Journal of Photochemistry and Photobiology A-chemistry最新文献

Engineering a pH-responsive fluorometric system: Dual-emission carbon dots and BTB for selective urea sensing

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-29 DOI: 10.1016/j.jphotochem.2025.116416

Al-Montaser Bellah H. Ali , Mohamed R. Elmasry , Yousef A. Bin Jardan , Mohamed M. El-Wekil

{"title":"Engineering a pH-responsive fluorometric system: Dual-emission carbon dots and BTB for selective urea sensing","authors":"Al-Montaser Bellah H. Ali , Mohamed R. Elmasry , Yousef A. Bin Jardan , Mohamed M. El-Wekil","doi":"10.1016/j.jphotochem.2025.116416","DOIUrl":"10.1016/j.jphotochem.2025.116416","url":null,"abstract":"<div><div>Reliable detection of urea levels is critical for tracking kidney health, identifying diseases, and studying essential physiological functions. Here, we present a novel, straightforward, and selective fluorometric method for urea detection based on a dual-emission carbon dots system coupled with bromothymol blue (BTB) as a pH-sensitive indicator. The sensing platform consists of uniquely engineered carbon dots exhibiting dual emission peaks at 442 nm and 612 nm, working in conjunction with BTB in the presence of urease. The detection mechanism relies on urease-catalyzed hydrolysis of urea, which generates ammonia and subsequently increases the local pH. This pH elevation triggers a distinct color transformation of BTB from yellow (430 nm) to blue (615 nm), simultaneously causing a drop in fluorescence intensity at 612 nm and a rise at 442 nm, enabling ratiometric detection of urea. The developed method demonstrates excellent analytical performance with good linearity (R<sup>2</sup> = 0.9937) across a concentration range of 10.0–100.0 μM and achieves a detection limit of 2.86 μM. Notably, the method exhibits remarkable selectivity in complex biological matrices, successfully quantifying urea in human serum samples with high recovery values despite the presence of potential interferents. Furthermore, we extended the application of this sensing system to develop a smartphone-based colorimetric detection platform, enhancing its accessibility for point-of-care diagnostics. This dual-mode detection method provides a fast and dependable tool for urea monitoring in clinical and biological applications.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116416"},"PeriodicalIF":4.1,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct roles of subphthalocyanine in the ultrafast photodynamics of three donor–acceptor conjugates directly linked by a single B-N bond revealed by nonadiabatic dynamics simulations

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-27 DOI: 10.1016/j.jphotochem.2025.116415

Xiao-Mei Tang , Xin Wei , Ya-Qiong Guo , Yuxin Heng , Xiaoqin Liang , Laicai Li , Xiang-Yang Liu

{"title":"Distinct roles of subphthalocyanine in the ultrafast photodynamics of three donor–acceptor conjugates directly linked by a single B-N bond revealed by nonadiabatic dynamics simulations","authors":"Xiao-Mei Tang , Xin Wei , Ya-Qiong Guo , Yuxin Heng , Xiaoqin Liang , Laicai Li , Xiang-Yang Liu","doi":"10.1016/j.jphotochem.2025.116415","DOIUrl":"10.1016/j.jphotochem.2025.116415","url":null,"abstract":"<div><div>Herein, we investigate the photodynamics of three donor–acceptor subphthalocyanine (SubPc)-based conjugates, namely SubPc-PDI, PTZ-SubPc, and PTZ-SubPcF, by leveraging the synergy of linear-response time-dependent density functional theory (LR-TDDFT) for static electronic structure analysis and nonadiabatic molecular dynamics (NAMD) simulations. Based on the obtained results, the distinct roles of SubPc in different conjugates are confirmed. In SubPc-PDI, the SubPc fragment acts as an electron donor, whereas in PTZ-SubPc and PTZ-SubPcF, it functions as an electron acceptor. Consequently, the photodynamics of these conjugates vary upon excitation around the lowest absorption band of SubPc. In the case of SubPc-PDI, energy transfer from SubPc to PDI occurs on an ultrafast timescale, completing within 500 fs. In contrast, hole transfer from SubPc/SubPcF is observed in the PTZ-SubPc/SubPcF conjugates. Furthermore, the introduction of fluorine substitution notably lowers the energy of charge transfer states in PTZ-SubPc conjugates, thereby enhancing charge transfer efficiency. The findings of our current study strongly align with previous experimental results and provide a more comprehensive understanding of the photoinduced dynamics in SubPc-based donor–acceptor systems. Additionally, the methodologies employed in this work prove effective for investigating the photodynamics of these systems, offering valuable insights for analyzing complex photodynamic behaviors in diverse organic donor–acceptor systems.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116415"},"PeriodicalIF":4.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability, electronic, optical and vibrational spectra of copper octa-fluorophthalocyanine (F8CuPc) and its conformations : A DFT/TDDFT study

