Journal of Surgical Research最新文献

{"title":"Expanding the Methodology Toolkit for Surgical Research in a Data-Rich Era","authors":"Kanhua Yin MD, MPH ,&nbsp;Lakshika Tennakoon MD, MPhil, DrPH ,&nbsp;Amro M. Abdelrahman MBBS, MS","doi":"10.1016/j.jss.2025.12.037","DOIUrl":"10.1016/j.jss.2025.12.037","url":null,"abstract":"<div><h3>Introduction</h3><div>The volume and variety of available data sources in surgical research continue to expand. While these advances enable increasingly sophisticated analyses, they also introduce substantial methodological complexity, which often exceeds the training in biostatistics and data science for surgeon investigators. Inefficiencies in collaboration between surgeons and methodological experts further compound these challenges.</div></div><div><h3>Methods</h3><div>This special edition was developed to address these gaps by providing clear, introductory, and clinically grounded explanations of emerging research methodologies, each illustrated with surgery-relevant examples.</div></div><div><h3>Results</h3><div>The included articles cover high-impact topics, such as cost-effectiveness analysis, causal inference, spatial analysis, natural language processing, and modern survival analysis. Together, they aim to improve methodological literacy and promote more effective interdisciplinary collaboration in surgical research.</div></div><div><h3>Conclusions</h3><div>By making modern research methods more accessible, understandable, and clinically relevant, this issue seeks to support rigorous study design, sound interpretation, and evidence-based decision making within the surgical community.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 208-210"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Splenic Ruptures: A Contemporary Systematic Review","authors":"Marti Pastak ,&nbsp;Sten Saar MD, PhD ,&nbsp;Edgar Lipping MD, PhD ,&nbsp;Peep Talving MD, PhD","doi":"10.1016/j.jss.2025.12.029","DOIUrl":"10.1016/j.jss.2025.12.029","url":null,"abstract":"<div><h3>Introduction</h3><div>Spontaneous splenic rupture (SSR) is a rare, life-threatening condition. The current study aims to provide a comprehensive recent overview of SSR.</div></div><div><h3>Methods</h3><div>A comprehensive search was performed in PubMed (MEDLINE), Google Scholar, and Scopus to identify relevant case reports and case series published during the last decade (January 1, 2015-July 1, 2025).</div></div><div><h3>Results</h3><div>We identified 351 eligible studies with 400 cases of SSR. The two most common etiologies for SSR were infectious (25.6%) and neoplastic (22.9%) conditions. Drug- or treatment-related etiologies were reported in 19% of cases, and noninfectious inflammatory conditions in 14.6%. Idiopathic SSRs accounted for 4.1% of the cases. Other less frequent, noncategorized etiologies accounted for the remaining 13.7% of the cases. Abdominal pain was the most common symptom, reported in 94.6% of the patients. Overall, 74.4% of the patients were subjected to splenectomy, followed by conservative management in 12.3%, angioembolization in 10.8%, and spleen-preserving surgery in 1.3%. The overall SSR-related mortality rate was 8.7% (95% confidence interval: 6.2%–12.1%).</div></div><div><h3>Conclusions</h3><div>Infectious and neoplastic causes comprise the most common etiologies of SSR. Compared with previous studies the rate of drug- or treatment-related etiologies has evolved, which may be related to the wider use of antiplatelet and anticoagulant drugs, particularly novel direct oral anticoagulants. The rate of angioembolization has significantly increased, whereas splenectomy numbers have declined. Neoplastic etiology and age over 50 years were associated with higher mortality on multivariate analysis. Overall, SSR-related mortality has decreased.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 249-254"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter Regarding: Impact of Etiology on Predictive Models for Acute Pancreatitis Severity: A Retrospective Study","authors":"Xingyu Huang MD","doi":"10.1016/j.jss.2025.11.070","DOIUrl":"10.1016/j.jss.2025.11.070","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Page 396"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Injury - Exploring the Foundations of Health-Related Quality of Life in Older Adults and Their Caregivers","authors":"Krista L. Haines DO, MA ,&nbsp;Carrie Dombeck MA ,&nbsp;Gi Jung Shin BA ,&nbsp;Rachel Morris MD ,&nbsp;Suresh Agarwal MD ,&nbsp;Christopher Cox MD, MPH ,&nbsp;Bryce Reeve PhD ,&nbsp;Kenneth Schmader MD ,&nbsp;Amy Corneli PhD","doi":"10.1016/j.jss.2025.12.033","DOIUrl":"10.1016/j.jss.2025.12.033","url":null,"abstract":"<div><h3>Background</h3><div>Older adults (aged ≥65 years) represent 21% of the trauma admissions in the United States, yet little is known about their health-related quality of life at baseline prior to injury. This study aimed to describe the pre-injury daily activities and social engagement of older adult trauma patients and their caregivers.