Journal of Pharmacopuncture最新文献

{"title":"Therapeutic Potential of Active Components from <i>Acorus gramineus</i> and <i>Acorus tatarinowii</i> in Neurological Disorders and Their Application in Korean Medicine.","authors":"Cheol Ju Kim,&nbsp;Tae Young Kwak,&nbsp;Min Hyeok Bae,&nbsp;Hwa Kyoung Shin,&nbsp;Byung Tae Choi","doi":"10.3831/KPI.2022.25.4.326","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.4.326","url":null,"abstract":"<p><p>Neurological disorders represent a substantial healthcare burden worldwide due to population aging. <i>Acorus gramineus</i> Solander (AG) and <i>Acorus tatarinowii</i> Schott (AT), whose major component is asarone, have been shown to be effective in neurological disorders. This review summarized current information from preclinical and clinical studies regarding the effects of extracts and active components of AG and AT (e.g., α-asarone and β-asarone) on neurological disorders and biomedical targets, as well as the mechanisms involved. Databases, including PubMed, Embase, and RISS, were searched using the following keywords: asarone, AG, AT, and neurological disorders, including Alzheimer's disease, Parkinson's disease, depression and anxiety, epilepsy, and stroke. Meta-analyses and reviews were excluded. A total of 873 studies were collected. A total of 89 studies were selected after eliminating studies that did not meet the inclusion criteria. Research on neurological disorders widely reported that extracts or active components of AG and AT showed therapeutic efficacy in treating neurological disorders. These components also possessed a wide array of neuroprotective effects, including reduction of pathogenic protein aggregates, antiapoptotic activity, modulation of autophagy, anti-inflammatory and antioxidant activities, regulation of neurotransmitters, activation of neurogenesis, and stimulation of neurotrophic factors. Most of the included studies were preclinical studies that used <i>in vitro</i> and <i>in vivo</i> models, and only a few clinical studies have been performed. Therefore, this review summarizes the current knowledge on AG and AT therapeutic effects as a basis for further clinical studies, and clinical trials are required before these findings can be applied to human neurological disorders.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 4","pages":"326-343"},"PeriodicalIF":1.4,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/26/jop-25-4-326.PMC9806153.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10870342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Chemical Analysis of Various Disposable Acupuncture Needles Used in South Korea.","authors":"Dong Yong Park,&nbsp;JiYoon Ahn,&nbsp;Hyeon Jeong Park,&nbsp;Doo Suk Lee,&nbsp;Dae-Hyun Jo,&nbsp;Jonghoon Kim,&nbsp;Choulmin Kim,&nbsp;Heebum Chung,&nbsp;Ji Hye Hwang","doi":"10.3831/KPI.2022.25.4.382","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.4.382","url":null,"abstract":"<p><strong>Objectives: </strong>The Korean Industrial Standard (KS) for sterile acupuncture needles was established in 2009 based on research on the quality control of acupuncture needles. We aimed to determine the quality of acupuncture needles available in South Korea in 2021 by examining their surface condition and chemical composition using field-emission scanning electron microscopy (FE-SEM) and energy-dispersive X-ray spectroscopy (EDS).</p><p><strong>Methods: </strong>In South Korea, there are 23 brands of acupuncture needles, and we examined 10-15 needles from each brand, resulting in a total of 285 needles. The microstructures of the needles were assessed by SEM. Using SEM images, we evaluated the acupuncture needle tips for the following defects/aspects scratches, lumps, detached coating, bent tip, and tip sharpness. EDS was used to determine the chemical composition of the selected acupuncture needles.</p><p><strong>Results: </strong>Overall, 88.4% of 285 needles were found to have at least one type of abnormality. The most frequently observed abnormalities were scratches and dents on the surface (68.1%), followed by detached coating (63.2%), and lumps (61.8%); blunt tips were observed in about 24% of them. Of 252 needles with at least one defect, 86.9% had two or more types of defects. The ratio of the number of needles with any defect to that of needles without any defect varied among brands, ranging from 50% to 100%. Regarding foreign materials, higher proportions of Si and O were observed on the needles, indicating incomplete or detached silicone coating.</p><p><strong>Conclusion: </strong>The quality of acupuncture needles varied among brands, suggesting that further improvements can be made through various inspection methods.