S I Barth, S M DeMonaco, B J Conner, P B S Serpa, A R Wilkinson
{"title":"Plasma ADAMTS13 activity in healthy dogs and dogs with chronic enteropathy.","authors":"S I Barth, S M DeMonaco, B J Conner, P B S Serpa, A R Wilkinson","doi":"10.1111/jsap.70172","DOIUrl":"https://doi.org/10.1111/jsap.70172","url":null,"abstract":"<p><strong>Objectives: </strong>A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 is a von Willebrand factor cleaving enzyme that is associated with prothrombotic/hypercoagulable states in humans. In people, A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity is reduced with inflammatory bowel disease. Objectives of the study were to measure plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity, von Willebrand factor antigen and von Willebrand factor collagen binding activity in dogs with chronic enteropathy. Additionally, the study aimed to investigate whether plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity correlated with von Willebrand factor antigen, von Willebrand factor collagen binding activity and disease activity, which was assessed using the Canine Chronic Enteropathy Clinical Activity Index.</p><p><strong>Materials and methods: </strong>Plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity, von Willebrand factor antigen and von Willebrand factor collagen binding activity were measured in 19 dogs with chronic enteropathy. In a prior study, plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity was measured in 40 healthy dogs. Twenty of the 40 healthy dogs had plasma von Willebrand factor antigen and von Willebrand factor collagen binding activity measured. Plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity was measured using a commercially available enzyme-linked immunosorbent assay kit (Diapharma®). For each variable, differences between medians were compared between dogs with chronic enteropathy and healthy dogs by permutation testing with 95% bootstrap confidence intervals. Correlations between A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity, von Willebrand factor antigen, von Willebrand factor collagen binding activity and Canine Chronic Enteropathy Clinical Activity Index were assessed using Spearman's non-parametric test. Significance was set at P < .05.</p><p><strong>Results: </strong>Plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity and von Willebrand factor antigen in dogs with chronic enteropathy were not different from healthy dogs. Thirty-three percent (2/6) of the dogs with chronic enteropathy and hypoalbuminemia had plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity below the reference interval. Plasma von Willebrand factor collagen binding activity was lower in dogs with chronic enteropathy than in healthy dogs. Plasma A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity negatively correlated with plasma von Willebrand factor collagen binding activity, von Willebrand factor ant","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cervicothoracic myelopathy and radiculopathy associated with vertebral vein and internal vertebral venous plexus congestion secondary to a locally invasive cardiac mass lesion.","authors":"C Brojba, I Carrera, K M Santifort","doi":"10.1111/jsap.70170","DOIUrl":"https://doi.org/10.1111/jsap.70170","url":null,"abstract":"","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aggressive sarcoma in a young dog initially suspected to be trauma-associated.","authors":"Z Dahl, W Robinson, C Anselmi, C Toni","doi":"10.1111/jsap.70164","DOIUrl":"https://doi.org/10.1111/jsap.70164","url":null,"abstract":"","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gaze-evoked nystagmus in a dog with neuronal ceroid lipofuscinosis.","authors":"K M Santifort, J Lemos","doi":"10.1111/jsap.70161","DOIUrl":"https://doi.org/10.1111/jsap.70161","url":null,"abstract":"","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Nagumo, Y Hoshino, S Kobayashi, R Fujiwara, M Yamasaki, K Nakata, M Katayama
{"title":"Predictive utility of computed tomography-derived renal parenchymal volume for long-term postoperative renal function in cats with hydronephrosis.","authors":"T Nagumo, Y Hoshino, S Kobayashi, R Fujiwara, M Yamasaki, K Nakata, M Katayama","doi":"10.1111/jsap.70167","DOIUrl":"https://doi.org/10.1111/jsap.70167","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the utility of preoperative feline renal parenchymal volume derived from computed tomography in predicting the serum creatinine concentration during the long-term postoperative period.