Evolutionary Applications最新文献

{"title":"Genetic Monitoring of Brown Trout Released Into a Novel Environment: Establishment and Genetic Impact on Natural Populations","authors":"Anastasia Andersson,&nbsp;Sara Kurland,&nbsp;Sten Karlsson,&nbsp;Nils Ryman,&nbsp;Linda Laikre","doi":"10.1111/eva.70084","DOIUrl":"https://doi.org/10.1111/eva.70084","url":null,"abstract":"<p>Translocations are carried out either unintentionally or intentionally for conservation or management reasons. In both cases, translocated populations may genetically impact natural populations via introgression. Understanding how genetic background may affect an establishment in a novel environment and the potential risks for native populations is important for biodiversity conservation. Here, using a panel of 96 SNPs, we monitor the establishment of two genetically and ecologically distinct brown trout populations released into a mountain lake system in central Sweden where trout did not occur prior to the release. The release was carried out in 1979, and we monitor the establishment over the first three decades (5–6 generations) in seven lakes downstream of the release site. We find that extensive hybridization has occurred, and genes from both populations exist in all lakes examined. Genes from the population that was nonmigratory in its native environment have remained to a higher degree in the area close to the release site, while genes from the population that was more migratory in its native habitat have spread further downstream. All established populations exhibit higher levels of genetic diversity than the released populations. Natural, stream-resident brown trout populations occur ~15 km downstream of the release site and below a waterfall that acts as an upstream migration barrier. Released fish have spread genes to these populations but with low introgression rates of 3%–8%. Recently adopted indicators for monitoring genetic diversity were partly able to detect this introgression, emphasizing the usefulness of genetic indicators in management. The SNP panel used in this study provides a similar picture as previously used allozymes, showing that older marker systems with fewer loci may still be useful for describing the population structure.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 3","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do European Seabass Larvae Grow Better in Their Natural Temperature Regime?","authors":"Crestel Damien,&nbsp;Vergnet Alain,&nbsp;Clota Frédéric,&nbsp;Blanc Marie-Odile,&nbsp;Navarro Théo,&nbsp;Lallement Stéphane,&nbsp;Moulard Félix,&nbsp;McKenzie David,&nbsp;Allal François,&nbsp;Vandeputte Marc","doi":"10.1111/eva.70083","DOIUrl":"https://doi.org/10.1111/eva.70083","url":null,"abstract":"<p>Understanding how warming surface waters impact the larval growth of highly prized marine fishes such as the European seabass, <i>Dicentrarchus labrax</i>, is important for sustainable fisheries and aquaculture. We studied the growth of larvae from three genetically differentiated seabass populations, Atlantic (AT), Western Mediterranean (WM), and Eastern Mediterranean (EM), reared in a common garden under three thermal regimes, representative of seasonal changes in a relatively cold Atlantic (<i>rAT</i>), intermediate Western Mediterranean (<i>rWM</i>), and warm Eastern Mediterranean (<i>rEM</i>). Survival was higher in warmer regimes until larvae reached a length of 23 mm, after which there was no major difference. Growth was monitored from 20 days posthatch to 1.5 g, with individuals sampled at regular intervals and their population of origin identified by parentage assignment using their genotypes for 96 SNPs. Significant length differences emerged among populations, the AT population being longer than WM and EM in all thermal regimes. In conclusion, the AT population had higher growth than the WM and EM populations in all thermal regimes, not just in its own, and the AT population can be considered the most robust to temperature variations at the larval stage. Further research is required to understand whether the high growth rate of the AT population reflects a process of local adaptation to a relatively cold thermal regime.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Genetics and Trajectory Simulation Reveals the Invasion Process of the Fall Armyworm (Spodoptera frugiperda) in the Eastern Hemisphere","authors":"Pengfei Fu,&nbsp;Xijie Li,&nbsp;Zhongxiang Sun,&nbsp;Yaping Chen,&nbsp;Zhihui Lu,&nbsp;Caihong Tian,&nbsp;Gao Hu,&nbsp;Furong Gui","doi":"10.1111/eva.70086","DOIUrl":"https://doi.org/10.1111/eva.70086","url":null,"abstract":"<p>As a migratory agricultural pest, the fall armyworm has been in the spotlight since it invaded Africa in 2016. Invasive populations have now colonized much of the Eastern Hemisphere, causing severe damage to a wide range of crops. However, there is still disagreement internationally on the origin and mode of invasion of fall armyworm populations, especially from the Americas to China. In this study, we provided an in-depth insight into the invasion of the fall armyworm in the Eastern hemisphere based on genome-wide data from 124 fall armyworm individuals collected from 14 sites across three continents and trajectory simulation. First, based on 770,423 high-quality SNPs, the PCA and ADMIXTURE analyses clearly distinguished the geographical populations of the Eastern and Western hemispheres. Second, the genetic