基于边缘照明技术的x射线应变成像在生物医学应用中的适用性。

IF 3.2 3区 物理与天体物理 Q2 PHYSICS, APPLIED
Carlo Peiffer, A Astolfo, M Endrizzi, C K Hagen, A Olivo, P R T Munro
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引用次数: 0

摘要

使用传统的x射线断层成像技术进行应变成像是一种广泛建立的技术,用于研究材料的机械变形,包括水泥和电池。然而,由于软组织对比度较低,其生物医学应用主要局限于骨组织。x射线相位对比成像,在软组织中提供优越的对比度-噪声比,原则上可以克服这一限制。本研究探索了使用边缘照明(EI)的软组织x射线应变成像的可行性,这是一种基于实验室的x射线相衬技术。一种模拟健康和肿瘤软组织机械特性的假体,具有常规x射线成像无法看到的坚硬内含物,与固定在乙醇中的鸡肉软组织一起进行了测试。虽然我们的研究证实,与吸收成像相比,EI相对比成像为此类样品提供了更好的对比度,但它也显示了应变检索精度的降低。掩模设计中的吸收桥引起的伪影和扫描之间空间变化的差分相位信号积分引起的误差被认为是关键的限制因素。因此,基于机械对比度的EI相衬应变成像无法定位幻体内含物。然而,EI在不影响视场的情况下增加空间采样频率的能力提高了应变检索精度,利用其吸收对比度优于传统的x射线应变成像。这些发现突出了将EI应用于软组织应变分析的潜力和挑战,提供了对其局限性和进一步改进的机会的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
On the applicability of x-ray strain imaging using the edge illumination technique in biomedical applications.

Strain imaging using conventional x-ray tomography is a widely established technique for investigating the mechanical deformation of materials, including cement and batteries. However, its biomedical applications are primarily restricted to bone tissue due to the low contrast of soft tissues. X-ray phase contrast imaging, offering superior contrast-to-noise ratios in soft tissues, can in principle overcome this limitation. This study explores the feasibility of x-ray strain imaging for soft tissues using edge illumination (EI), a laboratory-based x-ray phase contrast technique. A phantom mimicking the mechanical properties of healthy and tumorous soft tissues, with a stiff inclusion invisible to conventional x-ray imaging, was tested alongside chicken soft tissue fixed in ethanol. While our study confirmed that EI phase contrast imaging provides improved contrast for such samples compared to absorption imaging, it also revealed a reduction in strain retrieval precision. Artefacts caused by absorbing bridges in the mask design and errors arising from differential phase signal integration, which vary spatially between scans, were identified as key limiting factors. Consequently, EI phase contrast strain imaging was unable to locate phantom inclusions based on mechanical contrast. However, EI's capability to increase spatial sampling frequency without compromising the field of view improved strain retrieval precision using its absorption contrast beyond that achieved with conventional x-ray strain imaging. These findings highlight the potential and challenges of applying EI to strain analysis in soft tissues, providing insights into its limitations and opportunities for further improvement.

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来源期刊
Journal of Physics D: Applied Physics
Journal of Physics D: Applied Physics 物理-物理:应用
CiteScore
6.80
自引率
8.80%
发文量
835
审稿时长
2.1 months
期刊介绍: This journal is concerned with all aspects of applied physics research, from biophysics, magnetism, plasmas and semiconductors to the structure and properties of matter.
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