanoma Development and Progression Are Associated with Rad6 Upregulation and β -Catenin Relocation to the Cell Membrane. 黑色素瘤的发生和发展与Rad6上调和β -Catenin迁移到细胞膜有关。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-05-06 DOI: 10.1155/2014/439205

Karli Rosner, Darius R Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P V Shekhar

{"title":"Melanoma Development and Progression Are Associated with Rad6 Upregulation and β -Catenin Relocation to the Cell Membrane.","authors":"Karli Rosner, Darius R Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P V Shekhar","doi":"10.1155/2014/439205","DOIUrl":"https://doi.org/10.1155/2014/439205","url":null,"abstract":"We have previously demonstrated that Rad6 and β -catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression. While β -catenin has been implicated in melanoma pathogenesis, Rad6 function has not been investigated. Here, we examined the relationship between Rad6 and β -catenin in melanoma development and progression. Eighty-eight cutaneous tumors, 30 nevi, 29 primary melanoma, and 29 metastatic melanomas, were immunostained with anti- β -catenin and anti-Rad6 antibodies. Strong expression of Rad6 was observed in only 27% of nevi as compared to 100% of primary and 96% of metastatic melanomas. β -Catenin was strongly expressed in 97% of primary and 93% of metastatic melanomas, and unlike Rad6, in 93% of nevi. None of the tumors expressed nuclear β -catenin. β -Catenin was exclusively localized on the cell membrane of 55% of primary, 62% of metastatic melanomas, and only 10% of nevi. Cytoplasmic β -catenin was detected in 90% of nevi, 17% of primary, and 8% of metastatic melanoma, whereas 28% of primary and 30% of metastatic melanomas exhibited β -catenin at both locations. These data suggest that melanoma development and progression are associated with Rad6 upregulation and membranous redistribution of β -catenin and that β -catenin and Rad6 play independent roles in melanoma development. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"439205"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/439205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32394086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions. 基底细胞癌光动力治疗六年经验:191个病灶的结果和荧光诊断。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-09-14 DOI: 10.1155/2014/849248

M Fernández-Guarino, A Harto, B Pérez-García, A Royuela, P Jaén

{"title":"Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions.","authors":"M Fernández-Guarino, A Harto, B Pérez-García, A Royuela, P Jaén","doi":"10.1155/2014/849248","DOIUrl":"https://doi.org/10.1155/2014/849248","url":null,"abstract":"Background. Photodynamic therapy (PDT) has become a therapeutic option for basal cell carcinoma (BCC) in the last decade. Objectives. To study the results and predictors of BCC response to treatment with PDT and to evaluate fluorescence diagnosis of BCC. Methods. A descriptive, retrospective, and observational study was carried out. Patients with biopsy-confirmed BCC who were treated with methyl aminolevulinate and red light according to standard treatment protocols (2 sessions separated by 2 weeks, 630 nm, 37 J/cm(2), 8 minutes, Aktilite) were selected. Response was scored as clinically complete and incomplete and the patients were followed up every three months. Results. Data from 191 BCC in 181 patients with a mean age of 69.55 years and a mean follow-up period of 34.4 months were collected. The overall response was 74% of the BCC treated, with the best response in superficial BCC with a 95% of complete response. The regression analysis revealed that the superficial histological type was the primary factor predictive of a complete response. Conclusions. In the treatment of BCC with PDT, the most significant factor for predicting response is the histological type. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"849248"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/849248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32735194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Histopathological study of skin adnexal tumours-institutional study in South India. 皮肤附件肿瘤的组织病理学研究-印度南部的机构研究。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-05 DOI: 10.1155/2014/543756

Ankit Sharma, Deepak G Paricharak, Jitendra Singh Nigam, Shivani Rewri, Priyanka Bhatia Soni, Anita Omhare, Preethi Sekar

{"title":"Histopathological study of skin adnexal tumours-institutional study in South India.","authors":"Ankit Sharma, Deepak G Paricharak, Jitendra Singh Nigam, Shivani Rewri, Priyanka Bhatia Soni, Anita Omhare, Preethi Sekar","doi":"10.1155/2014/543756","DOIUrl":"https://doi.org/10.1155/2014/543756","url":null,"abstract":"Objective. The aim of this study was correlation of skin adnexal tumors with age, sex, and location and determining its incidence in the Department of Pathology at Dr. D. Y. Patil Medical College and Hospital, Kolhapur, Maharashtra. Material and Methods. 56 cases were included in this study from Jan 2004 to June 2010 with respect to incidence of adnexal tumors, age, and sex distribution. All slides were stained with haematoxylin and eosin and then findings were corroborated with special stains like PAS and reticulin wherever required. Results. 80.36% (45/56) were benign and 19.64% (11/56) were malignant adnexal tumors. The sweat gland tumors constituted the largest group (42.86% 24/56) cases followed by the hair follicle tumors (35.71%, 20/56) of cases and sebaceous gland tumors (21.43%, 12/56) cases. Overall male : female ratio was 1.07 : 1. The commonest age group was 51-60 years and the commonest affected body part was head and neck region (64.28%, 36/56) followed by trunk (14.28%, 8/56). Clear cell hidradenoma and pilomatricoma were commonest benign tumors and sebaceous carcinoma was the only malignant tumor seen. Conclusion. The incidence of benign skin adnexal tumors was more as compared to the malignant tumors. Malignant tumors were seen in older age group, usually over 50 years of age. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"543756"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/543756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32191983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Kaposi's Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis. 卡波西肉瘤相关疱疹病毒对人体皮肤细胞抗炎反应的破坏揭示了潜伏和疾病发病机制的相关性

