Journal of Pharmacy and Nutrition Sciences最新文献

{"title":"Effects of Controlled Culture Conditions on Chemical Composition and Antimicrobial Activities of Mentha rotundifolia Essential Oils","authors":"A. Benahmed, Khaoula Cherouana, Imen Benchikhelhocine, Assia Ikhlef, Asma Meghezzi, B. Harfi","doi":"10.29169/1927-5951.2022.12.14","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.14","url":null,"abstract":"The study objectives were the determination of Mentha rotundifolia essential oils composition using GC/MS analysis and the evaluation of their antimicrobial activities. In addition, the determination of the relationships between plants acclimatization conditions, essential oils composition and antimicrobial activities.\u0000Essential oils extracted via hydrodistillation method from wild plants and acclimatized plants in different culture conditions of Mentha rotundifolia. Five selected pathogenic microbial strains were used to evaluate EOs in vitro antimicrobial activities.\u0000Essential oils GC/MS analysis revealed the dominance of the oxygenated monoterpene (piperitenone oxide). A significant effect of plant culture conditions in acclimatization room on essential oils composition compared to the control was observed. We also noted that antimicrobial activities of extracted essential oils from acclimatized plants were higher than those from field-grown M. rotundifolia plants.\u0000Content of Piperitenone Oxide in acclimatized plantlets is 93.07% for plantlets cultured at 16°C and a photoperiod of 16 hours light / 8 hours dark, statistically higher than wild plants where it is around 78%. We also noted the presence of Limonene (5.7%) in plantlets grown at 35°C which is significantly different than that of the wild plants (1.55 %). Essential oils antimicrobial activities showed that the plantlets grown at 16 °C or in total darkness were more active towards the tested strains. While, the EO of plantlets cultured at 35 °C were the least active.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79094232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions","authors":"S. W. Qader, L. S. Chua, Janelle Fournier, Mehmet Ozdemir","doi":"10.29169/1927-5951.2022.12.09","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.09","url":null,"abstract":"Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important to discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian plants were collected and analyzed to understand the underlying pathways. Keywords include peptic ulcer, gastric ulcer, NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Helicobacterpylori, medicinal plant, gastroprotection, antiulcer, acid secretion, cytoprotective, and digestion processes were applied in the search engines. Twenty-two of the plants had been reported based on the collected data. The review concludes that Malaysian plants could protect the gastric wall against necrotizing agents like ethanol and NSAIDs. This is mainly due to four critical defensive mechanisms: cytoprotective barriers, regulation of heat-shock protein 70 (HSP70) and pro-apoptotic protein (BAX), gastric acid secretion, and antioxidant capability. The mechanisms have been illustrated in the schematic diagrams for better understanding.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74909136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Araliaceae in Southern Africa: A Review of Ethnobotanical Uses, Phytochemistry, Pharmacology, and Toxicology","authors":"A. Maroyi","doi":"10.29169/1927-5951.2022.12.10","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.10","url":null,"abstract":"There is widespread use of species belonging to family Araliaceae in traditional medicine in southern Africa. The aim of this review was to assess medicinal uses, phytochemistry, pharmacology and toxicological properties of indigenous species belonging to family Araliaceae in southern Africa. Relevant articles, books, theses, dissertations, patents, and other English-only reports on the medicinal uses, phytochemistry, pharmacological and toxicological properties of species belonging to the family Araliaceae in southern Africa (Angola, Botswana, Eswatini, Lesotho, Malawi, Mozambique, Namibia, South Africa, Zambia and Zimbabwe) were reviewed. Databases such as PubMed, Web of Science, Elsevier, Google Scholar, Scopus, Springer, Science Direct, Taylor and Francis between January and July 2022. Eleven species, namely Cussonia. arborea, C. arenicola, C. natalensis, C. nicholsonii, C. paniculata, C. sphaerocephala, C. spicata, C. transvaalensis, C. thyrsiflora, C. zuluensis and Neocussonia umbellifera