Journal of Skin Cancer最新文献_第9页

Skin cancer knowledge, attitudes, and behaviors in collegiate athletes. 大学生运动员皮肤癌知识、态度和行为。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-03-24 DOI: 10.1155/2014/248198

Courtney Hobbs, Vinayak K Nahar, M Allison Ford, Martha A Bass, Robert T Brodell

{"title":"Skin cancer knowledge, attitudes, and behaviors in collegiate athletes.","authors":"Courtney Hobbs, Vinayak K Nahar, M Allison Ford, Martha A Bass, Robert T Brodell","doi":"10.1155/2014/248198","DOIUrl":"https://doi.org/10.1155/2014/248198","url":null,"abstract":"Outdoor athletes represent an important group at risk for skin cancer because they are routinely exposed to high levels of ultraviolet radiation. The purpose of this study was to assess current skin cancer knowledge, attitudes, and behaviors among collegiate athletes. A modified version of the Melanoma Risk Behavior Survey was completed by 343 athletes attending a Southern University in the USA, generating an 87% response rate. Survey results demonstrated that the majority of the athletes do not limit their sun exposure and reported low levels of sun protective behaviors. In addition, athletes lacked knowledge about skin cancer and sun protection. Eighty-three percent of the athletes stated that tanning beds improve one's overall health. Race was significantly associated with skin cancer knowledge, whereas, gender was found to be significantly associated with knowledge, attitudes, and behaviors towards skin cancer. Additionally, there was a significant relationship between knowledge and behavior, but not between attitude and behavior. This study highlights the need to educate athletes about the hazards of tanning to minimize UV exposure and promote sun protection habits. Moreover, athletes should be educated on the dangers of indoor tanning facilities and encouraged to avoid these facilities. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"248198"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/248198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32304850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Squamous cell carcinomas of the skin explore angiogenesis-independent mechanisms of tumour vascularization. 皮肤鳞状细胞癌探索血管生成-肿瘤血管化的独立机制。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-05-06 DOI: 10.1155/2014/651501

Ievgenia Pastushenko, Tamara Gracia-Cazaña, Sandra Vicente-Arregui, Gert G Van den Eynden, Mariano Ara, Peter B Vermeulen, Franciso José Carapeto, Steven J Van Laere

{"title":"Squamous cell carcinomas of the skin explore angiogenesis-independent mechanisms of tumour vascularization.","authors":"Ievgenia Pastushenko, Tamara Gracia-Cazaña, Sandra Vicente-Arregui, Gert G Van den Eynden, Mariano Ara, Peter B Vermeulen, Franciso José Carapeto, Steven J Van Laere","doi":"10.1155/2014/651501","DOIUrl":"10.1155/2014/651501","url":null,"abstract":"Aims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Methods. We performed CD31 (i.e., panendothelial marker) and CD105 (i.e., proliferating endothelium marker) immunostaining on samples of 70 SCCs and 70 BCCs of the skin. We evaluated the relative blood vessel area using the Chalkley counting method in each histologic subtype of these tumours. We calculated the degree of proliferation of blood vessel endothelium dividing CD105-Chalkley score by CD31-Chalkley score. Results. We found significantly higher peritumoral and intratumoral blood vessel area in SCC when compared to BCC (both with CD31 and CD105). Chalkley counts differed significantly between groups with different BCC histologic subtypes and SCC with different grade of differentiation. Surprisingly, the degree of proliferation of blood vessel endothelium was higher in BCC when compared to SCC. Conclusions. While SCC exhibited significantly higher intratumoral and peritumoral blood vessel areas compared to BCC, the relatively low rate of proliferating endothelium in this tumour type suggests the existence of endothelial-sprouting-independent mechanisms of vascularization in SCC. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"651501"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/651501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32394087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Melanocyte and melanoma cell activation by calprotectin. 钙保护蛋白激活黑素细胞和黑色素瘤细胞。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-08-12 DOI: 10.1155/2014/846249

