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Relationship between Hydrophobic Beads Attachment and Fluid Flow in PDMS Microchannel PDMS微通道中疏水微珠附着与流体流动的关系
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251506
T. Okamoto, T. Yamamoto, Atsuko Takamatsu, N. Kaneko, T. Fujii
{"title":"Relationship between Hydrophobic Beads Attachment and Fluid Flow in PDMS Microchannel","authors":"T. Okamoto, T. Yamamoto, Atsuko Takamatsu, N. Kaneko, T. Fujii","doi":"10.1109/MMB.2006.251506","DOIUrl":"https://doi.org/10.1109/MMB.2006.251506","url":null,"abstract":"The hydrophobic beads as mimic of the living cell attachment to microchannel in fluid flow were observed and analyzed. Beads were collided to the microchannel wall by the right angle flow. We found that beads attachment in the fluid flow should be decided by the fluid velocity to the wall, and hydrophobic interaction between the channel and beads. Shear force is less effective in this case","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123827036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 15-Channel Wireless Neural Recording System Based on Time Division Multiplexing of Pulse Width Modulated Signals 基于脉宽调制信号时分复用的15路无线神经记录系统
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251555
M. Yin, R. Field, Maysam Ghovanloo
{"title":"A 15-Channel Wireless Neural Recording System Based on Time Division Multiplexing of Pulse Width Modulated Signals","authors":"M. Yin, R. Field, Maysam Ghovanloo","doi":"10.1109/MMB.2006.251555","DOIUrl":"https://doi.org/10.1109/MMB.2006.251555","url":null,"abstract":"This paper describes a 15-channel wireless implantable neural recording (WINeR) system for long-term in vivo experiments. WINeRS consists of an implantable part that contains a system-on-a-chip (SoC) application-specific integrated circuit (ASIC) and an external receiver. The 3 mmtimes3 mm ASIC is fabricated in the MOSIS AMI 0.5-mum 3-poly 3-metal n-well standard CMOS process. The chip contains 15 low-noise amplifier/filters, time division multiplexer (TDM), sample-and-hold (S&H), pulse width modulator (PWM), on-chip clock generator, 32-bit register for control commands, ISM-band VCO transmitter, reference generator, and inductive power management circuitry. The use of PWM technique has lowered power consumption, improved robustness against noise, and reduced complexity by eliminating ADC and its associated circuitry. A commercial FM receiver is used as the external part of the system. The received PWM signal is further demodulated off-line by a MATLAB program. Finally by time division demultiplexing the demodulated samples, the original neural signals are being reconstructed. A custom wideband receiver with real-time PWM/TDM demodulator/demultiplexer is currently under construction","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126451861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Development of Biosensor Chip for Clinical Diagnosis Using Surface Plasmon Resonance Imaging with Multi-Microchannels 多微通道表面等离子体共振成像临床诊断用生物传感器芯片的研制
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251505
T. Suzuki, Y. Teramura, K. Inokuma, I. Kanno, H. Iwata, H. Kotera
{"title":"Development of Biosensor Chip for Clinical Diagnosis Using Surface Plasmon Resonance Imaging with Multi-Microchannels","authors":"T. Suzuki, Y. Teramura, K. Inokuma, I. Kanno, H. Iwata, H. Kotera","doi":"10.1109/MMB.2006.251505","DOIUrl":"https://doi.org/10.1109/MMB.2006.251505","url":null,"abstract":"A compact biosensor chip for clinical diagnosis is presented. The proposed biochip integrated three independent microchannels on one chip partially coated with Au thin film as a surface plasmon resonance (SPR) excitation layer. For clinical diagnosis, the affinity binding of unlabeled biological molecules onto the Au surface can be quantitatively analyzed by SPR imaging with the multi-microchannels, i.e. one biosample and two reference flows to obtain an analytical curve","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"246 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132027775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On-Chip In vivo Functional Imaging of the Mouse Brain Using a CMOS Image Sensor 利用CMOS图像传感器对小鼠大脑进行体内功能成像
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251531
D. C. Ng, T. Tokuda, K. Kagawa, H. Tamura, Sadao Shiosaka, J. Ohta