</div></div><div><h3>Materials and Methods</h3><div>We conducted a longitudinal mixed-methods study including critically injured older adult trauma patients (aged ≥60) and their self-identified caregivers (aged ≥55). This manuscript reports qualitative findings from baseline semi-structured interviews with 16 patient-caregiver dyads enrolled at a single academic trauma center. Interviews were transcribed and analyzed using applied thematic analysis.</div></div><div><h3>Results</h3><div>Two themes emerged: (1) older adults maintained active and socially engaged routines before injury and (2) family relationships were a consistent source of connection and support. Prior to injury, most participants reported involvement in physically and cognitively engaging tasks, including exercise, volunteering, spiritual activities, and caregiving responsibilities. Family interactions, irrespective of frequency, provided comfort and meaning for participants.</div></div><div><h3>Conclusions</h3><div>Older adult trauma patients and caregivers engaged in a wide range of meaningful daily activities and social roles prior to injury. These findings underscore the importance of contextualizing health-related quality of life following injury within the lived experiences of older trauma patients.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 241-248"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Arm Phase Ⅱ Study About a Tissue Oxygen Saturation Monitor in Gastric Tube Reconstruction","authors":"Kenjiro Ishii MD, PhD ,&nbsp;Yasuhiro Tsubosa MD, PhD ,&nbsp;Shuhei Mayanagi MD, PhD ,&nbsp;Keita Mori PhD ,&nbsp;Masazumi Inoue MD, PhD ,&nbsp;Kazunori Tokizawa MD ,&nbsp;Ryoma Haneda MD","doi":"10.1016/j.jss.2025.12.002","DOIUrl":"10.1016/j.jss.2025.12.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Insufficient blood flow at the cervical anastomosis site can cause anastomotic leakage following radical esophagectomy. Previously, we reported the use of a tissue oxygen saturation monitor in a case series study, and we aimed to present the results of the prospective study.</div></div><div><h3>Methods</h3><div>This single-arm phase Ⅱ study involved patients who underwent radical esophagectomy with gastric tube reconstruction and cervical site anastomosis. Regional tissue oxygen saturation (rSO2) was measured at the tip and 2, 4, and 6 cm on the caudal side of the tip before gastric tube elevation through the retrosternal route. After elevating the gastric tube, rSO2 was measured at the same points: 3 cm above the edge of the sternal bone and the chest skin. The primary endpoint was the rate of having rSO2 &gt; 45% 3 cm above the edge of the sternal bone, which was the anastomotic site. The secondary endpoint was the relationship between anastomotic leakage and the rate of change in rSO2 before and after gastric tube elevation. Based on the calculated sample size, 42 patients were enrolled.</div></div><div><h3>Results</h3><div>The rate of having rSO2 &gt; 45% 3 cm above the edge of the sternal bone was 83.3%. Anastomotic leakage was found in seven patients. Only the rSO2 at the tip after gastric tube elevation was significantly lower in patients with anastomotic leakage.</div></div><div><h3>Conclusions</h3><div>Monitoring tissue oxygen saturation was a feasible indicator of blood flow insufficiency in the gastric tube during radical esophagectomy.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-Assisted Simultaneous Bilateral Native Nephrectomy and Living Donor Kidney Transplantation","authors":"Rodrigo Vianna MD, PhD ,&nbsp;Mahmoud Morsi MD ,&nbsp;Armando Salim Munoz-Abraham MD, MBEE ,&nbsp;Giselle Guerra MD ,&nbsp;Gaetano Ciancio MD, MBA","doi":"10.1016/j.jss.2025.12.015","DOIUrl":"10.1016/j.jss.2025.12.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Simultaneous bilateral nephrectomy and living donor kidney transplantation (LDKT) is often indicated for autosomal dominant polycystic kidney disease (ADPKD) with end-stage kidney disease (ESKD). Robotic-assisted surgery offers a minimally invasive alternative to open approaches and may reduce perioperative morbidity and length of stay.</div></div><div><h3>Methods</h3><div>Four adults with ADPKD/ESKD underwent fully robotic-assisted simultaneous bilateral nephrectomy/LDKT (RASBN/LDKT) at a single high-volume transplant center. All procedures used an intra-abdominal approach with a Pfannenstiel incision and GelPort for native kidney extraction and allograft introduction. Clinical, perioperative, and functional outcomes were recorded prospectively and analyzed retrospectively.</div></div><div><h3>Results</h3><div>Median total operative time was 462.5 min (range, 401-544 min). Median length of stay was 3.5 days (range, 3-5 d). There were no intraoperative or postoperative vascular, urological, or surgical complications, and no conversions or hand assistance were required. All recipients had immediate graft function without delayed graft function (no hemodialysis in the first postoperative week). Kidney allograft function remained stable through 12 mo after transplant.