2006 International Conference on Microtechnologies in Medicine and Biology最新文献_第6页

Flexible Regeneration-type Nerve Electrode with Integrated Microfluidic Channels 集成微流控通道的柔性再生型神经电极

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251557

T. Suzuki, N. Kotake, K. Mabuchi, S. Takeuchi

引用次数: 9

Maskless direct cell patterning by laser writing 激光书写的无掩模直接细胞图案

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251550

J.Y. Cheng, Hsueh-Yi Lee, M. Yen, T. Young

{"title":"Maskless direct cell patterning by laser writing","authors":"J.Y. Cheng, Hsueh-Yi Lee, M. Yen, T. Young","doi":"10.1109/MMB.2006.251550","DOIUrl":"https://doi.org/10.1109/MMB.2006.251550","url":null,"abstract":"A simple and effective method for patterning cell on glass substrate is reported. A passivation layer that is capable of preventing cell adhesion was first coated onto glass surface. The passivation coatings that were tested include 3-[Bis(2-hydroxyethyl)amino]propyl-triethoxysilane, 3-Aminopropyltriethoxysilane, 1H, 1H, 2H, 2H-Perfluorodecyl-triethoxysilane, 3 -Glycidyloxypropyltriethoxysilane, Octade cyltrimethoxysilane, and Octadecyltrichlorosilane. A CO2 laser and a UV laser were used to remove the passivation layer and define patterns according to user design. Cell arrays and arbitrary pattern were demonstrated. The minimal feature attainable by the CO2 laser is about 100 mum. The minimal feature for reliable cell adhesion is found to be about 25 mum. Cells adhere and grow cleanly in the laser defined pattern. The pattern can be re-designed and fabricated easily and rapidly. Living cell staining by CMFDA and antibody staining for epidermal growth factor receptor (EGFR) detection were successfully performed on the surface bound cells. This method can be very useful for developing drug screening tools that utilize cell-based detection","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116323891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A 15-Channel Wireless Neural Recording System Based on Time Division Multiplexing of Pulse Width Modulated Signals 基于脉宽调制信号时分复用的15路无线神经记录系统

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251555

M. Yin, R. Field, Maysam Ghovanloo

{"title":"A 15-Channel Wireless Neural Recording System Based on Time Division Multiplexing of Pulse Width Modulated Signals","authors":"M. Yin, R. Field, Maysam Ghovanloo","doi":"10.1109/MMB.2006.251555","DOIUrl":"https://doi.org/10.1109/MMB.2006.251555","url":null,"abstract":"This paper describes a 15-channel wireless implantable neural recording (WINeR) system for long-term in vivo experiments. WINeRS consists of an implantable part that contains a system-on-a-chip (SoC) application-specific integrated circuit (ASIC) and an external receiver. The 3 mmtimes3 mm ASIC is fabricated in the MOSIS AMI 0.5-mum 3-poly 3-metal n-well standard CMOS process. The chip contains 15 low-noise amplifier/filters, time division multiplexer (TDM), sample-and-hold (S&H), pulse width modulator (PWM), on-chip clock generator, 32-bit register for control commands, ISM-band VCO transmitter, reference generator, and inductive power management circuitry. The use of PWM technique has lowered power consumption, improved robustness against noise, and reduced complexity by eliminating ADC and its associated circuitry. A commercial FM receiver is used as the external part of the system. The received PWM signal is further demodulated off-line by a MATLAB program. Finally by time division demultiplexing the demodulated samples, the original neural signals are being reconstructed. A custom wideband receiver with real-time PWM/TDM demodulator/demultiplexer is currently under construction","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126451861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Development of Biosensor Chip for Clinical Diagnosis Using Surface Plasmon Resonance Imaging with Multi-Microchannels 多微通道表面等离子体共振成像临床诊断用生物传感器芯片的研制

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251505

T. Suzuki, Y. Teramura, K. Inokuma, I. Kanno, H. Iwata, H. Kotera

引用次数: 0

On-Chip In vivo Functional Imaging of the Mouse Brain Using a CMOS Image Sensor 利用CMOS图像传感器对小鼠大脑进行体内功能成像

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251531

D. C. Ng, T. Tokuda, K. Kagawa, H. Tamura, Sadao Shiosaka, J. Ohta

{"title":"On-Chip In vivo Functional Imaging of the Mouse Brain Using a CMOS Image Sensor","authors":"D. C. Ng, T. Tokuda, K. Kagawa, H. Tamura, Sadao Shiosaka, J. Ohta","doi":"10.1109/MMB.2006.251531","DOIUrl":"https://doi.org/10.1109/MMB.2006.251531","url":null,"abstract":"We have developed a new method for in vivo functional imaging of the mouse brain using a dedicated CMOS image sensor chip. The image sensor has 176times144-pixels with pixel size of 7.5times7.5 mum 2. A novel packaging process is developed to enable on-chip fluorescence imaging. The sensor chip is attached to a flexible polyimide substrate and sealed in epoxy. A thin-film resist is spin-coated directly onto the image sensor chip for excitation light filtering. By applying multiple coating, a transmittance below -44 dB is achieved. Also, the device has a selectivity of more than 80% for the fluorescence emission of 7-amino-4-methylcoumarin (AMC). The entire packaged device is about 350 mum thick, hence minimizing injury during invasive imaging inside the brain. In vivo functional imaging is performed by using a synthetic fluorogenic substrate which detects the presence of two serine proteases species in the brain. The introduction of kainic acid induces the expression of these protease species, which then reacts with the substrate to release the AMC fluorophore. Imaging of the AMC fluorescence allows the serine protease activity to be measured in real-time. We have successfully measured the protease activity and accurately determined its reaction onset","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132045441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The NanoCytometer: Screening Cells Based on Cell Size 纳米细胞计:基于细胞大小筛选细胞

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251529

A. Carbonaro, L. Godley, L. Sohn

引用次数: 0

3D Microelectrodes for Coulometric Screening in Microfabricated Lab-on-a-Chip Devices 微制造芯片实验室设备库仑筛选的三维微电极

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251537

T. Roussel, R. Pai, M. Grain, D. Jackson, L. Sztaberek, K. Walsh, J. Naber, R. Baldwin, R. Keynton

引用次数: 2

Application of Microstencil Lithography on Polymer Surfaces for Microfluidic Systems with Integrated Microelectrodes 微模板光刻技术在集成微电极微流控系统聚合物表面的应用

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251511

N. Takano, L. Doeswijk, M. van den Boogaart, J. Brugger

引用次数: 1

Finite Element Analysis of Planar Micromachined Silicon Electrodes for Cortical Stimulation 平面微加工硅电极皮层刺激的有限元分析

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251533

R. Field, Maysam Ghovanloo

引用次数: 0

Evaluation of Cell Velocity Regulation in a Microfabricated Adhesion-Based Cell Separation Device 微制造黏附细胞分离装置中细胞速度调节的评价

2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251501

J. Miwa, Y. Suzuki, N. Kasagi

引用次数: 2