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-26 DOI: 10.1016/j.jphotochem.2025.116397

B.L. Pandi , C.L. Malonga Matanou , B.R. Malonda-Boungou , A.T. Raji

{"title":"Stability, electronic, optical and vibrational spectra of copper octa-fluorophthalocyanine (F8CuPc) and its conformations : A DFT/TDDFT study","authors":"B.L. Pandi , C.L. Malonga Matanou , B.R. Malonda-Boungou , A.T. Raji","doi":"10.1016/j.jphotochem.2025.116397","DOIUrl":"10.1016/j.jphotochem.2025.116397","url":null,"abstract":"<div><div>We report on the energetics of formation, geometric optimization, ionization energies, Ultraviolet–visible (UV–Vis) spectroscopy, vibrational frequency analysis, and electronic properties of pristine Copper octa-fluorophthalocyanine (F<sub>8</sub>CuPc) and its four different conformations as obtained using the ground-state density-functional theory (DFT) and time-dependent density-functional theory (TDDFT) approaches. The conformations have been constructed by permutation and substitution between fluorine and hydrogen atoms of the F<sub>8</sub>CuPc. Based on the calculated formation energy, we found that one of the conformations, termed ’A’, is the most stable, and is even more stable than the widely known pristine F<sub>8</sub>CuPc. Our vibrational analysis show an absence of imaginary frequencies thus suggesting the stability of F<sub>8</sub>CuPc and its four conformations. The structural parameters obtained for the conformations are consistent with the available experimental and theoretical data. Across the conformations, the band gap, E<span><math><msub><mrow></mrow><mrow><mi>g</mi></mrow></msub></math></span> varies. Of particular interest is the <span><math><msub><mrow><mi>E</mi></mrow><mrow><mi>g</mi></mrow></msub></math></span>= 0.80 eV obtained for the most stable conformation A. Such a value of band gap makes this conformation of F<sub>8</sub>CuPc suitable for absorbing sunlight in the near-infrared region thereby making it useful for harvesting energy from this part of the solar spectrum. More interestingly is the fact that the electronic and optical properties of this important molecule, i.e Fe<sub>8</sub>CuPc can be tuned by permutations of the constituents atoms of fluorine and hydrogen. This opens the possibility of functionalization of surfaces or nanostructures with the conformations, for specific applications.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116397"},"PeriodicalIF":4.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly selective fluorescent detection of Al3+ and HSO4− using supramolecular coordination polymers in aqueous solutions

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-26 DOI: 10.1016/j.jphotochem.2025.116412

Yang Liu, Jin Tong, Hong-Lin Lu, Zhi-Feng Wang, Shu-Yan Yu

引用次数: 0

A fluorescence sensor based on surface functionalization and heteroatom co-doped carbon dots for detection of tetracycline

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-25 DOI: 10.1016/j.jphotochem.2025.116411

Weifeng Hou, Chuyao Liang, Yi Li, Cuicui Shao, Yanghuan Zheng, Zhijian Li, Shouzhi Pu, Congbin Fan