</div></div><div><h3>Conclusions</h3><div>Robotic-assisted simultaneous bilateral nephrectomy/LDKT is feasible and safe in carefully selected ADPKD/ESKD recipients, providing excellent early clinical outcomes and expanding the role of minimally invasive techniques for complex scenarios.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 211-218"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving College Readiness Through a High School Surgery Exposure Program","authors":"Kevin T. Mutore MD ,&nbsp;Katalina Acevedo BA, MS ,&nbsp;Phillip Taboada BS ,&nbsp;Munir Buhaya MD,&nbsp;Geli Kane BA,&nbsp;Anthony Froix MD,&nbsp;Thomas Shoultz MD","doi":"10.1016/j.jss.2025.12.025","DOIUrl":"10.1016/j.jss.2025.12.025","url":null,"abstract":"<div><h3>Introduction</h3><div>Racial and ethnic minorities remain significantly underrepresented in the health care workforce. Despite ongoing efforts, gains in representation have been limited and the disparity widens across successive stages of medical training. Early interventions are essential to empower underrepresented minority students interested in health care with the tools to navigate the educational path toward health careers. This study evaluated whether a three-session college preparatory course could influence the attitudes and perceived preparedness for college among high school students enrolled in a medical and surgical exposure program.</div></div><div><h3>Methods</h3><div>Seventy-nine 10th grade students participated in a three-session workshop. Preintervention and postintervention surveys were administered using a modified version of the validated College-Going Self-Efficacy Scale and College Planning Behaviors Scale. Paired presurvey and postsurvey data were analyzed using student's <em>t</em>-tests and Fisher's exact tests, with statistical significance defined as <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Forty-four students (56%) completed both surveys. Postintervention, more students had researched the college application process (<em>P</em> = 0.02), college costs (<em>P</em> &lt; 0.01), and identified someone to answer their college-related questions (<em>P</em> &lt; 0.01). Students also reported increased confidence in choosing a good college (<em>P</em> = 0.01) and belief in their academic ability to finish college (<em>P</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>This is the first study to assess and improve college planning attitudes and behaviors in high school students participating in a surgery exposure program. This suggests that integrating college preparation into health care exposure programs may better support students' educational advancement. Future work should examine whether these improvements lead to increased college application and matriculation rates.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 200-207"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blending Life and the Scalpel: A Financial Literacy Workshop for the Transition Beyond Training","authors":"Martha Godfrey MD ,&nbsp;Ming-Li Wang MD","doi":"10.1016/j.jss.2025.12.039","DOIUrl":"10.1016/j.jss.2025.12.039","url":null,"abstract":"<div><div>Although surgical training programs have formalized curricula for professional knowledge and skills acquisition, there is still a gap in nonclinical knowledge that surgical trainees suffer when transitioning to practice (TTP). Financial literacy is one topic that has been identified by both trainees and program directors as a high-yield topic for TTP. Traditionally, surgical trainees relied on formative experience, self-motivated learning, or one-off local institutional efforts. Due to the high demands of time in surgical training and the frequent accumulation of large amounts of educational debt during this process, financial well-being may be neglected, which can lead to professional and personal stress and burnout. The paucity of formal education on this TTP topic causes surgical graduates to rely on informal mentorship during contract negotiation or expensive legal advice. This situation jeopardizes long-term recruitment and retention of surgeons from nonprivileged backgrounds who are less likely to have access to robust informal financial literacy resources. Financially literate surgeons are more likely to enjoy careers that have longevity and high overall career satisfaction. The topic of financial literacy was the focus of a Hot Topic session during the 2025 Academic Surgical Congress. This article covers the content included in that session, including TTP challenges, employment contract basics, negotiation, compensation models, and insurance. This serves as a real-world guide for those who are preparing for TTP or those interested in supporting the recruitment and retention of the next generation of surgical trainees.