Journal of Pharmacopuncture最新文献

{"title":"Acupuncture for Attenuating Frontal Lobe α Band Asymmetry Induced by Anger: a pilot study.","authors":"Sung-A Kim,&nbsp;Yujin Choi,&nbsp;Seung-Hun Cho","doi":"10.3831/KPI.2023.26.3.276","DOIUrl":"10.3831/KPI.2023.26.3.276","url":null,"abstract":"<p><strong>Objectives: </strong>Previous studies have shown that anger can lead to frontal lobe α (8-13 Hz) band asymmetry (FAA) in electroencephalogram (EEG), in accordance with motivational direction. This pilot study aimed to investigate the impact of acupuncture on FAA elicited by anger.</p><p><strong>Methods: </strong>Thirty-four right-handed participants scoring above 75 points on the Novaco Anger Scale were included. Baseline EEG signals were recorded for eight minutes using a 32-channel cap under comfortable conditions. Anger was induced through a nine-minute sequence of Articulated Thoughts in Simulated Situations (ATSS) task. Following that, participants received acupuncture at GB20 and GB21 for 10 minutes. Fast Fourier transform was employed for frequency analysis, and repeated measure ANOVA was conducted for statistical analysis.</p><p><strong>Results: </strong>The results revealed that participants exhibited significantly higher FAA (p = 0.026), particularly in the left hemisphere, after the ATSS task sequence compared to the baseline. During acupuncture treatment, the greater left-sided FAA was significantly reduced (p = 0.027) and reversed. Upon the cessation of acupuncture, FAA returned to a value between the baseline and the anger-evoked stage (p = 0.046).</p><p><strong>Conclusion: </strong>The EEG results of this study revealed that anger stimulation induced an increase in left-sided FAA, which was effectively alleviated by acupuncture. This led to an immediate restoration of FAA asymmetry induced by anger. These findings suggest the potential of acupuncture as a treatment option for reducing FAA associated with anger.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"276-284"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/ed/jop-26-3-276.PMC10547816.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41136243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Silico</i> Studies of Indole Derivatives as Antibacterial Agents.","authors":"Mridul Shah,&nbsp;Adarsh Kumar,&nbsp;Ankit Kumar Singh,&nbsp;Harshwardhan Singh,&nbsp;Balasubramanian Narasimhan,&nbsp;Pradeep Kumar","doi":"10.3831/KPI.2023.26.2.147","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.147","url":null,"abstract":"<p><strong>Objectives: </strong>Molecular docking and QSAR studies of indole derivatives as antibacterial agents.</p><p><strong>Methods: </strong>In this study, we used a multiple linear regressions (MLR) approach to construct a 2D quantitative structure activity relationship of 14 reported indole derivatives. It was performed on the reported antibacterial activity data of 14 compounds based on theoretical chemical descriptors to construct statistical models that link structural properties of indole derivatives to antibacterial activity. We have also performed molecular docking studies of same compounds by using Maestro module of Schrodinger. A set the molecular descriptors like hydrophobic, geometric, electronic and topological characters were calculated to represent the structural features of compounds. The conventional antibiotics sultamicillin and ampicillin were not used in the model development since their structures are different from those of the created compounds. Biological activity data was first translated into pMIC values (i.e. -log MIC) and used as a dependent variable in QSAR investigation.</p><p><strong>Results: </strong>Compounds with high electronic energy and dipole moment were effective antibacterial agents against <i>S. aureus</i>, indole derivatives with lower κ₂ values were excellent antibacterial agents against MRSA standard strain, and compounds with lower R value and a high ²χ^v value were effective antibacterial agents against MRSA isolate.</p><p><strong>Conclusion: </strong>Compounds 12 and 2 showed better binding score against penicillin binding protein 2 and penicillin binding protein 2a respectively.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"147-157"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/12/jop-26-2-147.PMC10315882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Treatment of Pyritum for Musculoskeletal Trauma: a protocol for systematic review.","authors":"Ji Hye Hwang,&nbsp;Su Hyun Choi","doi":"10.3831/KPI.2023.26.2.192","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.192","url":null,"abstract":"<p><strong>Objectives: </strong>Musculoskeletal trauma is a common type of injury that can result from damage to the muscular or skeletal system and has been recognized as a leading cause of death and disability worldwide. This study aims to analyze the efficacy of Pyritum external treatment for musculoskeletal trauma.