Journal of Photochemistry and Photobiology A-chemistry最新文献

{"title":"Construction and photodegradation performance of CdS-Sn3O4 heterojunction","authors":"Cunxin Wei ,&nbsp;Dongyuan Miao ,&nbsp;Zhihe Xie ,&nbsp;Bin Zhang ,&nbsp;Huiping Qi ,&nbsp;Yan Liu","doi":"10.1016/j.jphotochem.2025.116811","DOIUrl":"10.1016/j.jphotochem.2025.116811","url":null,"abstract":"<div><div>A uniformly distributed photocatalytic composite material CdS-Sn₃O₄ heterojunction was constructed. Mixed valence tin oxide Sn₃O₄ was selected as a co-catalyst to improve the stability and photocatalytic activity of the composite because Sn₃O₄ possesses adjustable band gap and matches well with the CdS band position. The characterizations of EDS and XPS proved that Sn₃O₄ was successfully loaded on CdS. The composite material exhibits an excellent band gap of 2.25 eV, a high photo-generated current intensity and good photoluminescence properties. Due to the timely transfer of photo-generated electrons from CdS material to Sn₃O₄, the recombination of electron and hole is reduced, resulting in significant increase of photocurrent density and photocatalytic efficiency. The photocatalytic degradation experiments show that CdS-Sn₃O₄ possesses a significant degradation effect on antibiotics norfloxacin and tetracycline. Simultaneously, it also exhibits certain degradation effects on organic dye pollutants methylene blue and Rhodamine B. The active substances analysis shows that H₂O₂ and hole (h⁺) are the main active substances. Composite CdS-Sn₃O₄ still maintains a stable structure and good photocatalytic activity after several photocatalysis cycles. In brief, this heterojunction material is promising in water treatment and environmental protection.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116811"},"PeriodicalIF":4.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fragment-based and perturbation theories treatment of the excited benzene excimer","authors":"Ilya O. Glebov,&nbsp;Georgii A. Akimov,&nbsp;Andrey V. Stolyarov","doi":"10.1016/j.jphotochem.2025.116805","DOIUrl":"10.1016/j.jphotochem.2025.116805","url":null,"abstract":"<div><div>The non-orthogonal product approach (NOPA) was combined with complete degenerate active space perturbation theory (CDAS-PT2) in order to investigate the excited electronic states of the benzene dimer molecule (Bz<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>), which is supposed to play a precursor role in the chemical growth of polycyclic aromatic hydrocarbons in the interstellar gas medium. The fraction contribution of Rydberg and charge-transfer states into the total electronic density of low-lying exciton states of Bz<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span> was analyzed in the framework of the NOPA. A general mechanism of the photo-induced formation of the Bz<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span> excimer states, their subsequent stabilization due to a vibrational relaxation to the minimum of the optically inactive states plus the parallel predissociative decay caused by the intramolecular coupling with repulsive states manifold, is considered.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116805"},"PeriodicalIF":4.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchically structured NiFe2O4/CeO2 nanocomposites for visible light photocatalytic degradation of oxytetracycline","authors":"J. Vargas-Bustamante ,&nbsp;E. Benítez-Flores ,&nbsp;Juan C. Durán-Álvarez ,&nbsp;Amauri Serrano-Lázaro ,&nbsp;J. Pilo ,&nbsp;J.E. Antonio ,&nbsp;H. Muñoz ,&nbsp;J.M. Cervantes ,&nbsp;E.P. Arévalo-López ,&nbsp;R. Escamilla ,&nbsp;M. Romero","doi":"10.1016/j.jphotochem.2025.116803","DOIUrl":"10.1016/j.jphotochem.2025.116803","url":null,"abstract":"<div><div>Nickel ferrite (NiFe₂O₄, NFO)/cerium dioxide (CeO₂) nanocomposites (NFCs) with varying ratios were synthesized by a hydrothermal route and tested as photocatalysts for oxytetracycline (OTC) degradation under visible light. Unlike conventional ferrite-ceria composites, this work introduces hierarchical flower-like architectures with reduced crystallite sizes (<span><math><mo>≈</mo></math></span>8.2<!