Journal of Pharmacy and Nutrition Sciences最新文献

{"title":"Review of Medicinal Applications, Phytochemistry and Pharmacological Properties of Aristea ecklonii -","authors":"Alfred Maroyi","doi":"10.29169/1927-5951.2020.10.02.1","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.02.1","url":null,"abstract":"Background: Aristea ecklonii is a perennial herb widely used as herbal medicine in southern Africa. Plants used as traditional medicines to treat various human diseases and illnesses play an important role in the primary healthcare of local communities in developing countries.Purpose: The current study critically reviewed the medicinal uses, phytochemistry and pharmacological properties of A. ecklonii.Methods: Literature on medicinal uses, phytochemical and pharmacological properties of A. ecklonii was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct, and Scopus. Additional information was also obtained from pre-electronic sources such as books, book chapters, theses, scientific reports and journal articles obtained from the university library.Results: This study revealed that A. ecklonii is used as an ornamental plant, protective charm, and herbal medicine for internal sores, cough, fever, syphilis, shingles, and venereal diseases. Ethnopharmacological research identified quinones and sterols from leaves and rhizomes of A. ecklonii. The crude extracts of A. ecklonii and the compound plumbagin isolated from the species exhibited antibacterial and antifungal activities.Conclusion: Aristea ecklonii should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological properties.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91352907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Dietary and Lifestyle Modifications in the Secondary Prevention of Biomarkers of Plaque recurrence in Omani Coronary Revascularized Patients -","authors":"Amanat Ali, Noura S.M. Al-Alawi, M. Sadiq, M. Waly","doi":"10.29169/1927-5951.2020.10.02.3","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.02.3","url":null,"abstract":"Objective: To assess the role of various dietary and lifestyle modifications in the secondary prevention of biomarkers of plaque recurrence in Omani coronary revascularized patients.Methods: Seventy-two patients, from the outpatient cardiology clinic of Sultan Qaboos University Hospital, were included in the study after obtaining an informed consent. In a questionnaire-based study, we collected data about four lifestyle modifications; physical activity, weight reduction, dietary intake and healthy eating patterns and smoking or non-smoking status, in personal interviews. A modified previously validated study questionnaire, which comprised of a semi-quantitative food frequency questionnaire, was used to assess the demographic information, eating patterns, diet quality index score, and daily dietary intake of study participants. The data about patient’s baseline characteristics, revascularization information and biochemical laboratory tests was harvested from the SQUH’s electronic record system. The statistical analysis of data was made using R-studio v.7 and Microsoft excel v.7.Results: The males had higher educational level as compared to females and were more active than females. The data indicated that 16% males and females were diabetic, 10% males and 21% females were hypertensive, and 30% males and 42% females had both diabetes and hypertension. Forty eight percent males and 63% females had body mass index (BMI) >30. However, no significant (P < 0.05) differences were observed in the BMI, diabetes and hypertension status in males and females. Both genders had poor nutritional knowledge. Although the LDL-C and HDL-C values in males and females differed, they were within the normal therapeutic limits. The HbA1c and C-reactive protein values were above the normal ranges with no significant (P < 0.05) difference in both males and females. The average daily energy intake in males (2694 kcalories) was significantly higher compared to females (1603 kcalories). The proportionate contribution of energy from macronutrients was within the acceptable macronutrient distribution ranges. Omani diet score for males (75.5) and females (74.6) didn’t differ significantly (P < 0.05), indicating their adherence to healthy dietary patterns.Conclusions: The results suggest that dietary and lifestyle modifications play significant role in the secondary prevention of biomarkers of plaque recurrence in Omani coronary revascularized patients. Behavioral counseling to promote healthy modifications in dietary and lifestyle factors are therefore recommended in the secondary prevention of risk of plaque recurrence.