Journal of Surgical Research最新文献

{"title":"AAS Blog JSR Ad 2025 Print","authors":"","doi":"10.1016/S0022-4804(25)00118-0","DOIUrl":"10.1016/S0022-4804(25)00118-0","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Page IFC"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Breast and Lung Cancer Screening Among Dual-Eligible Women: A Descriptive Study","authors":"Tiffany Yue BS ,&nbsp;Lye-Yeng Wong MD ,&nbsp;Chinmay Jani MBBS ,&nbsp;Lipisha Agarwal MBBS ,&nbsp;Omar Al Omari MBBS ,&nbsp;Ghazal Aghagoli BS ,&nbsp;Alaaeldin Ahmed MD ,&nbsp;Padmanabh Bhatt MD ,&nbsp;Angela Lee NP ,&nbsp;Margaret Lotz PhD ,&nbsp;Hannah Marmor MD, MPH ,&nbsp;Giulia Paliotti BS ,&nbsp;Susan Pories MD ,&nbsp;Jennifer Richmond PhD, MSPH ,&nbsp;Laura Shula PA-C ,&nbsp;Kim L. Sandler MD ,&nbsp;Carey Conley Thomson MD, MPH ,&nbsp;Leah M. Backhus MD, MPH","doi":"10.1016/j.jss.2024.05.024","DOIUrl":"10.1016/j.jss.2024.05.024","url":null,"abstract":"<div><h3>Introduction</h3><div>Lung cancer is consistently the leading cause of cancer death among women in the United States, yet lung cancer screening<span> (LCS) rates remain low. By contrast, screening mammography rates are reliably high, suggesting that screening mammography can be a “teachable moment” to increase LCS uptake among dual-eligible women.</span></div></div><div><h3>Materials and methods</h3><div>This is a prospective survey study conducted at two academic institutions. Patients undergoing screening mammography were evaluated for LCS eligibility and offered enrollment in a pilot dual-cancer screening program. A series of surveys was administered to characterize participants’ knowledge, perceptions, and attitudes about LCS before and after undergoing dual screening. Data were descriptively summarized.</div></div><div><h3>Results</h3><div>Between August 2022 and July 2023, 54 LCS-eligible patients were enrolled. The study cohort was 100% female and predominantly White (81%), with a median age of 57 y and median of 36 pack-y of smoking. Survey results showed that 98% felt they were at risk for lung cancer, with most (80%) motivated by early detection of potential cancer. Regarding screening barriers, 58% of patients lacked knowledge about LCS eligibility and 47% reported concerns about screening cost. Prior to undergoing LCS, 87% of patients expressed interest in combined breast and lung screening. Encouragingly, after LCS, 84% were likely or very likely to undergo dual screening again and 93% found the shared decision-making visit helpful or very helpful.</div></div><div><h3>Conclusions</h3><div>Pairing breast and LCS is a feasible, acceptable intervention that, along with increasing patient and provider education about LCS, can increase LCS uptake and reduce lung cancer mortality.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 204-211"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On The Cover","authors":"","doi":"10.1016/S0022-4804(25)00117-9","DOIUrl":"10.1016/S0022-4804(25)00117-9","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Page vii"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover 1: Update","authors":"","doi":"10.1016/S0022-4804(25)00112-X","DOIUrl":"10.1016/S0022-4804(25)00112-X","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Page OFC"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing Air Leak After Empyema Surgery: COPD’s Role and Patient Management","authors":"Daniel Scheese MD ,&nbsp;Devon C. Freudenberger MD ,&nbsp;Elizabeth Mastoloni BS ,&nbsp;Luke G. Wolfe MS ,&nbsp;Bhavishya Ramamoorthy MD ,&nbsp;Walker Julliard MD","doi":"10.1016/j.jss.2025.01.020","DOIUrl":"10.1016/j.jss.2025.01.020","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite medical advancements, the rise in pleural empyemas persists in the United States. Surgical decortication for pleural empyema subjects patients to the potential complication of a prolonged air leak (PAL). This study aims to uncover the incidence, predictors, and outcomes of PAL following surgical decortication for pleural empyemas within a single tertiary institution.</div></div><div><h3>Materials and methods</h3><div>Patients who underwent surgical decortication for plural empyema between 2011 and 2021 were identified in our single tertiary institution and divided into two groups: PAL and no PAL. Preoperative characteristics and postoperative outcomes were compared, and the results of the descriptive univariate analyses were reported.