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 4","pages":"382-389"},"PeriodicalIF":1.4,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/ec/jop-25-4-382.PMC9806154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Reverse Mutation Test of Verbenalin.","authors":"Hye Jeong Shin,&nbsp;Yi Gun Lim,&nbsp;Ji Su Ha,&nbsp;Gabsik Yang,&nbsp;Tae Han Yook","doi":"10.3831/KPI.2022.25.4.364","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.4.364","url":null,"abstract":"<p><strong>Objectives: </strong>Verbenalin is a compound found in herbs such as <i>Cornus officinalis</i> and <i>Verbena</i> <i>officinalis</i>. This study investigated whether verbenalin is safe by analyzing its mutagenicity.</p><p><strong>Methods: </strong>To examine the mutagenic potential of verbenalin, a bacterial reverse mutation test (Ames test) was conducted with <i>Salmonella typhimurium</i> and <i>Escherichia coli</i> strains. Experiments with and without metabolic activity were performed.</p><p><strong>Results: </strong>The mean colony number was less than double that of the control. Growth inhibition and precipitation of verbenalin were not apparent in all strains at different concentrations regardless of metabolic activity.</p><p><strong>Conclusion: </strong>Verbenalin did not show any signs of mutagenicity in this study. Additional toxicity studies including repeated oral toxicity, reproductive toxicity, and carcinogenicity tests are needed.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 4","pages":"364-368"},"PeriodicalIF":1.4,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/b4/jop-25-4-364.PMC9806159.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10574537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of <i>Inula racemosa</i> Hook Extract on Cardioprotection by Ischemic Preconditioning in Hyperlipidaemic Rats.","authors":"Arun Kumar Tiwari,&nbsp;Pushpraj S Gupta,&nbsp;Mahesh Prasad,&nbsp;Paraman Malairajan","doi":"10.3831/KPI.2022.25.4.369","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.4.369","url":null,"abstract":"<p><strong>Objectives: </strong>Hyperlipidemia (HL) is a major cause of ischemic heart diseases. The size-limiting effect of ischemic preconditioning (IPC), a cardioprotective phenomenon, is reduced in HL, possibly because of the opening of the mitochondrial permeability transition pore (MPTP). The objective of this study is to see what effect pretreatment with <i>Inula racemosa</i> Hook root extract (IrA) had on IPC-mediated cardioprotection on HL Wistar rat hearts. An isolated rat heart was mounted on the Langendorff heart array, and then ischemia reperfusion (I/R) and IPC cycles were performed. Atractyloside (Atr) is an MPTP opener.</p><p><strong>Methods: </strong>The animals were divided into ten groups, each consisting of six rats (n = 6), to investigate the modulation of <i>I. racemosa</i> Hook extract on cardioprotection by IPC in HL hearts Sham control, I/R Control, IPC control, I/R + HL, I/R + IrA + HL, IPC + HL, IPC + NS + HL, IPC + IrA+ HL, IPC + Atr + oxidative stress, mitochondrial function, integrity, and hemodynamic parameters are evaluated for each group.</p><p><strong>Results: </strong>The present experimental data show that pretreatment with IrA reduced the LDH, CK-MB, size of myocardial infarction, content of cardiac collagen, and ventricular fibrillation in all groups of HL rat hearts. This pretreatment also reduced the oxidative stress and mitochondrial dysfunction. Inhibition of MPTP opening by Atr diminished the effect of IrA on IPC-mediated cardioprotection in HL rats.</p><p><strong>Conclusion: </strong>The study findings indicate that pretreatment with IrA e restores IPC-mediated cardioprotection in HL rats by inhibiting the MPTP opening.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 4","pages":"369-381"},"PeriodicalIF":1.4,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/8b/jop-25-4-369.PMC9806160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Glasthma Syrup in Asthma: a study protocol for a triple-blind randomized controlled trial.","authors":"Ali Reza Derakhshan,&nbsp;Shahin Saeidinejat,&nbsp;Majid Khadem-Rezaiyan,&nbsp;Amir-Mohammad-Hashem Asnaashari,&nbsp;Majid Mirsadraee,&nbsp;Roshanak Salari,&nbsp;Farahzad Jabbari-Azad,&nbsp;Shima Jalali,&nbsp;Shabnam Jalali","doi":"10.3831/KPI.2022.25.3.233","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.3.233","url":null,"abstract":"<p><strong>Objectives: </strong>Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics.</p><p><strong>Methods: </strong>The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed.</p><p><strong>Results: </strong>The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial.</p><p><strong>Conclusion: </strong>In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 3","pages":"233-241"},"PeriodicalIF":1.