Journal of Pharmacy and Nutrition Sciences最新文献

Assessing the Efficacy of Natural Pet Products in Protecting Gastric Cells and Reducing Cytotoxicity under Hyperacidity Conditions: An In Vitro Study 评估天然宠物产品在高酸度条件下保护胃细胞和降低细胞毒性的功效：体外研究

Journal of Pharmacy and Nutrition Sciences Pub Date : 2024-08-08 DOI: 10.29169/1927-5951.2024.14.02

N. Lonigro, E. Martello, F. Perondi, M. Bigliati, Z. R. Mohammed, A. Costale, E. Rosso, N. Bruni

引用次数: 0

Antioxidant Effect of a Combination of S-Acetyl-L-Glutathione, Vitamin E, Silybum Marianumon Hepatic Cells under Oxidative Stress: An In Vitro Study S-乙酰-L-谷胱甘肽、维生素 E 和 Silybum Marianumon 组合对氧化应激下肝细胞的抗氧化作用：体外研究

Journal of Pharmacy and Nutrition Sciences Pub Date : 2024-03-25 DOI: 10.29169/1927-5951.2024.14.01

N. Lonigro, Z. R. Mohammed, F. Perondi, E. Martello, A. Costale, E. Rosso, N. Bruni

引用次数: 0

Protective Effect of Curcuminoids Consumption on Cadmium-Induced Testicular Injury in Albino Rats 姜黄素对镉诱发的白化大鼠睾丸损伤的保护作用

Journal of Pharmacy and Nutrition Sciences Pub Date : 2024-01-02 DOI: 10.29169/1927-5951.2023.13.06

Amusan A. Timothy, Emokpae A. Mathias

{"title":"Protective Effect of Curcuminoids Consumption on Cadmium-Induced Testicular Injury in Albino Rats","authors":"Amusan A. Timothy, Emokpae A. Mathias","doi":"10.29169/1927-5951.2023.13.06","DOIUrl":"https://doi.org/10.29169/1927-5951.2023.13.06","url":null,"abstract":"This study evaluated the protective effects of curcuminoids against cadmium-induced testicular injury in Albino rats. Male albino rats were divided into nine groups, group 1 (control), groups 2-4 received 120 mg/kg, 240 mg/kg, and 360 mg/kg curcuminoids daily for 28 days without testicular injury. Group 5 received 20 mg/kg cadmium chloride (CdCl2) solution every other day for 28 days (positive control), while group 6 received 20mg/kg CdCl2 + 240 mg/kg curcuminoids every other day for 28 days. Group 7 received 20mg/kg CdCl2 every other day for 28 days, then treated with 240 mg/kg for 14 days. Group 8 received 20 mg/kg CdCl2 solution every other day for 28 days, then treated with 240 mg curcuminoids for 28 days. Group 9 received 20 mg/kg CdCl2 solution every other day for 28 days and left to recover 28 days. Serum and seminal plasma malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase were assayed using Spectrophotometry technique. Semen analysis was determined microscopically. Sperm motility and count were significantly reduced, acrosome defect and percent abnormal sperm morphology were increased among the positive control group when compared with negative control group (p<0.05). Serum GPX, GSH, and SOD, semen GPx , GSH and SOD were significantly reduced (p<0.001), while MDA was significantly increased (p<0.001) in CdCl2 administered rats than negative control. The supplementation of Curcumins resulted in the improvement of sperm quality indices in a dose-dependent manner. Curcumin supplementation may significantly reverse the adverse effects of cadmium chloride testicular injury.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Trial: Management of Post-Haemorrhoidectomy Wound Healing by Bergamot Flavonoid-Based Gel and Sodium Hyaluronate: An Observational, Multicentric Trial 临床试验:佛手柑黄酮凝胶和透明质酸钠治疗痔疮切除术后伤口愈合:一项观察性多中心试验

Journal of Pharmacy and Nutrition Sciences Pub Date : 2023-10-13 DOI: 10.29169/1927-5951.2023.13.05

Danilo Cafaro, Luciano Onofrio, Alessandro Sturiale, Salvatore Puglia, Maria Stefania Sinicropi, Alessia Catalano, Gabriele Naldini