</p><p><strong>Materials and methods: </strong>In this retrospective clinical study, we included 13 client-owned cats with normal kidneys and 24 cats with hydronephrosis (16 with chronic kidney disease and 8 without chronic kidney disease). The renal parenchymal volume was derived from CT images and normalised to the body weight. The reference intervals for renal parenchymal volume/body weight and total renal parenchymal volume/body weight were calculated from the control group. We performed between-group comparisons of the preoperative hydronephrotic renal parenchymal volume, contralateral renal parenchymal volume and total renal parenchymal volume/body weight; additionally, we analysed the relationships among hydronephrotic renal parenchymal volume/body weight, contralateral renal parenchymal volume/body weight, total renal parenchymal volume /body weight and serum creatinine concentration during the preoperative and long-term postoperative periods (>3 months). The long-term postoperative chronic kidney disease stages were classified based on the International Renal Interest Society guidelines.</p><p><strong>Results: </strong>The non-chronic kidney disease subgroup had a significantly greater hydronephrotic renal parenchymal volume/body weight than the control group. The non-chronic kidney disease subgroup had a significantly greater contralateral renal parenchymal volume/body weight than the control group and the chronic kidney disease subgroup. In the non-chronic kidney disease subgroup, contralateral renal parenchymal volume/body weight showed a strong negative relationship with postoperative serum creatinine concentration (r = -0.79). In the hydronephrosis group, total renal parenchymal volume /body weight showed a moderate negative correlation with postoperative serum creatinine concentration (r = -0.46). In the non-chronic kidney disease subgroup, contralateral renal parenchymal volume/body weight was significantly greater in International Renal Interest Society stages I-II than in International Renal Interest Society stages III-IV.</p><p><strong>Clinical significance: </strong>The preoperative contralateral renal parenchymal volume/body weight in non-chronic kidney disease cats with hydronephrosis is associated with the long-term postoperative serum creatinine concentration. CT-based quantification of renal parenchymal volume may be useful for predicting postoperative chronic kidney disease staging based on serum creatinine concentration in cats with hydronephrosis.</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Noli, H. Dropsy, A. Cozar, X. De Jaeger, R. Kesteman, A. Beck, R. Cristante, M. Debraine, F. Leymarios, A. Puozzo-Barichard, M. Gatellet
{"title":"Evaluation of safety and efficacy of an ophytrium and seboliance-containing mousse with or without shampoo in cats with keratinisation disorders","authors":"C. Noli, H. Dropsy, A. Cozar, X. De Jaeger, R. Kesteman, A. Beck, R. Cristante, M. Debraine, F. Leymarios, A. Puozzo-Barichard, M. Gatellet","doi":"10.1111/jsap.70104","DOIUrl":"10.1111/jsap.70104","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to assess the effectiveness of a protocol involving the application of topical products (DOUXO® S3 SEB Shampoo and Mousse; Ceva Santé Animale) containing ophytrium for managing feline keratinisation disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Nineteen client-owned cats with a history of keratinisation disorders exhibited greasy or dry seborrhoea. Cats were treated with either a shampoo or mousse on day 0 (D0) and subsequently with the mousse every 48 to 72 hours for 3 weeks. Clinical signs were evaluated on D0, D7 and D21 using a modified Skin Seborrheic Index, which measured the percentage of body area affected, scaling, coat greasiness and secondary dermatological signs. Both veterinarians and owners provided subjective evaluations of overall skin condition and product efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 17 cats that completed the study, SSI scores improved significantly by D7 and D21, with reductions of ≥50% in 82.4% of cats. By D21, the affected body surface had decreased by 92.9%, scaling by 70.5% and greasiness by 68.3%. Veterinarians rated the improvement as satisfactory, good or excellent in 100% of cases. The protocol was deemed effective and practical by 100% and 88.2% of owners, respectively, with 94.1% declaring an improved condition of their cats' skin and coat.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>The ophytrium-containing mousse and shampoo protocol was well tolerated and effective in significantly reducing seborrhoea in cats with keratinisation disorders. High satisfaction levels were reported by both veterinarians and owners, highlighting the protocol's efficacy and practicality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"67 7","pages":"619-626"},"PeriodicalIF":1.