The influence of the coexpression of CD4 and CD8 in cutaneous lesions on prognosis of mycosis fungoides: a preliminary study.

IF 1.2 Q3 DERMATOLOGY
Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-07-20 DOI:10.1155/2014/624143
Sergio Umberto De Marchi, Giuseppe Stinco, Enzo Errichetti, Serena Bonin, Nicola di Meo, Giusto Trevisan
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引用次数: 8

Abstract

Background. Although techniques of immunophenotyping have been successful in characterizing the cells in the cutaneous infiltrates of mycosis fungoides little evidence suggests that variations in the phenotypic characterization correlate with prognosis. Objectives. In a preliminary prospective, single-centre, study we correlated the T-cell phenotype in cutaneous biopsies with the progression of the disease to determine whether the coexpression of CD4 and CD8 has an impact on prognosis. Methods. Skin biopsy specimens from 30 newly diagnosed patients were stained with immunoperoxidase techniques to determine their phenotypic characteristics. After a median followup of 42 months patients were divided into two groups with stable and progressive disease. Results. Eighteen patients had the conventional CD4+CD8- T-cell phenotype. Ten patients showed the coexpression of CD4 and CD8 and had a slightly lower rate of progressive disease. Conclusions. The coexpression of CD4 and CD8 in cutaneous lesions is not rare and is associated with a slightly lower rate of progressive disease. Since double positive CD4/CD8 phenotype is rarely reported in mycosis fungoides the presence on conventional immunophenotyping of both CD may be due to a "mixture" of neoplastic cells and inflammatory CD8+ tumor infiltrating lymphocytes. Immunohistochemical study combined with confocal microscopy could clarify this issue.

皮肤病变组织中CD4和CD8共表达对蕈样真菌病预后影响的初步研究
背景。尽管免疫表型技术已经成功地表征了真菌样真菌病皮肤浸润细胞,但很少有证据表明表型特征的变化与预后相关。目标。在一项初步的前瞻性单中心研究中,我们将皮肤活检中的t细胞表型与疾病进展联系起来,以确定CD4和CD8的共表达是否对预后有影响。方法。采用免疫过氧化物酶技术对30例新诊断患者的皮肤活检标本进行染色,以确定其表型特征。中位随访42个月后,将患者分为病情稳定和进展两组。结果。18例患者具有常规CD4+CD8- t细胞表型。10例患者出现CD4和CD8共表达,病情进展率略低。结论。CD4和CD8在皮肤病变中的共表达并不罕见,且与疾病进展率稍低相关。由于双阳性CD4/CD8表型在蕈样真菌病中很少报道,两种CD在常规免疫表型上的存在可能是由于肿瘤细胞和炎性CD8+肿瘤浸润淋巴细胞的“混合”。免疫组织化学联合共聚焦显微镜研究可以澄清这一问题。
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来源期刊
Journal of Skin Cancer
Journal of Skin Cancer DERMATOLOGY-
CiteScore
2.30
自引率
18.20%
发文量
12
审稿时长
21 weeks
期刊介绍: Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.
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