{"title":"A fluorescence sensor based on surface functionalization and heteroatom co-doped carbon dots for detection of tetracycline","authors":"Weifeng Hou, Chuyao Liang, Yi Li, Cuicui Shao, Yanghuan Zheng, Zhijian Li, Shouzhi Pu, Congbin Fan","doi":"10.1016/j.jphotochem.2025.116411","DOIUrl":"10.1016/j.jphotochem.2025.116411","url":null,"abstract":"<div><div>Tetracycline (TC), as a budget broad-spectrum antibiotic, its wide-ranging use might result in residues being left in the environment and existed potential harm. Hence, we designed a ratiometric fluorescence probe (N,P@CDs@Eu) based on Eu functionalized nitrogen and phosphorus elements in-situ self-doping carbon dots (CDs) for detection of TC. The N,P@CDs was synthesized utilizing adenosine triphosphate (ATP) contained a significant amount of phosphate groups. These phosphate groups served as binding sites for Eu, facilitating functionalization of N,P@CDs to form the N,P@CDs@Eu. Under ultraviolet irradiation, N,P@CDs@Eu only exhibited the intense emission at 440 nm. However, during the sensing process, TC quenched the fluorescence at 440 nm of via inner filter effect (IFE), and induced N,P@CDs@Eu to exhibited fluorescence at 617 nm through antenna effect (AE). So that, a ratiometric fluorescence sensor for detection of TC had been constructed, which could achieve quantitative determination within 0.1–50 μM range, the detection limit of 22.6 nM. Moreover, N,P@CDs@Eu exhibited outstanding detection capabilities of TC in milk and tap water, with high recovery rates (99.47 %–108.12 %) and low errors (R < 4.68 %), indicating N,P@CDs@Eu had enormous application prospects in the field of food safety and environmental detection.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116411"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A water-soluble phosphorus-dipyrromethene fluorescent probes for visualization of hydrogen sulfide in plants under abiotic stresses

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-24 DOI: 10.1016/j.jphotochem.2025.116409

Xiaoyang Ji, Zhaoyang Hu, Ziwen Dong, Jun Huo, Shuangyi Liu, Ligang Chen, Na Niu

{"title":"A water-soluble phosphorus-dipyrromethene fluorescent probes for visualization of hydrogen sulfide in plants under abiotic stresses","authors":"Xiaoyang Ji, Zhaoyang Hu, Ziwen Dong, Jun Huo, Shuangyi Liu, Ligang Chen, Na Niu","doi":"10.1016/j.jphotochem.2025.116409","DOIUrl":"10.1016/j.jphotochem.2025.116409","url":null,"abstract":"<div><div>Hydrogen sulfide (H<sub>2</sub>S) usually acts as a gaseous signaling molecule that plays an essential role in regulating plant physiological activities. Consequently, in-situ detection of H<sub>2</sub>S in plants is of great significance for studying the physiological mechanisms of H<sub>2</sub>S within the plant system. In this study, a highly water-soluble probe with long-wavelength emission for in-situ detection of H<sub>2</sub>S in plants was synthesized. The ring-forming structure of phosphorus atom improves its water solubility. By introducing 2,4-dimethoxyphenyl to the boron-dipyrromethene (BODIPY) structure, DPOD-NO<sub>2</sub> possesses a large Stokes Shift (76 nm). Furthermore, the long-wavelength emission at 616 nm reduces the interference from plant self-fluorescence. The nitro group was chosen as the recognition group, and the specific recognition of H<sub>2</sub>S was achieved through the intramolecular charge transfer (ICT) mechanism. The DPOD-NO<sub>2</sub> shows excellent linearity within the H<sub>2</sub>S concentration range of 0.1 to 90 μM, with a detection limit of 0.063 μM. Importantly, DPOD-NO<sub>2</sub> enabled successfully in situ detection and imaging of H<sub>2</sub>S in plants due to its excellent biocompatibility and detection performance. The imaging results reveal the variations in H<sub>2</sub>S content within the root systems of wheat seedlings under Al<sup>3+</sup> stress, drought stress, and flooding stress. Consequently, this work presents a novel probe for further exploring the role and mechanism of H<sub>2</sub>S in plants’ responses to environmental stresses.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116409"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced photoluminescence properties of Eu3+/Li+ co-doped ZrO2: A focus on red and far-red emissions

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-24 DOI: 10.1016/j.jphotochem.2025.116408

Abeer S. Altowyan , U.H. Kaynar , H. Aydin , M.B. Coban , Z.G. Portakal , S. Akça-Özalp , Jabir Hakami , M. Ayvacikli , M. Topaksu , N. Can