</p><p><strong>Methods: </strong>Randomized controlled trials evaluating the external treatment effect of Pyritum on various types of musculoskeletal traumatic injuries will be considered and identified in the searches of eight databases from their inception to Feb 2023. There will be no restrictions with respect to the publication status, language, or country. The experimental intervention group will be treated with external application of Pyritum alone or in combination with other therapies, and the comparator intervention group will include all types of control interventions. The primary outcome will be measured as treatment efficacy rate, and secondary outcomes will include pain reduction, pain disappearance time, swelling, joint function, and recovery period. Assessment of the methodological quality of this study will be concluded using the risk of bias assessment recommended by the Cochrane Collaboration. If there are sufficient numbers of studies per group in terms of specific rating scales to compare the treatment effects of Pyrium alone and combined external treatment groups, we will consider subgroup analysis.</p><p><strong>Results: </strong>This systematic review will be conducted in compliance with the PRISMA-P statement.</p><p><strong>Conclusion: </strong>We will conduct an extensive search on the proposed topic within the available literature and provide systematic evidence for the efficacy and safety of external application of Pyritum for all types of musculoskeletal trauma. The evidence generated will help design interventions for the external use of Pyritum for this patient group.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"192-197"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/a2/jop-26-2-192.PMC10315878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Immunological, Biochemical, and Histopathological Changes of Airway Remodeling by <i>Withania somnifera</i> in an Experimental Model of Allergic Asthma in Rats.","authors":"Nafaa Hasan Ali,&nbsp;Sana Rehman,&nbsp;Maaz Naqvi,&nbsp;Kavita Gulati,&nbsp;Arunabha Ray","doi":"10.3831/KPI.2023.26.2.158","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.158","url":null,"abstract":"<p><strong>Objectives: </strong>Airway remodeling in asthma involves chronic inflammation associated with structural changes, which result in severe airflow limitation and very few therapeutic options. Thus, the present study was designed to experimentally evaluate the ameliorative effects of <i>Withania somnifera</i> (WS) root extract against Ovalbumin (OVA)-induced airway remodeling in a rat model of asthma.</p><p><strong>Methods: </strong>Wistar rats were immunized (i.p) and challenged (aerosol) with ovalbumin (OVA), and the effects of WS extract were investigated on the development and progress of airway remodeling by assessing immunological, biochemical, and histological changes in these rats.</p><p><strong>Results: </strong>OVA-immunization and challenge in rats resulted in significant increases in the levels of IL-13, 8-OhdG, TGF-β, hydroxyproline, and periostin in bronchoalveolar lavage fluid (BALF) and serum/lung homogenate compared to normal control (saline only) rats, and these changes were attenuated after WS extract (200 and 400 mg/kg), as well as dexamethasone (DEX, 1 mg/kg) pretreatments. Further, WS extract attenuated histopathological changes and maintained lung integrity. In herb-drug interactions, sub-threshold doses of WS extract and DEX showed synergistic effects on all parameters studied as compared to either form of monotherapy.</p><p><strong>Conclusion: </strong>These results indicated that WS exerted significant protective effects against airway remodeling in the experimental model by modulating inflammatory and fibrotic cytokines, and could have the potential for developing a therapeutic alternative/adjunct for the treatment of airway remodeling of bronchial asthma.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"158-166"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/23/jop-26-2-158.PMC10315884.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> Antibacterial Activity and Wound Healing Effects of <i>Achillea millefolium</i> Essential Oil in Rat.","authors":"Mohammad Reza Ghasemi,&nbsp;Akram Ranjbar,&nbsp;Pari Tamri,&nbsp;Shabnam Pourmoslemi,&nbsp;Alireza Nourian,&nbsp;Dara Dastan","doi":"10.3831/KPI.2023.26.2.167","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.167","url":null,"abstract":"<p><strong>Objectives: </strong>In this study we aimed to evaluate the <i>in vitro</i> antibacterial activity and wound healing properties of <i>Achillea millefolium</i> essential oil (AMEO) in full-thickness wound model in rat. The antibacterial activity of AMEO was evaluated against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> using the broth dilution method.