Journal of Skin Cancer最新文献_第8页

Prognostic value of melanoma inhibitory activity protein in localized cutaneous malignant melanoma. 黑色素瘤抑制活性蛋白在局部皮肤恶性黑色素瘤中的预后价值。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-06-22 DOI: 10.1155/2014/843214

Angela Sandru, Eugenia Panaitescu, Silviu Voinea, Madalina Bolovan, Adina Stanciu, Sabin Cinca, Alexandru Blidaru

{"title":"Prognostic value of melanoma inhibitory activity protein in localized cutaneous malignant melanoma.","authors":"Angela Sandru, Eugenia Panaitescu, Silviu Voinea, Madalina Bolovan, Adina Stanciu, Sabin Cinca, Alexandru Blidaru","doi":"10.1155/2014/843214","DOIUrl":"https://doi.org/10.1155/2014/843214","url":null,"abstract":"Background. Cutaneous malignant melanoma (CMM) is a heterogeneous disease, acknowledged for its lack of predictability regarding clinical evolution. In order to appreciate a patient's individual prognosis, an attempt is made to find new tumor markers that parallel the disease progression. Objective. To identify if melanoma inhibitory activity (MIA) protein could represent a tool for selecting high risk early stages melanoma patients. Method. Between 2008 and 2013, 155 patients with CMM were treated in our clinic. 84 of them were classified into stages I and II, according to TNM 2009. MIA serum concentration was measured in all patients and 50 healthy donors. A cut-off value of 9.4 ng/ml was established using the ROC curve. Results. All patients were followed up by periodic investigations every 6 months. We have noticed that 66% of patients with MIA serum values at diagnosis greater than 9.4 ng/mL have relapsed, while only 5% of patients with MIA serum concentration below the estimated threshold, recurred during the follow-up period (P = 0.000). The death risk was 12 times higher in pathological MIA group of patients (P = 0.0001). Conclusions. Our data suggest that MIA is an independent prognostic factor for patients with localized CMM. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"843214"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/843214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32520027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The influence of the coexpression of CD4 and CD8 in cutaneous lesions on prognosis of mycosis fungoides: a preliminary study. 皮肤病变组织中CD4和CD8共表达对蕈样真菌病预后影响的初步研究

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-07-20 DOI: 10.1155/2014/624143

Sergio Umberto De Marchi, Giuseppe Stinco, Enzo Errichetti, Serena Bonin, Nicola di Meo, Giusto Trevisan

{"title":"The influence of the coexpression of CD4 and CD8 in cutaneous lesions on prognosis of mycosis fungoides: a preliminary study.","authors":"Sergio Umberto De Marchi, Giuseppe Stinco, Enzo Errichetti, Serena Bonin, Nicola di Meo, Giusto Trevisan","doi":"10.1155/2014/624143","DOIUrl":"https://doi.org/10.1155/2014/624143","url":null,"abstract":"Background. Although techniques of immunophenotyping have been successful in characterizing the cells in the cutaneous infiltrates of mycosis fungoides little evidence suggests that variations in the phenotypic characterization correlate with prognosis. Objectives. In a preliminary prospective, single-centre, study we correlated the T-cell phenotype in cutaneous biopsies with the progression of the disease to determine whether the coexpression of CD4 and CD8 has an impact on prognosis. Methods. Skin biopsy specimens from 30 newly diagnosed patients were stained with immunoperoxidase techniques to determine their phenotypic characteristics. After a median followup of 42 months patients were divided into two groups with stable and progressive disease. Results. Eighteen patients had the conventional CD4+CD8- T-cell phenotype. Ten patients showed the coexpression of CD4 and CD8 and had a slightly lower rate of progressive disease. Conclusions. The coexpression of CD4 and CD8 in cutaneous lesions is not rare and is associated with a slightly lower rate of progressive disease. Since double positive CD4/CD8 phenotype is rarely reported in mycosis fungoides the presence on conventional immunophenotyping of both CD may be due to a \"mixture\" of neoplastic cells and inflammatory CD8+ tumor infiltrating lymphocytes. Immunohistochemical study combined with confocal microscopy could clarify this issue. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"624143"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/624143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32602862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Characterization of the Merkel Cell Carcinoma miRNome. 默克尔细胞癌miRNome的特征分析。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-03 DOI: 10.1155/2014/289548

Matthew S Ning, Annette S Kim, Nripesh Prasad, Shawn E Levy, Huiqiu Zhang, Thomas Andl