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/1b/jop-25-3-233.PMC9510144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous Injection of Bee Venom in Wistar Rats: effects on blood cells and biochemical parameters.","authors":"Yaser Yousefpoor,&nbsp;Mahmoud Osanloo,&nbsp;Mohamad Javad Mirzaei-Parsa,&nbsp;Mohammad Reza Hoseini Najafabadi,&nbsp;Seyyed Mohammad Hashemi,&nbsp;Mitra Abbasifard","doi":"10.3831/KPI.2022.25.3.250","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.3.250","url":null,"abstract":"<p><strong>Objectives: </strong>Bee venom (BV) therapy is performed by a bee sting or subcutaneous injection of BV. However, there is not much information on the effect of BV on blood parameters after entering the body. This project aimed to assess the side effects of subcutaneous BV injections in healthy rats by measuring the hematological and biochemical parameters.</p><p><strong>Methods: </strong>Various amounts of BV, including 100, 200, and 500 (µg/day), were subcutaneously injected into rats for 30 days. The results showed that BV affected the metabolism of the liver, kidney, and glands.</p><p><strong>Results: </strong>An increase in blood sugar and a decrease in other biochemical parameters, including cholesterol, triglyceride, urea, creatinine AST, ALT, ALP, and phosphorous, were observed. Results also showed increased counts of white blood cells, neutrophils (%), and platelets and decreased levels of red cells, hemoglobin, and hematocrit.</p><p><strong>Conclusion: </strong>This study demonstrates that BV therapy in medical clinics requires routine care and testing to prevent eventual metabolic and anemia side effects.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 3","pages":"250-257"},"PeriodicalIF":1.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/04/jop-25-3-250.PMC9510133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Mechanistic Study on the Trachea Smooth Muscle Relaxant Activity of Aqueous Leaf Extract of <i>Tridax Procumbens</i> in Male Wistar Rats.","authors":"Shakiru Ademola Salami,&nbsp;Hussein Mofomosara Salahdeen,&nbsp;Babatunde Shuaib Anidu,&nbsp;Babatunde Adekunle Murtala,&nbsp;AbdulRasak Akinola Alada","doi":"10.3831/KPI.2022.25.3.209","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.3.209","url":null,"abstract":"<p><strong>Objectives: </strong>Aqueous leaf extract of <i>Tridax procumbens</i> (ALETP) has potent relaxant activity. However, this relaxant activity in respiratory smooth muscle remains uninvestigated. This study investigates the effect of ALETP on the contractile activity of tracheal smooth muscle (TSM) in adult male Wistar rats.</p><p><strong>Methods: </strong>Twelve male Wistar rats divided into 2 groups and were treated with either 100 mg/kg of ALETP (ALETP treatment group) or vehicle (distilled water; control group) through oral gavage for 4 weeks. Dose responses of TSM from the 2 groups to acetylcholine (10^-9 to 10^-5 M), phenylephrine (10^-9 to 10^-5 M), and potassium chloride (KCl; 10^-9 to 10^-4 M) were determined cumulatively. Furthermore, cumulative dose responses to acetylcholine (10^-9 to 10^-5 M) after pre-incubation of TSM with atropine (10^-5 M), L-NAME (10^-4 M), indomethacin (10^-4 M), and nifedipine (10^-4 M), were determined.</p><p><strong>Results: </strong>Treatment with ALETP substantially inhibited TSM contraction stimulated by cumulative doses of acetylcholine, phenylephrine, and KCl. Furthermore, preincubation of TSM from the 2 groups in atropine significantly inhibited contractility in TSM. Incubation in L-NAME and indomethacin also significantly inhibited contractility in TSM of ALETP-treated rats compared to that of controls. Contractile activity of the TSM was also inhibited significantly with incubation in nifedipine in ALETP-treated rats.</p><p><strong>Conclusion: </strong>ALETP enhanced relaxant activity in rat TSM primarily by blocking the L-type calcium channel and promoting endothelial nitric oxide release. ALETP contains agents that may be useful in disorders of the respiratory tract.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 3","pages":"209-215"},"PeriodicalIF":1.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/fd/jop-25-3-209.PMC9510139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview on Plant Derived Phenolic Compounds and Their Role in Treatment and Management of Diabetes.","authors":"Himangshu Deka,&nbsp;Ananta Choudhury,&nbsp;Biplab Kumar Dey","doi":"10.3831/KPI.2022.25.3.199","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.3.199","url":null,"abstract":"<p><strong>Objectives: </strong>In recent decades, the trend for treating diabetes mellitus (DM) has shifted toward alternative medicines that are obtained from plant sources. Existing literature suggests that phenolic compounds derived from plants possess promising health-promoting properties. This study aimed to discuss the role of plant-derived phenolic compounds in the effective treatment and management of diabetes.</p><p><strong>Methods: </strong>Information about plant secondary metabolites, phenolic compounds, and their role in the treatment and management of diabetes was collected from different databases, such as Pubmed, ScienceDirect, Scopus, and Google Scholar. Keywords like secondary metabolites, phenolic compounds, simple phenol, flavonoids, lignans, stilbenes, and diabetes were searched. Research and review articles with relevant information were included in the study.