</p><p><strong>Methods: </strong>The 2 cm × 2 cm full-thickness excisional wounds were created on the back of animals. Topical therapy was applied twice a day using 1%, 2%, and 3% w/w AMEO ointments, and the measurement of the wounds area was carried out every 3 days, after that the wound closure percentage was calculated in these days. Hydroxyproline content and histopathological evaluation of wound tissue samples were carried out on day 7 and 14 post wounding. Eucerin was used for the treatment of vehicle control group and negative control group received no treatment.</p><p><strong>Results: </strong>Our results revealed the bacteriostatic activity of AMEO against <i>S. aureus</i> and <i>P. aeruginosa</i>. Wound healing activity evaluation of AMEO showed the significant increase (p < 0.05) in the wound closure percentages in rats treated with AMEO 1% and 2% comparing to those of non-treatment group. In addition, hydroxyproline contents of tissue significantly (p < 0.01) increased in AMEO 1% and 2% comparing to non-treatment group. Histopathological evaluations of wound tissue samples on day 7 and 14 demonstrated higher accumulation of collagen fibers, reduction of edema and inflammation and also formation of tissue appendages in 1% and 2% AMEO treated groups in comparison with non-treatment group.</p><p><strong>Conclusion: </strong>The results of this study indicated that AMEO has the potential to be used as a safe and effective wound healing agent.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"167-174"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/a2/jop-26-2-167.PMC10315885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and Anti-Glucosyltransferase Activity of <i>Verbascum speciosum</i> Against Cariogenic Streptococci.","authors":"Shabnam Pourmoslemi,&nbsp;Amir Larki-Harchegani,&nbsp;Sajad Daneshyar,&nbsp;Dara Dastan,&nbsp;Amir Nili-Ahmadabadi,&nbsp;Mina Jazaeri","doi":"10.3831/KPI.2023.26.2.139","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.139","url":null,"abstract":"<p><strong>Objectives: </strong>Dental caries is a prevalent chronic human infection worldwide and several plants have shown anticariogenic properties through antibacterial activity against oral pathogens. The present study aimed to assess anticariogenic activity of <i>Verbascum speciosum</i>, in search of novel agents for the prevention and treatment of dental caries.</p><p><strong>Methods: </strong>Hydro-alcoholic extracts from flowers and total aerial parts of the plant were prepared by maceration. Antibacterial activity of the extracts against <i>Streptococcus mutans</i> (ATCC 35668) and <i>Streptococcus sobrinus</i> (ATCC 27607) was investigated by agar diffusion and microdilution techniques. Inhibitory concentration-fifty values of the flowers' extract against <i>Streptococcus mutans</i> glucosyltransferase enzymes were determined. The total flavonoid content of the extracts was determined using an aluminum chloride reaction.</p><p><strong>Results: </strong><i>Verbascum speciosum</i> flowers' extract showed significantly higher flavonoid content and antibacterial activity; with minimum inhibitory concentrations of 100 and 200 µg/mL for <i>Streptococcus mutans</i> and <i>Streptococcus sobrinus</i>, respectively. The extract inhibited the synthesis of glucan by cell-associated and extracellular glucosyltransferase enzymes in a dose-dependent manner with higher activity against the extracellular enzyme.</p><p><strong>Conclusion: </strong>This study indicated effective anticariogenic activity of Verbascum speciosum flowers extract. This extract can be considered as an alternative to current anticaries therapies or an additive to dental care products.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"139-146"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/92/jop-26-2-139.PMC10315880.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction and Perceived Effectiveness on Herbal Decoctions for Postpartum Care: a cross-sectional survey of mother's experience.","authors":"Min Kyung Hyun,&nbsp;Jang Kyung Park,&nbsp;Sung Yoon Oh","doi":"10.3831/KPI.2023.26.2.175","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.175","url":null,"abstract":"<p><strong>Objectives: </strong>In East Asia, postpartum care has traditionally been considered important for maternal health; however, studies on this are still insufficient. Therefore, we examined the satisfaction and perceived effectiveness of herbal decoctions used in postpartum care in a city in the Republic of Korea (ROK).