Journal of Physics D: Applied Physics最新文献

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Reassessing magnetic tunnel junction detectability for ultrasensitive sensing using small-field sensitivity and Jiles-Atherton modeling. 利用小场灵敏度和Jiles-Atherton模型重新评估超灵敏传感的磁隧道结可探测性。
IF 3.2 3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2026-07-03 Epub Date: 2026-07-02 DOI: 10.1088/1361-6463/ae802f
Benjamin J Brown, Liam K Mitchell, Hongzhou Yu, Gang Xiao
{"title":"Reassessing magnetic tunnel junction detectability for ultrasensitive sensing using small-field sensitivity and Jiles-Atherton modeling.","authors":"Benjamin J Brown, Liam K Mitchell, Hongzhou Yu, Gang Xiao","doi":"10.1088/1361-6463/ae802f","DOIUrl":"10.1088/1361-6463/ae802f","url":null,"abstract":"<p><p>Magnetic tunnel junction (MTJ) sensors are attractive for detecting extremely small magnetic fields, yet their performance is often quantified using sensitivities derived from major loops or larger-field minor loops which inherently include hysteretic contributions. As a result, these conventional metrics significantly overestimate detectability by including irreversible processes that vanish in the small-field limit. Here, we systematically measure the low-field response of uniaxial MTJs under both ac and dc magnetic excitation and demonstrate a distinct transition from hysteretic to fully reversible behavior as the field amplitude is reduced. By adapting the Jiles-Atherton model to analyze MTJ conductance, we establish a unified framework that captures magnetization processes down to nanotesla range, yielding quantitative parameters that resolve reversible and irreversible dynamics with excellent fidelity. In the reversible regime, the sensitivity converges to a constant value of 0.55%Oe <math> <mrow><msup><mi></mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </mrow> </math> , defining an intrinsic, history-independent response of the MTJ. Importantly, this is less than half of the 1.2%Oe <math> <mrow><msup><mi></mi> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </mrow> </math> obtained from higher-field minor loop estimates but is physically representative of the sensing response in low-field operation. The constant and intrinsic sensitivity corresponds to the true value of detectability, confirmed by noise spectral density measurements under low-field ac excitation. These results establish a quantitative framework for MTJ evaluation that emphasizes intrinsic, hysteresis-free performance, providing both a realistic basis for calculating field detectability and a general methodology for probing magnetization in micron- and nano-scale ferromagnets.</p>","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 26","pages":"265002"},"PeriodicalIF":3.2,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 2026 guided acoustic waves roadmap. 2026年引导声波路线图。
IF 3.2 3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2026-03-06 Epub Date: 2026-03-02 DOI: 10.1088/1361-6463/ae258d
Hubert J Krenner, Paulo V Santos, Christoph Westerhausen, Gustav Andersson, Andrew N Cleland, Hermann Sellier, Shintaro Takada, Christopher Bäuerle, Daniel Wigger, Tilmann Kuhn, Paweł Machnikowski, Matthias Weiß, Galan Moody, Alberto Hernández-Mínguez, Snežana Lazić, Alexander S Kuznetsov, Matthias Küß, Manfred Albrecht, Mathias Weiler, Jorge Puebla, Yunyoung Hwang, Yoshichika Otani, Krishna C Balram, I-Tung Chen, Keji Lai, Mo Li, Geoff R Nash, Emeline D S Nysten, Paromita Bhattacharjee, Himakshi Mishra, Parameswar K Iyer, Harshal B Nemade, Abdelkrim Khelif, Sarah Benchabane, Gao Feng, Yabin Jin, Ausrine Bartasyte, Samuel Margueron, Massimiliano Marangolo, Laura Thevenard, Pauline Rovillain, Catherine Gourdon, Sami Hage-Ali, Omar Elmazria, Hagen Schmidt, Leslie Y Yeo, Lizebona A Ambattu, Jessie S Jeon, Daesik Kwak, Joseph Rufo, Shujie Yang, Tony Jun Huang