{"title":"Characterization of the Merkel Cell Carcinoma miRNome.","authors":"Matthew S Ning, Annette S Kim, Nripesh Prasad, Shawn E Levy, Huiqiu Zhang, Thomas Andl","doi":"10.1155/2014/289548","DOIUrl":"https://doi.org/10.1155/2014/289548","url":null,"abstract":"MicroRNAs have been implicated in various skin cancers, including melanoma, squamous cell carcinoma, and basal cell carcinoma; however, the expression of microRNAs and their role in Merkel cell carcinoma (MCC) have yet to be explored in depth. To identify microRNAs specific to MCC (MCC-miRs), next-generation sequencing (NGS) of small RNA libraries was performed on different tissue samples including MCCs, other cutaneous tumors, and normal skin. Comparison of the profiles identified several microRNAs upregulated and downregulated in MCC. For validation, their expression was measured via qRT-PCR in a larger group of MCC and in a comparison group of non-MCC cutaneous tumors and normal skin. Eight microRNAs were upregulated in MCC: miR-502-3p, miR-9, miR-7, miR-340, miR-182, miR-190b, miR-873, and miR-183. Three microRNAs were downregulated: miR-3170, miR-125b, and miR-374c. Many of these MCC-miRs, the miR-183/182/96a cistron in particular, have connections to tumorigenic pathways implicated in MCC pathogenesis. In situ hybridization confirmed that the highly expressed MCC-miR, miR-182, is localized within tumor cells. Furthermore, NGS and qRT-PCR reveal that several of these MCC-miRs are highly expressed in the patient-derived MCC cell line, MS-1. These data indicate that we have identified a set of MCC-miRs with important implications for MCC research. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"289548"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/289548","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32176417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Assessing the current market of sunscreen: a cross-sectional study of sunscreen availability in three metropolitan counties in the United States. 评估当前的防晒霜市场:美国三个大都市县防晒霜可用性的横断面研究。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-05-15 DOI: 10.1155/2014/285357

Kyle T Amber, Romi Bloom, Patrick Staropoli, Sonam Dhiman, Shasa Hu

{"title":"Assessing the current market of sunscreen: a cross-sectional study of sunscreen availability in three metropolitan counties in the United States.","authors":"Kyle T Amber, Romi Bloom, Patrick Staropoli, Sonam Dhiman, Shasa Hu","doi":"10.1155/2014/285357","DOIUrl":"https://doi.org/10.1155/2014/285357","url":null,"abstract":"Sunscreen use is recommended for the prevention of sunburn and skin cancer. Little is known regarding sunscreen availability in high versus low income communities. We analyzed sunscreen availability in three large metropolitan counties to determine the relationship between availability and community demographics. We included sun care products in all pharmacies and supermarkets open as of July 2013 in representative high and low income zip codes in Cook County, Illinois, Miami-Dade County, Florida, and San Diego County, California. We recorded the percentage of tanning oil, sunscreens with a sun protection factor (SPF) < 15, SPF > 15, physical sunscreens, spray sunscreens, mean price per ounce (PPO), and mean SPF. Of the total products assessed, 11.0% were tanning oils, with physical sunscreens accounting for only 3.4% of the available sunscreens and 46.2% of sunscreens being spray-on. A comparison between higher and lower income zip codes demonstrated a significantly increased percentage of sunscreens with SPF < 15 in high income zip codes. Lower income zip codes had higher percentages of sunscreens with SPF > 15 and higher PPO, even when taking into account SPF. Further studies of sunscreen usage patterns in different populations must take into account sunscreen availability and price, as these significantly differ based on the community demographic. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"285357"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/285357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32447484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Basal cell carcinoma of the head and neck region: a retrospective analysis of completely excised 331 cases. 头颈部基底细胞癌：对完全切除的 331 例病例的回顾性分析。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-04-17 DOI: 10.1155/2014/858636

Duriye Deniz Demirseren, Candemir Ceran, Berrak Aksam, Mustafa Erol Demirseren, Ahmet Metin

{"title":"Basal cell carcinoma of the head and neck region: a retrospective analysis of completely excised 331 cases.","authors":"Duriye Deniz Demirseren, Candemir Ceran, Berrak Aksam, Mustafa Erol Demirseren, Ahmet Metin","doi":"10.1155/2014/858636","DOIUrl":"10.1155/2014/858636","url":null,"abstract":"The aim of the study is to analyze all completely excised BCCs in the head and neck region with regard to age, sex, personal and familial history, skin type, tumor localization and size, histopathological subtype of tumor, reconstruction method, and recurrence rates. Incompletely excised BCCs were not included in this study since incomplete excision is the most important preventable risk factor for recurrence. In 320 patients, 331 lesions were retrospectively evaluated by dividing into the following 8 subunits: scalp, frontotemporal, orbital, nose, cheek, auricula, perioral, and chin-neck area. Most of the patients were in 60-70 age group (34.7%). The nose (32.3%) was the most common site of presentation. Clinically, all lesions and, histopathologically, most of the lesions (42.2%) presented were of the nodular type. All cases of recurrence after complete excision (n = 9, 2.7%) were located in the median parts of the head and neck region and were mainly diagnosed histopathologically as sclerotic and micronodular. Even though completely excised, head and neck region BCCs, especially which are more prone to recurrence due to anatomical and histopathological properties, should be more closely monitored in order to decrease morbidity and health care costs. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"858636"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32370553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of second cancers in merkel cell carcinoma: a meta-analysis of population based cohort studies. 默克尔细胞癌的第二癌风险:基于人群队列研究的荟萃分析。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-12-10 DOI: 10.1155/2014/184245