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76416322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Pharmacological Activities of Ardisia solanacea Roxb: An Ethnomedicinal Plant used in Bangladesh -","authors":"Mohammad Rashedul Islam, Nawreen Monir Proma, Jannatul Naima, Md. Giash Uddin, Syeda Rubaiya Afrin, Mohammed Kamrul Hossain","doi":"10.29169/1927-5951.2020.10.05.17","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.05.17","url":null,"abstract":"Objective: This study aims to uncover the anti-diarrheal, antioxidant, thrombolytic, and anthelmintic activities of methanol extract of A. solanacea (ASME) and its soluble n-hexane fraction in methanol (ASNH).Materials and Methods: The phytochemical assessment of this plant was performed by using the standard method. The anti-diarrheal property was screened by castor oil induced diarrhea in Swiss albino mice and plant extract was administered into mice by oral gavage. The antioxidant property was being investigated by two different in vitro methods such as ferric reducing effect assay and superoxide scavenging activity assay. The thrombolytic activity was evaluated by in vitro clot lysis procedure, and the anthelmintic study was carried out on earthworm Pheretima posthuma.Results: In castor-oil induced diarrhea, ASME and ASNH induced a significant decrease (**P","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72527337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, and Characterization of Carotenoids from 11 Allelopathic Plant Species as Potential Halal Food Colorants and Active Pharmaceutical Ingredients -","authors":"R. Othman, R. Ramya, Muhammad Azzubair Azeman, N. Hassan, Suhair Kammona","doi":"10.29169/1927-5951.2020.10.01.4","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.01.4","url":null,"abstract":"Carotenoids are a class of natural product compound that are currently being used as colouring agents and widely used in food industry. Carotenoids are bioactive pigments obtained mainly from plants through dietary intake. \u0000They possess good features in terms of dietary supplement, food colourant, and polymer stabiliser. The presence of 4 \u0000main carotenoids, which are β-carotene, zeaxanthin, lutein, and violaxanthin, were determined in 4 classes of \u0000allelopathic plant groups namely trees, ferns, grasses and herbaceous plants. This research aims to explore the \u0000carotenoid’s content and composition in 11 allelopathic species by HPLC analysis. A. auriculiformis (tree) was found to have the highest total carotenoid concentration (146.36 μg/g DW) that was substantially higher than all other species tested whereas the lowest total carotenoid concentration was found in S. palustris (fern) (3.76 μg/g DW). Lutein and β-carotene were detected highest in A. auriculiformis (tree), with 1024 ± 25.5 μg/g DW and 37.55 ± 3.16 μg/g DW, respectively. Violaxanthin and zeaxanthin were found substantially highest in M. cajuputi (tree) (5.02 ± 0.5 μg/g DW) and S. palustris (fern) (5.88 ± 0.19μg/g DW), respectively.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"9 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84562704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of Pharmacological Properties, Phytochemistry and Medicinal Uses of Baccharoides adoensis","authors":"Alfred Maroyi","doi":"10.29169/1927-5951.2020.10.05.8","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.05.8","url":null,"abstract":"Baccharoides adoensis is a shrub widely used as traditional medicine throughout its distributional range in tropical Africa. This study is aimed at providing a critical review of the pharmacological properties, phytochemistry, and medicinal uses of B. adoensis. Documented information on the pharmacological properties, phytochemistry, and medicinal uses of B. adoensis was collected from several online sources which included Scopus, Google Scholar, PubMed and Science Direct. Additional information on the pharmacological properties, phytochemistry, and medicinal uses of B. adoensis was gathered from pre-electronic sources such as book chapters, books, journal articles, and scientific publications sourced from the university library. The articles published between 1962 and 2020 were used in this study. This study showed that the roots, flowers, stems, and leaves of B adoensis are widely used as ethnoveterinary medicine and traditional medicines for backbone pain, reproductive problems, kidney