Journal of Skin Cancer最新文献

{"title":"Squamous Cell Carcinoma Arising from Chronic Osteomyelitis in the Extremities: Treatment Approach and Oncological Outcomes-A Systematic Review of the Literature.","authors":"Mayte Bryce-Alberti,&nbsp;M R Gonzalez,&nbsp;Andres Quevedo-Ramirez,&nbsp;Juan Pretell-Mazzini","doi":"10.1155/2022/2671420","DOIUrl":"10.1155/2022/2671420","url":null,"abstract":"<p><strong>Aims: </strong>In chronic osteomyelitis-derived squamous cell carcinoma, what are the demographic and clinical variables, risk factors associated with worse outcomes, and results of treatment modalities used?</p><p><strong>Methods: </strong>A systematic review was performed using PubMed and EMBASE. Articles were evaluated for inclusion and exclusion criteria, and for quality analysis. PRISMA guidelines were applied. Demographic and clinical data and therapeutic approaches were presented narratively and in descriptive statistics registered at PROSPERO.</p><p><strong>Results: </strong>Most patients were male (40/49), trauma was the most common etiology (27/36), and about half of all SCC were in the tibia (25/48). Amputation was the main definitive treatment (42/47). Adjuvant treatments were not analyzed. Well-differentiated SCC accounted for 58.3% (21/36) of all tumors. Bone invasion was described in 82.8% (24/29); recurrence, in 7.7% (3/39); and metastasis, in 7.7% (3/39). Recurrence and metastasis occurred more frequently when bone invasion was present (<i>p</i> = 0.578 and <i>p</i> = 0.646, respectively). SCC with lymph node involvement showed a higher tendency to metastasize (<i>p</i> = 0.377). Compared with limb salvage, amputation was associated with a tendency for less recurrence (<i>p</i> = 0.312) and longer survival (<i>p</i> = 0.219).</p><p><strong>Conclusions: </strong>COM-derived SCC mostly occurs after trauma and is usually located in the tibia. Bone invasion is common, and patients predominantly undergo amputation. This treatment is associated with a trend toward higher survival, compared to limb salvage.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"2022 ","pages":"2671420"},"PeriodicalIF":1.1,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Characteristics of Cutaneous Melanoma in Isfahan, Iran, from 2013 to 2018.","authors":"Zahra Malakoutikhah,&nbsp;Fatemeh Mohaghegh,&nbsp;Siavash Karimi,&nbsp;Parvin Rajabi,&nbsp;Elham T Tabatabaei","doi":"10.1155/2022/4490648","DOIUrl":"https://doi.org/10.1155/2022/4490648","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the histopathological characteristics of cutaneous melanoma in Isfahan from 2013 to 2018, according to histopathological subtype, lesions location, Clark level, and Breslow thickness.</p><p><strong>Methods: </strong>A descriptive, retrospective study in reports of Alzahra Hospital and Dr. Rajabi Pathology Laboratory in Isfahan.</p><p><strong>Results: </strong>In total, 45 patients were included in this study. The most prevalent histopathological subtype was acral lentiginous melanoma (48.89%), followed by lentigo maligna melanoma (17.78%), nodular melanoma (11.11%), and superficial spreading melanoma (8.89%). Most malignant lesions were on the foot and toes (31.1%) and face (24.4%). Tumor invasion level was mainly at Clark level IV (42.2%). Furthermore, the mean depth of tumor penetration (Breslow thickness) was 3.87 ± 3.35.</p><p><strong>Conclusions: </strong>Our study revealed the characteristics of melanoma in the Iranian population. Our results showed a similar trend with previous studies in the Asian population. Further investigations are needed to elucidate the role of ethnic and environmental risk factors for developing melanoma in different populations.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":" ","pages":"4490648"},"PeriodicalIF":1.1,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40382122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Squamous and Basal Cell Carcinomas in African Albino Skin Cancer Lesions: A Systematic Review and Meta-Analysis of Proportion.","authors":"Nnaemeka T Onyishi,&nbsp;Samuel R Ohayi","doi":"10.1155/2022/5014610","DOIUrl":"https://doi.org/10.1155/2022/5014610","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the prevalence of cutaneous SCC and BCC in all histologically confirmed skin cancer lesions in African albinos.The following five databases are as follows: African Journals Online (AJOL), PubMed, Europe PMC, and Google Scholar were searched for relevant articles. Study Selection: included studies were case series and cross-sectional studies of histologically confirmed skin cancers in African albinos. Data extraction and synthesis: data extraction and synthesis was informed by the meta-analysis of observational studies in epidemiology guideline. By random effect meta-analysis, we calculated the pooled prevalence of SCC and BCC in skin cancer lesions of the African albinos.