</div></div><div><h3>Results</h3><div>Among the 228 patients who met inclusion criteria, 7.5% undergoing surgical decortication for pleural empyema were diagnosed with PAL. While demographic differences were not significant between PAL and no PAL groups, PAL patients showed higher chronic obstructive pulmonary disease prevalence (82.4% <em>versus</em> 34.1%, <em>P</em> &lt; 0.001) and lifetime tobacco use. PAL cases had increased rates of reoperation (29.4% <em>versus</em> 8.1%, <em>P</em> = 0.015) and remained intubated at the conclusion of the case.</div></div><div><h3>Conclusions</h3><div>Patients with chronic obstructive pulmonary disease were significantly more likely to develop PAL, which is associated with higher rates of reoperation and extended hospital stays. These findings underscore the importance of preoperative identification of high-risk patients and the implementation of targeted preventive measures to improve surgical and postoperative outcomes, thereby reducing morbidity and healthcare costs.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 116-121"},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Variability in Platelet Response Among Patients With Peripheral Artery Disease","authors":"Sasha P. Suarez Ferreira MD ,&nbsp;Adriana A. Rodriguez Alvarez MD ,&nbsp;Isabella Ferlini Cieri MD ,&nbsp;Shiv Patel BA ,&nbsp;Mounika Boya MD ,&nbsp;Kellie Machlus PhD ,&nbsp;Trisha Roy MD ,&nbsp;Anahita Dua MD, MBA, MSC","doi":"10.1016/j.jss.2025.01.022","DOIUrl":"10.1016/j.jss.2025.01.022","url":null,"abstract":"<div><h3>Introduction</h3><div>Peripheral artery disease (PAD) is prevalent among the elderly population, with Black Americans facing a higher incidence and complications than White Americans. Antiplatelet therapy is crucial for PAD. This observational study aims to discern racial variability in platelet function using viscoelastic assays in patients’ postrevascularization for PAD.</div></div><div><h3>Methods</h3><div>Patients with PAD who underwent revascularization between December 2020 and October 2023 were prospectively enrolled. The cohort was divided by race and antiplatelet therapy regimen. Serial perioperative Thromboelastography with Platelet Mapping assays were performed, and the platelet function was evaluated.</div></div><div><h3>Results</h3><div>A total of 42 patients met the study criteria, and 99 samples were analyzed. In the Thromboelastography with Platelet Mapping assay, the White-Americans cohort showed a significantly lower maximum amplitude (clot strength), lower percentage of platelet aggregation (platelet reactivity), and a significantly higher percentage of platelet inhibition than Black, Asian, and Hispanic Americans on the same antiplatelet regimen.</div></div><div><h3>Conclusions</h3><div>These findings suggest potential racial disparities in platelet response to standard medications, highlighting the critical need for personalized pharmacological approaches that account for genetic and physiological variations across different ethnic populations. Further research is essential to elucidate the underlying mechanisms of these differential platelet responses, which could have significant implications for precision medicine and targeted therapeutic strategies.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 107-115"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Treatment Modalities on Lung Injury in Experimental Pulmonary Contusion Model","authors":"Mustafa Kuzucuoğlu MD ,&nbsp;Cenk Balta MD ,&nbsp;Eren Altun MD ,&nbsp;Ali Cem Yekdeş ,&nbsp;Arkın Acar MD","doi":"10.1016/j.jss.2025.01.017","DOIUrl":"10.1016/j.jss.2025.01.017","url":null,"abstract":"<div><h3>Introduction</h3><div>The study experimentally evaluated the efficacies of different agents in treating pulmonary contusion.</div></div><div><h3>Methods</h3><div>In our study, 42 Wistar albino rats were divided into six groups of seven animals each. A model of lung contusion with blunt chest trauma was performed in five groups, except for the control group. One group with pulmonary contusion was considered an untreated group, and saline was administered. For other groups, prednisolone, tranexamic acid, N-acetylcysteine, and vitamin E were applied to determine their efficacy in treatment. The rats were sacrificed 24 h after trauma, and their injured lungs were collected for histopathological examination and blood samples for blood gas analysis. Histopathologically, bronchial damage, alveolar hemorrhage, emphysema, and leukocyte infiltration were assessed using the scoring system.