diseases, fever and febrile complaints, wounds, ulcers, sexually transmitted infections, skin complaints, malaria, gastro-intestinal problems and respiratory problems. Phytochemical compounds identified from the species include alkaloids, carbohydrates, chondrillasterol, flavonoids, free sugars, glaucolides, glycosides, phenols, proanthocyanidin, saponins, steroids, tannins and terpenoids. Pharmacological research revealed that B. adoensis extracts and compounds isolated from the species have antimicrobial, antimycobacterial, anti-inflammatory, antioxidant, antiplasmodial, anti-pyretic, antitrypanosomal, antileishmanial, anti-ulcer and gastroprotective, immunomodulating, inhibition of Helicobacter pylori adhesion, larvicidal, cytotoxicity and toxicity activities. Baccharoides adoensis should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88251619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Synthesis and Review of Medicinal uses, Phytochemistry and Pharmacological Properties of Maerua crassifolia Forssk. (Capparaceae) -","authors":"Alfred Maroyi","doi":"10.29169/1927-5951.2020.10.05.2","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.05.2","url":null,"abstract":"Maerua crassifolia Forssk. is an evergreen tree widely used as traditional medicine throughout its distributional range in the Sahel region, peninsular Arabia east to Pakistan, east and west Africa. This study is aimed at providing a critical review of medicinal uses, phytochemical and pharmacological properties of M. crassifolia. Documented information on medicinal uses, phytochemical and pharmacological properties of M. crassifolia was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the university library. The articles published between 1964 and 2020 were used in this study. This study revealed that the bark, fruit, leaf and twig infusion and/or decoction of M. crassifolia are mainly used as ethnoveterinary medicine, and traditional medicine for cephalalgia, headache, fever, malaria, wounds, skin infections, toothache and gastro-intestinal problems. Phytochemical compounds identified from the species include alkaloids, amino acids, betaines, cardiac glycosides, fatty acids, flavonoids, lignan glucosides, phenolics, quaternary ammonium compounds, saponins, steroids, tannins and terpenoids. The M. crassifolia extracts exhibited antibacterial, anti-diarrhoeal, analgesic, anti-inflammatory, antioxidant, antiplasmodial, antiprotozoal, antitrypanosomal, antipyretic and cytotoxicity activities. Maerua crassifolia should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88858926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Phenolic Content and Antioxidant Activity of Two Teucrium Species from Syria","authors":"Reem Ghassan Alali, Mays Khazem","doi":"10.29169/1927-5951.2020.10.01.7","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.01.7","url":null,"abstract":"Germander (Teucrium, Lamiaceae) is a genus commonly used as a medicinal herb in the middle east. The aim of this study was to estimate total polyphenols and antioxidant activity of different extracts from two Syrian Teucrium species (Teucrium polium and Teucrium creticum). Total polyphenols content was measured using Folin-Ciocalteu assay and the antioxidant activity was evaluated in vitro by DPPH assay (free radical scavenging activity against 1, 1 – diphenyl-2-picrylhydrazyl). The total polyphenols content and antioxidant activity of T. creticum extracts were higher than T. polium ones. Phenols contents ranged from 16.388 to 105.672 mg GA E/ g dry weight extract. The extracts showed significant scavenging activity against DPPH, with IC50 values ranging between 0.195 and 0.710 mg/ml. The methanolic extracts show higher antioxidant activity from the two species. A good correlation between DPPH scavenging activities and contents of polyphenols was found. These results show that Syrian Teucrium species, especially T. creticum least Known among all, is a rich source of phenols and natural antioxidant compounds, that can be used as a natural food preservative.