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 339-345"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Textbook Outcome After Gastrectomy is Associated With Improved Survival: An Observational Study","authors":"Ebbe Juul Kragbak BScMed ,&nbsp;Andreas Weise Mucha MD ,&nbsp;Pieter de Heer MD, PhD ,&nbsp;Paul Morten Mau-Sørensen MD, PhD ,&nbsp;Nikolaj Nerup MD, PhD ,&nbsp;Michael Patrick Achiam MD, PhD, DMSc","doi":"10.1016/j.jss.2025.12.020","DOIUrl":"10.1016/j.jss.2025.12.020","url":null,"abstract":"<div><h3>Introduction</h3><div>Curative treatment of gastric cancer requires surgery combined with perioperative chemotherapy. Textbook outcome (TO) and textbook oncological outcome (TOO) have gained increasing attention as composite measures representing an ideal surgical and oncological course. We aimed to evaluate the rates of TO and TOO after gastrectomy and their association with long-term outcomes.</div></div><div><h3>Materials and Methods</h3><div>A single-center retrospective observational study was conducted. TO was defined as achieving all of the following: macroscopic radical resection, R0 resection, removal of ≥15 lymph nodes, absence of severe complications (Clavien–Dindo grade &gt;II), no intraoperative complications, hospital stay &lt;21 days, no 30-day mortality, and no unplanned intensive care unit admission, reintervention, or readmission within 30 days after surgery. TOO was defined as TO plus adherence to guideline-compliant chemotherapy. Univariate analyses and multivariable logistic regression were used to identify predictors for TO and TOO. Associations between TO, TOO, and long-term outcomes were analyzed using Kaplan–Meier and Cox regression.</div></div><div><h3>Results</h3><div>We included 141 patients. TO was achieved in 56.7% and TOO in 25.9% of patients. TO was significantly associated with improved overall survival (hazard ratio: 0.31, <em>P</em> &lt; 0.001) and recurrence-free survival (hazard ratio: 0.31, <em>P</em> &lt; 0.001). TOO was not significantly associated with improved survival outcomes. The most common reasons for failing to achieve TO were severe complications (24.8%), reintervention (22.0%), and readmission (17.7%).</div></div><div><h3>Conclusions</h3><div>This study found TO and TOO rates of 56.7% and 25.9%, suggesting quality of care on an international level. TO was significantly associated with long-term survival, supporting its future use as an important quality metric.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 126-135"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review Focused on Cooperative Group Involvement in Surgical Randomized Controlled Trials","authors":"Eloise Papet MD ,&nbsp;Grégoire Moutel MD, PhD ,&nbsp;Jean Pinson MD ,&nbsp;Edouard Roussel MD ,&nbsp;Valérie Bridoux MD, PhD ,&nbsp;Jean-Jacques Tuech MD, PhD","doi":"10.1016/j.jss.2025.12.008","DOIUrl":"10.1016/j.jss.2025.12.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical randomized controlled trials (RCTs) are increasingly conducted in complex, multicenter contexts. Despite growing emphasis on research transparency and rigor, concerns remain regarding the methodological and ethical standards of such trials. Cooperative groups (CGs), well-established in oncology research, may play a role in improving trial quality in surgery—a domain where their influence remains underexplored. This scoping review aims to map the methodological and ethical quality of phase III surgical RCTs published between 2016 and 2020 in international surgical journals, with a focus on the potential impact of CG involvement.</div></div><div><h3>Material and methods</h3><div>We systematically searched ten major surgical journals for RCTs published between January 2016 and December 2020. Eligible trials were assessed using the Jadad scale (methodological quality) and the Berdeu score (ethical quality). We recorded study characteristics including sample size, funding source, multicenter design, and presence of a CG.</div></div><div><h3>Results</h3><div>A total of 520 surgical RCTs were included. The mean Jadad score was 10.0 (±1.54) and the mean Berdeu score was 0.8 (±0.11). Only 50 trials (10%) involved a CG. These trials showed a trend toward higher methodological quality (mean Jadad 10.4 <em>versus</em> 9.97; <em>P</em> = 0.0593) and more frequent inclusion of quality-of-life assessments (28% <em>versus</em> 13%; <em>P</em> = 0.0056). Public funding was significantly more common in CG-led trials (56% <em>versus</em> 33%; <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This scoping review highlights that CG involvement in surgical RCTs is still limited but may be associated with improved methodological practices and broader outcome measures, such as quality of life. These findings suggest that greater involvement of CGs could strengthen research infrastructure and make surgical trials more patient-centered.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"318 ","pages":"Pages 120-125"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}