{"title":"Clinical Trial: Management of Post-Haemorrhoidectomy Wound Healing by Bergamot Flavonoid-Based Gel and Sodium Hyaluronate: An Observational, Multicentric Trial","authors":"Danilo Cafaro, Luciano Onofrio, Alessandro Sturiale, Salvatore Puglia, Maria Stefania Sinicropi, Alessia Catalano, Gabriele Naldini","doi":"10.29169/1927-5951.2023.13.05","DOIUrl":"https://doi.org/10.29169/1927-5951.2023.13.05","url":null,"abstract":"Objective: Haemorrhoidal disease (HD) is a very diffuse anorectal condition that involves a large part of the population, both male and female of every age. Among the procedures proposed to treat HD, conventional excisional surgery remains one of the most performed. Milligan-Morgan (MM) technique is one of the most used haemorrhoidectomy techniques. In this technique, the wounds are left open and re-epithelialization requires almost 3-5 weeks, in which patients generally experience pain and intense discomfort improving over the weeks. Methods: The aim of this study was to evaluate the effect of topic administration of Benebeo Gel®, mainly composed by bergamot-derived flavonoids and hyaluronic acid, on post-operative wound healing after open MM haemorrhoidectomy. An observational prospective study was carried out, involving 205 patients aged between 18 and 75. Results and Conclusion: The results after 2 weeks of treatment seem to be promising with a very good clinical outcome and patient satisfaction within 1 month.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135857073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acid Suppressant Activity of Feed Dietary Supplements for Dogs 犬饲粮添加物的抑酸活性研究

Journal of Pharmacy and Nutrition Sciences Pub Date : 2023-08-30 DOI: 10.29169/1927-5951.2023.13.04

N. Bruni, E. Martello, Valeria Gabriele, Francesca Perondi

引用次数: 0

Clinical considerations on nutrition and lifestyle in old people with osteoporosis and sarcopenia by the CReI-Food study group of the Italian College of Rheumatologists 意大利风湿病学会CReI-Food研究组对老年骨质疏松症和肌肉减少症患者营养和生活方式的临床考虑

Journal of Pharmacy and Nutrition Sciences Pub Date : 2023-08-18 DOI: 10.29169/1927-5951.2023.13.03

R. Laurenti, Martina Fioretti, Luis Severino Martin Martin, Francesca Tanzini, D. Marotto, E. Gubinelli, A. Migliore

{"title":"Clinical considerations on nutrition and lifestyle in old people with osteoporosis and sarcopenia by the CReI-Food study group of the Italian College of Rheumatologists","authors":"R. Laurenti, Martina Fioretti, Luis Severino Martin Martin, Francesca Tanzini, D. Marotto, E. Gubinelli, A. Migliore","doi":"10.29169/1927-5951.2023.13.03","DOIUrl":"https://doi.org/10.29169/1927-5951.2023.13.03","url":null,"abstract":"Osteoporosis is considered the most frequent rheumatic pathology in the elderly population. It is often accompanied by sarcopenia, defined as the progressive loss of skeletal muscle mass and strength. Together, these conditions increase the risk of falls, fractures, disability, lower quality of life, and frequent hospitalization. This means increased healthcare costs for all European countries, due to the increase in the average age and elderly population. Multiple pharmacological therapies are available for osteoporosis, but the prevention seems to be an important tool to reduce the risk of fracture and hospitalization of patients. A healthy lifestyle, consisting of the right amount of nutrients and micronutrients and physical exercise can help prevent the development of osteoporosis and sarcopenia in the elderly. This review brings together the information present in the literature on the benefits that nutrients and micronutrients, naturally present in foods, have on the prevention of these pathologies. it is suggested that a correct intake of proteins, calcium, phosphorus, magnesium, vitamin.D, vitamin C and antioxidants, vitamin K and omega 3, associated with constant physical exercise, can help to contain osteoporosis. It also indicates the right physical exercise for older osteoporotic adults. This document drawn up by the CReI-Food study group of the Italian College of Rheumatologists aims to provide, based on the most recent scientific evidence, indications on correct nutrition and lifestyle for the prevention and treatment of osteoporosis in older people.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86985890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Assessment of Pulps and Partial Characterization of Seed Oils from Varieties of Pear Fruits 梨品种果肉的营养评价及籽油的部分特性

