Journal of Surgical Research最新文献

{"title":"Association for Academic Surgery Founder's Lecture - Addressing the Surgical Workforce Crisis: Retention Strategies for a Thriving Future.","authors":"Gopika SenthilKumar, Reagan A Collins, Patricia Turner, Callisia N Clarke","doi":"10.1016/j.jss.2026.03.101","DOIUrl":"https://doi.org/10.1016/j.jss.2026.03.101","url":null,"abstract":"<p><p>The United States is projected to have a shortage of 10,000 to 19,900 surgeons by 2036, driven by our growing population, an aging surgical workforce, and rising attrition among both practicing surgeons and trainees. Dr. Turner's Founders Lecture at the 2025 American Surgical Congress addresses this surgical workforce crisis by outlining both the origins and current status of the surgeon shortage, while offering an aspirational and achievable vision for expanding our workforce. This address emphasizes the importance of focusing on retention, not just recruitment of surgeons. Through targeted, strategic action and collaboration across national surgical societies, surgeons can be supported, valued, and retained.</p>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Letter Regarding: Barriers and Facilitators to Enhanced Recovery Protocol Implementation for Neonatal Intestinal Surgery.","authors":"Mallory N Perez, Mehul V Raval, Jane L Holl, Willemijn L A Schäfer","doi":"10.1016/j.jss.2026.04.008","DOIUrl":"https://doi.org/10.1016/j.jss.2026.04.008","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric Oxide-releasing Nanofibers Prevent Restenosis After Arterial Injury in a Renal Failure Model.","authors":"C Chase Binion, Paige A Tannhauser, Mark H Barlek, David C Gillis, Lu Yu, Mark R Karver, Samuel I Stupp, Nick D Tsihlis, Melina R Kibbe","doi":"10.1016/j.jss.2026.03.115","DOIUrl":"https://doi.org/10.1016/j.jss.2026.03.115","url":null,"abstract":"<p><strong>Background: </strong>Restenosis from neointimal hyperplasia is a common cause of failure for vascular interventions. Targeted nitric oxide (NO)-releasing peptide amphiphile (PA) nanofibers have been successfully developed to prevent neointimal hyperplasia after vascular injury; however, it remains unknown if comorbid renal failure will affect the efficacy of this nanotherapeutic. We hypothesize that NO-releasing targeted nanofibers will effectively inhibit neointimal hyperplasia following arterial injury in a rat model of renal failure.</p><p><strong>Methods: </strong>PA molecules were synthesized, purified, and co-assembled into nanofibers, which were visualized by transmission electron microscopy (TEM). Twelve-week-old male Sprague Dawley rats (n= 6-7/group) underwent a 5/6^th nephrectomy, followed by carotid artery balloon injury. Rats received saline, targeted nanofiber, or NO-releasing targeted nanofiber. Hemodynamics and blood chemistries were assessed at baseline, 2 wk, and 4 wk, followed by morphometric analysis of carotid arteries.</p><p><strong>Results: </strong>TEM confirmed nanofiber formation for all co-assemblies. Renal failure was confirmed with elevated creatinine (0.70 versus 0.35 mg/dL, P< 0.05), blood urea nitrogen (27.3 versus 18.1 mg/dL, P< 0.05), and mean arterial pressure (116.3 versus 94.8 mmHg, P< 0.05) 2 wk post-nephrectomy compared to baseline. Rats with renal failure which underwent balloon arterial injury and were treated with the NO-releasing targeted nanofiber developed 57.6% less neointimal hyperplasia compared to saline controls (59,136 versus 139,356 μm², P< 0.001).</p><p><strong>Conclusions: </strong>This study demonstrates a single injection of an NO-releasing targeted nanofiber inhibits neointimal hyperplasia in the setting of renal failure with efficacy comparable to historic data in healthy rats. These data have positive implications for translation of this NO-releasing nanotherapeutic to clinical care.</p>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Acute Care and Colorectal Surgeon Views on Management of Patients With Acute Surgical Conditions\".","authors":"Neeraj Singh, Monika Srivastav","doi":"10.1016/j.jss.2026.03.116","DOIUrl":"https://doi.org/10.1016/j.jss.2026.03.116","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Regarding: Nuance in Surgeon Responsibility for Acute Lower Gastrointestinal Surgical Conditions.","authors":"Sara Myers, Jennifer S Davids","doi":"10.1016/j.jss.