are used as traditional medicines against 48 human and animal diseases. This study showed that alkaloids, anthocyanins, anthracene glycosides, botulin, flavonoids, free gallic acid, iridoids, phenolics, saponins, steroids, tannins, triterpenoids and volatile oils have been identified from these species. Pharmacological research revealed that the crude extracts and compounds demonstrated isolated from these species are characterized by Aβ42 protein reduction, acetylcholinesterase, analgesic, antibacterial, antifungal, antiviral, anticancer, antihyperglycemic, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, antiprotozoal, anti-ulcer, immunomodulatory, larvicidal, molluscicidal, spermicidal, cytotoxicity and toxicity activities. Reports of medicinal uses, phytochemistry, pharmacology and toxicological properties of species belonging to the family Araliaceae in southern Africa could only be found for 11 species, suggesting that further investigation of largely unexplored family members is necessary.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87956004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Review on Extraction of Biomolecules","authors":"S. Shireen, A. S. Zarena","doi":"10.29169/1927-5951.2022.12.15","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.15","url":null,"abstract":"Nature has given us a wide range of biological compounds that can be utilized to help combat health problems, but sometimes with over-processing, these advantages are diminished or lost. Food and pharmaceutical companies have developed a range of new approaches to harness and retain the naturally occurring diversity and quality of bioactive compounds efficiently and effectively. Pharmaceutically important plant products have been known for millennia; they have been used in crude and unrefined forms. One of the best ways to pick the best plant bioactive is through genetic engineering, omics, and plant tissue culture. Many laboratories routinely screen plant species for bioactive compounds to discover new ones. All extraction methods depend on the researcher's preference and what exactly the research entails. Successful extraction begins with the careful selection and preparation of plant samples and thorough knowledge and review of the appropriate literature. Here we have attempted to describe the different stages and methods of extraction from the medicinal plants. From the review, it can be concluded that no universal extraction method is ideal and that each extraction procedure is unique.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89696591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycine Betaine","authors":"Aman Singh, Pooja Singh, K. Choudhary","doi":"10.29169/1927-5951.2022.12.12","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.12","url":null,"abstract":"\u0000Abiotic stresses like temperature, water, salinity, ultraviolet (UV) radiations, heavy metals, etc., affect plants’ growth and yield. Despite these constraints, plants produce a variety of metabolites to maintain their survival. Primary metabolites, produced through crucial metabolic processes, are essential for plants survival. Additionally, secondary metabolites (SMs) are synthesized from primary metabolites and are mainly used as a defensive mechanism and a means of interacting with unfavorable environmental conditions. In addition to their defensive function in plants, SMs are significant in the pharmaceutical industry. Glycine betaine (GB) is a quaternary ammonium compound that belongs to a class of SMs, present in plants, animals, and microbes. It functions as a compatible solute and reflects potential bioactivity against various abiotic stresses like salinity, water, heat, heavy metals, UV radiations, etc. Due to high solubility and low viscosity, its accumulation is commonly observed in chloroplasts and plastids. The accumulation level generally depends on plant species, growth stage, exposure duration, and stress's nature. GB reduces oxidative stress and prevents the damaging of photosystems and other biomolecules under stressful conditions. It is important for maintaining the water potential and osmotic pressure of cells and hence functions as a potent osmolyte under salinity stress. Excessive production of ROS during temperature stress is responsible for damage to oxygen-evolving complexes, electron transport chains, and photosystems. In order to protect plants from these damages, GB activates the genes responsible for synthesizing heat shock proteins, glycoproteins, and antioxidants via various signaling pathways. GB alleviates the effect of water stress by maintaining the function of rubisco and calcium ion ATPase activity via crosstalk with Abscisic acid (ABA) and ethylene. GB supports the proper functioning of the ascorbate-glutathione cycle, superoxide dismutase, catalase, peroxidase, and ascorbate peroxidase (antioxidative enzymes) to overcome various stresses. Phytohormones like salicylic acid (SA), jasmonic acid (JA), ABA, ethylene, and polyamines (PAS) coordinate well with GB via different signaling pathways to ensure plant protection under various abiotic stresses. The potential bioactivity of GB against various abiotic stresses in plants has been summarized in this review.