{"title":"The 2026 guided acoustic waves roadmap.","authors":"Hubert J Krenner, Paulo V Santos, Christoph Westerhausen, Gustav Andersson, Andrew N Cleland, Hermann Sellier, Shintaro Takada, Christopher Bäuerle, Daniel Wigger, Tilmann Kuhn, Paweł Machnikowski, Matthias Weiß, Galan Moody, Alberto Hernández-Mínguez, Snežana Lazić, Alexander S Kuznetsov, Matthias Küß, Manfred Albrecht, Mathias Weiler, Jorge Puebla, Yunyoung Hwang, Yoshichika Otani, Krishna C Balram, I-Tung Chen, Keji Lai, Mo Li, Geoff R Nash, Emeline D S Nysten, Paromita Bhattacharjee, Himakshi Mishra, Parameswar K Iyer, Harshal B Nemade, Abdelkrim Khelif, Sarah Benchabane, Gao Feng, Yabin Jin, Ausrine Bartasyte, Samuel Margueron, Massimiliano Marangolo, Laura Thevenard, Pauline Rovillain, Catherine Gourdon, Sami Hage-Ali, Omar Elmazria, Hagen Schmidt, Leslie Y Yeo, Lizebona A Ambattu, Jessie S Jeon, Daesik Kwak, Joseph Rufo, Shujie Yang, Tony Jun Huang","doi":"10.1088/1361-6463/ae258d","DOIUrl":"10.1088/1361-6463/ae258d","url":null,"abstract":"<p><p>Guided elastic waves are a truly cross-disciplinary key enabling technology. For more than five decades, surface acoustic wave (SAW) and bulk acoustic wave devices find widespread applications. Nowadays, different types of guided elastic waves cover the wide spectrum of applications spanning from quantum technologies to the life sciences, from controlling single excitations to macroscopic collective states in condensed matter. Six years after the first 2019 SAW roadmap, we believe it is time to make a step back and take a fresh look at the status of the field and its future challenges. Since the first roadmap in 2019, the spectrum clearly expanded and this new edition presents a current snapshot of the status of this vibrant field and prospects for potential future developments.</p>","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 9","pages":"093001"},"PeriodicalIF":3.2,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large-area and cost-effective flexible Ga 2 O 3 based self-powered solar-blind ultraviolet photodetector prepared by scrape coating method 采用刮涂法制备大面积、高性价比的柔性ga2o3自供电日盲紫外探测器
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2026-01-19 DOI: 10.1088/1361-6463/ae39ea
Zihao Zhao, Zhiyuan Chen, Zhi Wan, Mingxin Ren, Peilin Zuo, Feng Teng, Peng Hu, Haibo Fan
{"title":"Large-area and cost-effective flexible Ga <sub>2</sub> O <sub>3</sub> based self-powered solar-blind ultraviolet photodetector prepared by scrape coating method","authors":"Zihao Zhao, Zhiyuan Chen, Zhi Wan, Mingxin Ren, Peilin Zuo, Feng Teng, Peng Hu, Haibo Fan","doi":"10.1088/1361-6463/ae39ea","DOIUrl":"https://doi.org/10.1088/1361-6463/ae39ea","url":null,"abstract":"Abstract With the development of science and technology, wearable flexible devices have attracted more and more attention, but their development has been greatly limited due to the complex preparation process and high cost. In this work, a flexible large-area self-powered solar blind ultraviolet (UV) photodetector (SBPDs) with Ga 2 O 3 /Ti 3 C 2 Schottky contact was successfully constructed by a more cost-effective scrape coating method. The constructed Schottky junction greatly promotes the separation of carriers and the presence of Ti 3 C 2 also greatly reduces the charge transfer resistance. The detector has excellent self-powered response and excellent performance under UV irradiation at 0 V bias, with high responsivity (10.67 mA W −1 ), detectivity (17.80 * 10 8 jones) and fast response speed (0.07 s/0.08 s). Through bending experiments, it can also be proved that the detector has excellent robust characteristics and can still maintain 80% performance after 100 times of bending at 30° This work has developed a new idea for the preparation of large-area and cost-effective flexible SBPDs.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 4","pages":"045104-045104"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma-activated hydrosol and graphene oxide nanoparticles exhibit synergistic anticancer effects 等离子活化纯溶胶和氧化石墨烯纳米颗粒具有协同抗癌作用
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2026-01-14 DOI: 10.1088/1361-6463/ae383b
Zewei Wang, Danqi Zhang, Xixi Jing, Zimu Yu, Jishen Zhang, Zifeng Wang, Hao Zhang, Maksudbek Yusupov, O. A. Koval, Jamoliddin Razzokov, Dingxin Liu