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.jss.2026.04.005","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Regarding: Prehospital Experience for Left Ventricular Assist Devices.","authors":"Emily L Larson, Ahmet Kilic","doi":"10.1016/j.jss.2026.02.025","DOIUrl":"10.1016/j.jss.2026.02.025","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":"688"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoanalgesia in Patients Undergoing Surgical Stabilization of Rib Fractures: A Comparative Study.","authors":"Alejandro Carmona, Matias Nicolas, Gerardo Tusman, Luzia Toselli, Alejandro García-Pérez, Gastón Bellia-Munzon","doi":"10.1016/j.jss.2025.11.061","DOIUrl":"10.1016/j.jss.2025.11.061","url":null,"abstract":"<p><strong>Introduction: </strong>Effective pain management is crucial to reduce complications and enhance recovery in patients with multiple rib fractures. Although intercostal cryoanalgesia is emerging as a promising strategy to optimize conventional multimodal analgesia in these patients, the literature remains sparse. Since 2019, we have been using cryoanalgesia in surgical stabilization of rib fractures (SSRF), and we hypothesize that it is associated with lower opioid requirements. Thus, we decided to perform a comparative study between patients undergoing SSRF with and without cryoanalgesia.</p><p><strong>Methods: </strong>This retrospective study comprised patients with multiple traumatic rib fractures, who underwent SSRF with multimodal analgesia without cryo (group A) compared with a cohort of similar patients managed with multimodal analgesia with cryo (group B). Multimodal analgesia comprised epidural analgesia, opioids, and nonsteroidal anti-inflammatory drugs. Demographics, severity of pain using the visual analog scale, and median requirement of morphine equivalent dose (MED) were analyzed in both groups. Factors associated with postoperative opioid use were evaluated using descriptive and multivariable analyses.</p><p><strong>Results: </strong>Thirty-six patients were studied, 9 in group A and 27 in group B. Both groups were similar in age, number of rib fracture fixations required, preoperative requirement of opioids, and length of stay. Regarding postoperative opioid consumption, group A required more than twice MED than group B [37.2 mg (interquartile range [IQR] 28.7-47) versus 14.7 mg (IQR 8.25-19.1); P < 0.001]. This difference increased in the outpatient setting [group A: 18.8 mg (IQR 15-27) versus group B: 0.0 mg (IQR 0-3.45); P < 0.001]. The comparison between visual analog scale at discharge also showed significant differences at 7, 14, and 30 d (P < 0.0001) in both groups. In multivariable analysis, only preoperative MED and cryoanalgesia was independently associated with postoperative opioid requirements (R² = 0.58), with cryoanalgesia associated with a mean reduction of 19.9 MED units (95% confidence interval, -28.0 to -11.0).</p><p><strong>Conclusions: </strong>Percutaneous intercostal cryoanalgesia was associated with reduced postoperative and outpatient opioid use and improved pain control in patients undergoing surgical stabilization of rib fractures, supporting its potential role as an adjunct to multimodal analgesia.</p>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":"679-685"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter Regarding: Feasibility of Low-Volume Atomized Povidone-Iodine as a Peritoneal Antiseptic in Complicated Appendicitis.","authors":"Mustafa Alper Akay, Semih Metin, Mustafa Enes Özden","doi":"10.1016/j.jss.2026.02.034","DOIUrl":"10.1016/j.jss.2026.02.034","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":"689-690"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter Regarding: Cryoanalgesia in Patients Undergoing Surgical Stabilization of Rib Fractures: A Comparative Study.","authors":"Kishankumar Mahida, Snehal Rajendra Jagtap","doi":"10.1016/j.jss.2026.01.033","DOIUrl":"10.1016/j.jss.2026.01.033","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":"691-692"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter Regarding: Prehospital Experience With Left Ventricular Assist Devices.","authors":"Chang Meng, Jing Sun, Guobin Miao","doi":"10.1016/j.jss.2025.12.045","DOIUrl":"10.1016/j.jss.2025.12.045","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":" ","pages":"686-687"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}