\u0000","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74103388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Phosphate Binding Capacity of a Dietary Supplement for Dogs and Cats","authors":"N. Bruni, E. Martello, R. Adami, G. Meineri, F. Perondi, Annalisa Costale, Elena Rosso, I. Lippi","doi":"10.29169/1927-5951.2022.12.08","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.08","url":null,"abstract":"\u0000Hyperphosphatemia has been recognized as a serious and frequent complication in dogs and cats with Chronic Kidney Disease (CKD). The veterinary approach is mainly based on reducing phosphorus in the diet and with phosphate (P) binders. In this in vitro study we compared seven supplements with a different combination of ingredients for dogs and cats at pH 3 and 7 to estimate the P binding capacity overtime. Our results confirmed the best binding capacity of supplements at acid compared to basic condition. The P binding capacity of two products containing mainly calcium carbonate, calcium lactate-gluconate and chitosan was higher compared to the other tested at the same conditions.\u0000","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82885900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cross-Sectional Study of Self Efficacy, Diet Compliance, and Blood Sugar Levels on Diabetes Mellitus Patients in Indonesia","authors":"Putri Dafriani, Roza Marlinda, Mahira Prameswari, Ratna Sari Dewi, Fajrilhuda Yuniko","doi":"10.29169/1927-5951.2022.12.07","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.07","url":null,"abstract":"Diabetes mellitus (DM) has become a global health problem because the prevalence of diabetes mellitus continues to increase. Data from the West Sumatra Provincial Health Office (2018), DM cases totalled 44,280 cases, with a DM prevalence of 1.6% in 2018. Self-efficacy plays an important role in controlling blood sugar levels. Lack of self-efficacy causes the patient's blood sugar levels to become abnormal, resulting in a risk of complications. This research aims to study the relationship between self-efficacy and diet compliance with blood sugar levels in DM patients at the Andalas Public Health Center, Padang City. The research method is descriptive-analytic with a cross-sectional approach, with a total sample of 75 people. The results showed that 78.7% of the respondents have hyperglycemia, 72.0% with non-compliant to their diet limitation, and 68.0% with low self-efficacy. A relationship exists between diet compliance and blood sugar levels in type 2 DM patients. There is a relationship between self-efficacy and blood sugar levels in type 2 diabetes mellitus patients at the Padang Andalas Public Health Center in 2022.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85148526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence, Clinical and Economic Impact of Infliximab CT-P13 in Rheumatoid Arthritis, Psoriatic Arthropathy and Ankylosing Spondylitis Naïve and Switched Patients: After 5 Years of Follow-Up","authors":"J. Borrás-Blasco, Alejandro Valcuende-Rosique, D. Rosique-Robles, E. Casterá","doi":"10.29169/1927-5951.2022.12.06","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.06","url":null,"abstract":"Objective: Study the economic impact and persistence of Inflectra® in rheumatoid arthritis (RA), psoriatic arthropathy (PSA), psoriasis, ankylosing spondylitis (AS) naïve, and Remicade® switched patients. \u0000Methods: Retrospective observational cohort study of patients treated with Inflectra® for more than six months in a five years analysis. We collected age, sex, indication, dose, and persistence (in years) for Inflectra® naïve and Remicade® switched patients. Efficacy endpoints included a disease activity score calculator for rheumatoid arthritis (DAS28) and bath ankylosing spondylitis disease activity index (BASDAI). Safety was also assessed. We determined each patient's actual cost of Inflectra® treatment from individualized IV administration and correlated dates during the study period. We simulated the actual cost of these patients if the patients received Remicade®. \u0000Results: During five years, 62 patients (38 women; 31 AS, 18 RA, 13 PSA were treated with Inflectra®. 