diversity results revealed that the invasive populations exhibited higher heterozygosity than the native populations. Third, the results of integrated individual assignment tests and migration path simulations showed that the W1 (Florida, Texas, and Puerto Rico) population may be the potential source of the invasive populations in Africa, and a low possibility of trans-sea migration between the Americas and Africa suggested that fall armyworms may have spread through trade in goods. Fourth, our results indicate that the Indian population is a genetically admixed group derived from the E1 (Benin, Ethiopia, and South Africa) population, which subsequently migrated to the Indo-China Peninsula through natural trans-sea dispersal and to Yunnan via Myanmar. These findings not only provide new insights into the invasion of the fall armyworm in the Eastern Hemisphere but also present a method to improve the prediction accuracy of migratory pests.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Architecture Underlying Response to the Fungal Pathogen Dothistroma septosporum in Lodgepole Pine, Jack Pine, and Their Hybrids","authors":"Mengmeng Lu,&nbsp;Nicolas Feau,&nbsp;Brandon Lind,&nbsp;Dragana Obreht Vidakovic,&nbsp;Pooja Singh,&nbsp;Sally N. Aitken,&nbsp;Richard C. Hamelin,&nbsp;Sam Yeaman","doi":"10.1111/eva.70078","DOIUrl":"https://doi.org/10.1111/eva.70078","url":null,"abstract":"<p>In recent decades, <i>Dothistroma</i> needle blight (DNB), a pine tree disease caused by the fungal pathogen <i>Dothistroma septosporum,</i> has severely damaged lodgepole pine (<i>Pinus contorta</i> Dougl. ex. Loud.) in British Columbia, Canada, and raised health concerns for jack pine (<i>Pinus banksiana</i> Lamb.). The pathogen has already shown signs of host shift eastward to the hybrid populations between lodgepole pine and jack pine (<i>Pinus contorta</i> × <i>P. banksiana</i>), and possibly into pure jack pine. However, we have little knowledge about mechanisms of resistance to <i>D</i>. <i>septosporum</i>, especially the underlying genetic basis of variation in pines. In this study, we conducted controlled inoculations to induce infection by <i>D. septosporum</i> and performed a genome-wide case–control association study with pooled sequencing (pool-seq) data to dissect the genetic architecture underlying response in lodgepole pine, jack pine, and their hybrids. We identified candidate genes associated with <i>D. septosporum</i> response in lodgepole pine and in hybrid samples. We also assessed genetic structure in hybrid populations and inferred how introgression may affect the distribution of genetic variation involved in <i>D. septosporum</i> response in the studied samples. These results can be used to develop genomic tools to evaluate DNB risk, guide forest management strategies, and potentially select for resistant genotypes.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Monitoring of a Reintroduced Butterfly Uncovers Contrasting Founder Lineage Survival","authors":"Georgina Halford,&nbsp;Dirk Maes,&nbsp;Carl J. Yung,&nbsp;Sam Whiteford,&nbsp;Nigel A. D. Bourn,&nbsp;Caroline R. Bulman,&nbsp;Philippe Goffart,&nbsp;Jenny A. Hodgson,&nbsp;Ilik J. Saccheri","doi":"10.1111/eva.70074","DOIUrl":"https://doi.org/10.1111/eva.70074","url":null,"abstract":"<p>Genetic factors can have a major influence on both short- and long-term success of reintroductions. Genomic monitoring can give a range of insights into the early life of a reintroduced population and ultimately can help to avoid wasting limited conservation resources. In this study, we characterise the genetic diversity of a reintroduced <i>Carterocephalus palaemon</i> (Chequered Skipper butterfly) population in England with respect to the spatial genetic structure and diversity of the source populations in south Belgium. We aim to evaluate the success of the reintroduction, including the effectiveness of the donor sampling strategy, and assess genetic vulnerabilities that may affect the population's future. We also use an isolation-by-distance approach to make quantitative inferences about dispersal, and we explore covariance between host mitochondrial and <i>Wolbachia</i> genomes. We find that, four generations following the initial release, the reintroduced population, founded by 66 wild-caught adults, has an effective size of c. 33, yet has retained similar levels of genomic heterozygosity to those in the source subpopulations in Belgium and shows low levels of inbreeding. However, the restricted number of founders and variance in reproductive success among the surviving families have resulted in a higher level of kinship, likely to result in somewhat higher rates of inbreeding in the future. Furthermore, there is a distinct split between two source landscapes in Belgium, and all genomic evidence suggests that the reintroduced population is descended from only one of these landscapes (called Fagne). We discuss potential causes behind these results, including whether <i>Wolbachia</i> strains are causing genetic incompatibility between clades. We conclude that a conservative strategy for any further translocations would prefer Fagne sites as sources because of the strong evidence of their ability to survive. However, our results warrant further investigation into the reasons for the divergence found in Belgium.