--> <!-->nm–10<!--> <!-->nm) and an S-scheme (broken-gap) heterojunction that promotes efficient charge separation. Structural and spectroscopic analyses, including X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), infrared spectroscopy (IR), and ultraviolet–visible diffuse reflectance spectroscopy (UV–Vis DRS) confirmed strong interfacial coupling and defect-rich surfaces, enhancing redox activity. Among the samples, NFC4 achieved the highest degradation efficiency (84.72%), while NFC1 exhibited the fastest kinetics (<span><math><mrow><mi>k</mi><mo>=</mo><mn>0</mn><mo>.</mo><mn>0122</mn></mrow></math></span> min⁻¹). Scavenger tests identified hydroxyl radicals ( <figure><img></figure> ) as the main active species, synergistically assisted by <figure><img></figure> and <figure><img></figure> redox cycling through a photo-Fenton-like pathway. The composites showed high stability, with NFC4 retaining <span><math><mo>&gt;</mo></math></span>96% activity after four reuse cycles. These findings highlight the novelty of designing hierarchical NFO/CeO₂ nanocomposites as efficient, durable, and magnetically recoverable photocatalysts for the visible-light remediation of emerging pharmaceutical contaminants.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116803"},"PeriodicalIF":4.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembly of Pillar[5]arene and phenazine enables FRET-based VOCs detection","authors":"Guo-Yan Liang,&nbsp;Shao-Ping Tao,&nbsp;Bing-Bing Shi,&nbsp;Qi Lin,&nbsp;Jin-Fa Chen,&nbsp;Tai-Bao Wei","doi":"10.1016/j.jphotochem.2025.116807","DOIUrl":"10.1016/j.jphotochem.2025.116807","url":null,"abstract":"<div><div>With Pyridine (<strong>Py</strong>) and Tetrahydrofuran (<strong>THF</strong>) being listed as class 2B carcinogens by the World Health Organization, and considering their extensive use as volatile organic solvents (VOCs), detection of <strong>Py</strong> and <strong>THF</strong> is critically important. This study introduced a novel sensing platform <strong>CP[5]A@G</strong> based on Förster resonance energy transfer (FRET) system to successfully realized the detection of these two toxic gasses. The sensing platform <strong>CP[5]A@G</strong> was developed through supramolecular self-assembly between the coumarin-modified pillar[5]arene (<strong>CP[5]A</strong>) and phenazine derivative (<strong>G</strong>). In which, the <strong>CP[5]A</strong> acted as host molecule and energy donor, accordingly, the <strong>G</strong> acted as the guest molecule and energy acceptor. This platform <strong>CP[5]A@G</strong> exhibited significant aggregation-caused quenching (ACQ) effects in chloroform and n-hexane mixed solvent. Generally speaking, ACQ effect is untoward for luminescence properties of organic compounds and is more severe in the solid state. However, based on the ACQ property of platform <strong>CP[5]A@G</strong>, we have realized the detection of <strong>Py</strong> and <strong>THF</strong> in solvent and film states through the host-guest competitive assembly and lone pair···π interaction mechanisms. The responses were manifested in the opening and quenching effects on the fluorescence luminescence. These findings represent substantial advancements in the adsorption of <strong>Py</strong> and <strong>THF</strong>, with promising applications in commercial gas recognition systems and sensor design.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116807"},"PeriodicalIF":4.