Journal of Photochemistry and Photobiology A-chemistry最新文献

{"title":"Mechanistic insights into the G-quadruplex-duplex equilibrium in the c-kit promoter: Role of ions and flanking sequences","authors":"Manali Basu,&nbsp;Padmaja Prasad Mishra","doi":"10.1016/j.jphotochem.2025.116424","DOIUrl":"10.1016/j.jphotochem.2025.116424","url":null,"abstract":"<div><div>Nucleic acid-ion interactions constitute an intrinsic cornerstone of the physicochemical, energetic, and structural attributes of DNA and RNA. These interactions determine the folding and stabilization of intricate secondary and tertiary architectures, such as G-quadruplexes (GQs), which have pivotal functional significance in telomeric regions, origins of replication, and various gene promoter sequences. Earlier studies have elucidated that the 22-mer <em>c-kit</em> promoter sequence adopts a parallel-stranded G-quadruplex conformation, exhibiting a high degree of structural conservation within its duplex and quadruplex form. However, detailed mechanistic insight into this interconversion of these two conformations at single-molecule resolution has not been explored explicitly. In this work we have employed single-molecule FRET experiments (smFRET) to investigate the dynamic interconversion between the usual Watson-Crick duplex structure and the G-quadruplex structure. Herein, we assess the sensitivity of the G quadruplex-duplex equilibrium by introducing a short complementary strand as a pharmacological agent in the presence of Na⁺/K⁺ ions. This subtle mechanistic detail of the opening of the quadruplex, because of the hybridization with the complementary strand, reveals that the opening of the K⁺-stabilised G-quadruplex is slower than the opening of the Na⁺-stabilised form. smFRET along with CD and ensemble fluorescence measurements demonstrated the ion-mediated effect on the stability and equilibrium of the G-quadruplex and duplex structure. Furthermore, we explored the influence of flanking bases on quadruplex stability and duplex formation in the c-kit promoter region, providing a detailed analysis of how these factors modulate structural transitions.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116424"},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive oxygen species mediated-degradation of antiglaucoma drugs. An approach to oxidative stress conditions","authors":"Charis Parramón Jurado ,&nbsp;Cecilia Liaudat ,&nbsp;Marcela Altamirano ,&nbsp;Cecilia Challier ,&nbsp;Susana Criado","doi":"10.1016/j.jphotochem.2025.116428","DOIUrl":"10.1016/j.jphotochem.2025.116428","url":null,"abstract":"<div><div>Reactive oxygen species (ROS) are generated as by-products of oxygen metabolism and play multiple roles in biological systems. In addition, these species can be generated in the eye as a result of the photosensitizing action of pigments that are naturally present in this organ, such as riboflavin. An imbalance between the production of ROS and the response of the antioxidant defense system results in oxidative stress.</div><div>In humans, the oxidative stress can lead to the initiation or development of many ocular diseases and injuries (glaucoma, cataracts, macular degeneration). In this highly oxidative cellular environment, topically administered drugs for the treatment of various pathologies may be susceptible to be attacked by ROS and consequently degraded, losing their clinical efficacy or generating toxic products.</div><div>In this contribution, the kinetics of ROS-mediated degradation of the antiglaucoma drugs, acetazolamide and methazolamide, was investigated. In order to analyze the effects that these drugs and their derivatives produce on the viability of normal human cells, this parameter was evaluated in the MRC-5 line.</div><div>Results showed that acetazolamide and methazolamide interact with the electronic triplet state of riboflavin and with different photo-generated ROS from this state. Both drugs were chemically degraded by singlet oxygen, although methazolamide was more reactive than acetazolamide. The experiments demonstrated that neither the drugs nor their ROS-mediated oxidation products exhibited cytotoxicity in the MRC-5 cell line.</div><div>On the other hand, under direct UV irradiation, AZ and MZ generated O₂(¹Δ_g) with considerable efficiency compared to other ophthalmic drugs and would be considered good sensitizers.