</p><p><strong>Result: </strong>We abstracted 695 skin cancer lesions from 540 African albinos (275 male and 241 female albinos with sex not stated in 24 subjects). There were 419 SCCs and 249 BCCs. By meta-analysis, the pooled prevalence of SCC is 64% (95% CI; 50-77%). The prevalence for BCC is 31% (95% CI; 19-45%).</p><p><strong>Conclusion: </strong>Overall, squamous cell carcinoma is the predominant type of keratinocyte carcinoma reported in African albinos. SCC is preponderant in case series of surgical excision biopsies while BCC predominates in studies reporting on albino skin surveillance programmes.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":" ","pages":"5014610"},"PeriodicalIF":1.1,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33454878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interest and Utility of <i>MC1R</i> Testing for Melanoma Risk in Dermatology Patients with a History of Nonmelanoma Skin Cancer.","authors":"Jennifer L Hay, Erica H Lee, Stephanie N Christian, Elizabeth Schofield, Jada G Hamilton, Ciyu Yang, Bobak Hedayati, Keimya Sadeghi, Mark E Robson, Allan Halpern, Liying Zhang, Irene Orlow","doi":"10.1155/2022/4046554","DOIUrl":"10.1155/2022/4046554","url":null,"abstract":"<p><p>Public access to genetic information is increasing, and community dermatologists may progressively encounter patients interested in genetic testing for melanoma risk. Clarifying potential utility will help plan for this inevitability. We determined interest and uptake of genetic risk feedback based on melanocortin receptor gene (<i>MC1R</i>) variants, immediate (two weeks) responses to risk feedback, and test utility at three months in patients (age ≥ 18, with a history of nonmelanoma skin cancer). Participants (<i>N</i> = 50) completed a baseline survey and were invited to consider <i>MC1R</i> testing via the study website. Testing interest and uptake were assessed through registration of test decision, request of a saliva test kit, and kit return (all yes/no). Immediate responses to risk feedback included feedback-relevant thoughts, emotions, communication, and information seeking after result receipt; test utility outcomes included family and physician communication and information seeking. Results indicated good retention at both time points (76%; 74%). Half (48%) logged onto the study website, and of these, most (92%) chose testing and (95%) returned a saliva sample. After two weeks, most (94%) had read all the risk feedback information and distress was low (<i>M</i> = 8.81, 7-28, SD = 2.23). Many (69%) had talked with their family about the results. By three months, most had spoken with family (92%) and physicians (80%) about skin cancer risk. Physician communication was higher (70%) in those tested versus those not tested (40%, <i>p</i> = 0.02). The substantial interest and promising outcomes associated with <i>MC1R</i> genetic testing in dermatology patients inform intervention strategies to enhance benefits and minimize risks of skin cancer genetic testing.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":" ","pages":"4046554"},"PeriodicalIF":0.9,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40692497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Risk and Responses to Tanning Bed Warning Labels: A Pilot Study.","authors":"John M McGrath,&nbsp;Harry Wallace","doi":"10.1155/2022/1090619","DOIUrl":"https://doi.org/10.1155/2022/1090619","url":null,"abstract":"<p><p>Tanning bed use has been linked to increases in skin cancer among young women. Although a causal relationship between ultraviolet radiation emitted by tanning beds and melanoma is well established, it is unclear if tanning bed users are aware of the risk and how they would respond to a warning message. Two hundred and ten women aged 16-29 who had used a tanning bed at least once in the last year were asked about their perceptions of risk and their responses to a warning label. Participants were already aware that tanning beds could cause cancer, but after viewing a warning label, most people said they would stop or reduce their tanning bed use. Reactions to a prototype warning label were encouraging and future research should pursue the possibility that current guidelines for tanning bed warning labels may need to be revised.