Stephanie H Shirley, Kristine von Maltzan, Paige O Robbins, Donna F Kusewitt

{"title":"Melanocyte and melanoma cell activation by calprotectin.","authors":"Stephanie H Shirley, Kristine von Maltzan, Paige O Robbins, Donna F Kusewitt","doi":"10.1155/2014/846249","DOIUrl":"https://doi.org/10.1155/2014/846249","url":null,"abstract":"Calprotectin, a heterodimer of S100A8 and S100A9, is a proinflammatory cytokine released from ultraviolet radiation-exposed keratinocytes. Calprotectin binds to Toll-like receptor 4, the receptor for advanced glycation end-products, and extracellular matrix metalloproteinase inducer on target cells to stimulate migration. Melanocytes and melanoma cells produce little if any calprotectin, but they do express receptors for the cytokine. Thus, keratinocyte-derived calprotectin has the potential to activate melanocytes and melanoma cells within the epidermis in a paracrine manner. We examined the ability of calprotectin to stimulate proliferation and migration in normal human melanocytes and melanoma cells in vitro. We first showed, by immunofluorescence and quantitative RT-PCR, that the melanocytic cells employed expressed a calprotectin receptor, the receptor for advanced end-products. We then demonstrated that calprotectin significantly enhanced proliferation, migration, and Matrigel invasion in both normal human melanocytes and melanoma cells. Thus, calprotectin is one of the numerous paracrine factors released by ultraviolet radiation-exposed keratinocytes that may promote melanomagenesis and is a potential target for melanoma prevention or therapy. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"846249"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/846249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32648290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Decrease in Self-Reported Tanning Frequency among Utah Teens following the Passage of Utah Senate Bill 41: An Analysis of the Effects of Youth-Access Restriction Laws on Tanning Behaviors. 犹他州参议院第41号法案通过后，犹他州青少年自我报告的晒黑频率下降:青少年访问限制法律对晒黑行为的影响分析。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-08-20 DOI: 10.1155/2014/839601

Rebecca G Simmons, Kristi Smith, Meghan Balough, Michael Friedrichs

{"title":"Decrease in Self-Reported Tanning Frequency among Utah Teens following the Passage of Utah Senate Bill 41: An Analysis of the Effects of Youth-Access Restriction Laws on Tanning Behaviors.","authors":"Rebecca G Simmons, Kristi Smith, Meghan Balough, Michael Friedrichs","doi":"10.1155/2014/839601","DOIUrl":"https://doi.org/10.1155/2014/839601","url":null,"abstract":"Introduction. Adolescent use of indoor tanning facilities is associated with an increased risk in later development of melanoma skin cancers. States that have imposed age restrictions on access to indoor tanning generally show lower self-reported rates of indoor tanning than states with no restrictions, but currently no studies have assessed indoor tanning use before and after such restrictions. Methods. In 2013, we compared self-reported indoor tanning data collected in the Prevention Needs Assessment (PNA) survey in 2011 to PNA 2013 data. We also assessed predictors of continued tanning after passage of the bill. Results. Prior to the passage of Senate Bill 41, 12% of students reported at least one incident of indoor tanning in the past 12 months. After passage, only 7% of students reported indoor tanning in the past 12 months (P < 0.0001). Students who continued indoor tanning were more likely to be older and female and to engage in other risk behaviors, including smoking and alcohol use. Lower parental education levels were also associated with continued tanning. Conclusion. Indoor tanning restrictions showed beneficial impact on tanning rates in adolescents in Utah. Stricter restrictions may show even greater impact than restrictions that allow for parental waivers. Stronger enforcement of bans is needed to further reduce youth access. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"839601"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/839601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Sun Protection Beliefs among Hispanics in the US. 美国西班牙裔美国人的防晒信仰

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-11-09 DOI: 10.1155/2014/161960

Marimer Santiago-Rivas, Chang Wang, Lina Jandorf

{"title":"Sun Protection Beliefs among Hispanics in the US.","authors":"Marimer Santiago-Rivas, Chang Wang, Lina Jandorf","doi":"10.1155/2014/161960","DOIUrl":"https://doi.org/10.1155/2014/161960","url":null,"abstract":"Purpose. We reviewed the literature on sun protection beliefs in Hispanics living in the United States to explore what challenges are faced by area of research. Method. A review of PubMED, PsycINFO, and CINAHL databases was performed. Studies were published in peer-reviewed journals (in all years available) and written in English. The search terms used were [\"skin cancer\" OR \"sun protection\"] AND [\"Latino\" OR \"Hispanic\"] AND \"beliefs.\" Eligible papers were included in the final analysis after meeting the following inclusion criteria: (1) the records had to quantitatively examine and report sun protection beliefs in Hispanics, (2) the number of Hispanic participants in the sample had to be clearly specified, and (3) studies reporting differences in sun protection beliefs between Hispanics and other racial and ethnic groups were included in the review. Results. Of the 92 articles identified, 11 met inclusion criteria and addressed sun protection beliefs regarding skin cancer seriousness and susceptibility, and benefits and barriers of sun protection and skin cancer risk behaviors. Characteristics of studies and results were examined. Conclusion. There is insufficient evidence to determine a pattern of sun protection beliefs among Hispanics in the United States. More quality studies are needed which focus on sun protection beliefs in Hispanics. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"161960"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/161960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32844359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The experience of melanoma follow-up care: an online survey of patients in australia. 黑素瘤随访护理的经验:澳大利亚患者的在线调查。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-11-19 DOI: 10.1155/2014/429149