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"102 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76406095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Pre-Eclampsia, Renal Impairment and Hepatic Insufficiency among Pregnant Women in Al-Jouf Area -","authors":"Omnia Magdy Hendawy, Shaimaa Hussein, Eman A. Harahsheh","doi":"10.29169/1927-5951.2020.10.05.16","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.05.16","url":null,"abstract":"Background: Pre-eclampsia is a pregnancy-specific syndrome. It affects 3-5% of pregnant women and is characterized by oedema, high blood pressure, and proteinuria. Moreover, in women with pre-eclampsia dysfunction of many organs, such as kidney and liver, is diagnosed, while in the case of foetus growth restriction is observed. Pre-eclampsia, when left untreated, can lead to a high mortality rate. In low-income countries, this disorder is one of the main causes of maternal and child mortality. Pre-eclampsia predisposes women in later life to cardiovascular diseases. So far, in acute cases of pre-eclampsia stabilization of the mother and fotus, and finally, termination of pregnancy at a time optimal for both sides can only be considered.Methods: The present work is designed to investigate the relationship between pre-eclampsia, renal and hepatic insufficiency in the Al-Jouf area through collecting information from the electronic database of maternity hospital for 100 pregnant women who suffered from pre-eclampsia compared with normal pregnancies.Results: The prevalence of pre-eclampsia is more prone in eldest women (older than 35 years old) almost 45% than younger women (20-25 years old), PC to MPV ratio value showed a significant suppression in pre-eclamptic pregnancies in comparison with normal pregnant women while HbA1c % value indicated a significant increase in the pre-eclamptic cases than the healthy pregnant women. Renal indices, serum creatinine, urea, and albumin were significantly higher in the pre-eclamptic women than in women with normal pregnancies.Conclusion: There is a tight relationship between hypertensive disorders during pregnancies, chronic renal disorders and hepatic insufficiency.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81501017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gymnanthemum coloratum: Review of its Medicinal uses, Phytochemistry and Pharmacological Properties -","authors":"Alfred Maroyi","doi":"10.29169/1927-5951.2020.10.05.4","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.05.4","url":null,"abstract":"Gymnanthemum coloratum is a shrub or a small tree widely used as traditional medicine throughout its distributional range in tropical Africa. The current study is aimed at reviewing the phytochemistry, pharmacological properties and medicinal uses of G. coloratum. Literature on pharmacological properties, phytochemistry and medicinal uses of G. coloratum was obtained from numerous internet sources such as Scopus, Elsevier, SciFinder, Google Scholar, Pubmed, ScienceDirect, BMC and Web of Science. Other sources of information included pre-electronic sources such as journal articles, theses, book chapters, books and other scientific publications obtained from the university library. The articles published between 1964 and 2020 were used in this study. The current study showed that G. coloratum is used as an anthelmintic, and traditional medicine for reproductive problems, schistosomiasis, liver diseases, sexually transmitted infections, diabetes, sores and wounds, respiratory problems, malaria, skin diseases, fever and gastro-intestinal problems. Ethnopharmacological research identified glaucolides, lactones, amino acids, essential oils, alkaloids, anthocyanins, cardenolids, coumarins, flavonoids, glycosides, leucoanthocyanins, phenols, quinones, reducing sugars, saponins, steroids, tannins, terpenoids and triterpenes from the aerial parts, leaves, roots and stems of G. coloratum. The aerial parts, leaves, roots and whole plant parts of G. coloratum and compounds isolated from the species exhibited anthelmintic, antimicrobial, anti-Blastocystis, anti-inflammatory, anti-sickling, insecticidal and larvicidal, antiplasmodial, antimalarial, antioxidant, antiproliferative, anti-Toxoplasma, hypoglycaemic and antidiabetic and cytotoxicity activities. Gymnanthemum coloratum should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81898489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Trends in the Treatment of Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer -","authors":"P. Sivanandy, S. Shanmugam, Rui Ying Lau, Jonathan Yvong Syen Chin, X. Lee, Y. Y. Lau, Wai Ching Lee, I. Said, Jingyun Lee, Karthika Krishnasamy","doi":"10.29169/1927-5951.2020.10.01.8","DOIUrl":"https://doi.org/10.29169/1927-5951.2020.10.01.8","url":null,"abstract":"","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"11 1","pages":"155-168"},"PeriodicalIF":0.0,"publicationDate":"2020-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90414101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}