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":" ","pages":"1090619"},"PeriodicalIF":1.1,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40670390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Photoaging Intervention Delivered to Adolescents in Secondary Schools: A Feasibility Study.","authors":"Bronwen M McNoe,&nbsp;Kate C Morgaine,&nbsp;Anthony I Reeder,&nbsp;Ella Iosua","doi":"10.1155/2022/9434176","DOIUrl":"https://doi.org/10.1155/2022/9434176","url":null,"abstract":"<p><p>Excessive exposure to ultraviolet radiation during adolescence can have a lasting effect on long-term skin cancer risk. Skin cancer prevention interventions for adolescents have been less commonly investigated than those for children and adults. The study objectives were to develop and evaluate the feasibility of a secondary school-based appearance focused intervention, including the development and testing of protocols and instruments, as a resource module that could be efficiently integrated into the secondary school science curriculum. This longitudinal study was conducted with a convenience sample of 38 13-14 year-old students attending one New Zealand (NZ) urban secondary school. The recruitment rate was excellent with only one student not participating because of parental concern. In terms of the implementation practicality, the intervention, as it stands, was extremely resource intensive, involving four research staff to deliver. This will not work if delivered in a classroom setting by a single teacher. However, the intervention was well received by students, so it shows promise if a less resource intensive version could be produced. The acceptability of the intervention with the students was good with the majority (61%) having no suggestions for improvements. Suggested improvements were minor and could be easily addressed.</p>","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":" ","pages":"9434176"},"PeriodicalIF":1.1,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa","authors":"J. C. Gallo, J. Schneider, J. D. De Wet, K. Moxley, H. Jordaan, W. Visser, B. Tod","doi":"10.1155/2022/8443867","DOIUrl":"https://doi.org/10.1155/2022/8443867","url":null,"abstract":"Background Basal cell carcinoma (BCC) is an important malignancy in sub-Saharan Africa. There is a paucity of data regarding BCC in South Africa. Aims To describe the clinicopathological features of patients presenting with BCC in a cohort of South African patients. Methods This retrospective descriptive study reviewed the medical records of 149 patients with BCC who attended the dermatology clinic at Tygerberg Academic Hospital from September 2015 to August 2016. Demographic and clinical data of those patients with histologically proven BCC were retrieved from clinical records. The data included the assessment for BCC recurrence after three years (September 2016–August 2019). Results Of 390 patients, 155 (39.7%) had histologically confirmed BCCs. Complete medical records were available for 149 of these patients, and most were male (55.7%) and white (85.9%) with a median age of 70 years. Most patients had their BCC lesions for 12 months (43.1%) before diagnosis. BCCs were mostly located on the head and neck area (58.1%). In most patients (72.0%), a diagnostic punch biopsy confirmed BCC. Plastic surgeons subsequently excised the BCC lesions in 74.0% of these patients. The most common histological subtype was nodular BCC (74.0%). The National Comprehensive Cancer Network (NCCN) risk of recurrence was approximately evenly distributed between high- (54.1%) and low-risk groups (45.9%). The major high-risk feature was the location (36.6%). Histologically confirmed BCC recurrence occurred in 9 of the 149 patients (3.7%) over three years. Conclusions BCC represents a high burden of disease in our setting. Compared to existing studies, the BCCs in this study are clinically and histologically similar to international reports.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"21 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83722400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Differing Machine Learning Algorithms and Their Related Performance in Detecting Skin Cancers and Melanomas","authors":"Suboh Alkhushayni, Du’a Al-zaleq, Luwis Andradi, Patrick Flynn","doi":"10.1155/2022/2839162","DOIUrl":"https://doi.org/10.1155/2022/2839162","url":null,"abstract":"Skin cancer, and its less common form melanoma, is a disease affecting a wide variety of people. Since it is usually detected initially by visual inspection, it makes for a good candidate for the application of machine learning. With early detection being key to good outcomes, any method that can enhance the diagnostic accuracy of dermatologists and oncologists is of significant interest. When comparing different existing implementations of machine learning against public datasets and several we seek to create, we attempted to create a more accurate model that can be readily adapted to use in clinical settings. We tested combinations of models, including convolutional neural networks (CNNs), and various layers of data manipulation, such as the application of Gaussian functions and trimming of images to improve accuracy. We also created more traditional data models, including support vector classification, K-nearest neighbor, Naïve Bayes, random forest, and gradient boosting algorithms, and compared them to the CNN-based models we had created. Results had indicated that CNN-based algorithms significantly outperformed other data models we had created. Partial results of this work were presented at the CSET Presentations for Research Month at the Minnesota State University, Mankato.