Anshul Saxena, Muni Rubens, Venkataraghavan Ramamoorthy, Hafiz Khan

{"title":"Risk of second cancers in merkel cell carcinoma: a meta-analysis of population based cohort studies.","authors":"Anshul Saxena, Muni Rubens, Venkataraghavan Ramamoorthy, Hafiz Khan","doi":"10.1155/2014/184245","DOIUrl":"https://doi.org/10.1155/2014/184245","url":null,"abstract":"The risk of second cancers in Merkel cell carcinoma (MCC) remains uncertain since risk estimates vary worldwide. The global MCC population is growing and there is a demand for better knowledge of prognosis of this disease. The Cochrane Database of Systematic Reviews, MEDLINE, and EMBASE search engines were searched for the relevant literature between January 1999 and September 2014 by use of explicit search criteria. The main outcome was second malignancies associated with MCC patients measured by standardized incidence ratios (SIRs) or other estimates of risks. Five papers fulfilled the inclusion criteria and reported SIRs of second cancer in MCC which varied from 1.07 to 2.80. Performing meta-analysis using random effects model revealed that there was an increased risk for second malignancies due to MCC (SIR, 1.52; 95% CI, 1.10-2.11). There was a significant increase in risk for malignant melanoma (SIR, 3.09; 95% CI, 2.02-4.73) as compared to all common second malignancies among the studies. Updated knowledge about risk of second malignancies in MCC will help in better assessment of the disease prognosis and will help in optimizing the medical and surgical treatment, radiotherapy, follow-up, and surveillance procedures. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"184245"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/184245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32963657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Sun-tanning perceptions of a new zealand urban population (1994-2005/6). 新西兰城市人口对太阳晒黑的看法(1994-2005/6)。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-02-10 DOI: 10.1155/2014/135473

A I Reeder, G F H McLeod, A R Gray, R McGee

{"title":"Sun-tanning perceptions of a new zealand urban population (1994-2005/6).","authors":"A I Reeder, G F H McLeod, A R Gray, R McGee","doi":"10.1155/2014/135473","DOIUrl":"https://doi.org/10.1155/2014/135473","url":null,"abstract":"Background. Sun-tanning perceptions are monitored to identify changes and help refine targeting of skin cancer prevention messages. Aim. To investigate associations between perceptions of sun-tanning and demographic factors among a New Zealand urban population, 1994-2006. Methods. A telephone survey series was conducted during summer in 1994, 1997, 1999/2000, 2002/2003, and 2005/2006. Demographic and personal information (sex, age group, skin sun-sensitivity, and self-defined ethnicity) obtained from 6,195 respondents, 50.2% female, 15-69 years, was investigated in relation to six sun-tanning related statements. A total \"positive perceptions of tanning\" (ProTan) score was also calculated. Regression analyses modelled each component and the ProTan score against survey year and respondent characteristics. Results. Statistically significantly higher ProTan scores were found for age group (strong reverse dose-response effect), male sex, residence (highest in Auckland), ethnicity (highest among Europeans), and sun sensitivity (an n-shaped association). There was no statistically significant change in total ProTan scores from baseline. Conclusions. The development, pretesting, and evaluation of messages for those groups most likely to endorse ProTan statements should be considered for the New Zealand skin cancer prevention program. To achieve and embed significant change, mass media campaigns may require greater intensity and reinforcement with sustained contextual support for settings-based behavioural change. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"135473"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/135473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32200117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Skin cancer knowledge, attitudes, and behaviors in collegiate athletes. 大学生运动员皮肤癌知识、态度和行为。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-03-24 DOI: 10.1155/2014/248198