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-efficiency photocatalytic water splitting via direct Z-scheme charge transfer in GaN/ZrS2 van der Waals heterojunction","authors":"Liqin Zhang ,&nbsp;Qingquan Xiao ,&nbsp;Shengyong Jian ,&nbsp;Jianfeng Ye ,&nbsp;Fuqiang Ai ,&nbsp;Sheng Li ,&nbsp;Xiaoping Wu","doi":"10.1016/j.jphotochem.2025.116801","DOIUrl":"10.1016/j.jphotochem.2025.116801","url":null,"abstract":"<div><div>Employing density functional theory-based first-principles computations, the optoelectronic properties and photocatalytic water splitting performance of the GaN/ZrS₂ van der Waals heterostructure are comprehensively investigated, along with the regulatory effect of biaxial strain. The GaN/ZrS₂ heterojunction forms a type-II band alignment with efficient charge separation enabled by van der Waals interactions and Z-scheme charge transfer. The GaN/ZrS₂ heterojunction achieves a visible optical absorption rate of up to 13 %, with the absorption spectrum exhibiting a pronounced red shift, significantly superior to single-component materials. Catalytic performance calculations show that the GaN/ZrS₂ heterojunction, driven by the synergistic effect of the interfacial built-in electric field and the <em>Z</em>-scheme charge transfer mechanism, enables the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) to proceed spontaneously, with a solar-to‑hydrogen efficiency (<span><math><msub><mi>η</mi><mi>STH</mi></msub></math></span>) of 28.02 %. Biaxial strain regulation of the GaN/ZrS₂ heterojunction reveals that compressive strain (−6 % to 0) decreases the bandgap while inducing a red shift in the absorption edge, whereas tensile strain (0 to 10 %) leads to bandgap widening and a blue shift of the absorption edge, demonstrating the effectiveness of strain engineering in tuning optical absorption. The study demonstrates the broad application prospects of the GaN/ZrS₂ heterojunction in photocatalytic water splitting.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116801"},"PeriodicalIF":4.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of bimetallic sulfide/carbon nitride nanocomposites for photocatalytic hydrogen evolution from simulated or natural seawater","authors":"Qiaoyi Xiao ,&nbsp;Yaoyao Fan ,&nbsp;Li Zhou ,&nbsp;Qiqi Gu ,&nbsp;Feifei Yan ,&nbsp;Yuan Lian ,&nbsp;Hongmei Wang ,&nbsp;Jie Yi ,&nbsp;Miao Cao ,&nbsp;Xiao Wang","doi":"10.1016/j.jphotochem.2025.116810","DOIUrl":"10.1016/j.jphotochem.2025.116810","url":null,"abstract":"<div><div>ZnCo₂S₄/g-C₃N₄ (ZCS/CNN) nanocomposites were synthesized using the impregnation method and employed for photocatalytic hydrogen evolution from various water sources. The structural, morphological, and photoelectrochemical properties were also thoroughly examined. The optimized 10 % ZCS/CNN nanocomposite demonstrated hydrogen production rates of 358.9 μmol·g⁻¹·h⁻¹ in deionized water, 726.5 μmol·g⁻¹·h⁻¹ in simulated seawater, 656.3 μmol·g⁻¹·h⁻¹ in Bohai seawater, and 516.4 μmol·g⁻¹·h⁻¹ in Zhoushan seawater, outperforming both CNN and ZCS. Besides its exceptional photocatalytic performance, the catalyst exhibited high stability over four cycles. The enhanced activity is primarily attributed to the formation of an S-scheme heterojunction, which lowers reactive impedance, increases photocurrent, and promotes efficient electron-hole separation. The g-C₃N₄-based photocatalytic materials developed in this study hold promise for practical applications in marine hydrogen production.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116810"},"PeriodicalIF":4.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical investigate of an excited state intramolecular proton transfer mechanism of Br-3N-OH: Single or double","authors":"Zhiqiang Chen,&nbsp;Qiyun Wang,&nbsp;Yilin Zhang,&nbsp;Yilin Cao,&nbsp;Yi Wang","doi":"10.1016/j.jphotochem.2025.116808","DOIUrl":"10.1016/j.jphotochem.2025.116808","url":null,"abstract":"<div><div>The dual-locked probe Br-3 N-2Et can be used to detect esterase in cells and endometrial cancer tissues. Br-3 N-2Et undergoes twisted intramolecular charge transfer (TICT) in the S₁ state, resulting in fluorescence quenching. Its formation only requires overcoming an energy barrier of 6.37 kcal/mol, and the reverse energy barrier is higher, indicating that the TICT state stably