Use of Intraoperative Frozen Section in the Surgical Management of Patients with Nonmelanoma Skin Cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-11-01 eCollection Date: 2021-01-01 DOI:10.1155/2021/4944570

LiAnn Loh, Priya Tiwari, Jingtzer Lee, O-Wern Low, Vigneswaran Nallathamby, Hanjing Lee, Jane Lim, Thiam Chye Lim, Yan Lin Yap

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引用次数: 3

Abstract

Background: Intraoperative frozen section (IFS) is often utilised in the surgical treatment of nonmelanocytic skin cancer (NMSC) in sensitive facial regions when Mohs micrographic surgery (MMS) is not available.

Objective: To compare the outcome of NMSC patients with excision performed with and without IFS.

Materials and methods: A retrospective, single-centre study was performed on all patients who had undergone resection of NMSC with and without IFS control at the National University Hospital (NUH) from 2010 to 2015.

Results: 116 patients were recruited, of which 86 had IFS and 30 did not. The complete excision rate of patients with IFS was higher at 87.2% (p=0.0194), need for secondary operation was lower at 1.2% (p=0.005), and need for postsurgery radiotherapy or chemotherapy was lower at 1.2% (p=0.001). The average duration of surgery in patients who underwent IFS was 95.4 minutes compared to 70.1 minutes in cases which did not undergo IFS.

Conclusion: Our study showed an increased complete excision rate and reduced need for secondary surgeries and adjuvant therapy in patients with IFS. However, a longer operative duration was required. Use of IFS may be useful in patients with NMSC lesions in sensitive regions requiring complex reconstruction after tumour excision.

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术中冷冻切片在非黑色素瘤皮肤癌患者手术治疗中的应用。

背景:术中冷冻切片(IFS)常用于敏感面部区域非黑素细胞皮肤癌(NMSC)的手术治疗，当莫氏显微摄影手术(MMS)不可用时。目的:比较有IFS和没有IFS的NMSC患者的预后。材料和方法:2010年至2015年，在国立大学医院(NUH)进行了一项回顾性、单中心研究，研究对象是所有在有和没有IFS对照的情况下接受了NMSC切除术的患者。结果:招募了116例患者，其中86例有IFS, 30例无IFS。IFS患者的完全切除率较高，为87.2% (p=0.0194)，二次手术需求较低，为1.2% (p=0.005)，术后放疗或化疗需求较低，为1.2% (p=0.001)。接受IFS的患者平均手术时间为95.4分钟，而未接受IFS的患者平均手术时间为70.1分钟。结论:我们的研究表明，IFS患者的完全切除率增加，二次手术和辅助治疗的需求减少。然而，需要更长的手术时间。对于肿瘤切除后需要复杂重建的敏感区域的NMSC病变患者，使用IFS可能是有用的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.