Journal of Pharmacopuncture最新文献

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Awareness of Apitherapy: a study of healthcare professionals in Türkiye. 对 Apitherapy 的认识:对土耳其医疗保健专业人员的研究。
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.35
İçim Gökkaya, Gülin Renda, Fatma Ayhan, Nurdan Yazici
{"title":"Awareness of Apitherapy: a study of healthcare professionals in Türkiye.","authors":"İçim Gökkaya, Gülin Renda, Fatma Ayhan, Nurdan Yazici","doi":"10.3831/KPI.2025.28.1.35","DOIUrl":"10.3831/KPI.2025.28.1.35","url":null,"abstract":"<p><strong>Objectives: </strong>Apitherapy is a part of traditional and complementary medicine (TCM) in Türkiye. It is defined as using bees and bee products as supplementation in the cure of several diseases. This study was conducted between 05.05.2023 and 05.06.2023 throughout Türkiye using an online survey to examine healthcare professionals' levels of knowledge concerning apitherapy and the factors affecting these.</p><p><strong>Methods: </strong>Seven hundred-three questionnaires of suitable data quality were included. SPSS 23.0 software was used in the data analysis. Binary logistic regression analysis was performed using the Backward LR elimination method to determine the factors with the most impact on awareness of apitherapy. Statistical significance was considered to be p < 0.05.</p><p><strong>Results: </strong>Analysis showed that 55.9% of healthcare professionals were aware of apitherapy. Educational attainment (p = 0.023), profession (p = 0.000), work experience (p = 0.017), and the presence of chronic disease (p = 0.012) all had an effect on awareness of the concept of apitherapy. It was determined that 60.8% of the participants were unaware that apitherapy is subject to certain regulation in Türkiye. Although apitherapy is practiced by a certified physician, 49.9% of respondents were unaware of this information. On the other hand, 87.5% of healthcare professionals thought that apitherapy should be applied by a physician. Social media was the main source of knowledge regarding apitherapy for healthcare professionals. Only 30.5% chose undergraduate courses as a source of information.</p><p><strong>Conclusion: </strong>The results highlighted that healthcare professionals had insufficient knowledge regarding apitherapy practices. Incorporating compulsory and/or elective courses on apitherapy into the curriculum of health education universities could improve knowledge and awareness of this topic.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"35-46"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study Protocol for Multi-Center, Open-Label, Randomized Controlled Trial for Assessing the Efficacy and Safety of Electroacupuncture for Cold Hypersensitivity in Hands and Feet. 多中心、开放标签、随机对照试验《评估电针治疗手脚冰凉过敏症的有效性和安全性》研究方案。
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.47
Kyou-Young Lee, Dong-Nyung Lee, Na-Yoen Kwon, Dong-Il Kim, Jun-Sang Yu, Seung-Ho Sun
{"title":"Study Protocol for Multi-Center, Open-Label, Randomized Controlled Trial for Assessing the Efficacy and Safety of Electroacupuncture for Cold Hypersensitivity in Hands and Feet.","authors":"Kyou-Young Lee, Dong-Nyung Lee, Na-Yoen Kwon, Dong-Il Kim, Jun-Sang Yu, Seung-Ho Sun","doi":"10.3831/KPI.2025.28.1.47","DOIUrl":"10.3831/KPI.2025.28.1.47","url":null,"abstract":"<p><strong>Objectives: </strong>Cold hypersensitivity in the hands and feet (CHHF) is defined as the symptom of a sensation of coldness in the extremities under conditions that are not considered cold by an unaffected person. CHHF can affect the quality of life by placing restrictions on one's daily activities. Although electroacupuncture (EA) and acupuncture have been widely used for treating CHHF, randomized clinical trial (RCT) has not yet been conducted for evaluating the safety and efficacy of EA or acupuncture for the treatment of CHHF. This study aims to evaluate the effects of EA in CHHF patients.