</p><p><strong>Methods: </strong>We analyzed anonymized secondary data obtained from a retrospective cross-sectional survey of women who had taken herbal decoctions provided by the support service for women giving birth in a local city in ROK. The questionnaire items consisted of basic information regarding childbirth, the need for the herbal decoction support service, satisfaction, and the effectiveness of the service received.</p><p><strong>Results: </strong>A total of 68 women were included in the study, and those aged 30-39 accounted for 73.13%. Of the 68 women, 79.37% visited within 3 weeks of childbirth. Women's satisfaction regarding herbal decoction support for postpartum care was 76.47%, and most women (98.53%) responded that they needed it more than twice. More than 50% of women showed improvement in puerperal wind disorders, weight gain, and delayed eliminated lochia.</p><p><strong>Conclusion: </strong>A large proportion of women who took herbal decoctions reported satisfaction and perceived effectiveness when used to treat puerperal wind disorders. Nevertheless, future well-designed clinical studies are needed to provide information on whether herbal decoctions effectively prevent and treat puerperal wind disorders.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"175-183"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/6f/jop-26-2-175.PMC10315879.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials.","authors":"Alireza Derakhshan,&nbsp;Masoumeh Sadeghi,&nbsp;Amir-Mohammad-Hashem Asnaashari,&nbsp;Mohsen Dehghani,&nbsp;Roshanak Salari,&nbsp;Majid Khadem-Rezaiyan,&nbsp;Majid Mirsadraee,&nbsp;Shahin Saeidinejat,&nbsp;Shima Jalali,&nbsp;Shabnam Jalali","doi":"10.3831/KPI.2023.26.2.124","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.124","url":null,"abstract":"<p><strong>Objectives: </strong>The present study was designed to conduct a comprehensive systematic review and meta-analysis to assess the efficacy of herbal medicines as add-on therapy on lung function in asthmatic patients.</p><p><strong>Methods: </strong>A comprehensive search of online databases was performed up to December 2021 to identify randomized controlled trials that used orally herbal preparations for asthma as add-on therapy. Studies were assessed for methodological quality using the Cochrane Collaboration's Risk of Bias tool. The main outcome was percent predicted value of forced expiratory volume (% predicted FEV1). Pooled weighted mean difference (WMD) estimate with corresponding 95% confidence interval (CI) was calculated using inverse-variance weights method while random effects meta-analysis was used, taking into account clinical and conceptual heterogeneity.</p><p><strong>Results: </strong>As a result, 1,525 studies were identified. 169 studies were reviewed in-depth and 23 studies met our systematic review inclusion criteria. Finally, nine randomized controlled trials were included in the meta-analysis. Findings indicated that use of herbal medicines in patients with asthma significantly improved % predicted FEV1 (WMD 3.73, 95% CI 1.76-5.70), with no evidence for significant heterogeneity (p = 0.56 [Q statistic], I² = 0.0%). In subgroup analysis by age, improvement in % predicted FEV1 was higher and significant in adults (WMD 5.16; 95% CI 2.68-7.63) compared to children (WMD = 1.27; 95% CI -1.98-4.51). Sensitivity analysis showed the significant effect of herbal medicine consumption on improving FEV1 was consistently (range of summary WMDs 3.27-4.59), indicating that the meta-analysis model was robust. There was no evidence of publication bias both visually and statistically.</p><p><strong>Conclusion: </strong>Findings support, the complementary use of herbal medicines resulted in significant improvement in the lung function compared to standard treatment in asthmatic patients with no considerable adverse events. This improvement is more likely to be observed amongst adults.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"124-138"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/a8/jop-26-2-124.PMC10315876.