{"title":"Plasma-activated hydrosol and graphene oxide nanoparticles exhibit synergistic anticancer effects","authors":"Zewei Wang, Danqi Zhang, Xixi Jing, Zimu Yu, Jishen Zhang, Zifeng Wang, Hao Zhang, Maksudbek Yusupov, O. A. Koval, Jamoliddin Razzokov, Dingxin Liu","doi":"10.1088/1361-6463/ae383b","DOIUrl":"https://doi.org/10.1088/1361-6463/ae383b","url":null,"abstract":"Abstract Cold atmospheric plasma-activated hydrosol (PAH) is a novel plasma application mode for the effective loading and delivery of plasma-generated reactive oxygen/nitrogen species (RONS). In this study, plasma-activated sodium alginate hydrosol (PAH SA ) was obtained from air discharge plasma, and the synergistic anticancer effects of PAH SA combined with graphene oxide nanoparticles (GO) were investigated. The results demonstrated that the oxidation-reduction potential of PAH SA increased significantly after long-lived and short-lived plasma-generated RONS, such as H 2 O 2 , NO 2 −, 1 O 2 , and ONOO − &amp;O 2 − , were loaded. In vitro studies revealed that PAH SA exhibited significant anticancer effects by inducing intracellular oxidative stress. While B16F10 cell viability tended to decrease with increasing GO concentration, only at high concentrations did GO significantly inhibit tumor cell proliferation. In addition, when PAH SA was combined with low-dose GO (0.5 mg ml −1 ), the proliferation of B16F10 melanoma cells was significantly inhibited compared with treatment with PAH SA or GO alone at the same dose. These findings indicate that PAH SA can be combined with novel materials, thus expanding the application of plasma technology for anticancer therapy and providing new cancer treatment strategies.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 4","pages":"045205-045205"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The determinant role of ground electrode design on steering reactive species in PAW for enhanced anticancer therapy 地电极设计对PAW中导向活性物质的决定性作用,以增强抗癌治疗
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2025-12-16 DOI: 10.1088/1361-6463/ae2d67
Zekai Zhang, Zhijie Liu, Bo Yu, Bolun Pang, Hongqiang Guo, Xin Li, Yuting Gao
{"title":"The determinant role of ground electrode design on steering reactive species in PAW for enhanced anticancer therapy","authors":"Zekai Zhang, Zhijie Liu, Bo Yu, Bolun Pang, Hongqiang Guo, Xin Li, Yuting Gao","doi":"10.1088/1361-6463/ae2d67","DOIUrl":"https://doi.org/10.1088/1361-6463/ae2d67","url":null,"abstract":"Abstract Plasma activated water (PAW) produced via underwater bubble discharge (UBD) has attracted considerable attention due to its exceptional properties, yet limited research has been conducted on the impact of ground electrodes on PAW generation. This study utilized a UBD plasma generator with three distinct ground electrodes: a copper mesh along the side wall (GND.1), a copper foil affixed to the bottom (GND.2), and a copper wire positioned at the bottom (GND.3), to assess the characteristics of the resulting PAW. The findings indicate that the discharge intensity for GND.1 surpassed that of GND.2, which in turn exceeds that of GND.3, as a consequence of the different electric field distributions. The variations in discharge intensity led to differing concentrations of reactive species in the produced PAW, thereby affecting its anticancer efficacy. Notably, the PAW generated by GND.1 contained the highest concentrations of aqueous reactive species (NO 2 − , H 2 O 2 , ONOO − /O 2 − , and OH) and demonstrated the most pronounced anticancer effect, which can be linked to a substantial increase in intracellular reactive oxygen species driven by the elevated levels of aqueous reactive species. These experimental results underscore the critical role of electric field distribution within the UBD system on the properties of the resultant PAW, potentially offering avenues to enhance the anticancer capabilities of PAW and facilitate its clinical application.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 2","pages":"025208-025208"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strong enhancement of spin waves in 2D antiferromagnetic NiO nanoflakes 二维反铁磁NiO纳米片中自旋波的强增强
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2025-12-09 DOI: 10.1088/1361-6463/ae2a4b
An nan An, Yixin Zhao, Wen-Juan Huang, Si‐Jing Ding, Liang Ma, Xiang‐Bai Chen
