Journal of Small Animal Practice最新文献

{"title":"A retrospective analysis of postoperative gastrointestinal dehiscence and ileus in dogs receiving carprofen or not receiving carprofen following gastrointestinal surgery","authors":"E. Riddle,&nbsp;K. C. Maritato,&nbsp;S. H. Schwartz","doi":"10.1111/jsap.13875","DOIUrl":"10.1111/jsap.13875","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the relationship between nonsteroidal anti-inflammatory drugs and the occurrence of gastrointestinal dehiscence and ileus in dogs following gastrointestinal surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>Retrospective cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seven hundred and twenty-one dogs had surgery related to foreign body obstruction between January 2009 and December 2020. Records were reviewed and postoperative NSAID administration, ileus, and gastrointestinal dehiscence were recorded. The data were then analyzed for any correlation between age, surgical procedure, NSAID administration, and occurrence of gastrointestinal dehiscence or ileus postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>69/721 dogs received carprofen. The distribution by surgery type for dogs receiving carprofen was 43/307 for gastrotomy, 11/216 for enterotomy, and 15/198 for enterectomy. A total of 199 dogs experienced ileus, and 13 dogs experienced intestinal dehiscence. 18/199 dogs that experienced ileus received carprofen, and 0/13 dogs that experienced dehiscence received carprofen. No difference in the occurrence of ileus or intestinal dehiscence was observed for dogs receiving carprofen. The odds of developing postoperative ileus increased by 53% (OR = 1.53, 95% CI: 1.065 to 2.209) for an enterectomy in comparison to a gastrotomy or enterotomy. The odds of developing postoperative ileus increased by approximately 10% for every year increase in age. The odds of dehiscence increased 6.2 times for an enterectomy in comparison to a gastrotomy or enterotomy; however, age and carprofen had no effect on the rate of dehiscence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>Carprofen did not significantly increase the risk of intestinal dehiscence and can be considered part of multimodal pain control following gastrointestinal surgery with appropriate patient selection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"665-669"},"PeriodicalIF":1.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of behavioural signs commonly associated with feline hyperaesthesia syndrome among healthy cats","authors":"M. Avril,&nbsp;A. Lamoureux,&nbsp;S. Valentin,&nbsp;A. Jeandel","doi":"10.1111/jsap.13878","DOIUrl":"10.1111/jsap.13878","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The most common clinical signs of feline hyperaesthesia syndrome are rolling skin and behavioural abnormalities (e.g. licking or biting the tail, flanks, anal region or lumbar region). This study aimed to determine the prevalence of behavioural signs commonly associated with feline hyperaesthesia syndrome among healthy cats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This descriptive cross-sectional bicentric prospective study included 208 healthy cats that presented for vaccination. A survey about the cats' behaviour was completed by caregivers and six general practice veterinarians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventy-three per cent of the cats presented at least one behavioural sign of feline hyperaesthesia syndrome. Only 26.9% of the caregivers report zero behavioural of feline hyperaesthesia syndrome at home. Eighty per cent of the indoor-only cats and 65.3% of the outdoor cats had at least one behavioural sign (odds ratio 2.08, 95% confidence interval 1.12 to 3.88). Thirty-one per cent of the cats reacted to lumbar palpation by veterinarians, and 18.7% of these cats were not reported to present signs of feline hyperaesthesia syndrome at home.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>In this population of healthy cats, 73.1% of cats consistently displayed at least one behavioural sign of feline hyperaesthesia syndrome at home. Adverse reactions after lumbar palpation by a veterinarian were also reported in healthy cats, including cats without behavioural signs at home. The results suggest that many of these behavioural signs have no diagnostic value in isolation. A scoring system could be used to differentiate cats with feline hyperaesthesia syndrome from cats with normal behaviour.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 10","pages":"700-707"},"PeriodicalIF":1.