Journal of Pharmacy and Nutrition Sciences Pub Date : 2023-04-28 DOI: 10.29169/1927-5951.2023.13.02

N. Obasi, C. Aloke, S. E. Obasi, A. Famurewa, S. Elom, P. M. Aja, L. O. Ajala

{"title":"Nutritional Assessment of Pulps and Partial Characterization of Seed Oils from Varieties of Pear Fruits","authors":"N. Obasi, C. Aloke, S. E. Obasi, A. Famurewa, S. Elom, P. M. Aja, L. O. Ajala","doi":"10.29169/1927-5951.2023.13.02","DOIUrl":"https://doi.org/10.29169/1927-5951.2023.13.02","url":null,"abstract":"\u0000The nutrients and chemical contents of Persea americana, Dacryodes edulis, and Canarium scheinfurthi fruits and partial characterization of their seed oils were carried out to ascertain their nutritional benefits. The fruit pulps were analyzed for chemical (proximate) composition, amino acids profile, vitamins, and phytochemical and anti-nutritional compositions. Oils were extracted from the fruit seeds and the physico-chemical properties of the seed oils were determined according to the standard protocols. The results showed that the fruit pulps contained an abundance of macro- and micro-nutrients which varied significantly (p < 0.05) among the varieties with low anti-nutrients. The essential amino acid contents were high and varied significantly (p < 0.05) among the varieties. Glutamic acid, followed by aspartic acid had the highest concentration of the amino acids, while the concentrations of methionine and cysteine were low in all the varieties. The results also revealed high essential amino acids score values, above 100% for isoleucine and total aromatic amino acids. The physicochemical properties of the fruit oils showed that the oils were edible (low acid value) and may have industrial potential due to their low peroxide, iodine, and saponification values. Overall, the results showed that the pears are nutritionally rich and could serve dietetic and industrial purposes.\u0000","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89914749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological Assessment of Selenium Protective Effect Against Diclofenac Sodium-Induced Nephrotoxicity in Rats 硒对双氯芬酸钠所致大鼠肾毒性保护作用的组织学评价

Journal of Pharmacy and Nutrition Sciences Pub Date : 2023-04-26 DOI: 10.29169/1927-5951.2023.13.01

Suhair Albassit, Shaza Al laham, A. Al-Manadili

{"title":"Histological Assessment of Selenium Protective Effect Against Diclofenac Sodium-Induced Nephrotoxicity in Rats","authors":"Suhair Albassit, Shaza Al laham, A. Al-Manadili","doi":"10.29169/1927-5951.2023.13.01","DOIUrl":"https://doi.org/10.29169/1927-5951.2023.13.01","url":null,"abstract":"Drug-induced nephrotoxicity is a matter of global significance, with widespread implications for human health. Non-steroidal anti-inflammatory drugs (NSAIDs), such as Diclofenac Sodium, are widely used but have been associated with numerous adverse effects, including those on the gastrointestinal tract, liver, and kidney. Selenium, an essential element in mammalian biology, has demonstrated antioxidant properties that enable it to antagonize the effects of free radicals. The present study aimed to investigate the potential protective effect of Selenium against Diclofenac Sodium-induced nephrotoxicity in rats. The study sample consisted of 32 male albino Wistar rats and was randomly divided into 4 groups: Control group, Diclofenac group (Dic group) (administered at a dose of 50 mg/kg I.M., for 3 days), Selenium group (Se group) (administered at a dose of 1 mg/kg I.P., for 8 days), and Diclofenac plus Selenium group (Dic + Se group). Rats were sacrificed on the 9th day. The results were analyzed with a significance level of p<0.05. The findings revealed significant tubular and glomerular injuries in the Diclofenac group compared to the control group. However, there was no statistically significant improvement observed in the Dic + Se group. In conclusion, the results of this study suggest that Selenium affords partial protection against Diclofenac Sodium-induced nephrotoxicity, but it is not sufficient to provide complete protection.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83668908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mitigation of the Oxidative Damage in Liver Caused by Influenza Virus Infection in Mice by an Effective Combination of Oseltamivir and S-adenosyl-L-methionine (SAM) 奥司他韦与s -腺苷- l-蛋氨酸联合有效减轻流感病毒感染小鼠肝脏氧化损伤