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116428"},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoreactivity of 1-azidostyrene and 3-phenyl-2H-azirine in acetonitrile and cryogenic matrices","authors":"W.Dinindu Mendis ,&nbsp;Abdelqader M. Jamhawi ,&nbsp;Rajkumar Merugu ,&nbsp;Dmitrii Govorov ,&nbsp;Katrin H. Vilinsky ,&nbsp;Bakar Alomari ,&nbsp;Bruce S. Ault ,&nbsp;A.Jean-Luc Ayitou ,&nbsp;Anna D. Gudmundsdottir","doi":"10.1016/j.jphotochem.2025.116427","DOIUrl":"10.1016/j.jphotochem.2025.116427","url":null,"abstract":"<div><div>Despite their versatile synthetic utility, vinyl azides have complex and poorly understood photochemistry. To address this, we investigated the photoreactivity of 1-azidostyrene <strong>1</strong> and 3-phenyl-<em>2H</em>-azirine <strong>2</strong> in solution and cryogenic matrices. In argon matrices, irradiation of <strong>1</strong> at 254 nm yielded <strong>2</strong>, phenyl nitrile ylide <strong>3</strong>, and N-phenyl ketenimine <strong>4</strong>, whereas irradiation at wavelengths above 300 nm produced only <strong>2</strong> and <strong>4</strong>. Similarly, irradiation of <strong>1</strong> in 2-methyltetrahydrofuran (mTHF) glass at 77 K mainly yielded absorption corresponding to the formation of <strong>2</strong> (λ_max ∼ 252 nm). In contrast, irradiation of <strong>2</strong> at wavelengths above 300 nm in Argon matrices yielded no photoproducts, whereas irradiation at 254 nm resulted in the formation of <strong>3</strong>. Furthermore, femto- and nano-second transient absorption and laser flash photolysis were performed to ascertain the transient species and reactive intermediates formed during the photochemical transformations of <strong>1</strong> and <strong>2</strong>. The ultrafast transient absorption spectroscopy of <strong>1</strong> resulted in a transient absorption band centered at ca. 472 nm with a time constant τ ∼ 22 ps, which was assigned to the first singlet excited state (S₁) of <strong>1</strong>. The nano-second flash photolysis of <strong>1</strong> (308 nm laser) generated <strong>2</strong> within the laser pulse (∼17 ns), and subsequently <strong>2</strong> is excited to yield triplet vinylnitrene ³<strong>1N</strong> with an absorption centered at ∼ 440 nm. In contrast, the nano-second laser flash photolysis of<!--> <strong>2<!--> </strong>with 266 nm laser produced a weak absorption corresponding to<!--> <strong>3</strong>, whereas 308 nm laser yielded absorption due to triplet vinylnitrene ³<strong>1N</strong> (λ_max ∼ 440 nm). These findings demonstrate that the direct irradiation of <strong>1</strong> populates S₁ of <strong>1</strong>, which does not intersystem cross to form ³<strong>1N</strong>, but instead decays to yield <strong>2</strong>. Density functional theory calculations supported the characteristics of the excited states and reactive intermediates formed upon irradiation of <strong>1</strong> and <strong>2</strong>.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116427"},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tactfully regulating the ESIPT mechanism in the Cyanine-n probe molecules by electron withdrawing substitutions","authors":"Min Yang,&nbsp;Xiaonan Wang,&nbsp;Hongyan Mu,&nbsp;Yifu Zhang,&nbsp;Hui Li","doi":"10.1016/j.jphotochem.2025.116425","DOIUrl":"10.1016/j.jphotochem.2025.116425","url":null,"abstract":"<div><div>In this study, we analyzed the dynamics of excited hydrogen bonds and the ESIPT process in Cyanine-n. According to the assessment of hydrogen bond energy and the redshift in the infrared (IR) vibration spectra, we propose that during the photoexcitation, the hydrogen bond interaction of Cyanine-n is enhanced, and Cyanine-9 exhibiting the strongest intramolecular hydrogen bond (IHB) strength and a higher likelihood to initiate the ESIPT process. The redistribution of excited state charges validates strong intramolecular charge transfer (ICT) characteristics in Cyanine-n, which acts as a driving force for the ESIPT process. Notably, the evidence from the scanned potential energy curves (PECs) and the intrinsic reaction coordinate (IRC) collectively confirms the easy order of the ESIPT process follows: Cyanine-9 &gt; Cyanine-8 &gt; Cyanine-7. Additionally, the simulated electronic spectra clearly elucidate how electron-withdrawing group substitution affects fluorescence emission mechanisms. In particular, our analysis suggests that Cyanine-9 is most likely to undergo the ESIPT process. From this paper, the novel dynamics in the Cyanine-n system not only comprehensively set forth, but the optimal substitution form is identified. We hope our work can offer new insights into the design and synthesis of bioimaging and environmental science applications.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116425"},"PeriodicalIF":4.