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of lung lobectomy and adjuvant treatment for primary pulmonary carcinoma in dogs: 89 cases (2005-2022)","authors":"E. Treggiari,&nbsp;G. Romanelli,&nbsp;P. Valenti,&nbsp;V. Montinaro,&nbsp;M. Rossanese","doi":"10.1111/jsap.13874","DOIUrl":"10.1111/jsap.13874","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Primary lung cancer is relatively common in dogs. Despite the existing literature on long-term follow-up and outcome, further clinical studies focusing on a single histotype are needed, specifically about epithelial tumours since they are the ones most frequently detected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The medical records of four European institutions were reviewed to identify dogs undergoing lung lobectomy for a primary lung carcinoma between 2005 and 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 89 dogs were included. Median age was 11 years (range 5 to 17 years) and median body weight was 23 kg (range 2.5 to 47 kg). Overall median survival time was 252 days (range 6 to 1558 days) and overall progression-free interval was 140 days (range 7 to 684 days). The 1-, 2- and 3-year survival rates were 61%, 47% and 30%, respectively. Presence of clinical signs at presentation, pleural effusion, completeness of surgical margins, histopathological features and use of adjuvant chemotherapy did not influence survival. Patients with maximum tumour diameter ≥ 5 cm had a reduced survival compared to patients with smaller tumours (median survival time 284 days vs. 717 days, 95% CI 8 to 719), and dogs with histologically confirmed lymph node metastasis had a reduced survival compared to patients with no evidence of local metastasis (median survival time 162 days vs. 614 days, 95% CI 39 to 760). None of the other assessed variables influenced progression-free interval.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>Dogs with primary pulmonary carcinoma with no lymph node involvement and with a maximum tumour diameter of &lt; 5 cm may have a better prognosis and prolonged survival. Further studies are needed to elucidate the role of adjuvant chemotherapy in case of clinically aggressive lung cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"654-664"},"PeriodicalIF":1.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spina bifida aperta in a cat","authors":"A. E. Bakker,&nbsp;K. M. Santifort,&nbsp;N. Bergknut","doi":"10.1111/jsap.13873","DOIUrl":"10.1111/jsap.13873","url":null,"abstract":"","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-dose induction therapy and treatment termination criteria for feline infectious peritonitis with remdesivir, GS-441524 and adjunctive mefloquine: 46 cases (2023)","authors":"T. Kamiyoshi,&nbsp;N. Kamiyoshi,&nbsp;C. Jintake","doi":"10.1111/jsap.13869","DOIUrl":"10.1111/jsap.13869","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Feline infectious peritonitis can be treated with antiviral agents, such as remdesivir and GS-441524. Standard treatment duration is 12 weeks, but no criteria have been established for individualising the timing of treatment cessation based on specific case characteristics. This study aimed to investigate whether treatment cessation for feline infectious peritonitis could be determined using acute-phase proteins and albumin/globulin ratio and to evaluate whether treatment duration, following high-dose induction, could be safely shortened.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty-six cats with feline infectious peritonitis, excluding those with only ocular or neurological signs, were treated with a high initial dose (&gt;20 mg/kg/day) of either injectable remdesivir or oral GS-441524. Surviving cats continued on a maintenance dose tailored to their clinical signs after initial improvements. Clinical signs, acute-phase protein levels, and albumin/globulin ratios were regularly monitored to assess when to end treatment. Cases where treatment was concluded in less than 12 weeks received supplementary mefloquine therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 46 included cats, 42 (91.3%) achieved long-term survival, with 28 (66.7%) meeting the criteria for treatment cessation [median treatment duration, 57 days (range, 45 to 74 days)]. No recurrence was observed in any of the 42 cats, either during the treatment or within the 3-month follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>In some cats with feline infectious peritonitis a high-dose induction protocol, using acute-phase proteins and the albumin/globulin ratio for treatment cessation, enabled a shorter treatment period than the conventional 12 weeks, without observed recurrence. The criteria used in this study appear adequate for determining appropriate times for feline infectious peritonitis treatment cessation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"617-626"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of left vagus nerve retraction on post-operative unilateral left-sided laryngeal paralysis following surgical closure of patent ductus arteriosus in dogs","authors":"S. Manzoni,&nbsp;N. Van Israël,&nbsp;M. Santos,&nbsp;A. Bongartz","doi":"10.1111/jsap.13867","DOIUrl":"10.1111/jsap.13867","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study was aimed at determining the incidence of left-sided laryngeal paralysis in dogs that underwent patent ductus arteriosus open surgical ligation and at identifying whether left vagus nerve retraction during surgery might be a risk factor for post-operative left-sided laryngeal paralysis development.