</p><p><strong>Methods: </strong>This study is a randomized, multicenter, and parallel design clinical trial. Overall, 72 participants will be randomly assigned to the EA treatment group, acupuncture treatment group, and untreated control group in 111 ratio via a web-based randomization system. The EA treatment group and acupuncture treatment group will receive EA or acupuncture treatment by visiting ten times at intervals of twice a week for five weeks. Follow-up visits will be made four weeks after the end of treatment. For the untreated control group, three visits will be made. The primary outcome measures will be the CHHF visual analogue scale score. Secondary outcome measures will be the body temperature of hands and feet, total scores of the Korean version of the World Health Organization Quality of Life Scale abbreviated version, the results of the questionnaire of health-related quality of life, questionnaire of demonstration, and questionnaire of cold hypersensitivity.</p><p><strong>Conclusion: </strong>This study will be the first clinical trial to evaluate the efficacy and safety of EA for the treatment of CHHF. We expect this study to provide basic evidence for the treatment of CHHF with EA and future large-scale RCTs.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"47-56"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bupleuri Radix Ameliorates Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Modulation of Tight Junction Protein Expression and Inhibition of Nuclear Factor-κB Activation.
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.57
Min Yeong Kim, Eun Jin Bang, Yung Hyun Choi, Su Hyun Hong
{"title":"Bupleuri Radix Ameliorates Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Modulation of Tight Junction Protein Expression and Inhibition of Nuclear Factor-κB Activation.","authors":"Min Yeong Kim, Eun Jin Bang, Yung Hyun Choi, Su Hyun Hong","doi":"10.3831/KPI.2025.28.1.57","DOIUrl":"10.3831/KPI.2025.28.1.57","url":null,"abstract":"<p><strong>Objectives: </strong>The vascular endothelium plays a central role in the maintenance of vascular homeostasis. Inflammation of vascular endothelial cells has been closely related to the development of a wide range of cardiovascular diseases, including atherosclerosis. Bupleuri Radix (BR) possesses several biological properties, including anticancer, antimicrobial, antiviral, immunomodulatory, and anti-inflammatory properties. Furthermore, it can prevent and cure several diseases, such as the common cold, hepatitis, menoxenia, and hyperlipidemia. However, it is unclear whether BR can regulate vascular endothelial function under inflammatory conditions induced by interleukin-1β (IL-1β), a key proinflammatory cytokine. Therefore, in this study, we aimed to investigate the effect of BR on endothelial cell function using human umbilical vein endothelial cells (HUVECs) with IL-1β-induced inflammation.</p><p><strong>Methods: </strong>The effects of BR on cell migration, angiogenesis, and monocyte adhesion were determined using scratch wound-healing assay, tube-formation assay, cell adhesion assay, fluorescein isothiocyanate-dextran Transwell assay, and transepithelial electrical resistance assay. The expression of tight junction (TJ) protein and adhesion molecules was estimated using western blotting and immunofluorescence assay. The generation of reactive oxygen species was assessed using flow cytometry.</p><p><strong>Results: </strong>BR significantly suppressed the proliferation, migration, and tube-formation ability of IL-1β-stimulated HUVECs, and the expression of adhesion molecules, especially intracellular adhesion molecule-1. BR also regulated TJ protein expression, thereby restoring the transepithelial electrical resistance value to a level comparable to that of IL-1β-treated HUVECs. Moreover, BR decreased the production of intracellular reactive oxygen species and the nuclear translocation of the nuclear factor-kappa-B p65 subunit.</p><p><strong>Conclusion: </strong>These findings revealed for the first time that BR prevents IL-1β-induced inflammation of blood vessel. Therefore, BR has the potential to protect the damage of vascular endothelial cells and prevent the progression of cardiovascular diseases.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"57-68"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experience and Prior-Education in Medical Volunteering among Korean Medicine Students: a survey study.