Courtney Hobbs, Vinayak K Nahar, M Allison Ford, Martha A Bass, Robert T Brodell

{"title":"Skin cancer knowledge, attitudes, and behaviors in collegiate athletes.","authors":"Courtney Hobbs, Vinayak K Nahar, M Allison Ford, Martha A Bass, Robert T Brodell","doi":"10.1155/2014/248198","DOIUrl":"https://doi.org/10.1155/2014/248198","url":null,"abstract":"Outdoor athletes represent an important group at risk for skin cancer because they are routinely exposed to high levels of ultraviolet radiation. The purpose of this study was to assess current skin cancer knowledge, attitudes, and behaviors among collegiate athletes. A modified version of the Melanoma Risk Behavior Survey was completed by 343 athletes attending a Southern University in the USA, generating an 87% response rate. Survey results demonstrated that the majority of the athletes do not limit their sun exposure and reported low levels of sun protective behaviors. In addition, athletes lacked knowledge about skin cancer and sun protection. Eighty-three percent of the athletes stated that tanning beds improve one's overall health. Race was significantly associated with skin cancer knowledge, whereas, gender was found to be significantly associated with knowledge, attitudes, and behaviors towards skin cancer. Additionally, there was a significant relationship between knowledge and behavior, but not between attitude and behavior. This study highlights the need to educate athletes about the hazards of tanning to minimize UV exposure and promote sun protection habits. Moreover, athletes should be educated on the dangers of indoor tanning facilities and encouraged to avoid these facilities. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"248198"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/248198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32304850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Squamous cell carcinomas of the skin explore angiogenesis-independent mechanisms of tumour vascularization. 皮肤鳞状细胞癌探索血管生成-肿瘤血管化的独立机制。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-05-06 DOI: 10.1155/2014/651501

Ievgenia Pastushenko, Tamara Gracia-Cazaña, Sandra Vicente-Arregui, Gert G Van den Eynden, Mariano Ara, Peter B Vermeulen, Franciso José Carapeto, Steven J Van Laere

{"title":"Squamous cell carcinomas of the skin explore angiogenesis-independent mechanisms of tumour vascularization.","authors":"Ievgenia Pastushenko, Tamara Gracia-Cazaña, Sandra Vicente-Arregui, Gert G Van den Eynden, Mariano Ara, Peter B Vermeulen, Franciso José Carapeto, Steven J Van Laere","doi":"10.1155/2014/651501","DOIUrl":"10.1155/2014/651501","url":null,"abstract":"Aims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Methods. We performed CD31 (i.e., panendothelial marker) and CD105 (i.e., proliferating endothelium marker) immunostaining on samples of 70 SCCs and 70 BCCs of the skin. We evaluated the relative blood vessel area using the Chalkley counting method in each histologic subtype of these tumours. We calculated the degree of proliferation of blood vessel endothelium dividing CD105-Chalkley score by CD31-Chalkley score. Results. We found significantly higher peritumoral and intratumoral blood vessel area in SCC when compared to BCC (both with CD31 and CD105). Chalkley counts differed significantly between groups with different BCC histologic subtypes and SCC with different grade of differentiation. Surprisingly, the degree of proliferation of blood vessel endothelium was higher in BCC when compared to SCC. Conclusions. While SCC exhibited significantly higher intratumoral and peritumoral blood vessel areas compared to BCC, the relatively low rate of proliferating endothelium in this tumour type suggests the existence of endothelial-sprouting-independent mechanisms of vascularization in SCC. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"651501"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/651501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32394087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Melanocyte and melanoma cell activation by calprotectin. 钙保护蛋白激活黑素细胞和黑色素瘤细胞。

IF 1.1

Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-08-12 DOI: 10.1155/2014/846249

Stephanie H Shirley, Kristine von Maltzan, Paige O Robbins, Donna F Kusewitt

{"title":"Melanocyte and melanoma cell activation by calprotectin.","authors":"Stephanie H Shirley, Kristine von Maltzan, Paige O Robbins, Donna F Kusewitt","doi":"10.1155/2014/846249","DOIUrl":"https://doi.org/10.1155/2014/846249","url":null,"abstract":"Calprotectin, a heterodimer of S100A8 and S100A9, is a proinflammatory cytokine released from ultraviolet radiation-exposed keratinocytes. Calprotectin binds to Toll-like receptor 4, the receptor for advanced glycation end-products, and extracellular matrix metalloproteinase inducer on target cells to stimulate migration. Melanocytes and melanoma cells produce little if any calprotectin, but they do express receptors for the cytokine. Thus, keratinocyte-derived calprotectin has the potential to activate melanocytes and melanoma cells within the epidermis in a paracrine manner. We examined the ability of calprotectin to stimulate proliferation and migration in normal human melanocytes and melanoma cells in vitro. We first showed, by immunofluorescence and quantitative RT-PCR, that the melanocytic cells employed expressed a calprotectin receptor, the receptor for advanced end-products. We then demonstrated that calprotectin significantly enhanced proliferation, migration, and Matrigel invasion in both normal human melanocytes and melanoma cells. Thus, calprotectin is one of the numerous paracrine factors released by ultraviolet radiation-exposed keratinocytes that may promote melanomagenesis and is a potential target for melanoma prevention or therapy. ","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2014 ","pages":"846249"},"PeriodicalIF":1.1,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/846249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32648290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13