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-17 DOI: 10.1155/2014/246076

Judith M Fontana, Justin G Mygatt, Katelyn L Conant, Chris H Parsons, Johnan A R Kaleeba

{"title":"Kaposi's Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis.","authors":"Judith M Fontana, Justin G Mygatt, Katelyn L Conant, Chris H Parsons, Johnan A R Kaleeba","doi":"10.1155/2014/246076","DOIUrl":"https://doi.org/10.1155/2014/246076","url":null,"abstract":"KSHV is the etiologic agent for Kaposi's sarcoma (KS), a neoplasm that manifests most aggressively as multifocal lesions on parts of human skin with a propensity for inflammatory reactivity. However, mechanisms that control evolution of KS from a benign hyperplasia to the histologically complex cutaneous lesion remain unknown. In this study, we found that KSHV induces proteomic and morphological changes in melanocytes and melanoma-derived cell lines, accompanied by deregulation of the endogenous anti-inflammatory responses anchored by the MC1-R/ α -MSH signaling axis. We also identified two skin-derived cell lines that displayed differences in ability to support long-term KSHV infection and mapped this dichotomy to differences in (a) NF- κ B activation status, (b) processing and expression of KSHV latency-associated nuclear antigen isoforms putatively associated with the viral lytic cycle, and (c) susceptibility to virus-induced changes in expression of key anti-inflammatory response genes that antagonize NF- κ B, including MC1-R, POMC, TRP-1, and xCT. Viral subversion of molecules that control the balance between latency and lytic replication represents a novel correlate of KSHV pathogenesis and tropism in skin and underscores the potential benefit of harnessing the endogenous anti-inflammatory processes as a therapeutic option for attenuating cutaneous KS and other proinflammatory outcomes of KSHV infection in high-risk individuals. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"246076"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/246076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32236500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens. 鉴定福尔马林固定石蜡包埋黑色素瘤和黑色素细胞痣标本中的 DLEC1 D215N 基因组突变

IF 1.1

Journal of Skin Cancer Pub Date : 2013-01-01 Epub Date: 2013-10-13 DOI: 10.1155/2013/469671

Ricardo Vieira, Maria José Simões, Susana Carmona, Conceição Egas, Carlos Faro, Américo Figueiredo

{"title":"Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens.","authors":"Ricardo Vieira, Maria José Simões, Susana Carmona, Conceição Egas, Carlos Faro, Américo Figueiredo","doi":"10.1155/2013/469671","DOIUrl":"10.1155/2013/469671","url":null,"abstract":"DLEC1 has been suggested as a tumor suppressor gene in several cancers. DLEC1 D215N somatic mutation (COSM36702) was identified in a melanoma cell line through whole genome sequencing. However, little is known about the implication and prevalence of this mutation in primary melanomas or in melanocytic nevi. The aim of this study was to genotype DLEC1 D215N mutation in melanoma tissue and melanocytic nevi samples to confirm its occurrence and to estimate its prevalence. Primary melanomas (n = 81) paired with synchronous or asynchronous metastases (n = 21) from 81 melanoma patients and melanocytic nevi (n = 28) were screened for DLEC1 D215N mutation. We found the mutation in 3 primary melanomas and in 2 melanocytic nevi, corresponding to a relatively low prevalence (3.7% and 7.1%, resp.). The pathogenic role of DLEC1 215N mutation is unclear. However, since the mutation has not been previously described in general population, its involvement in nevogenesis and melanoma progression remains a possibility to be clarified in future studies. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2013 ","pages":"469671"},"PeriodicalIF":1.1,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31859019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models. stat3在皮肤癌发生中的作用:从相关小鼠模型中获得的见解

IF 1.1

Journal of Skin Cancer Pub Date : 2013-01-01 Epub Date: 2013-03-21 DOI: 10.1155/2013/684050

Everardo Macias, Dharanija Rao, John Digiovanni

{"title":"Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models.","authors":"Everardo Macias, Dharanija Rao, John Digiovanni","doi":"10.1155/2013/684050","DOIUrl":"https://doi.org/10.1155/2013/684050","url":null,"abstract":"Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2013 ","pages":"684050"},"PeriodicalIF":1.1,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/684050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31349800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation. 皮肤鳞状细胞癌的模拟器:小活检和临床病理相关性的诊断挑战。

IF 1.1

Journal of Skin Cancer Pub Date : 2013-01-01 Epub Date: 2013-06-25 DOI: 10.1155/2013/752864

Kong-Bing Tan, Sze-Hwa Tan, Derrick Chen-Wee Aw, Huma Jaffar, Thiam-Chye Lim, Shu-Jin Lee, Yoke-Sun Lee

{"title":"Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation.","authors":"Kong-Bing Tan, Sze-Hwa Tan, Derrick Chen-Wee Aw, Huma Jaffar, Thiam-Chye Lim, Shu-Jin Lee, Yoke-Sun Lee","doi":"10.1155/2013/752864","DOIUrl":"https://doi.org/10.1155/2013/752864","url":null,"abstract":"Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2013 ","pages":"752864"},"PeriodicalIF":1.1,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/752864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31601163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48