</div></div><div><h3>Results</h3><div>In our study, statistically significant differences were detected between the rat groups in terms of intraalveolar hemorrhage, leukocyte infiltration, and bronchial damage. In post hoc analysis, intraalveolar hemorrhage was significantly higher in the untreated group compared to the control group (<em>P</em> = 0.012). A near-significant difference was observed between the untreated group and the N-acetylcysteine group (<em>P</em> = 0.061). Regarding leukocyte infiltration, the tranexamic acid group showed significantly higher values compared to both the prednisolone and control groups (<em>P</em> = 0.007; <em>P</em> = 0.016, respectively). For bronchial damage, the levels observed in the vitamin E and tranexamic acid groups were significantly higher than those in the control group (<em>P</em> = 0.08 and <em>P</em> = 0.037, respectively).</div></div><div><h3>Conclusions</h3><div>Many agents are used to treat pulmonary contusion, but no gold standard treatment exists. Prednisolone and N-acetylcysteine play significant roles in treatment. These two drugs contributed to the regression of the findings in pulmonary contusion treatment.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 100-106"},"PeriodicalIF":1.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Disproportionate Increase in Pediatric Laparoscopic Cholecystectomies During the COVID-19 Pandemic","authors":"Philip M. Lee BS ,&nbsp;Cameron Harvey DO ,&nbsp;Eli Snyder BS ,&nbsp;Sneha Singh MD ,&nbsp;Kaushal Desai MD, MPH ,&nbsp;Benjamin Tabak MD ,&nbsp;Sidney Johnson MD ,&nbsp;Devin Puapong MD ,&nbsp;Russell Woo MD","doi":"10.1016/j.jss.2025.01.008","DOIUrl":"10.1016/j.jss.2025.01.008","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic limited many patients to an unhealthy, sedentary lifestyle, with literature specifically demonstrating an increasing trend of obesity in pediatric patients. The goal of this study is to assess the relationship between the COVID-19 pandemic and total number of laparoscopic cholecystectomies performed pre-COVID compared to during COVID.</div></div><div><h3>Methods</h3><div>Data between 2017 and 2021 were collected from the National Surgical Quality Improvement Program on patients ≤18 ys who underwent elective or urgent cholecystectomies. Data was categorized as pre-COVID (2017-2018) or during COVID (2020-2021). Analysis subcategories included case acuity (elective <em>versus</em> urgent <em>versus</em> emergent), wound classification, race, weight, and complications.</div></div><div><h3>Results</h3><div>There were 13,579 pediatric laparoscopic cholecystectomies from 2017 to 2021. The COVID group had 7605 (56.0%) cases, and pre-COVID group 5974 (44.0%). The COVID group had significantly greater average weight and body mass index (BMI) than pre-COVID group (<em>P</em> &lt; 0.001). Increased BMI was associated with increased case acuity and complication rates. Minorities including African Americans and Native American/Pacific Islanders had an increase in number of cholecystectomies performed during COVID. Undergoing a cholecystectomy during COVID was more likely to be classified as urgent or emergent than pre-COVID (<em>P</em> &lt; 0.0001). The COVID group overall had less favorable surgical wound classification as more were classified as class III or class IV cases.</div></div><div><h3>Conclusions</h3><div>There were increases in weight/BMI, case severity, and total laparoscopic cholecystectomies performed during COVID-19. A statistically significant difference in average weight may suggest a relationship between isolation during the COVID-19 pandemic and rates of cholecystectomy. Future research is encouraged to identify contributing factors in these trends.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 93-99"},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Equity and Emergency Colorectal Surgery in the United States: A Scoping Review","authors":"Tamara Byrd MD ,&nbsp;Sebastian Boland MD ,&nbsp;Mary Lou Klem PhD, MLIS ,&nbsp;David Silver MD, MPH ,&nbsp;Liling Lu MS ,&nbsp;Matthew D. Neal MD ,&nbsp;Joshua B. Brown MD, MSc","doi":"10.1016/j.jss.2025.01.019","DOIUrl":"10.1016/j.jss.2025.01.019","url":null,"abstract":"<div><h3>Introduction</h3><div>The emergency colorectal surgery population represents one of the most vulnerable subsets of the larger emergency general surgery population, characterized by increased complication rates, mortality rates, health resource utilization, and hospitalization costs. Disparities and inequities are documented for the emergency general surgery population and its emergency colorectal subset. Addressing health inequities can lead to decreased costs and improvement in patient outcomes; however, it is important to have a full scope of drivers of health inequities in different populations. We summarize the scope of literature that evaluates inequities in patients who undergo emergency colorectal surgery using two equity-based frameworks.