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Medical records for dogs referred to our clinic for surgical patent ductus arteriosus closure between July 2012 and May 2022 were reviewed. The inclusion criteria were echocardiographic diagnosis of left-to-right shunting patent ductus arteriosus, standard surgical ligation of the patent ductus arteriosus, short-term follow-up at 30 days and long-term follow-up for at least 365 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 40 dogs included, left vagus nerve retraction was performed during surgical dissection in 25 dogs. All dogs survived the surgery, with full closure of the patent ductus arteriosus in 100% of cases. The overall incidence of post-operative left-sided laryngeal paralysis was 12.5%. Heavier weight was significantly associated with a greater risk of left-sided laryngeal paralysis after surgery (odds ratio = 1.19; P = 0.044). Left vagus nerve retraction during surgery was not significantly associated with left-sided laryngeal paralysis risk (P <i>=</i> 0.996). No dogs required arytenoid lateralisation. In long-term follow-up, 37/40 dogs remained alive at an average of 1874 days after surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>Endoscopic evaluation of laryngeal function after surgical patent ductus arteriosus ligation is recommended when dogs present with inspiratory stridor, vocal changes, exercise intolerance or regurgitation post-operatively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"609-616"},"PeriodicalIF":1.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, treatment, and outcomes of hypoadrenocorticism in dogs","authors":"T. N. Sherrod,&nbsp;E. Lashnits,&nbsp;K. F. Lunn","doi":"10.1111/jsap.13870","DOIUrl":"10.1111/jsap.13870","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To determine the long-term survival of dogs with hypoadrenocorticism during the period that desoxycorticosterone pivalate has become widely used. Secondary goals were to compare age at diagnosis, median survival times, and age at death for dogs with hyponatraemic and/or hyperkalaemic hypoadrenocorticism and eunatraemic eukalaemic hypoadrenocorticism, and to determine the frequency of glucocorticoid-related side effects in these dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Retrospective cohort study with data collected from medical records and from a questionnaire sent to owners of affected dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>141 cases were identified; 125 had spontaneous hypoadrenocorticism and 16 had iatrogenic hypoadrenocorticism secondary to treatment of hyperadrenocorticism. Dogs with spontaneous hyponatraemic and/or hyperkalaemic hypoadrenocorticism were significantly younger at the time of diagnosis (median age: 5.1, range: 0.8 to 14.1 years, <i>n</i> = 97) compared to dogs with spontaneous eunatraemic eukalaemic hypoadrenocorticism (median age: 8.3, range: 3.0 to 12.7 years, <i>n</i> = 26). Sixty-six dogs were included in the survival analysis. For dogs with spontaneous hyponatraemic and/or hyperkalaemic hypoadrenocorticism, all of which were managed with desoxycorticosterone pivalate, median survival time was 5.7 years (95% CI: 4.0 to 7.2 years; <i>n</i> = 47) and median age at death was 11.0 years (range: 4.0 to 17.0 years; <i>n</i> = 30). For dogs with spontaneous eunatraemic eukalaemic hypoadrenocorticism, median survival time was 5.6 years (95% CI: 4.1-N/A years; <i>n</i> = 9) and median age at death was 11.8 years (range: 11.0 to 13.0 years; <i>n</i> = 4). The majority of owners that completed the questionnaire reported side effects commonly associated with glucocorticoid therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>Hypoadrenocorticism carries an excellent prognosis. Desoxycorticosterone pivalate was the most frequently used mineralocorticoid therapy in this group of dogs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"627-635"},"PeriodicalIF":1.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.13870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-responsive generalised sterile necrotising pyogranulomatous lymphadenitis in a cat","authors":"L. Lecot,&nbsp;E. Ramery,&nbsp;M. Hugonnard,&nbsp;A. Tortereau,&nbsp;É. Krafft","doi":"10.1111/jsap.13872","DOIUrl":"10.1111/jsap.13872","url":null,"abstract":"<p>A 1.5-year-old neutered male cat was presented with fever, inappetence, lethargy and marked generalised lymphadenopathy of 4 days duration. Excisional biopsy of peripheral lymph nodes revealed necrotising pyogranulomatous lymphadenitis. Extensive investigation failed to identify an underlying infectious [bacterial (<i>Bartonella</i>, <i>Mycobacteria</i>, <i>Mycoplasma</i>, other Gram-positive or -negative bacteria), viral (feline infectious peritonitis), protozoal (toxoplasmosis), or fungal], neoplastic or inflammatory condition. No improvement was observed with short-term antimicrobial therapy with amoxicillin–clavulanate. Treatment with an immunosuppressive dosage of prednisolone resulted in complete resolution of clinical signs. Seven months after prednisolone withdrawal, the cat remained in good general condition. This is the first description of a steroid-responsive necrotising pyogranulomatous lymphadenitis in a cat, and this entity might be considered in cases with generalised lymphadenopathy and fever.