A retrospective analysis of postoperative gastrointestinal dehiscence and ileus in dogs receiving carprofen or not receiving carprofen following gastrointestinal surgery.
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引用次数: 0
Abstract
Objectives: To investigate the relationship between nonsteroidal anti-inflammatory drugs and the occurrence of gastrointestinal dehiscence and ileus in dogs following gastrointestinal surgery.
Study design: Retrospective cohort study.
Materials and methods: Seven hundred and twenty-one dogs had surgery related to foreign body obstruction between January 2009 and December 2020. Records were reviewed and postoperative NSAID administration, ileus, and gastrointestinal dehiscence were recorded. The data were then analyzed for any correlation between age, surgical procedure, NSAID administration, and occurrence of gastrointestinal dehiscence or ileus postoperatively.
Results: 69/721 dogs received carprofen. The distribution by surgery type for dogs receiving carprofen was 43/307 for gastrotomy, 11/216 for enterotomy, and 15/198 for enterectomy. A total of 199 dogs experienced ileus, and 13 dogs experienced intestinal dehiscence. 18/199 dogs that experienced ileus received carprofen, and 0/13 dogs that experienced dehiscence received carprofen. No difference in the occurrence of ileus or intestinal dehiscence was observed for dogs receiving carprofen. The odds of developing postoperative ileus increased by 53% (OR = 1.53, 95% CI: 1.065 to 2.209) for an enterectomy in comparison to a gastrotomy or enterotomy. The odds of developing postoperative ileus increased by approximately 10% for every year increase in age. The odds of dehiscence increased 6.2 times for an enterectomy in comparison to a gastrotomy or enterotomy; however, age and carprofen had no effect on the rate of dehiscence.
Clinical significance: Carprofen did not significantly increase the risk of intestinal dehiscence and can be considered part of multimodal pain control following gastrointestinal surgery with appropriate patient selection.
期刊介绍：
Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery.
In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world.
The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher.
The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association
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