</div></div><div><h3>Methods</h3><div>We conducted a systematic search using Medline, Embase, and Web of Science Core Collection databases. Articles were evaluated for inclusion based on evaluation of disparities, inequities, and social determinants in patients who underwent emergency abdominal colorectal surgery in the United States between 2014 and 2024. We extracted data based on components of the PROGRESS (place of residence, race/ethnicity/culture/language, occupation, gender/sex, religion, education, socioeconomic status, social capital) framework and classified studies based on the Phases of Health Disparity Research framework.</div></div><div><h3>Results</h3><div>Twenty-two articles met inclusion criteria. Race/ethnicity was most commonly evaluated in studies (86%) followed by socioeconomic status/insurance status/income. Sex/gender, social support, language, social support, and religion were less commonly evaluated. The majority of the studies focused on malignant disease were in the detecting phase of disparities research.</div></div><div><h3>Conclusions</h3><div>Future studies evaluating inequities in the emergency colorectal surgery population should consider a comprehensive analysis of social factors and measures of structural racism.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 86-92"},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Control Trial Investigating the Effect of Different Treatment Strategies on Mitochondrial Function in Peripheral Arterial Disease-A Study Protocol","authors":"Laura Schoenherr MD ,&nbsp;Juliana Heidler PhD ,&nbsp;Michaela Kluckner MD ,&nbsp;Daniela Lobenwein MD ,&nbsp;Dominik Pesta PhD ,&nbsp;Jan Paul Frese MD ,&nbsp;Sabine Helena Wipper MD ,&nbsp;Alexandra Gratl MD","doi":"10.1016/j.jss.2025.01.014","DOIUrl":"10.1016/j.jss.2025.01.014","url":null,"abstract":"<div><div>Peripheral arterial disease encompasses different clinical symptoms, depending on the severity of the disease. In early stages, a walking-induced pain, known as intermittent claudication, is the leading clinical symptom. Repeating cycles of ischemia and reperfusion induce a typical myopathy, with mitochondria playing the key role within this pathophysiological condition. The aim of this study is to further evaluate the effects of different treatment strategies on mitochondrial function and overall cardiovascular outcomes within a randomized controlled trial. After inclusion, patients will be randomized into different study groups. Study group 1 will receive conservative treatment, while study group 2 will receive revascularization of underlying atherosclerotic lesions. Additionally, a healthy control group will be included. Muscle biopsies will be obtained from ischemic and nonischemic muscle regions, being defined by the anatomic localization of the atherosclerotic lesion, before initiation of treatment as well as after a time interval of 12 wk. Mitochondrial function and content will be evaluated using high-resolution respirometry and citrate synthase activity measurements. Cardiovascular outcomes will be determined by established protocols. This study is registered on <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>–NCT05644158. This study aims to gain further insights into the exact pathophysiological mechanism underlying mitochondrial dysfunction in peripheral arterial disease. The potential effects of mitochondrial regeneration within ischemic muscle regions following a conservative treatment approach will be compared to those reported after revascularization procedures. Additionally, correlation with cardiovascular outcome parameters and <em>in vivo</em> methods will provide a comprehensive approach to this research question.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"307 ","pages":"Pages 78-85"},"PeriodicalIF":1.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}