</p><p><strong>Results: </strong>Anti-diabetic studies of the four major classes of phenolic compounds were included in this review. The plant-derived phenolic compounds were reported to have potent anti-diabetic activities. However, each class of phenolic compounds was found to behave differently according to various mechanisms.</p><p><strong>Conclusion: </strong>The obtained results suggest that phenolic compounds derived from natural sources display promising anti-diabetic activities. Based on the available information, it can be concluded that phenolic compounds obtained from various natural sources play key roles in the treatment and management of diabetes.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 3","pages":"199-208"},"PeriodicalIF":1.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/33/jop-25-3-199.PMC9510143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Acupuncture, Mind and Body Practices, and Natural Products for Insomnia: an overview of systematic reviews.","authors":"Jin Ju Yeo, Jang Won Lee, Kyung Sik Kim, Min Kyung Hyun","doi":"10.3831/KPI.2022.25.3.186","DOIUrl":"10.3831/KPI.2022.25.3.186","url":null,"abstract":"<p><strong>Objectives: </strong>This overview summarizes the evidence for the effectiveness and safety of complementary therapies for insomnia through systematic reviews (SRs) and meta-analyses (MAs).</p><p><strong>Methods: </strong>A comprehensive literature search on SRs and MAs for complementary therapies for insomnia was conducted using six databases.</p><p><strong>Results: </strong>This overview included 30 SRs/MAs. The Pittsburgh Sleep Quality Index (PSQI) analysis of insomnia included 383 randomized controlled trials and 31,748 participants. Twenty-four SRs/MAs (80%) out of 30 SRs/MAs reported a positive result, and six SRs/MAs reported a partially positive result. The most frequently used form of acupuncture reported a positive effect in 89.5% (17/19) of SRs/MAs and a superior effect to western medicine, sham/placebo, and no treatment. The lack of protocol registration and the excluded studies list resulted in generally poor methodological and reporting quality in SRs/MAs with AMSTAR 2.</p><p><strong>Conclusion: </strong>This overview confirmed that complementary therapies positively affected the PSQI scores in patients with insomnia. However, better-designed primary studies are needed to strengthen the relevant evidence in the future. A more stringent assessment of multiple systematic reviews 2 must be followed when performing SR and MA.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 3","pages":"186-198"},"PeriodicalIF":1.2,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/96/jop-25-3-186.PMC9510140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactive Effects of Nutrition Modification and Wet Cupping on Male Patients with Refractory Stable Angina.","authors":"Mohammad Abazari,&nbsp;Mahdi Yousefi,&nbsp;Vafa Baradaran Rahimi,&nbsp;Hamideh Vahid,&nbsp;Azadeh Saki,&nbsp;Arash Gholoobi","doi":"10.3831/KPI.2022.25.3.224","DOIUrl":"https://doi.org/10.3831/KPI.2022.25.3.224","url":null,"abstract":"<p><strong>Objectives: </strong>Routine therapies cannot control refractory stable angina, leading to a high economic burden and an impaired quality of life. Persian medicine incorporates exceptional attention to lifestyle and nutrition to prevent and treat various diseases. Previous studies have reported the analgesic and anti-inflammatory effects of wet cupping. The present study aims to determine the effects of nutrition and cupping on refractory stable angina patients.</p><p><strong>Methods: </strong>Forty male patients with refractory stable angina were randomly allocated to four groups, including nutrition modification based on Persian medicine, wet cupping, nutrition modification along with wet cupping, and control. The primary outcomes were the changes in pain score using a visual analog scale and quality of life using the Seattle angina questionnaire. The secondary outcomes were changes in the exercise test and blood pressure.</p><p><strong>Results: </strong>The results of the present study revealed that 30 days of treatment with nutrition modification based on Persian medicine, cupping, and modified nutrition and cupping along with standard treatment for stable angina significantly increased the patient's quality of life and exercise test results while reducing pain, and systolic and diastolic blood pressure.</p><p><strong>Conclusion: </strong>Applying complementary Persian medicine methods such as nutrition modification and cupping along with the classical medical treatments may improve outcomes for refractory stable angina patients.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"25 3","pages":"224-232"},"PeriodicalIF":1.4,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/57/jop-25-3-224.PMC9510135.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40390127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}