{"title":"Enhanced photoluminescence properties of Eu3+/Li+ co-doped ZrO2: A focus on red and far-red emissions","authors":"Abeer S. Altowyan , U.H. Kaynar , H. Aydin , M.B. Coban , Z.G. Portakal , S. Akça-Özalp , Jabir Hakami , M. Ayvacikli , M. Topaksu , N. Can","doi":"10.1016/j.jphotochem.2025.116408","DOIUrl":"10.1016/j.jphotochem.2025.116408","url":null,"abstract":"<div><div>In this study, Eu<sup>3+</sup> and Li<sup>+</sup> co-doped ZrO<sub>2</sub> nanophosphors were synthesized using a microwave-assisted gel combustion method. While the synthesis method ensures phase stabilization, it does not directly enhance photoluminescence (PL) intensity. Instead, the observed PL enhancement originates from Li<sup>+</sup> co-doping, which improves charge compensation and modifies local symmetry. Structural analysis confirmed the stabilization of the tetragonal phase due to Li<sup>+</sup> co-doping, which introduced controlled oxygen vacancies. These structural changes led to a 4.67-fold intensity enhancement in red emission at 611 nm (<sup>5</sup>D<sub>0</sub> → <sup>7</sup>F<sub>2</sub> transition), and a 4.26-fold increase in far-red emission at 711 nm (<sup>5</sup>D<sub>0</sub> → <sup>7</sup>F<sub>4</sub> transition). Optimal doping concentrations of Eu<sup>3+</sup> (0.02) and Li<sup>+</sup> (0.03) achieved the highest luminescence intensity while maintaining color purity values up to 88.71 %. High-temperature PL measurements revealed stable emission peaks up to 550 K, demonstrating the material’s thermal stability despite intensity reductions due to thermal quenching. These findings establish Eu<sup>3</sup><sup>+</sup>/Li<sup>+</sup> co-doped ZrO<sub>2</sub> nanophosphors as promising candidates for solid-state lighting, plant growth lighting, and optoelectronic applications requiring enhanced red and far-red emissions.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116408"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adopted green spectrophotometric determination of futibatinib based on diazo coupling with 1-naphthol and assisted computational calculations

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-24 DOI: 10.1016/j.jphotochem.2025.116396

Reem M. Alnemari , Saleh l. Alaqel , Atiah H. Almalki , Maram H. Abduljabbar , Arwa S. Alqahtani , Ahmed H. Abdelazim

{"title":"Adopted green spectrophotometric determination of futibatinib based on diazo coupling with 1-naphthol and assisted computational calculations","authors":"Reem M. Alnemari , Saleh l. Alaqel , Atiah H. Almalki , Maram H. Abduljabbar , Arwa S. Alqahtani , Ahmed H. Abdelazim","doi":"10.1016/j.jphotochem.2025.116396","DOIUrl":"10.1016/j.jphotochem.2025.116396","url":null,"abstract":"<div><div>Futibatinib, a potent fibroblast growth factor receptor inhibitor, received US approval on September 30, 2022, for treating breast, esophageal, and lung cancers by reducing cell viability. A new spectrophotometric method has been developed to accurately quantify this drug with the use of computational tools and matching environmentally friendly (green) principles. 1-Naphthol was found to be the best reagent for diazo-coupling of futibatinib based on the density functional theory calculations. The experimental process involves diazo coupling futibatinib with sodium nitrite to produce a diazonium ion, which then interacts with 1-Naphthol to develop a red-colored chromogen complex. At 514 nm, the resultant complex displays defined measurable quantitative absorption peaks. A number of elements that affect the diazotization were researched in order to optimize the process. The method exhibited excellent linearity within the range of 1–12 μg/mL (r<sup>2</sup> = 0.9996), with limits of detection and quantification at 0.10 μg/mL and 0.30 μg/mL, respectively. It also demonstrated high accuracy (99.32 %) and precision (%RSD < 1). The proposed method has a greener profile, scoring 0.69 compared to 0.48 for previously reported UPLC-MS/MS methods, offering reduced waste, shorter analysis times, and lower energy consumption. Additionally, it is more cost-effective and environmentally sustainable, making it a viable choice for both pure and pharmaceutical applications.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116396"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and luminescent properties of spiroindoloacridine-fluorene (SIAF)/oxadiazole hybrids as deep-blue emitters

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-24 DOI: 10.1016/j.jphotochem.2025.116410