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine-Scale Variation in Soil Properties Promotes Local Taxonomic Diversity of Hybridizing Oak Species (Quercus spp.)","authors":"Felix Zimmermann,&nbsp;Oliver Reutimann,&nbsp;Andri Baltensweiler,&nbsp;Lorenz Walthert,&nbsp;Jill K. Olofsson,&nbsp;Christian Rellstab","doi":"10.1111/eva.70076","DOIUrl":"https://doi.org/10.1111/eva.70076","url":null,"abstract":"<p>Although many tree species frequently hybridize and backcross, management decisions in forestry and nature conservation are usually concentrated on pure species. Therefore, understanding which environmental factors drive the distribution and admixture of tree species on a local stand scale is of great interest to support decision-making in the establishment and management of resilient forests. Here, we extensively sampled a mixed stand of hybridizing white oaks (<i>Quercus petraea</i> and <i>Q. pubescens</i>) near Lake Neuchâtel (Switzerland), where limestone and glacier moraine geologies coexist in proximity, to test whether micro-environmental conditions can predict taxonomic distribution and genetic admixture. We collected DNA from bud tissue, individual soil samples, and extracted high-resolution topographic data for 385 oak trees. We used 50 species-discriminatory single nucleotide polymorphism (SNP) markers to determine the taxonomic composition and admixture levels of individual trees and tested their association with micro-environmental conditions. We show that the trees' taxonomic distribution can be explained mainly by geographic position, soil pH, and potential rooting depth, a proxy for soil water availability. We found that admixed individuals tend to grow in habitats that are characteristic of the more drought-tolerant species <i>Q. pubescens</i> rather than in intermediate habitats. Using in situ measurements, we are the first to show that fine-scale variation in soil properties related to pH and water availability potentially drives the distribution of hybridizing tree species in a mixed stand. Microenvironmental variation therefore promotes local taxonomic diversity, facilitates admixture and adaptive introgression, and contributes to the resilience of forests under environmental change. Consequently, species such as white oaks should be managed and protected as a species complex rather than as pure species.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate-Associated Genetic Variation and Projected Genetic Offsets for Cryptomeria japonica D. Don Under Future Climate Scenarios","authors":"Kentaro Uchiyama,&nbsp;Tokuko Ujino-Ihara,&nbsp;Katsuhiro Nakao,&nbsp;Jumpei Toriyama,&nbsp;Shoji Hashimoto,&nbsp;Yoshihiko Tsumura","doi":"10.1111/eva.70077","DOIUrl":"https://doi.org/10.1111/eva.70077","url":null,"abstract":"<p>Revealing the spatial distribution of adaptive genetic variation is both a challenging and crucial task in evolutionary ecology, essential for understanding local adaptation within species, and in management, for predicting species responses to future climate change. This understanding is particularly important for long-lived tree species, which may not be able to migrate quickly enough to adapt to rapid climate changes and may need to rely on their standing genetic variation. In this study, we focused on <i>Cryptomeria japonica</i>, a major component of Japan's temperate forests and an important forestry species adapted to the humid environment of monsoon Asia. We extracted climate-associated genetic variation from the entire genome and evaluated its distribution and vulnerability under future climate scenarios using spatial modeling techniques. We analyzed 31,676 high-quality SNPs from 249 individuals across 22 natural populations of <i>C. japonica</i>, covering its entire distribution range. We identified 239 candidate climate-associated SNPs and found winter temperature, summer precipitation, and winter precipitation as the most significant factors explaining the genetic variation in these SNPs. The climate-associated genetic variation deviated from non-associated (neutral) genetic variation in the opposite (the Sea of Japan and Pacific Ocean) sides of Japanese archipelago, suggesting natural selection of different climate conditions in these regions. Difference in estimated allele frequency at the climate-associated loci (genetic offset) between the present and future (2090 in the SSP5-8.5 scenario) climate conditions was predicted to be larger in three areas (not only southwestern Japan but also coastal area on the Sea of Japan side and inland area on the Pacific Ocean side in northeastern Japan). This prediction implies the discrepancy between standing genetic variation at the present and that adaptive to the future climate in these areas, which underscores the necessity for proactive management to adjust the adaptive genetic variation.