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.24
Ju Yeob Kim, So Yeong Park, Min Jeong Shin, Seon-Kyoung Kim, Chan-Young Kwon
{"title":"Experience and Prior-Education in Medical Volunteering among Korean Medicine Students: a survey study.","authors":"Ju Yeob Kim, So Yeong Park, Min Jeong Shin, Seon-Kyoung Kim, Chan-Young Kwon","doi":"10.3831/KPI.2025.28.1.24","DOIUrl":"10.3831/KPI.2025.28.1.24","url":null,"abstract":"<p><strong>Objectives: </strong>Medical volunteer activities of the college of Korean medicine (KM) are stipulated in Article 19 of the enforcement regulations of the medical law (medical practice of medical students, etc.). At D University, 31.8% of students are participating in medical volunteer activities during the summer vacation. Through students belonging to the three clubs, we would like to investigate and analyze the experience and form of medical service, participation motivation, satisfaction, mental growth, progress of prior education, and needs for improvement.</p><p><strong>Methods: </strong>Out of 289 students at D University, 92 students participated in summer medical volunteer activities through three clubs during July 2024. An online survey was conducted from July 30 to August 7, 2024, with 55 students responding (response rate 59.8%). The questions in the survey consisted of a total of 22 questions based on previous studies.</p><p><strong>Results: </strong>The main purpose of participation in medical service by KM university students was to gain new knowledge or experience. 90.9% of students were satisfied with the medical volunteer activities. Pre-education for medical volunteer activities was conducted to all students, and only 11.5% of students took formal pre-education at the school level. 67.3% of students answered that there was a need for improvement in regular school classes in acquiring prior knowledge, and in particular, there were many responses from 1st∙2nd graders of KM course.</p><p><strong>Conclusion: </strong>This study identifies the strengths and weaknesses of medical volunteer activities among KM students. While satisfaction is high (90.9%), the reliance on informal preparation indicates a need for formal support and training in the curriculum. With 70.9% interested in lifelong volunteering, improving structured programs could enhance educational outcomes and community healthcare engagement.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"24-34"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National Health Insurance Data as a Research Tool in Korean Medicine: a guide to database utilization and methodological approaches.
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.1
Chan-Young Kwon, Il-Su Park
{"title":"National Health Insurance Data as a Research Tool in Korean Medicine: a guide to database utilization and methodological approaches.","authors":"Chan-Young Kwon, Il-Su Park","doi":"10.3831/KPI.2025.28.1.1","DOIUrl":"10.3831/KPI.2025.28.1.1","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to provide a practical framework for Korean medicine (KM) researchers on effectively utilizing Korean National Health Insurance (NHI) data, focusing on database characteristics, access methods, and methodological considerations for generating high-quality evidence in KM research.</p><p><strong>Methods: </strong>This study analyzed the NHI data system structure, analyzing its two major databases the National Health Insurance Service (NHIS) and Health Insurance Review and Assessment Service (HIRA). We examined available data types, access protocols, and methodological approaches, with particular emphasis on their application in KM research. The study synthesized current challenges and opportunities specific to KM research using these databases.</p><p><strong>Results: </strong>Our analysis revealed three key findings 1) The distinct characteristics and complementary nature of NHIS and HIRA databases, with NHIS providing comprehensive longitudinal data suitable for cohort studies and HIRA offering detailed cross-sectional data optimal for utilization pattern analysis; 2) Multiple data access options including Sample Research DB and Customized Research DB from NHIS, and Patient Sample Data and Customized Research Data from HIRA, each with specific advantages for different research designs; 3) Critical methodological considerations for KM research, particularly addressing the limited coverage of KM services (0.8% of total covered items) and the high proportion of non-covered services in KM practices (24.2-49.2% across different institution types).