Shuomei Zhang , Tianzhi Yu , Chunrui Da , Yuling Zhao , Di Zhang , Wenming Su

{"title":"Synthesis and luminescent properties of spiroindoloacridine-fluorene (SIAF)/oxadiazole hybrids as deep-blue emitters","authors":"Shuomei Zhang , Tianzhi Yu , Chunrui Da , Yuling Zhao , Di Zhang , Wenming Su","doi":"10.1016/j.jphotochem.2025.116410","DOIUrl":"10.1016/j.jphotochem.2025.116410","url":null,"abstract":"<div><div>Two spiroindoloacridine-fluorene (SIAF)/oxadiazole hybrids (<strong>SIAF-tBuOXD</strong> and <strong>SIAF-MeOOXD</strong>) have been synthesized by the Suzuki cross-coupling reactions between the spiroindoloacridine-fluorene boronic ester and 2-(4-bromophenyl)-5-(4-(<em>tert</em>-butyl)phenyl)-1,3,4-oxadiazole (<strong>tBuOXD</strong>) and 2-(4-bromophenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole (<strong>MeOOXD</strong>), respectively. Their photophysical and electrochemical properties and thermal stabilities, as well as organic electroluminescent performances were investigated through theoretical calculations and experimental measurements. These compounds displayed excellent thermal stability (T<sub>d</sub> > 350 °C), and exhibited intense deep-blue emission (ca. 399 nm) with a full width at half maximum (FWHM) of 48 nm and high fluorescence quantum yield approaching 100 % in toluene solution. By using 1,3-bis(N-carbazolyl)benzene (mCP) as the host material and solution-processing the emitting layers, the doped devices without the hole-transporting layers exhibited deep-blue emissions with a maximum external quantum efficiencies (EQE<sub>max</sub>) of 5.01 % for <strong>SIAF-tBuOXD</strong> and 4.76 % for <strong>SIAF-MeOOXD</strong>.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116410"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles Pt-Pd (PAPLAL) catalyze tetrahydrobiopterin oxidation and this contributes to the therapy and phototherapy of vitiligo

IF 4.1 3区化学

Journal of Photochemistry and Photobiology A-chemistry Pub Date : 2025-03-23 DOI: 10.1016/j.jphotochem.2025.116404

T.A. Telegina , Yu.L. Vechtomova , D.A. Makarova , A.S. Nizamutdinov , A.A. Buglak

{"title":"Nanoparticles Pt-Pd (PAPLAL) catalyze tetrahydrobiopterin oxidation and this contributes to the therapy and phototherapy of vitiligo","authors":"T.A. Telegina , Yu.L. Vechtomova , D.A. Makarova , A.S. Nizamutdinov , A.A. Buglak","doi":"10.1016/j.jphotochem.2025.116404","DOIUrl":"10.1016/j.jphotochem.2025.116404","url":null,"abstract":"<div><div>Vitiligo is a dermatological autoimmune disease characterized by the loss of melanin pigment. The pathogenesis of vitiligo involves oxidative stress and the autoimmune response mediated by it. Given the current state of vitiligo treatment and the role of tetrahydrobiopterin (H<sub>4</sub>Bip) as a trigger of vitiligo, the purpose of this work is to study the effect of Pt-Pd nanoparticles (NPs) on the auto- and photooxidation H<sub>4</sub>Bip as a therapy for vitiligo.</div><div>Electron microscopy determined: the diameter of palladium NPs was 3.59 ± 0.56 nm and the diameter of platinum NPs was 1.93 ± 0.34 nm. The zeta potential was −16.9 ± 3.4 mV. It was demonstrated that Pt-Pd NPs catalyze the autoxidation of H<sub>4</sub>Bip to dihydropterins and their catalytic activity is proportional to the Pt-Pd NPs concentration. The therapeutic effect of NPs may be due to the fact that dihydropterins do not inhibit melanogenesis. NPs also catalyze the formation of dihydropterin dimers upon irradiation of H<sub>4</sub>Bip solutions at 308 and 325 nm. The removal of H<sub>4</sub>Bip by photooxidation is apparently the basis for phototherapy of vitiligo.</div><div>We have shown for the first time that, along with catalase-like and superoxide dismutase-like effects, one of the main pathways of action of Pt-Pd NPs is the catalysis of the oxidation of H<sub>4</sub>Bip to dihydropterins and their conversion into dimers under UV irradiation <em>in situ</em>. Thus, Pt-Pd NPs are apparently able to remove excess of H<sub>4</sub>Bip and thereby prevent the development of strong oxidative stress leading to the development of vitiligo.</div></div>","PeriodicalId":16782,"journal":{"name":"Journal of Photochemistry and Photobiology A-chemistry","volume":"466 ","pages":"Article 116404"},"PeriodicalIF":4.1,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0