33 (53%) patients were naïve patients, and 29 (47%) were Remicade® switched patients. In Sept 2019, 33 patients continued on Inflectra® treatment (11 naïve; 22 Remicade® switched) in clinical remission. Twenty-nine patients discontinued therapy, 24 due to relapse, and five due to adverse reactions. All patients with Inflectra® presented a persistence of 24.4±7.4 months. The persistence in naïve patients was 19.1±4.4 months and in Remicade® switched patients was 29.7±5.8 months. The total associated costs of the Inflectra® treatment throughout the observation period were 901.840€. If these patients had been treated with Remicade®, the total cost of therapy would have been 1.099.803€. The use of Inflectra® saved 197,964€ during five years. \u0000Conclusions: Inflectra® produces similar persistence and substantial cost savings when used in Infliximab naïve patients and Remicade® switched patients.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85356731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral Effects and Mechanisms of Action of Water Extracts and Polysaccharides of Microalgae and Cyanobacteria","authors":"N. Besednova, B. Andryukov, T. Kuznetsova, T. Zaporozhets, S. Kryzhanovsky, S. Ermakova, M. Shchelkanov","doi":"10.29169/1927-5951.2022.12.05","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.05","url":null,"abstract":"Microalgae (MA) and cyanobacteria (CB) are currently attracting much attention from scientists due to the high biological activity of many secondary metabolites of these aquatic organisms. This review presents up-to-date modern data on the prospects for using polysaccharides (PS) of these marine aquatic organisms as effective and practically safe antiviral agents. These natural biopolymers are polyvalent compounds, which allows them to bind to several complementary biological target receptors. Particular emphasis is placed on the exopolysaccharides (EPS) Spirulina sp. (Arthrospira sp.), Porphyridium sp., Chlorella sp., and Euglena sp., whose antiviral activity makes them promising for the creation of drugs, biologically active food supplements, and products for functional nutrition. The mechanisms of the biological action of PS and the targets of these compounds are presented with a brief description of PS's anti-inflammatory, immunomodulatory and antioxidant actions, which make the most significant contribution to the antiviral effects. The authors hope to draw the attention of researchers to the use of water extracts and polysaccharides of microalgae and cyanobacteria as potential broad-spectrum antiviral agents that can become the basis for new antivirus strategies.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":" 1274","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72377903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mode of Actions of Bile Acids in Avoidance of Colorectal Cancer Development; and their Therapeutic Applications in Cancers - A Narrative Review","authors":"K. Kaur, G. N. K. Allahbadia, M. Singh","doi":"10.29169/1927-5951.2022.12.04","DOIUrl":"https://doi.org/10.29169/1927-5951.2022.12.04","url":null,"abstract":"Bile Acids (BAs) possess a considerably significant part in the form of emulsifiers in digestion besides absorption of dietary lipids. BAs represent amphiphilic molecules, that are primary metabolites formed from cholesterol by the aid of enzymes acting on cholesterol. Earlier BAs were believed to be tumor repressors. The tumor repressive actions of BAs are correlated with programmed cell death (PCD). Furthermore, dependent on this observation different Synthetic BAs products have been generated along with their utilization regarding induction of PCD (in the form of apoptosis, autophagy or necroptosis in variable kinds of human cancers. Thus we conducted a narrative review till August 2022. The present article might form the basis of generationof such innovative therapies even for cancers/tumors that are cisplatin resistant. With time these therapies might be used for the treatment of neurodegenerative diseases (NDD), amyotrophic sclerosis, and numerous metabolic and haematological diseases as described for use of TUDCA.","PeriodicalId":16959,"journal":{"name":"Journal of Pharmacy and Nutrition Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77914396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}