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"3 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76147655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Nanoscale Materials for Skin Cancer Therapy and Detection","authors":"Hamza Abu Owida","doi":"10.1155/2022/2961996","DOIUrl":"https://doi.org/10.1155/2022/2961996","url":null,"abstract":"Skin cancer has developed as one of the most common types of cancer in the world, with a significant impact on public health impact and the economy. Nanotechnology methods for cancer treatment are appealing since they allow for the effective transport of medicines and other biologically active substances to specific tissues while minimizing harmful consequences. It is one of the most significant fields of research for treating skin cancer. Various nanomaterials have been employed in skin cancer therapy. The current review will summarize numerous methods of treating and diagnosing skin cancer in the earliest stages. There are numerous skin cancer indicators available for the prompt diagnosis of this type of disease. Traditional approaches to skin cancer diagnosis are explored, as are their shortcomings. Electrochemical and optical biosensors for skin cancer diagnosis and management were also discussed. Finally, various difficulties concerning the cost and ease of use of innovative methods should be addressed and overcome.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"60 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75912911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases","authors":"Syeed Mehbub Ul Kadir, Mukti Rani Mitra, Riffat Rashid, Murtuza Nuruddin, Md. Kamrul Hassan Khan, G. Haider, M. Nessa","doi":"10.1155/2022/4075668","DOIUrl":"https://doi.org/10.1155/2022/4075668","url":null,"abstract":"Background Eyelid tumours are common in our ophthalmic practice. Malignancy cases account only for one-fourth of all eyelid tumours. The most aggressive eyelid malignancy is sebaceous gland carcinoma, but its occurrences are rare in western countries. We found sebaceous gland carcinoma is as common as basal cell carcinoma in our clinical practices. Hence, it is essential to build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. Aim To assess the relative frequency of eyelid malignancies in the Bangladesh population, state their clinical features and outcome of management strategies and build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. Methods This was a retrospective case series study of 332 patients in Bangladesh. This study analyzed all the recorded data of the histologically proven primary eyelid malignancies and followed them up for at least six months from 2014 to 2019 (6 years). All patients were managed by surgical excision with tumor-free margins verified on histopathology, either the frozen section or excision biopsy with 2–3 mm microscopic view of normal tissue followed by eyelid reconstruction. Computer-based statistical software SPSS was used for the analysis, and an appropriate test of significance (chi-square) was used for the statistical analysis. Results Sebaceous gland carcinoma (SGC) was the highest in occurrence, at 42%, followed by 38% basal cell carcinoma (BCC), 18% squamous cell carcinoma (SqCC), and 02% malignant melanoma (MM). The mean age at presentation of SGC, BCC, SqCC, and MM were 57.41 years, 62.56 years, 64.73 years, and 59.28 years, respectively. Female (59%) was slightly more preponderance over the male (41%) for SGC than other malignancies. Pigmentation was associated with malignant melanoma (100%) and BCC (81%). Statistically, a significant difference was found between eyelid malignancies, including location, size, pigmentation, recurrence, and invasiveness. The recurrence rate was low lower in the patients who underwent frozen section biopsy (3%) for margin clearance than those who underwent excision biopsy (21.5%) in the follow-up time. Conjunctival map biopsy (8%) was performed as an essential tool for excluding the pagetoid spread of SGC. A new reconstruction method named triangular-shaped musculocutaneous tail flap was performed in 33 (11%) patients to reconstruct the moderate eyelid defect following local resection. Conclusion Sebaceous gland carcinoma (SGC) was the highest occurrence found to be the highest occurrence among all eyelid malignancies in Bangladesh. SGC is more aggressive and the recurrence rate was higher than BCC and SqCC.","PeriodicalId":17172,"journal":{"name":"Journal of Skin Cancer","volume":"30 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83361248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}