{"title":"Strong enhancement of spin waves in 2D antiferromagnetic NiO nanoflakes","authors":"An nan An, Yixin Zhao, Wen-Juan Huang, Si‐Jing Ding, Liang Ma, Xiang‐Bai Chen","doi":"10.1088/1361-6463/ae2a4b","DOIUrl":"https://doi.org/10.1088/1361-6463/ae2a4b","url":null,"abstract":"Abstract Two-dimensional (2D) antiferromagnetic (AFM) NiO is one of the promising candidates for developing next-generation room-temperature terahertz spin wave devices. However, the spin wave signal is generally weak. In this work, we report strong enhancement of room-temperature terahertz spin waves in 2D AFM NiO nanoflakes through coupling with tiny 1–2 nm Au nanodots. We reveal that the enhancement effect is mainly correlated with localized surface plasmon resonance, but the transfer mechanism is not changed—thus producing stronger enhancement of spin waves than of phonon vibration. Furthermore, our study suggests that this strong coupling should mainly originate from localized surface plasmons with surface spin waves, indicating that 2D AFM NiO nanoflakes have a promising surface spin ordering property which would be of great interest for developing next-generation ultrafast and ultrasmall spintronic devices.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 1","pages":"015003-015003"},"PeriodicalIF":0.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the bactericidal effect and its mechanism of nitrox surface discharge plasma-treated hydrogel 氮表面放电等离子体处理水凝胶的杀菌效果及机理研究
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2025-12-08 DOI: 10.1088/1361-6463/ae292b
Jishen Zhang, Xian Wang, Jinkun Chen, Mengke Li, Qiuyi Yue, Xinwei Lu, Weiji Yang, Zifeng Wang, Hao Zhang, Li Guo, Dingxin Liu, Jianbao Zheng, Mingzhe Rong
{"title":"Study on the bactericidal effect and its mechanism of nitrox surface discharge plasma-treated hydrogel","authors":"Jishen Zhang, Xian Wang, Jinkun Chen, Mengke Li, Qiuyi Yue, Xinwei Lu, Weiji Yang, Zifeng Wang, Hao Zhang, Li Guo, Dingxin Liu, Jianbao Zheng, Mingzhe Rong","doi":"10.1088/1361-6463/ae292b","DOIUrl":"https://doi.org/10.1088/1361-6463/ae292b","url":null,"abstract":"Abstract As novel carriers of plasma-generated reactive oxygen and nitrogen species (RONS), plasma-treated hydrogels (PTHs) have broad biomedical applications. Regulating the key reactive species in PTHs is crucial for optimal biomedical effects. This study focuses on how N 2 /O 2 ratios in discharge gas of surface dielectric barrier discharge affect RONS generation and its correlation with the bactericidal effect plasma-treated AVC hydrogel (PTH AVC ). It was found that PTH AVC achieved the best bactericidal effect and contained the highest concentration of ONOO − aq /ONOOH aq when the O 2 content was 70%, indicating that ONOO − aq /ONOOH aq may play a key role in the bactericidal effect of PTH AVC . This study provides a new strategy to regulate the biological activity of PTH AVC and valuable insights into its bactericidal mechanism.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"59 1","pages":"015205-015205"},"PeriodicalIF":0.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrospun indium gallium zinc oxide semiconductor nanofibers with different persistent photoconductivity effects at low and high temperatures 静电纺铟镓锌氧化物半导体纳米纤维在低温和高温下具有不同的持续光导效应
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2025-11-13 DOI: 10.1088/1361-6463/ae1f26
Wei Zheng, Jia-Bin Song, Jinhua Liu, Yuze Sun, Shuaijie Wang, Zhi Li, Shumeng Li, Wenyue Wang, Jian-Long Jiao, Lingyun Li, Hui Guo, Wen‐Peng Han, Yunze Long
{"title":"Electrospun indium gallium zinc oxide semiconductor nanofibers with different persistent photoconductivity effects at low and high temperatures","authors":"Wei Zheng, Jia-Bin Song, Jinhua Liu, Yuze Sun, Shuaijie Wang, Zhi Li, Shumeng Li, Wenyue Wang, Jian-Long Jiao, Lingyun Li, Hui Guo, Wen‐Peng Han, Yunze Long","doi":"10.1088/1361-6463/ae1f26","DOIUrl":"https://doi.org/10.1088/1361-6463/ae1f26","url":null,"abstract":"Abstract In recent years, persistent photoconductivity (PPC) has received significant attention due to its potential applications in a wide range of fields. This study focuses on the PPC observed in electrospun indium gallium zinc oxide (IGZO) semiconductor nanofibers, particularly the persistence of photoconductivity following the cessation of light excitation. The study delves into the mechanisms underlying the PPC effect in IGZO materials, with a specific focus on how the structure of electrospun nanofibers influences this phenomenon. We examine the effects of composition and temperature on the photoresponse of IGZO nanofibers, concluding that electrospun IGZO semiconductors exhibit distinct PPC mechanisms at low and high temperatures. This variation is primarily attributed to the significant role of interface defects, introduced during electrospinning, in influencing the PPC effect at elevated temperatures. This research introduces an innovative strategy for developing advanced photoelectric materials and devices.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"58 47","pages":"475302-475302"},"PeriodicalIF":0.0,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma-activated nano-Fe 3 O 4 hydrosol for cancer therapy 等离子体活化纳米fe3o4纯溶胶用于癌症治疗