</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"670-675"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.13872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of three surgical techniques used for managing congenital thoracic vertebral body malformations in brachycephalic dogs: 51 cases (2009-2023)","authors":"S. R. Picón,&nbsp;M. Baroni,&nbsp;G. B. Cherubini,&nbsp;D. Corlazzoli,&nbsp;L. Motta","doi":"10.1111/jsap.13871","DOIUrl":"10.1111/jsap.13871","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare three surgical techniques used for treating canine congenital thoracic vertebral body malformations and describe their complications and postoperative outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective multicentre study analysed data on signalment, preoperative and postoperative neurological status, surgical techniques, complications, and long-term outcomes using descriptive analysis across four referral centres.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 51 brachycephalic dogs (median age: 14.2 months) with clinical signs consistent with T3 to L3 myelopathy, from mild paraparesis and ataxia to paraplegia without nociception. The vertebral segment located between T7 and T9 was commonly affected. The mean duration of long-term follow-up was 825 days. Transthoracic vertebral distraction and stabilisation performed in 34 dogs exhibited notable long-term improvements in their neurological status; 28 (82%) of the 34 dogs became neurologically normal. Major implant-related complications were observed in three cases, with two requiring a second surgery leading to neurological improvement. Preoperative and postoperative vertebral canal angle and Cobb's angle measurements indicated variable degrees of surgical distraction. Dorsal laminectomy was performed in 11 dogs; of these, nine (81%) experienced immediate postoperative deterioration. In the long term, only two dogs achieved normal neurological status, and one with acute deterioration was euthanased. Laminectomy with dorsal vertebral stabilisation was performed in six dogs, with initial deterioration observed in five (83%) of the six dogs. In the long term, all but one dog remained ambulatory paraparetic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical significance</h3>\u0000 \u0000 <p>Dogs treated with spinal stabilisation techniques exhibited better outcomes. Specifically, the transthoracic distraction stabilisation technique appears to exhibit the most favourable short- and long-term outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":"636-645"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile nephropathy resembling human nephronophthisis–medullary cystic kidney disease in a 9-month-old domestic shorthaired cat","authors":"N. Goody,&nbsp;J. Poldy,&nbsp;A. Malbon,&nbsp;T. Morrison,&nbsp;I. Montanes-Sancho,&nbsp;S. Dancer,&nbsp;D. Gunn Moore","doi":"10.1111/jsap.13863","DOIUrl":"10.1111/jsap.13863","url":null,"abstract":"<p>A 9-month-old male neutered domestic shorthair cat presented with a 2-month history of progressive lethargy, inappetence, and polydipsia. Weekly weight measurements of the patient and its littermate showed initial reduced weight gain, then weight loss (Fig 1A). The initial bloodwork revealed elevated creatinine (516 μmol/L; reference interval [RI] 22–162 μmol/L), urea (40.2 mmol/L; RI 2.8–9.8 mmol/L), potassium (5.6 mmol/L; RI 4–5 mmol/L), and phosphate (3.6 mmol/L; RI 1.4–2.5 mmol/L), with a haematocrit of 18% (RI 30%–45%). Urine specific gravity was 1.006 (RI &gt; 1.035), without proteinuria, and sterile on culture. Ultrasonography revealed marked bilateral nephropathy (Fig 1B), seen as mild renomegaly (left length 4.6 cm, right 4.8 cm; RI &lt; 4.5 cm), mild pyelectasia (5 mm bilaterally; RI &lt; 3.5 mm), marked diffuse cortical and medullary hyperechogenicity, and numerous small, rounded anechoic cysts along the corticomedullary junction (CMJ). Each renal resistive index was within the normal range (right 0.58, left 0.62. Imaging differentials prioritized renal maldevelopment, acute kidney injury, or degeneration following nephrotoxicosis. Failure to respond to supportive therapy and acute deterioration warranted euthanasia. Necropsy confirmed numerous dilated cysts (up to 1 mm), bilaterally along the CMJ of the kidneys (Fig 1C). Histologically, these were markedly dilated corticomedullary tubules. Numerous oxalate crystals, chronic infarcts, and occasional atrophic and cystic glomeruli with pericapsular fibrosis were also present (Fig 1D). Although feline polycystic kidney disease (PKD) cysts are described at the CMJ, the clinical course and histological appearance were atypical of PKD. Juvenile onset, corticomedullary localization of the tubular cysts, and relatively limited glomerular lesions are features of human nephronophthisis-medullary cystic kidney disease. These features have been rarely reported in veterinary patients.</p><p><b>N. Goody:</b> Data curation (equal). <b>J. Poldy:</b> Data curation (equal). <b>A. Malbon:</b> Data curation (equal). <b>T. Morrison:</b> Data curation (equal). <b>I. Montanes-Sancho:</b> Data curation (equal). <b>S. Dancer:</b> Data curation (equal). <b>D. Gunn Moore:</b> Data curation (equal).</p>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"66 9","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.13863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}