{"title":"On-Chip In vivo Functional Imaging of the Mouse Brain Using a CMOS Image Sensor","authors":"D. C. Ng, T. Tokuda, K. Kagawa, H. Tamura, Sadao Shiosaka, J. Ohta","doi":"10.1109/MMB.2006.251531","DOIUrl":"https://doi.org/10.1109/MMB.2006.251531","url":null,"abstract":"We have developed a new method for in vivo functional imaging of the mouse brain using a dedicated CMOS image sensor chip. The image sensor has 176times144-pixels with pixel size of 7.5times7.5 mum 2. A novel packaging process is developed to enable on-chip fluorescence imaging. The sensor chip is attached to a flexible polyimide substrate and sealed in epoxy. A thin-film resist is spin-coated directly onto the image sensor chip for excitation light filtering. By applying multiple coating, a transmittance below -44 dB is achieved. Also, the device has a selectivity of more than 80% for the fluorescence emission of 7-amino-4-methylcoumarin (AMC). The entire packaged device is about 350 mum thick, hence minimizing injury during invasive imaging inside the brain. In vivo functional imaging is performed by using a synthetic fluorogenic substrate which detects the presence of two serine proteases species in the brain. The introduction of kainic acid induces the expression of these protease species, which then reacts with the substrate to release the AMC fluorophore. Imaging of the AMC fluorescence allows the serine protease activity to be measured in real-time. We have successfully measured the protease activity and accurately determined its reaction onset","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132045441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flexible Regeneration-type Nerve Electrode with Integrated Microfluidic Channels 集成微流控通道的柔性再生型神经电极
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251557
T. Suzuki, N. Kotake, K. Mabuchi, S. Takeuchi
{"title":"Flexible Regeneration-type Nerve Electrode with Integrated Microfluidic Channels","authors":"T. Suzuki, N. Kotake, K. Mabuchi, S. Takeuchi","doi":"10.1109/MMB.2006.251557","DOIUrl":"https://doi.org/10.1109/MMB.2006.251557","url":null,"abstract":"The development of a neural interface that will allow signals from the human nervous system to control external equipment is extremely important for the next generation of prosthetic systems. A novel multichannel regeneration-type nerve electrode designed to record from and stimulate peripheral nerves has been developed to allow the control of artificial hands and to generate artificial sensations. In this study a novel flexible regeneration microelectrode based on the nerve regeneration principle was designed and fabricated using MEMS technologies. The electrode, which was fabricated on a 20-mum-thick parylene C substrate, has multiple fluidic channels. Each fluidic channel was 100 mum widetimes40 mum hightimes1500 mum long and featured multiple electrodes inside them as recording and stimulating sites. They also served as guidance channels for the regenerating axons. The authors are currently attempting to evaluate the probes using the sciatic nerve of rats","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122184117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Application of Microstencil Lithography on Polymer Surfaces for Microfluidic Systems with Integrated Microelectrodes 微模板光刻技术在集成微电极微流控系统聚合物表面的应用
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251511
N. Takano, L. Doeswijk, M. van den Boogaart, J. Brugger
{"title":"Application of Microstencil Lithography on Polymer Surfaces for Microfluidic Systems with Integrated Microelectrodes","authors":"N. Takano, L. Doeswijk, M. van den Boogaart, J. Brugger","doi":"10.1109/MMB.2006.251511","DOIUrl":"https://doi.org/10.1109/MMB.2006.251511","url":null,"abstract":"Microstencil lithography, a resistless, single-step direct vacuum patterning method, is one of promising methods for metal micropattern definition on polymer substrates that are not suitable for conventional photolithography. We propose to apply microstencil lithography to fabricate microelectrodes on flat and pre-structured polymer substrates which form parts of microfluidic systems with incorporated microelectrodes. However, microstencil lithography is accompanied by two main issues when considered as a low-cost, reproducible alternative to standard photolithography on polymer substrates: clogging and blurring. The clogging of stencil apertures induced by metal evaporation was checked in detail, and it was determined that approximately 50 % of the thickness of the evaporated metals was deposited at the side walls of the stencil apertures. The influence of gap presence on the deposited structures was also analyzed experimentally, and we quantified the pattern blurring","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127402497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
3D Microelectrodes for Coulometric Screening in Microfabricated Lab-on-a-Chip Devices 微制造芯片实验室设备库仑筛选的三维微电极
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251537
T. Roussel, R. Pai, M. Grain, D. Jackson, L. Sztaberek, K. Walsh, J. Naber, R. Baldwin, R. Keynton