Journal of Pharmacy and Nutrition Sciences Pub Date : 2022-12-31 DOI: 10.29169/1927-5951.2022.12.11

M. Mileva, Adriana Dimitrova-Koleva, E. Tsvetanova, D. Krastev, A. Georgieva, A. Alexandrova, A. Galabov

{"title":"Mitigation of the Oxidative Damage in Liver Caused by Influenza Virus Infection in Mice by an Effective Combination of Oseltamivir and S-adenosyl-L-methionine (SAM)","authors":"M. Mileva, Adriana Dimitrova-Koleva, E. Tsvetanova, D. Krastev, A. Georgieva, A. Alexandrova, A. Galabov","doi":"10.29169/1927-5951.2022.12.11","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.11","url":null,"abstract":"\u0000This study aimed to estimate the protective effect of a combination of S-Adenosyl-L-methionine (SAM) as a precursor of glutathione and oseltamivir as a specific inhibitor of virus replication on oxidative damages caused by influenza infection in the liver of infected mice. Albino mice were inoculated with 10×LD50 of influenza virus A/Aichi/2/68(H3N2). Oseltamivir was applied for five days after infection, twice per day, in a dose of 2.5 mg/kg. SAM was applied for ten days in a 100 mg/kg dose, starting five days before inoculation. Markers of oxidative stress, mortality rate, mean survival time, index, and protection coefficient were followed. Influenza infection causes severe oxidative damage to the liver. All combinations of SAM and oseltamivir restored the levels of the biochemical markers to those in healthy animals and improved the virological parameters. A combination of SAM 100 mg/kg and oseltamivir 2.5 mg/kg, which is 1/4 of the optimal therapeutic mice dose, exhibits protection index and affects most effectively all the tested parameters. This study provides an easy-to-apply approach with a good therapeutic potential for co-medicating influenza infection with a specific antiviral agent and an antioxidant precursor.\u0000","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75194704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Activity of Bioactive Compounds of Green Coffee Beans on Periodontogenic and Nosocomial Bacteria 生咖啡豆生物活性化合物对牙周病细菌和医院细菌的抑菌活性

Journal of Pharmacy and Nutrition Sciences Pub Date : 2022-12-27 DOI: 10.29169/1927-5951.2022.12.13

S. Tripathi, N. Mishra, N. Mishra

{"title":"Antibacterial Activity of Bioactive Compounds of Green Coffee Beans on Periodontogenic and Nosocomial Bacteria","authors":"S. Tripathi, N. Mishra, N. Mishra","doi":"10.29169/1927-5951.2022.12.13","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.13","url":null,"abstract":"The emergence of antimicrobial resistance and the side effects of synthetic drugs have raised an interest in searching for new antimicrobial compounds. The present study aims to evaluate in vitro antibacterial activity of green coffee and its active compounds (chlorogenic acid extract and caffeine extract) against some periodontogenic and nosocomial bacteria. The bioactive compounds, viz. chlorogenic acid and caffeine, were extracted through soxhlet extraction using methanol and water, respectively, and HPLC UV quantified these compounds. The study reported 3 CQA, 4 CQA, and 5 CQA as the significant chlorogenic acids in green coffee beans. Aqueous extract of green coffee beans (AGCB), which is dominant in caffeine, has been found to be the least effective against both periodontal and nosocomial bacteria. The result of our study revealed that the methanol extract of green coffee bean (MGCB), rich in chlorogenic acid, exhibits the highest inhibitory activity against periodontogenic bacteria, followed by the ethanol extract of green coffee bean (EGCB) and AGCB extract. EGCB extract was significantly effective against Staphylococcus epidermidis among selected nosocomial pathogens. AGCB extract was least effective against all bacteria. The results highlight that green coffee polyphenols, especially chlorogenic acid, could be used as antimicrobial agents in different biotechnological applications. The antibacterial property of green coffee highlights its potential as a naturally active antibacterial compound.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"19 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82899271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0