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Trade-Off Between Antimicrobial Peptide Resistance and Sensitivity to Host Immune Effectors in Staphylococcus aureus In Vivo","authors":"Baydaa El Shazely,&nbsp;Jens Rolff","doi":"10.1111/eva.70068","DOIUrl":"https://doi.org/10.1111/eva.70068","url":null,"abstract":"<p>Antimicrobial peptides (AMPs) are essential immune effectors of multicellular organisms. Bacteria can evolve resistance to AMPs. Surprisingly, when used to challenge the yellow mealworm beetle, <i>Tenebrio molitor</i>, <i>Staphylococcus aureus</i> resistant to an abundant AMP (tenecin 1) of the very same host species did not increase host mortality or bacterial load compared to infections with wild-type <i>S. aureus</i>. A possible explanation is that antimicrobial resistance is costly due to the collaterally increased sensitivity of AMP-resistant strains to other immune effectors. Here, we study the sensitivity of a group of AMP-resistant <i>S. aureus</i> strains (resistant to tenecin 1 or a combination of tenecin 1 + 2) to other immune effectors such as phenoloxidase and other AMPs in vivo. Using RNAi-based knockdown, we investigate <i>S. aureus</i> survival in insect hosts lacking selected immune effectors. We find that all except one AMP-resistant strain displayed collateral sensitivity toward phenoloxidase. Some AMP-resistant strains show sensitivity to components of the yellow mealworm beetle AMP defense cocktail. Our findings are consistent with the idea that resistance to AMPs does not translate into changes in virulence because it is balanced by the collaterally increased sensitivity to other host immune effectors. AMP resistance fails to provide a net survival advantage to <i>S. aureus</i> in a host environment that is dominated by AMPs.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 2","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eva.70068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connections Across Open Water: A Bi-Organelle, Genomics-Scale Assessment of Atlantic-Wide Population Dynamics in a Pelagic, Endangered Apex Predator Shark (Isurus oxyrinchus)","authors":"Andrea M. Bernard,&nbsp;Marissa R. Mehlrose,&nbsp;Kimberly A. Finnegan,&nbsp;Bradley M. Wetherbee,&nbsp;Mahmood S. Shivji","doi":"10.1111/eva.70071","DOIUrl":"10.1111/eva.70071","url":null,"abstract":"<p>Large-bodied pelagic sharks are key regulators of oceanic ecosystem stability, but highly impacted by severe overfishing. One such species, the shortfin mako shark (<i>Isurus oxyrinchus</i>), a globally widespread, highly migratory predator, has undergone dramatic population reductions and is now Endangered (IUCN Red List), with Atlantic Ocean mako sharks in particular assessed by fishery managers as overfished and in need of urgent, improved management attention. Genomic-scale population assessments for this apex predator species have not been previously available to inform management planning; thus, we investigated the population genetics of mako sharks across the Atlantic using a bi-organelle genomics approach. Complete mitochondrial genome (mitogenome) sequences and genome-wide SNPs from sharks distributed across the Atlantic revealed contrasting patterns of population structure across marker types. Consistent with this species' long-distance migratory capabilities, SNPs showed high connectivity and Atlantic panmixia overall. In contrast, there was matrilineal population genetic structure across Northern and Southern Hemispheres, suggesting at least large regional-scale female philopatry. Linkage disequilibrium network analysis indicated that makos possess a chromosomal inversion that occurs Atlantic wide, a genome feature that may be informative for evolutionary investigations concerning adaptations and the global history of this iconic species. Mitogenome diversity in Atlantic makos was high compared to other elasmobranchs assessed at the mitogenome level, and nuclear diversity was high compared to the two other, highly migratory pelagic shark species assessed with SNPs. These results support management efforts for shortfin makos on at least Northern versus Southern Hemisphere scales to preserve their matrilineal genetic distinctiveness. The overall comparative genetic diversity findings provide a baseline for future comparative assessments and monitoring of genetic diversity, as called for by the United Nations Convention on Biological Diversity, and cautious optimism regarding the health and recovery potential of Atlantic shortfin makos if further population declines can be halted.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Do Trematodes Induce Cancer? A Possible Evolutionary Adaptation of an Oncogenic Agent Transmitted by Flukes","authors":"Péter Apari,&nbsp;Gábor Földvári","doi":"10.1111/eva.70070","DOIUrl":"10.1111/eva.70070","url":null,"abstract":"<p>There is strong epidemiological evidence that development of various cancer types is linked to infection with flukes (Platyhelminthes: Trematoda) in Africa, Asia and the Middle East. The exact nature of the mechanism by which cancer is induced by these parasites is unknown. Here, we provide a new hypothesis suggesting that flukes are not the primary cause of cancer but act as vectors of cancer-inducing microbial pathogens. These pathogens adaptively induce tumours to attract and help flukes to feed on blood from the tumour. Pathogen take-up by fluke vectors also takes place in the tumour; therefore, tumour formation in this case is the result of a mutualistic and adaptive relationship between the microbe and the helminth parasite. The suggested mechanism for cancer induction provided here may help us gain deeper understanding about cancer in general and its relationship with microbes and parasites. By further elaborating the unique nexus between flukes, carcinogenic microbes and cancer, in the future it will also help us to broaden our oncological perspective to reduce human death and suffering from this serious disease group.</p>","PeriodicalId":168,"journal":{"name":"Evolutionary Applications","volume":"18 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}