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Acupuncture Efficiency in Human Polycystic Ovary/Ovarian Syndrome.","authors":"Natália M de Oliveira,&nbsp;Jorge Machado,&nbsp;Lara Lopes,&nbsp;Maria Begoña Criado","doi":"10.3831/KPI.2023.26.2.105","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.105","url":null,"abstract":"<p><strong>Objectives: </strong>Human Polycystic Ovary/Ovarian Syndrome (PCOS), a frequent endocrine pathophysiology among women of fertile age, is associated with woman's lifespan endocrine, metabolic and psychological implications. Long-term usage side effects of allopathic strategies and their low efficacy made complementary medicine treatments a relevant subject for these patients. The main aim of this work is to review the efficiency of the acupuncture treatment reported in the latest studies on literature regarding PCOS patients.</p><p><strong>Methods: </strong>A comprehensive literature search, in English language, about the use of acupuncture on the management of PCOS, was conducted in October 2020 using EBSCO, Cochrane, PubMed, Medline, Embase, databases for randomised and non-randomised controlled trials between 2015 and 2020 (09/2015-10/2020), following the PRISMA protocol.</p><p><strong>Results: </strong>This research led us to an analysis, according to PICOS, of six final papers selected among 178 in total. The articles addressed distinct aspects of the PCOS condition, diverse acupuncture techniques and different main and secondary outcomes in agreement to the respective main objective. According to this review, acupuncture seems to be useful for the treatment of this debilitating and chronic health condition which affects millions of women worldwide, many of them part of the workforce in their community.</p><p><strong>Conclusion: </strong>Despite of the display of these positive results addressing acupuncture treatments to manage PCOS major symptoms - whether they are reproductive, metabolic, or mental health features - more research is urgent. Randomized, double blinded controlled trials with improved quality design and following STRICTA and/or CONSORT recommendations are necessary to engage acupuncture as a standardized and scientific validated technique in PCOS condition.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"105-123"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/c7/jop-26-2-105.PMC10315877.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Health Insurance Data Analysis for the Second-Wave Development of Korean Medicine Clinical Practice Guidelines in South Korea.","authors":"Chan-Young Kwon,&nbsp;Seungwon Shin,&nbsp;O-Jin Kwon,&nbsp;Wonkyung Moon,&nbsp;Namkwen Kim,&nbsp;Minjung Park","doi":"10.3831/KPI.2023.26.2.198","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.198","url":null,"abstract":"<p><strong>Objectives: </strong>After the evidence-based Korean medicine clinical practice guidelines (KM-CPGs) for 30 targeted diseases were developed in 2021, 34 diseases have been proposed for the second-wave development of the KM-CPGs. The purpose of this study was to investigate the development priorities of the candidate diseases into the second-wave development of KM-CPGs in south Korea.</p><p><strong>Methods: </strong>In this study, we analyzed the Health Insurance Review and Assessment Service National Patient Sample data from 2017 to 2018 to determine the demand and economic importance of the candidates for the second-wave development of KM-CPGs in real-world clinical settings in Korea.</p><p><strong>Results: </strong>The annual number of visits and patients, annual healthcare expenditure per patient, and healthcare expenditure per institution were analyzed. Musculoskeletal disorders, including sciatica and adhesive capsulitis of the shoulder, were the most important topics regarding the number of visits and patients and annual healthcare expenditure per institution. Specifically, sciatica (52.05% of the total number of visits, 48.34% of the total number of patients, and 42.12% of the total treatment expenditure per institution) showed overwhelmingly high proportions. However, cerebral palsy (36.03% of the total number of inpatient visits and 24.55% of the total number of inpatient patients) was a more important topic in inpatient clinical settings than musculoskeletal conditions or cancer, and healthcare expenditure per patient in this topic had the highest ranking. Furthermore, fractures were found to be highly important in inpatient clinical settings. No patients had influenza A virus infection or posttraumatic stress disorders who visited the KM medical institution of interest.</p><p><strong>Conclusion: </strong>This study highlights the gap between the real-world clinical setting and the research field in some topics. The results of this study can provide guidance for the second-wave development of KM-CPGs in the future.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"198-209"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/34/jop-26-2-198.PMC10315883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}