</p><p><strong>Conclusion: </strong>For effective utilization of NHI data in KM research, we recommend 1) Implementing hybrid research designs that combine health insurance data with institutional data to overcome limited KM coverage; 2) Establishing clear operational definitions and applying appropriate statistical methods for bias adjustment; 3) Working toward developing a specialized Korean Medicine Utilization Cohort Database. These approaches can enhance the quality and generalizability of KM research using health insurance data, ultimately contributing to evidence-based practice in Korean medicine.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"1-10"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorating Effect of Red Fruit (Pandanus conoides Lamk) Oil in Streptozotosin-Induced Diabetic Peripheral Neuropathy Rat Model: role of oxidative and neuroinflammatory pathways. 红果(Pandanus conoides Lamk)油对链脲佐菌素诱导的糖尿病周围神经病变大鼠模型的改善作用:氧化和神经炎症途径的作用。
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.11
Indah Tri Lestari, Kusnandar Anggadiredja, Afrillia Nuryanti Garmana, Ratna Annisa Utami
{"title":"Ameliorating Effect of Red Fruit (<i>Pandanus conoides</i> Lamk) Oil in Streptozotosin-Induced Diabetic Peripheral Neuropathy Rat Model: role of oxidative and neuroinflammatory pathways.","authors":"Indah Tri Lestari, Kusnandar Anggadiredja, Afrillia Nuryanti Garmana, Ratna Annisa Utami","doi":"10.3831/KPI.2025.28.1.11","DOIUrl":"10.3831/KPI.2025.28.1.11","url":null,"abstract":"<p><strong>Objectives: </strong>Diabetic peripheral neuropathy (DPN) is the most common cause of neuropathy worldwide, with oxidative and inflammatory being the pathways involved in the disease pathology. Red fruit (<i>Pandanus conoides</i> Lamk) oil (RFO) is known to have potent antioxidants and anti-inflammatory activities. To investigate the effects of RFO in a rat model of streptozotocin-induced DPN.</p><p><strong>Methods: </strong>Male Wistar rats were induced with 55 mg/kg streptozotocin (STZ) intraperitoneally. Rats with fasting blood glucose ≥ 200 mg/dL were assigned into groups treated with vehicle, pregabalin 30 mg/kg, and 0.3, 0.6, or 1.2 mL/kg RFO, respectively. The treatments were given for 3 weeks, six weeks after STZ induction. Neuropathic pain was evaluated by cold allodynia and thermal hyperalgesia tests. Histopathological changes of the pancreas and sciatic nerve were evaluated by the Gaussian adaptive threshold method. Feed and drinking intake, blood glucose levels, body weight, and sciatic nerve proinflammatory cytokines were also measured.</p><p><strong>Results: </strong>There were increases in blood glucose levels, feed and drink intake, levels of MDA, TNF-α, IL-6, NFκB, and iNOS; decrease in catalase level; and damage to the sciatic nerve in the vehicle-treated DPN rat model compared with normal rats (p < 0.05). Meanwhile, significant decrease in weight, number of pancreatic β cells, latency times for thermal hyperalgesia as well as cold allodynia were observed in this group of rats. RFO administration at 0.6 and 1.2 mL/kg significantly improved all of the measured indices, except for iNOS, where only decreasing trend was observed. Pregabalin did not affect blood glucose levels, body weight or pancreatic β cells but improved thermal hyperalgesia as well as cold allodynia, the sciatic nerve cell counts, TNF-α IL-6, NFκB, and iNOS levels.</p><p><strong>Conclusion: </strong>RFO improves DPN by neuroprotective effect through the involvement of the oxidative and neuroinflammatory pathways.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"11-23"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Biodegradable Microneedle Acupuncture in Mild to Moderate Atopic Dermatitis: a single-blinded randomized controlled pilot trial.