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photocatalytic degradation of tetracycline by Mn,S co-doped TiO2 under visible-light irradiation","authors":"Cui Li ,&nbsp;Shu Lin ,&nbsp;Weibin Zhang ,&nbsp;Kezhen Qi","doi":"10.1016/j.jphotochem.2025.116423","DOIUrl":"10.1016/j.jphotochem.2025.116423","url":null,"abstract":"<div><div>To mitigate the accumulation of toxic materials in the environment, the development of efficient photocatalysts offers a sustainable approach to solar energy-assisted environmental remediation. TiO₂-based photocatalysts are particularly attractive due to their favorable optical and electronic properties, low cost, and non-toxicity. In this study, Mn,S co-doped TiO₂ materials with varying doping ratios were synthesized using the sol–gel method and characterized via XRD, XPS, UV–vis DRS, SEM, and BET. Mn,S co-doping effectively reduced the band gap of TiO₂, enhancing light absorption. Specifically, the optimized 5%Mn-3%S-TiO₂ exhibited the smallest band gap of 2.28 eV. When applied to the photocatalytic degradation of tetracycline hydrochloride (TC), it achieved a degradation rate of 67.03 % within 180 min, marking a 31.63 % improvement compared to undoped TiO₂. These results underscore the potential of Mn,S co-doping to enhance the photocatalytic performance of TiO₂, presenting a promising approach for environmental restoration through the efficient degradation of harmful pollutants.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116423"},"PeriodicalIF":4.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and performance research of an AIE molecule","authors":"Yuehua Liang,&nbsp;Jiuzhi Wei,&nbsp;Juan Zhang,&nbsp;Tingting Zhang,&nbsp;Yanyan Li,&nbsp;Caiyuan Guo,&nbsp;Enke Feng,&nbsp;Xinxian Ma,&nbsp;Xinning Han","doi":"10.1016/j.jphotochem.2025.116420","DOIUrl":"10.1016/j.jphotochem.2025.116420","url":null,"abstract":"<div><div>This study utilized a simple design principle of using methoxy groups to restrict molecular rotation, converting ACQ molecules (BS-1) into AIE (BS-2) light sources. The BS-2 can recognize Al³⁺ and assemble into a supramolecular metallogel (BS-2-Al@gel). Furthermore, using the BS-2-Al³⁺ complex as a donor and Rhodamine 6G as acceptor, a artificial light–harvesting systems (ALHSs) has been prepared.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116420"},"PeriodicalIF":4.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the influence of π-conjugated bridge on photovoltaic parameters in A2-π2-D-π1-A1 dye sensitizers for efficient DSSCs","authors":"Hanane Etabti ,&nbsp;Omar Britel ,&nbsp;Nabeel Shahzad ,&nbsp;Arunkumar Ammasi ,&nbsp;Mohd Shkir ,&nbsp;Asmae Fitri ,&nbsp;Adil Touimi Benjelloun ,&nbsp;Mohammed Benzakour ,&nbsp;Mohammed Mcharfi","doi":"10.1016/j.jphotochem.2025.116407","DOIUrl":"10.1016/j.jphotochem.2025.116407","url":null,"abstract":"<div><div>Most notably, indole is the most abundantly found electron donor group. Eight <span><math><msub><mi>A</mi><mn>2</mn></msub></math></span>-<span><math><msub><mi>π</mi><mn>2</mn></msub></math></span>-D-<span><math><msub><mi>π</mi><mn>1</mn></msub></math></span>-<span><math><msub><mi>A</mi><mn>1</mn></msub></math></span> dyes as sensitizers to DSSCs have been successfully designed on the basis of two categories (R1/dyes and R2/dyes). All of these eight dyes have the same donor fragment (indole), π-conjugated bridge <span><math><msub><mi>π</mi><mn>1</mn></msub></math></span> (made of thiophene moiety/benzene) and acceptor fragment <span><math><msub><mi>A</mi><mn>1</mn></msub></math></span> (made of cyanoacrylic/cyanure). Additionally, an acceptor <span><math><msub><mi>A</mi><mn>2</mn></msub></math></span> group (cyanoacrylic acid) is incorporated with supplementary bridge <span><math><msub><mi>π</mi><mn>2</mn></msub></math></span> units.</div><div>The photochemical properties, electronically excited states, and chemical reactivity influencing the produced dyes have been evaluated through DFT and TD-DFT calculations. They include bond lengths, dihedral angles between fragments, frontier molecular orbitals, density of states, isosurface molecular electrostatic potential, charge density differences, fragment transition density matrix, UV–Vis absorption spectra, quantum chemical parameters, photovoltaic characteristics. The investigation compares the dyes features in photophysics, electrically excited states and chemical reactivity.</div><div>Among all the donor dyes designed, R1-D1 and R2-D1 exhibit the most favorable properties. They possess the smallest energy gap values (1.187 eV, 1.165 eV), lowest vertical excitation energies (2.32 eV, 1.85 eV), longest absorption peaks (535.51 nm, 671.67 nm), and the most negative free energy change for electron injection (−1.74 eV, −1.33 eV). These characteristics make them the optimal designs within the two molecular groups. In accordance with the appropriate photophysical characteristics expressed by the remaining organic dyes, all afore mentioned dyes can be considered suitable for application in DSSCs.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116407"},"PeriodicalIF":4.