Janine Mitchell, Peta Callaghan, Jackie Street, Susan Neuhaus, Taryn Bessen

{"title":"The experience of melanoma follow-up care: an online survey of patients in australia.","authors":"Janine Mitchell, Peta Callaghan, Jackie Street, Susan Neuhaus, Taryn Bessen","doi":"10.1155/2014/429149","DOIUrl":"https://doi.org/10.1155/2014/429149","url":null,"abstract":"Investigating patients' reports on the quality and consistency of melanoma follow-up care in Australia would assist in evaluating if this care is effective and meeting patients' needs. The objective of this study was to obtain and explore the patients' account of the technical and interpersonal aspects of melanoma follow-up care received. An online survey was conducted to acquire details of patients' experience. Participants were patients treated in Australia for primary melanoma. Qualitative and quantitative data about patient perceptions of the nature and quality of their follow-up care were collected, including provision of melanoma specific information, psychosocial support, and imaging tests received. Inconsistencies were reported in the provision and quality of care received. Patient satisfaction was generally low and provision of reassurance from health professionals was construed as an essential element of quality of care. \"Gaps\" in follow-up care for melanoma patients were identified, particularly provision of adequate psychosocial support and patient education. Focus on strategies for greater consistency in the provision of support, information, and investigations received, may generate a cost dividend which could be reinvested in preventive and supportive care and benefit patient well-being. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"429149"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/429149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32931667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Saphenous vein sparing superficial inguinal dissection in lower extremity melanoma. 保留隐静脉的下肢黑色素瘤腹股沟浅夹层。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-07-13 DOI: 10.1155/2014/652123

Muhammed Beşir Oztürk, Arzu Akan, Ozay Ozkaya, Onur Egemen, Ali Rıza Oreroğlu, Turgut Kayadibi, Mithat Akan

{"title":"Saphenous vein sparing superficial inguinal dissection in lower extremity melanoma.","authors":"Muhammed Beşir Oztürk, Arzu Akan, Ozay Ozkaya, Onur Egemen, Ali Rıza Oreroğlu, Turgut Kayadibi, Mithat Akan","doi":"10.1155/2014/652123","DOIUrl":"https://doi.org/10.1155/2014/652123","url":null,"abstract":"Aim. The classic inguinal lymph node dissection is the main step for the regional control of the lower extremity melanoma, but this surgical procedure is associated with significant postoperative morbidity. The permanent lymphedema is the most devastating long-term complication leading to a significant decrease in the patient's quality of life. In this study we present our experience with modified, saphenous vein sparing, inguinal lymph node dissections for patients with melanoma of the lower extremity. Methods. Twenty one patients (10 women, 11 men) who underwent saphenous vein sparing superficial inguinal lymph node dissection for the melanoma of lower extremity were included in this study. The effects of saphenous vein sparing on postoperative complications were evaluated. Results. We have observed the decreased rate of long-term lymphedema in patients undergoing inguinal lymphadenectomy for the lower extremity melanoma. Conclusion. The inguinal lymphadenectomy with saphenous vein preservation in lower extremity melanoma patients seems to be an oncologically safe procedure and it may offer reduced long-term morbidity. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"652123"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/652123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32587967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A clinicopathological and immunohistochemical correlation in cutaneous metastases from internal malignancies: a five-year study. 内部恶性肿瘤皮肤转移的临床病理和免疫组织化学相关性:一项为期五年的研究。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-08-25 DOI: 10.1155/2014/793937