IF 1.2
Journal of Pharmacopuncture Pub Date : 2025-03-31 DOI: 10.3831/KPI.2025.28.1.69
Soo-Yeon Park, Ji-Hoon Song, Nguyen Cong Duc, Gihyun Lee
{"title":"Effect of Biodegradable Microneedle Acupuncture in Mild to Moderate Atopic Dermatitis: a single-blinded randomized controlled pilot trial.","authors":"Soo-Yeon Park, Ji-Hoon Song, Nguyen Cong Duc, Gihyun Lee","doi":"10.3831/KPI.2025.28.1.69","DOIUrl":"10.3831/KPI.2025.28.1.69","url":null,"abstract":"<p><strong>Objectives: </strong>The need for alternative therapies for atopic dermatitis (AD) has emerged due to the side effects of conventional therapies. Biodegradable microneedle acupuncture (BMA) is a novel medical device that overcame the shortcomings of traditional intradermal acupuncture (IDA), such as foreign body feeling and allergic dermatitis. This study aimed to evaluate the efficacy and safety of BMA for patients with Mild to Moderate AD compared with the IDA.</p><p><strong>Methods: </strong>An assessor-blinded, parallel, non-superiority, randomized controlled pilot trial was conducted. Thirty adult participants were recruited from a single hospital and were equally divided into the experimental or control group. They were treated with BMA or IDA on both sides of LI11, ST36, and PC6 for four hours. Over four weeks, both interventions were performed eight times in total. The primary endpoint was the objective scoring AD (O-SCORAD) index. The secondary endpoints were visual analog scale (VAS) for itch and sleep disturbance, dermatology life quality index (DLQI), skin hydration, and transepidermal water loss (TEWL).</p><p><strong>Results: </strong>Enrolled thirty participants completed the trial. After the trial, all endpoints remarkably improved compared with the baseline in both groups, except for the TEWL. Between the two interventions, there were no remarkable differences in the fourth week, except for the VAS score for itch and DLQI. No serious adverse events occurred during the study period.</p><p><strong>Conclusion: </strong>Both BMA and IDA were effective in improving Mild to Moderate AD, and they were safe. BMA can be an alternative to conventional acupuncture for patients with sensitive skin, including metal allergies.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"28 1","pages":"69-79"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Hwa-byung Vulnerability Using the Hwa-byung Personality Scale: a comparative study of machine learning approaches. 使用Hwa-byung人格量表评估Hwa-byung脆弱性:机器学习方法的比较研究。
IF 1.2
Journal of Pharmacopuncture Pub Date : 2024-12-31 DOI: 10.3831/KPI.2024.27.4.358
Chan-Young Kwon, Boram Lee, Sung-Hee Kim, Seok Chan Jeong, Jong-Woo Kim
{"title":"Assessing Hwa-byung Vulnerability Using the Hwa-byung Personality Scale: a comparative study of machine learning approaches.","authors":"Chan-Young Kwon, Boram Lee, Sung-Hee Kim, Seok Chan Jeong, Jong-Woo Kim","doi":"10.3831/KPI.2024.27.4.358","DOIUrl":"10.3831/KPI.2024.27.4.358","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and compare machine learning models to classify individuals vulnerable to Hwa-byung (HB) using an existing HB personality scale and to evaluate the efficacy of these models in predicting HB vulnerability.</p><p><strong>Methods: </strong>We analyzed data from 500 Korean adults (aged 19-44) using HB personality and symptom scales. We used various machine learning techniques, including the random forest classifier (RFC), XGBoost classifier, logistic regression, and their ensemble method (RFC-XGC-LR). The models were developed using recursive feature elimination with cross-validation for feature selection and evaluated using multiple performance metrics, including accuracy, precision, recall, specificity, and area under the receiver operating characteristic curve (AUROC).