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.70104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147290321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nerve-sparing total prostatectomy with or without adjuvant chemotherapy is associated with a low rate of surgical complications, long-term continence and improved survival in 22 dogs with T1 to T3 prostatic tumours","authors":"A. G. Salmina, L. E. Chiti, F. Cinti, F. Massari","doi":"10.1111/jsap.70112","DOIUrl":"10.1111/jsap.70112","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate surgical outcomes, urinary continence and survival in dogs with stage T < 4 prostatic tumours or preneoplastic lesions treated with nerve-sparing total prostatectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A retrospective review of 22 dogs that underwent nerve-sparing total prostatectomy between 2018 and 2024 was conducted. Inclusion criteria included histologically confirmed prostatic neoplasia or preneoplastic lesions, complete preoperative staging (contrast-enhanced CT and urethrocystoscopy), absence of nodal or distant metastases (N0, M0) and no invasion of adjacent structures (<T4). Data collected included surgical complications, urinary continence (modified Byron scale), histopathology, adjuvant treatment, tumour progression and survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifteen dogs were staged as T2N0M0, five as T3N0M0 and two as T1N0M0. The average surgical time was 72.5 minutes. One minor intraoperative complication occurred, with no major postoperative complications observed. All dogs were incontinent immediately after catheter removal; however, improvement was seen in all cases during follow-up. Fifteen dogs (68.2%) regained full continence, while seven (31.8%) experienced persistent mild (grade 1) incontinence. No dogs developed severe permanent incontinence. Tumour progression was observed in six dogs (27.3%) at a median of 150 days post-surgery. The median follow-up and survival times were 570 and 900 days, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>In carefully selected dogs with early-stage (T < 4) prostatic disease, nerve-sparing total prostatectomy is associated with a low complication rate, favourable long-term continence and encouraging survival outcomes. This approach offers a viable treatment option for dogs with limited local disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"67 7","pages":"606-612"},"PeriodicalIF":1.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The fallacy of the ‘wall test’: differentiating postural reactions from cognitive intelligence in the era of social media","authors":"M. S. Akosman","doi":"10.1111/jsap.70107","DOIUrl":"10.1111/jsap.70107","url":null,"abstract":"<p>I am writing to draw attention to a widespread misconception currently proliferating on social media platforms, where pet owners are utilising the so-called ‘wall test’ to gauge their dogs' intelligence. This ‘challenge’ involves carrying a dog toward a vertical surface; if the animal extends its thoracic limbs to make contact, it is heralded as ‘intelligent’. As veterinary professionals, it is our duty to clarify that this manoeuvre is not a measure of canine cognition but is, in fact, a fundamental neurological assessment known as the <i>visual and tactile placing test</i> (de Lahunta et al., <span>2020</span>; Lorenz et al., <span>2010</span>).</p><p>The visual placing reaction is a complex postural response that requires the functional integrity of specific neuroanatomical pathways. The process begins with retinal reception, travelling through the optic nerves, optic tracts and the lateral geniculate nucleus, eventually projecting to the visual cortex. The motor component involves the frontal cortex and the activation of upper motor neuron pathways to initiate limb protraction (de Lahunta et al., <span>2020</span>; Lorenz et al., <span>2010</span>).</p><p>The clinical significance of this test is to localise lesions and confirm neurological health, not to measure IQ. A deficit in this reaction is a red flag for <i>cortical blindness, brainstem lesions or conscious proprioception loss</i>. Mistaking this for ‘low intelligence’ is clinically dangerous, as it may lead owners to overlook early signs of serious neurological decay.</p><p>Intelligence in Canidae involves complex cognitive processes such as problem-solving, memory and social adaptation, managed by the prefrontal cortex. In contrast, the placing reaction is a semi-automatic sensory-motor integration. Confusing a diagnostic reflex with cognitive ability is akin to mistaking a computer's ‘power-on self-test’ for its total computational power.</p><p>We must encourage pet owners to seek professional veterinary consultation when they observe ‘failed’ reactions, rather than dismissing them as a lack of intelligence. It is vital that we reclaim clinical diagnostic tools from social media trends to ensure the neurological well-being of our patients.</p><p>Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"67 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Hertel, V. Baldassarre, S. Gasparini, E. Bortolami, F. Cinti
