{"title":"芫荽和芫荽提取物对金黄色葡萄球菌和铜绿假单胞菌的抑菌作用。","authors":"Shahin Gavanji, Azizollah Bakhtari, Hojjat Baghshahi, Zahra Hamami Chamgordani, Akram Sadeghi","doi":"10.3831/KPI.2023.26.1.53","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The most prominent microorganisms that cause hospital infections and acquire antibiotic resistance are <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. The present study aimed to compare the phenolic and flavonoid compounds of various <i>Allium ampeloprasum</i> and <i>Allium porrum</i> extracts and evaluate the antibacterial effects of these extracts against these two microorganisms.</p><p><strong>Methods: </strong>The total phenolic and flavonoid contents of the acetone, methanol, aqueous, and hexane leeks extracts from <i>A. ampeloprasum</i> and <i>A. porrum</i> were measured. The antibacterial activity of these extracts against <i>S. aureus</i> and <i>P. aeruginosa</i> was tested using the disk diffusion method for 24, 48, and 72 hours. Further, the minimum inhibitory concentrations and the minimum bactericidal concentrations of these extracts for these two bacteria were evaluated and compared with those of common antibiotics.</p><p><strong>Results: </strong>The aqueous extracts showed the highest phenolic and flavonoid contents and at concentrations of 35 and 40 mg per disk, showed the most antibacterial activity against <i>S. aureus</i> and <i>P. aeruginosa</i>; <i>P. aeruginosa</i> showed more sensitivity to the aqueous extracts than <i>S. aureus</i>.</p><p><strong>Conclusion: </strong>Aqueous <i>A. ampeloprasum</i> and <i>A. porrum</i> extracts may prevent the growth of hospital pathogens, especially <i>P. aeruginosa</i>; our findings will aid the discovery of new antimicrobial substances against antibiotic-resistant bacteria.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 1","pages":"53-59"},"PeriodicalIF":1.2000,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/8e/jop-26-1-53.PMC10063418.pdf","citationCount":"0","resultStr":"{\"title\":\"Antibacterial Effect of <i>Allium ampeloprasum</i> and <i>Allium porrum</i> Extracts on <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>.\",\"authors\":\"Shahin Gavanji, Azizollah Bakhtari, Hojjat Baghshahi, Zahra Hamami Chamgordani, Akram Sadeghi\",\"doi\":\"10.3831/KPI.2023.26.1.53\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The most prominent microorganisms that cause hospital infections and acquire antibiotic resistance are <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. The present study aimed to compare the phenolic and flavonoid compounds of various <i>Allium ampeloprasum</i> and <i>Allium porrum</i> extracts and evaluate the antibacterial effects of these extracts against these two microorganisms.</p><p><strong>Methods: </strong>The total phenolic and flavonoid contents of the acetone, methanol, aqueous, and hexane leeks extracts from <i>A. ampeloprasum</i> and <i>A. porrum</i> were measured. The antibacterial activity of these extracts against <i>S. aureus</i> and <i>P. aeruginosa</i> was tested using the disk diffusion method for 24, 48, and 72 hours. Further, the minimum inhibitory concentrations and the minimum bactericidal concentrations of these extracts for these two bacteria were evaluated and compared with those of common antibiotics.</p><p><strong>Results: </strong>The aqueous extracts showed the highest phenolic and flavonoid contents and at concentrations of 35 and 40 mg per disk, showed the most antibacterial activity against <i>S. aureus</i> and <i>P. aeruginosa</i>; <i>P. aeruginosa</i> showed more sensitivity to the aqueous extracts than <i>S. aureus</i>.</p><p><strong>Conclusion: </strong>Aqueous <i>A. ampeloprasum</i> and <i>A. porrum</i> extracts may prevent the growth of hospital pathogens, especially <i>P. aeruginosa</i>; our findings will aid the discovery of new antimicrobial substances against antibiotic-resistant bacteria.</p>\",\"PeriodicalId\":16769,\"journal\":{\"name\":\"Journal of Pharmacopuncture\",\"volume\":\"26 1\",\"pages\":\"53-59\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/8e/jop-26-1-53.PMC10063418.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacopuncture\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3831/KPI.2023.26.1.53\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacopuncture","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3831/KPI.2023.26.1.53","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Antibacterial Effect of Allium ampeloprasum and Allium porrum Extracts on Staphylococcus aureus and Pseudomonas aeruginosa.
Objectives: The most prominent microorganisms that cause hospital infections and acquire antibiotic resistance are Staphylococcus aureus and Pseudomonas aeruginosa. The present study aimed to compare the phenolic and flavonoid compounds of various Allium ampeloprasum and Allium porrum extracts and evaluate the antibacterial effects of these extracts against these two microorganisms.
Methods: The total phenolic and flavonoid contents of the acetone, methanol, aqueous, and hexane leeks extracts from A. ampeloprasum and A. porrum were measured. The antibacterial activity of these extracts against S. aureus and P. aeruginosa was tested using the disk diffusion method for 24, 48, and 72 hours. Further, the minimum inhibitory concentrations and the minimum bactericidal concentrations of these extracts for these two bacteria were evaluated and compared with those of common antibiotics.
Results: The aqueous extracts showed the highest phenolic and flavonoid contents and at concentrations of 35 and 40 mg per disk, showed the most antibacterial activity against S. aureus and P. aeruginosa; P. aeruginosa showed more sensitivity to the aqueous extracts than S. aureus.
Conclusion: Aqueous A. ampeloprasum and A. porrum extracts may prevent the growth of hospital pathogens, especially P. aeruginosa; our findings will aid the discovery of new antimicrobial substances against antibiotic-resistant bacteria.
期刊介绍：
The Journal of Pharmacopuncture covers a wide range of basic and clinical science research relevant to all aspects of the biotechnology of integrated approaches using both pharmacology and acupuncture therapeutics, including research involving pharmacology, acupuncture studies and pharmacopuncture studies. The subjects are mainly divided into three categories: pharmacology (applied phytomedicine, plant sciences, pharmacology, toxicology, medicinal plants, traditional medicines, herbal medicine, Sasang constitutional medicine, herbal formulae, foods, agricultural technologies, naturopathy, etc.), acupuncture (acupressure, electroacupuncture, laser acupuncture, moxibustion, cupping, etc.), and pharmacopuncture (aqua-acupuncture, meridian pharmacopuncture, eight-principles pharmacopuncture, animal-based pharmacopuncture, mountain ginseng pharmacopuncture, bee venom therapy, needle embedding therapy, implant therapy, etc.). Other categories include chuna treatment, veterinary acupuncture and related animal studies, alternative medicines for treating cancer and cancer-related symptoms, etc. Broader topical coverage on the effects of acupuncture, the medical plants used in traditional and alternative medicine, pharmacological action and other related modalities, such as anthroposophy, homeopathy, ayurveda, bioelectromagnetic therapy, chiropractic, neural therapy and meditation, can be considered to be within the journal’s scope if based on acupoints and meridians. Submissions of original articles, review articles, systematic reviews, case reports, brief reports, opinions, commentaries, medical lectures, letters to the editor, photo-essays, technical notes, and book reviews are encouraged. Providing free access to the full text of all current and archived articles on its website (www.journal.ac), also searchable through a Google Scholar search.
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