</p><p><strong>Results: </strong>The 16 items on the HB personality scale were identified as optimal features to predict high HB symptom scores requiring further clinical evaluation. The ensemble model slightly outperformed the other models, with an accuracy of 0.80 and an AUROC of 0.86, in the test set. Notably, item 16 (\"<i>I often feel guilty easily</i>\") of the HB personality scale showed the greatest importance in predicting HB vulnerability across all models. Although all models showed consistent performance across training, validation, and test sets, the RFC model exhibited signs of slight overfitting, with a higher AUROC of 0.97 in the training dataset compared to 0.85 in the validation and 0.86 in the test datasets.</p><p><strong>Conclusion: </strong>Machine learning models, particularly the ensemble method, show capabilities promising for screening individuals with high HB symptom scores based on personality traits, potentially facilitating early referral for clinical evaluation. These models can improve the efficiency and accuracy of the HB risk assessment in clinical settings, potentially aiding early intervention and prevention strategies.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"27 4","pages":"358-366"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Herbal Medicine (Hwanglyeonhaedok-tang) on Insomnia Patients with Bedtime Procrastination: study protocol for a randomized controlled trial. 黄莲海德汤对失眠患者睡前拖延症的疗效:随机对照试验的研究方案。
IF 1.2
Journal of Pharmacopuncture Pub Date : 2024-12-31 DOI: 10.3831/KPI.2024.27.4.322
Yujin Choi, Pyung-Wha Kim, Hyo-Ju Park, So-Young Jung, Ojin Kwon, In Chul Jung, Hyungjun Kim, Kyung-Min Shin
{"title":"Effect of Herbal Medicine (Hwanglyeonhaedok-tang) on Insomnia Patients with Bedtime Procrastination: study protocol for a randomized controlled trial.","authors":"Yujin Choi, Pyung-Wha Kim, Hyo-Ju Park, So-Young Jung, Ojin Kwon, In Chul Jung, Hyungjun Kim, Kyung-Min Shin","doi":"10.3831/KPI.2024.27.4.322","DOIUrl":"10.3831/KPI.2024.27.4.322","url":null,"abstract":"<p><strong>Objectives: </strong>Insomnia, characterized by difficulty initiating or maintaining sleep, affects a significant portion of the global population. Bedtime procrastination, which is a voluntary delay in going to bed, is a major contributing factor to the prevalence of sleep deprivation in modern societies. Hwanglyeonhaedok-tang (HJD decoction) has shown promise in improving the symptoms of insomnia. This study aimed to evaluate the efficacy of HJD decoction in patients with insomnia and bedtime procrastination.</p><p><strong>Methods: </strong>This study employs a parallel-group design, comparing HJD decoction to usual care in a 11 ratio. Sixty participants with insomnia and bedtime procrastination will be enrolled. The experimental group will receive HJD decoction for 4 weeks, while both groups will undergo a brief behavioral treatment for insomnia. The primary outcome will be the change in the Insomnia Severity Index score (ISI) from baseline to 4 weeks. Secondary outcomes include sleep diary metrics, the Pittsburgh Sleep Quality Index (PSQI), and Bedtime Procrastination Scale (BPS). The exploratory outcomes include perceived stress, anxiety, smartphone use, and heart rate variability.</p><p><strong>Conclusion: </strong>This trial examines the role of herbal medicine in treating a specific type of insomnia that is increasingly common in modern society. The combination of HJD decoction with behavioral intervention offers a comprehensive approach to treating insomnia complicated by bedtime procrastination. The results will provide valuable insights into integrative treatment strategies for sleep disorders in the digital age.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"27 4","pages":"322-331"},"PeriodicalIF":1.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Sophora japonica L. Pill in Subjective Memory Complaints in Healthy Adults: a protocol of randomized, double-blind, placebo-controlled, parallel-group, clinical trial. 苦参丸对健康成人主观记忆疾患的疗效:随机、双盲、安慰剂对照、平行组临床试验方案
IF 1.2
Journal of Pharmacopuncture Pub Date : 2024-12-31 DOI: 10.3831/KPI.2024.27.4.349
Yunna Kim, Seung-Ho Lee, Yerim Jeon, Seung-Hun Cho
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