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Box-Behnken experimental design to optimize the degradation of methyl orange by β-cyclodextrin-assisted photo-Fenton","authors":"Leandro Fuentes ,&nbsp;Sebastián Robledo ,&nbsp;José Natera ,&nbsp;Walter A. Massad","doi":"10.1016/j.jphotochem.2025.116419","DOIUrl":"10.1016/j.jphotochem.2025.116419","url":null,"abstract":"<div><div>Cyclodextrins (CDs) are cyclic oligosaccharides that form inclusion complexes with organic pollutants due to their hydrophobic cavities. This study focused on optimizing the conditions for the degradation process of Methyl Orange (MO) in a homogeneous aqueous medium through β-cyclodextrin (β-CD) assisted photo-Fenton. A Box-Behnken experimental design was implemented, and the response surface methodology (RSM) was applied to predict and optimize the optimal conditions for MO removal. The experimental data fit a statistically valid quadratic model according to an analysis of variance (ANOVA), yielding a determination coefficient of R² = 0.9966, indicating a 95 % predictive accuracy. Optimization via RSM revealed that the ideal conditions to achieve a maximum removal of 96.4 % were: [β-CD] = 21 μM, [Fe²⁺] = 121 μM, [H₂O₂] = 7571 μM, and a pH of 4.2. Experimental verification of these conditions resulted in a degradation efficiency of 95.3 %, with a relative error of 1.15 %, demonstrating its proximity to the predicted value, highlighting the potential for scaling this approach to more complex systems. Thus, the methodology used proves to be an efficient and economically viable solution for the treatment of wastewater contaminated with dyes.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116419"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photoelectrochromic performance of a Nb-doped TiO2 colloid in DMF","authors":"Raivis Eglītis ,&nbsp;Martin Timusk ,&nbsp;Amit Das ,&nbsp;Andris Šutka","doi":"10.1016/j.jphotochem.2025.116406","DOIUrl":"10.1016/j.jphotochem.2025.116406","url":null,"abstract":"<div><div>Effective systems controlling light transmittance are essential for energy management regarding reduced energy consumption and for providing on-demand switchable privacy functions in buildings. Here, we report a photoelectrochromic device based on Nb-doped TiO₂ nanoparticles in <em>N,N</em>-dimethylformamide (DMF) sandwiched between two ITO-coated glass panes. Nb-doped TiO₂ nanoparticles allow selective control of the light absorption in the IR spectral range, leaving the visible range less affected. Upon irradiation under open circuit (OC) conditions, the transmittance change in the visible wavelength range of 400–700 nm was 59.0 ± 4.1 %, whereas, in the near-infrared wavelength range of 700–950 nm, it was 80.0 ± 2.9 % within 3 min of irradiation. This was achieved by irradiating the sample with UVA (365 nm) light. The recovery rate of photo-irradiated colloids can be modulated by applying an alternating electrical voltage. This allows for an increase in the recovery rate by several orders of magnitude.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"467 ","pages":"Article 116406"},"PeriodicalIF":4.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering a pH-responsive fluorometric system: Dual-emission carbon dots and BTB for selective urea sensing","authors":"Al-Montaser Bellah H. Ali ,&nbsp;Mohamed R. Elmasry ,&nbsp;Yousef A. Bin Jardan ,&nbsp;Mohamed M. El-Wekil","doi":"10.1016/j.jphotochem.2025.116416","DOIUrl":"10.1016/j.jphotochem.2025.116416","url":null,"abstract":"<div><div>Reliable detection of urea levels is critical for tracking kidney health, identifying diseases, and studying essential physiological functions. Here, we present a novel, straightforward, and selective fluorometric method for urea detection based on a dual-emission carbon dots system coupled with bromothymol blue (BTB) as a pH-sensitive indicator. The sensing platform consists of uniquely engineered carbon dots exhibiting dual emission peaks at 442 nm and 612 nm, working in conjunction with BTB in the presence of urease. The detection mechanism relies on urease-catalyzed hydrolysis of urea, which generates ammonia and subsequently increases the local pH. This pH elevation triggers a distinct color transformation of BTB from yellow (430 nm) to blue (615 nm), simultaneously causing a drop in fluorescence intensity at 612 nm and a rise at 442 nm, enabling ratiometric detection of urea. The developed method demonstrates excellent analytical performance with good linearity (R² = 0.9937) across a concentration range of 10.0–100.0 μM and achieves a detection limit of 2.86 μM. Notably, the method exhibits remarkable selectivity in complex biological matrices, successfully quantifying urea in human serum samples with high recovery values despite the presence of potential interferents. Furthermore, we extended the application of this sensing system to develop a smartphone-based colorimetric detection platform, enhancing its accessibility for point-of-care diagnostics. This dual-mode detection method provides a fast and dependable tool for urea monitoring in clinical and biological applications.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116416"},"PeriodicalIF":4.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}