{"title":"Histopathological findings of mammary tumours in male dogs and cats from a long-term institutional cohort","authors":"B. Hertel, V. Baldassarre, S. Gasparini, E. Bortolami, F. Cinti","doi":"10.1111/jsap.70103","DOIUrl":"10.1111/jsap.70103","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To describe the proportion, histological type and grade of mammary gland tumours in a population of male dogs and cats at a single institution over a period of 17 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>All histological specimens from mammary gland tumours in male dogs and cats submitted to the Pathology Service at a single institution in northern Italy between 2008 and 2025 were retrospectively reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred and ten tumours were identified in the study population: 83 tumours in 73 dogs and 27 tumours in 23 cats; multiple tumours were present in some animals. After exclusion of animals presenting with both benign and malignant tumours, malignant tumours were more prevalent in both species with 50/68 (73.5%) in dogs and 19/22 (86.4%) in cats, respectively. In male dogs, mammary gland V was most commonly involved, while mammary gland IV was most commonly involved in male cats. Complex carcinoma was most common in male dogs, and tubular carcinoma in male cats. Nodulectomy was the most commonly performed surgical procedure in both species. Low-grade (grade I) tumours were more common in dogs (37/46, 80%), and intermediate- (grade II) and high-grade (grade III) tumours in cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>Mammary gland tumours in male dogs and cats were predominantly malignant. Caudal mammary glands were the most involved. Although there was a high proportion of malignant tumours in male dogs, the majority were grade I. Instead, intermediate- (grade II) and high-grade (grade III) tumours were more common in cats, supporting the aggressive nature of feline mammary gland tumours.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"67 7","pages":"613-618"},"PeriodicalIF":1.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Sebestyén, U. Teubenbacher, G. Rosato, I. Lautenschläger, L. Golini
{"title":"MRI findings in a dog with calvarial squamous cell carcinoma","authors":"P. Sebestyén, U. Teubenbacher, G. Rosato, I. Lautenschläger, L. Golini","doi":"10.1111/jsap.70102","DOIUrl":"10.1111/jsap.70102","url":null,"abstract":"<p>A 9-year-old spayed female Jack Russell terrier was presented with a history of apathy, anorexia and progressive cranial deformation over several weeks. There was no history of trauma. Clinical examination revealed bilateral exophthalmos and a painful, crepitant, frontotemporal mass. Neurological examination showed mild obtundation and reduced menace response, indicating forebrain involvement. Bloodwork was unremarkable. MRI (Ingenia 3.0T, Philips AG, Zurich, Switzerland) revealed an extensive, polyostotic calvarial lesion with permeative osteolysis and osteoproliferation. The lesion caused severe, bilateral destructive sinorhinopathy, retrobulbar extension with exophthalmos, multifocal masticatory muscle infiltration and dural/meningeal enhancement. On T2-weighted fat-suppressed (T2wSPIR) sequences, it was predominantly hyperintense relative to the masticatory musculature, with multifocal T2-weighted hyperintense areas (Fig 1A). The lesion also displayed a thick, irregular, enhancing rim and multifocal to confluent regions of marked contrast enhancement on T1-weighted sequences after gadolinium-based contrast medium injection (post-contrast T1w, Fig 1B). Differential diagnoses included neoplasia (<i>e.g</i>. carcinoma, multilobular osteochondrosarcoma or soft tissue sarcoma), while inflammatory/infectious aetiologies (<i>e.g</i>. fungal osteomyelitis) were considered less likely. <i>Post mortem</i> examination revealed cranial deformities, exophthalmos and neoplastic infiltration of skull bones, meninges and temporal region, obstructing the caudal nasal cavity (Fig 1C). Histopathology confirmed a highly cellular, infiltrative squamous cell carcinoma (SCC) with high mitotic activity and vascular emboli (Fig 1D). SCC is a malignant epithelial tumour, and diffuse calvarial infiltration with extensive osteolysis and concurrent osteoproliferation, as in this case, is uncommon. This report highlights that SCC should be considered among differentials for polyostotic, osteolytic and osteoproliferative calvarial lesions with similar MRI features in dogs.</p><p><b>P. Sebestyén:</b> Conceptualization; writing – original draft; writing – review and editing. <b>Ursula Teubenbacher:</b> Conceptualization; writing – original draft; writing – review and editing; <b>Guiliana Rosato:</b> Conceptualization; writing – original draft; writing – review and editing; <b>Ines Lautenschläger:</b> Conceptualization; writing – original draft; writing – review and editing; <b>Lorenzo Golini:</b> Conceptualization; writing – original draft; writing – review and editing;</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"67 7","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}