{"title":"3D Microelectrodes for Coulometric Screening in Microfabricated Lab-on-a-Chip Devices","authors":"T. Roussel, R. Pai, M. Grain, D. Jackson, L. Sztaberek, K. Walsh, J. Naber, R. Baldwin, R. Keynton","doi":"10.1109/MMB.2006.251537","DOIUrl":"https://doi.org/10.1109/MMB.2006.251537","url":null,"abstract":"This paper presents results indicating the complete oxidation of an analyte using a three-dimensional, large surface area microelectrode in a lab-on-a-chip (LOC) device. Traditional photolithographic fabrication techniques were used to construct the microchip prototype, with the exception of the 3D electrodes. Experiments were performed using a flow-injection scheme, where a 1 mM sample of catechol was directed towards the detection reservoir. Oxidation voltage at a planar upstream electrode was increased from 0 to 1.2 V in 0.1 volt increments and was shown to reduce the detection level of the sample at a downstream planar electrode (1.2 V). Oxidation voltage at the upstream 3D electrode was changed in a similar manner and was shown to completely eliminate detection at a downstream planar electrode. These results indicate the complete removal of sample from the flow stream, suggesting that 3D micro fabricated electrodes could be used in an LOC device for coulometric screening","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115090210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The NanoCytometer: Screening Cells Based on Cell Size 纳米细胞计:基于细胞大小筛选细胞
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251529
A. Carbonaro, L. Godley, L. Sohn
{"title":"The NanoCytometer: Screening Cells Based on Cell Size","authors":"A. Carbonaro, L. Godley, L. Sohn","doi":"10.1109/MMB.2006.251529","DOIUrl":"https://doi.org/10.1109/MMB.2006.251529","url":null,"abstract":"Determination of cell size is crucial in many biomedical applications. Here, we show how resistive-pulse sensing and artificial pores can be used to detect and measure cell size accurately. Cell size is determined by measuring the change in resistance when an individual cell passes through the pore. As a proof-of-principle, we show that we are able to measure the change in size when cells undergo apoptosis","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122623001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic device for rapid detection of cytomegalovirus (CMV) by sequence-specific hybridization of PCR-amplified CMV-DNA pcr扩增CMV- dna序列特异性杂交快速检测巨细胞病毒(CMV)的微流控装置
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251530
M. P. Briones, K. Yamashita, S. Numata, M. Miyazaki, Y. Nakamura, H. Maeda
{"title":"Microfluidic device for rapid detection of cytomegalovirus (CMV) by sequence-specific hybridization of PCR-amplified CMV-DNA","authors":"M. P. Briones, K. Yamashita, S. Numata, M. Miyazaki, Y. Nakamura, H. Maeda","doi":"10.1109/MMB.2006.251530","DOIUrl":"https://doi.org/10.1109/MMB.2006.251530","url":null,"abstract":"This paper reports rapid detection of human CMV by using a microfluidic device fabricated on plastic chip. The method employs post PCR product analysis by sequence-specific hybridization between amplified CMV-DNA target and complementary PNA probe in microchannel for specific detection of CMV. The PCR product solution and PNA probe solution flowed simultaneously along the microchannel forming a laminar flow at the straight channel. Hybridization of PCR amplified target DNA and fluorescently labeled peptide nucleic acid (PNA) probe occurred at the interface of the laminar flow. Secondary laminar flow, on the other hand, is formed at the curving part of the microchannel allowing separation of DNA hybrids. Hybridized DNA were detected by laser induced fluorescence microscopy. Collectively, these features allowed identification of PCR amplified CMV-DNA. Compared to the conventional pp65 antigenemia test, microfluidic device is found to be more sensitive in detecting low-level viremia","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133966153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Self-Directed Movements of Droplets on Radially Patterned Surfaces Based on Self-Assembled Monolayers 基于自组装单层的径向图案表面上液滴的自定向运动
2006 International Conference on Microtechnologies in Medicine and Biology Pub Date : 2006-05-09 DOI: 10.1109/MMB.2006.251548
H. Khoo, F. Tseng
{"title":"Self-Directed Movements of Droplets on Radially Patterned Surfaces Based on Self-Assembled Monolayers","authors":"H. Khoo, F. Tseng","doi":"10.1109/MMB.2006.251548","DOIUrl":"https://doi.org/10.1109/MMB.2006.251548","url":null,"abstract":"This paper demonstrates macroscopic (millimetre-scale), self-directed transport of droplets on radially patterned silicon surfaces to induce wettability gradients based on self-assembled monolayers (SAMs). A difference in wettability between the opposite sides of the droplet edge creates a Laplace pressure gradient inside the droplet, forcing the droplet to move forward. Circulating wedge-shaped features with alternate hydrophobic and hydrophilic regions were photographically patterned and combined with selective coating of silanol- and thiol-based SAMs to transport the droplets right to the centre passively. Positions and velocities of the droplets were measured using high speed CCD camera","PeriodicalId":170356,"journal":{"name":"2006 International Conference on Microtechnologies in Medicine and Biology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132403037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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