exists. Upon reaction with esterase, Br-3 N-OH is generated. Hydrogen bond parameters, infrared vibrational spectra, and Reduced Density Gradient (RDG) analysis confirm the enhanced hydrogen bond strength in the S₁ state. However, the excited-state double proton transfer (ESDPT) process is energetically unfavorable due to high energy barrier. The single proton transfer products (Br-3 N-OH-SPT1 and Br-3 N-OH-SPT2) can be generated. While Br-3 N-OH-SPT1 is unstable, the fluorescence emission peak of Br-3 N-OH-SPT2 (534 nm) closely matches with the experimental result (498 nm), indicating that the fluorescence mainly originates from Br-3 N-OH-SPT2. In summary, this work elucidates the quenching mechanism of Br-3 N-2Et and the luminescence mechanism of Br-3 N-OH, providing a theoretical guidance for designing analogous probes.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116808"},"PeriodicalIF":4.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction mechanism of nano-curcumin induced by oil-in-water method with α-crystalline: Assessments through spectroscopy and molecular simulation techniques","authors":"Sara Niroumand ,&nbsp;Yasaman Rezvani ,&nbsp;Saeideh Hoseinpoor ,&nbsp;Negar Omidkhah ,&nbsp;Mohammad Reza Saberi ,&nbsp;Jamshidkhan Chamani","doi":"10.1016/j.jphotochem.2025.116806","DOIUrl":"10.1016/j.jphotochem.2025.116806","url":null,"abstract":"<div><div>In this research, the effect of Nano-Curcumin (Nano-Cur) on α-crystallin protein was examined through different spectroscopic techniques along with conductometry, zeta potential, calorimetry measurements, docking and MD simulation. Based on fluorescence spectroscopic data, the calculated values for K_sv and K_b in 298 k were (1.65 ± 0.05) × 10⁵ M⁻¹ and (1.13 ± 0.05) × 10⁵ M⁻¹ that demonstrated strong interaction of Nano-Cur with α-crystallin. The decreasing of K_sv and K_b amounts with increasing temperature, displayed the occurrence of the static quenching mode. The calculated thermodynamic parameters (ΔH⁰ = −83.22 kJ.mol⁻¹ and ΔS⁰ = −179.18 J.mol⁻¹.k⁻¹), displayed the existence of Van der Waals forces and hydrogen</div><div>bonds in the interaction. The negative value of ΔG⁰ indicates the spontaneous state of the binding process. Synchronous fluorescence results displayed complex formation in the vicinity of Trp residue and not Tyr residue. The improvement in RLS intensity, confirmed complex formation between Nano-Cur and α-crystallin. The r distance between donor and acceptor (3.38 nm) was determined through FRET technique that more confirmed existence of a high affinity contact and complex formation. CD spectra outcomes displayed reduction of the % α-helix from 14.83 ± 0.09 % to 13.81 ± 0.09 % and increase of % β-sheet from 44.71 ± 0.09 % to 47.11 ± 0.09 % in α-crystallin protein with increasing of Nano-Cur concentration, which affirms the conformational changes of α-crystallin. Conductometry evaluation displayed the occurrence of ionizable group transmission in α-crystalline-Nano-Cur complex. According to relative absorbance studies, the T_m values of α-crystallin in the absence and presence of Nano-Cur were measured to be 53.3 °C and 57.9 °C, respectively. The zeta potential evaluation proposed the induced conformation changes in α-crystallin structure that was in agreement with results from PDI and ITC measurements. Also, docking and MD simulation displayed the good ability of curcumin in interaction with α-crystallin.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116806"},"PeriodicalIF":4.