Sarita Nibhoria, Kanwardeep Kaur Tiwana, Manmeet Kaur, Sumir Kumar

{"title":"A clinicopathological and immunohistochemical correlation in cutaneous metastases from internal malignancies: a five-year study.","authors":"Sarita Nibhoria, Kanwardeep Kaur Tiwana, Manmeet Kaur, Sumir Kumar","doi":"10.1155/2014/793937","DOIUrl":"https://doi.org/10.1155/2014/793937","url":null,"abstract":"Cutaneous metastases from internal malignancies are uncommon and occur in 0.6%–10.4% of all patients with cancer. In most cases, cutaneous metastases develop after the initial diagnosis of the primary internal malignancy and late in the course of the disease. Skin tumors are infrequent in Asian population and cutaneous metastases are quite rare. Cutaneous metastases carry a poor prognosis with average survival of few months. In the present five-year study 1924 malignant tumors were screened which included only nine cases of cutaneous metastatic deposits. A wide range of site and clinical presentations including nodules, plaques, and ulcers was noted. Histopathological findings were significant and corresponded with the primary internal malignancy. Cutaneous metastases from breast carcinoma (44.4%) were the most common finding followed by non-Hodgkin lymphoma and renal cell carcinoma (22.2% each) and carcinoma cervix (11.1%). The aim of our study is to classify the cutaneous metastases and to evaluate their clinicopathologic and immunohistochemical correlation with the primary tumor.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"793937"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/793937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32662842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Gene expression differences predict treatment outcome of merkel cell carcinoma patients. 基因表达差异预测默克尔细胞癌患者的治疗结果。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-01-30 DOI: 10.1155/2014/596459

Loren Masterson, Bryan J Thibodeau, Laura E Fortier, Timothy J Geddes, Barbara L Pruetz, Rajwant Malhotra, Richard Keidan, George D Wilson

{"title":"Gene expression differences predict treatment outcome of merkel cell carcinoma patients.","authors":"Loren Masterson, Bryan J Thibodeau, Laura E Fortier, Timothy J Geddes, Barbara L Pruetz, Rajwant Malhotra, Richard Keidan, George D Wilson","doi":"10.1155/2014/596459","DOIUrl":"https://doi.org/10.1155/2014/596459","url":null,"abstract":"Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical. This study aimed to identify biomarkers with prognostic significance. While sixty-two patients were identified who were treated for MCC at our institution, only seventeen patients had adequate formalin-fixed paraffin-embedded archival tissue and followup to be included in the study. Patients were stratified into good, moderate, or poor prognosis. Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays. Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis. Immunohistochemistry further established that keratin 20 was overexpressed in the poor prognosis tumors. In addition, novel genes of interest such as phospholipase A2 group X, kinesin family member 3A, tumor protein D52, mucin 1, and KIT were upregulated in specimens from patients with poor prognosis. Our pilot study identified several gene expression differences which could be used in the future as prognostic biomarkers in MCC patients. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"596459"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/596459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32179811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The pink rim sign: location of pink as an indicator of melanoma in dermoscopic images. 粉红色边缘标志:在皮肤镜图像中，粉红色作为黑色素瘤的指示。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-03 DOI: 10.1155/2014/719740

Ryan K Rader, Katie S Payne, Uday Guntupalli, Harold S Rabinovitz, Maggie C Oliviero, Rhett J Drugge, Joseph J Malters, William V Stoecker

{"title":"The pink rim sign: location of pink as an indicator of melanoma in dermoscopic images.","authors":"Ryan K Rader, Katie S Payne, Uday Guntupalli, Harold S Rabinovitz, Maggie C Oliviero, Rhett J Drugge, Joseph J Malters, William V Stoecker","doi":"10.1155/2014/719740","DOIUrl":"https://doi.org/10.1155/2014/719740","url":null,"abstract":"Background. In dermoscopic images, multiple shades of pink have been described in melanoma without specifying location of these areas within the lesion. Objective. The purpose of this study was to determine the statistics for the presence of centrally and peripherally located pink melanoma and benign melanocytic lesions. Methods. Three observers, untrained in dermoscopy, each retrospectively analyzed 1290 dermoscopic images (296 melanomas (170 in situ and 126 invasive), 994 benign melanocytic nevi) and assessed the presence of any shade of pink in the center and periphery of the lesion. Results. Pink was located in the peripheral region in 14.5% of melanomas and 6.3% of benign melanocytic lesions, yielding an odds ratio of 2.51 (95% CI: 1.7-3.8, P < 0.0001). Central pink was located in 12.8% of melanomas and 21.8% of benign lesions, yielding an odds ratio of 0.462 (95% CI: 0.67, P = 0.204). Pink in melanoma in situ tended to be present throughout the lesion (68% of pink lesions). Pink in invasive melanoma was present in 17% of cases, often presenting as a pink rim. Conclusions. The presence of pink in the periphery or rim of a dermoscopic melanocytic lesion image provides an indication of malignancy. We offer the \"pink rim sign\" as a clue to the dermoscopic diagnosis of invasive melanoma. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"719740"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/719740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32184641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12