3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2025-11-03 DOI: 10.1088/1361-6463/ae1a94
Jishen Zhang, Xixi Jing, Tonghai Wu, Jinkun Chen, Zewei Wang, D Zhang, Shiyao Wang, Zhixiang Yu, Zifeng Wang, Hao Zhang, Li Guo, Dingxin Liu, Mingzhe Rong
{"title":"Plasma-activated nano-Fe <sub>3</sub> O <sub>4</sub> hydrosol for cancer therapy","authors":"Jishen Zhang, Xixi Jing, Tonghai Wu, Jinkun Chen, Zewei Wang, D Zhang, Shiyao Wang, Zhixiang Yu, Zifeng Wang, Hao Zhang, Li Guo, Dingxin Liu, Mingzhe Rong","doi":"10.1088/1361-6463/ae1a94","DOIUrl":"https://doi.org/10.1088/1361-6463/ae1a94","url":null,"abstract":"Abstract Cold atmospheric plasma (CAP) therapy has emerged as a promising cancer therapy. However, the rapid decay of reactive oxygen and nitrogen species (RONS) poses a significant challenge to its clinical application. To address this issue, a plasma-activated hyaluronic acid nano-Fe 3 O 4 (PAHA@Fe 3 O 4 ) hydrosol is developed with prolonged generation of short-lived RONS and enhanced ferroptosis-inducing capabilities. This advancement is achieved through the integration of plasma-activated hydrosol (PAH) with the Fenton reaction. The acidic environment generated by CAP promotes the rapid progression of the Fe 3 O 4 -induced Fenton reaction. Consequently, long-lived RONS in the PAHA@Fe 3 O 4 hydrosol are continuously converted into more reactive short-lived RONS, including ·OH, O 2 − , and ONOO − /ONOOH. Cellular experiments confirmed that PAHA@Fe 3 O 4 hydrosol exhibit a significantly stronger ability to induce ferroptosis, oxidative stress, and cytotoxicity compared with PAH alone, while exhibiting low toxicity to normal cells. Our study highlights the potential of combining PAH with the Fenton reaction to improve the therapeutic efficiency of cancer treatment.","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"58 46","pages":"465203-465203"},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles. 放射治疗的新策略:空间分割、超高剂量率和纳米粒子的前景和挑战。
IF 3.2 3区 物理与天体物理
Journal of Physics D: Applied Physics Pub Date : 2025-10-13 DOI: 10.1088/1361-6463/ae0e2d
Hamid Ghaznavi, Mohammad Rezaee, Francisco Reynoso, Arash Darafsheh
{"title":"Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles.","authors":"Hamid Ghaznavi, Mohammad Rezaee, Francisco Reynoso, Arash Darafsheh","doi":"10.1088/1361-6463/ae0e2d","DOIUrl":"10.1088/1361-6463/ae0e2d","url":null,"abstract":"<p><p>Radiation therapy (RT) employs ionizing radiation to kill cancerous cells. However, delivering radiation to tumors, typically embedded within normal tissues, inevitably exposes healthy organs to radiation, leading to collateral damage. This creates a tradeoff between the tumor control probability and normal tissue complication probability, ultimately limiting the dose that can be safely administered. While highly conformal RT techniques have improved tumor targeting and treatment efficacy, they remain inadequate for treating large and radioresistant tumors, pointing out the need for alternative strategies. Spatially fractionated RT, ultra-high dose rate RT, and nanoparticle-enhanced RT are emerging techniques with promise in enhancing tumor control while minimizing normal tissue toxicity. Successful clinical translation of these advanced techniques requires cross-disciplinary efforts aimed at technological innovation, a deeper understanding of the underlying radiobiological mechanisms, and the development of early-phase clinical trials. This paper provides an overview of these techniques and their associated challenges and opportunities.</p>","PeriodicalId":16789,"journal":{"name":"Journal of Physics D: Applied Physics","volume":"58 41","pages":"413002"},"PeriodicalIF":3.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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