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145267347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel thermally-stable red phosphor Ba6La2Ga4O15:Eu3+ for WLEDs, anti-counterfeit inks, and fingerprint analysis","authors":"Can Yuan,&nbsp;Xingyang Peng,&nbsp;Rongmao Li,&nbsp;Yanzhi Zhang,&nbsp;Chaoyong Deng,&nbsp;Ruirui Cui","doi":"10.1016/j.jphotochem.2025.116804","DOIUrl":"10.1016/j.jphotochem.2025.116804","url":null,"abstract":"<div><div>This work reports the characterization of Ba₆La₂Ga₄O₁₅:Eu³⁺ (BLGO:Eu³⁺), a new Eu³⁺ doped red luminescent phosphor prepared in a high-temperature solid-state reaction. The material was comprehensively characterized, including investigations of its structural features, morphological characteristics, photoluminescence behavior, and potential applications. The samples were systematically characterized by X-ray diffraction and electron microanalysis, and the Eu³⁺ ions effectively replaced the La³⁺ sites in the matrix, and the samples had uniform elemental distributions and high purity. Under 394 and 468 nm excitation, the phosphor exhibits strong red-light emission dominated by 590 nm (⁵D₀ → ⁷F₂ transition) with a color purity close to 100 %. The fluorescent intensity peaked when the doping concentration <em>x</em> = 0.9, and the luminous thermal stability was excellent (luminescence intensity retention at 473 K was 87.6 % and 83.1 %, respectively). The narrowing of the band gap (3.378 eV) and the electron-leaping mechanism after doping are revealed by density-functional theory calculations. The high-performance warm white Light-emitting diode device was successfully prepared by compounding this phosphor with commercially available blue-green fluorescent materials under 395 nm near-ultraviolet excitation. The test data show that the device exhibits excellent luminescence characteristics: the chromaticity coordinates are (0.3914, 0.3882), which corresponds to a comfortable warm color temperature of 3803 K, and the Color Rendering Index value is 87.6. In addition, when the phosphor is dispersed in a polyvinyl alcohol solution, it emits bright red fluorescence under near-ultraviolet excitation, demonstrating potential for application in the field of anti-counterfeit inks.</div><div>Although the quantum efficiency (21.31 %) still needs to be improved, BLGO:Eu³⁺ phosphor has a promising application in White light-emitting diodes (WLEDs), fingerprint analysis and anti-counterfeiting.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116804"},"PeriodicalIF":4.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria-targeted near-infrared fluorescent probe for detecting viscosity in tumor and inflammation models","authors":"Sichen Zhang ,&nbsp;Jie Wang ,&nbsp;Jiale Li ,&nbsp;Qi Su ,&nbsp;Chunxu Han ,&nbsp;Wenxuan Hu ,&nbsp;Lei Hu ,&nbsp;Hui Wang","doi":"10.1016/j.jphotochem.2025.116802","DOIUrl":"10.1016/j.jphotochem.2025.116802","url":null,"abstract":"<div><div>Dynamic changes in mitochondrial viscosity are key indicators of mitochondrial functional status and metabolic activity, which are closely related to the development of a variety of diseases, including cancer and inflammation. However, significant challenges remain in real-time, non-invasive monitoring and imaging of mitochondrial viscosity in complex physiological environments, especially at the in vivo level. Herein, we developed a series of mitochondria-targeted near-infrared fluorescent probes, designated <strong>PTN1-PTN4</strong>. Among these, <strong>PTN1</strong> demonstrated high sensitivity and selectivity in responding to changes in mitochondrial viscosity, enabling effective differentiation of mitochondrial viscosity in cells under different physiological or pathological states. Furthermore, probe <strong>PTN1</strong> was successfully applied for tumor tissue diagnosis across cellular to organ levels by monitoring mitochondrial viscosity variations, as well as non-invasive detection in an inflammation mouse model at the in vivo level. The fluorescent probe developed in this work not only provides a powerful molecular tool for investigating the association between mitochondrial dysfunction and disease, but also shows considerable potential for application in the non-invasive early diagnosis of inflammation in vivo.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"472 ","pages":"Article 116802"},"PeriodicalIF":4.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}