Journal of Pharmacopuncture最新文献

{"title":"Cucumber (<i>Cucumis sativus</i> L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II.","authors":"Tomi Hendrayana, Klaudia Yoana, I Ketut Adnyana, Elin Yulinah Sukandar","doi":"10.3831/KPI.2023.26.4.298","DOIUrl":"10.3831/KPI.2023.26.4.298","url":null,"abstract":"<p><strong>Objectives: </strong><i>Cucumis sativus</i> L. (<i>C. sativus</i>) is vegetable commonly used for managing blood pressure and often consumed in combination with standard antihypertensive therapy, despite lack of scientific evidence supporting their use. Combination of herbs and standard medication could have positive or negative effects. Therefore, this study aimed to evaluate the antihypertensive activity of <i>C. sativus</i> and the combined effect with losartan in the hypertensive rat model induced by angiotensin II. Angiotensin II is a component of the renin-angiotensin-aldosterone system that, upon binding to its receptor, constricts blood vessels leading to elevation of blood pressure.</p><p><strong>Methods: </strong>In an antihypertensive study, rats received <i>C. sativus</i> orally at doses of 9, 18, 27, and 36 mg/kg (full dose); while in a combination study, animals received losartan 2.25 mg/kg combined by either with <i>C. sativus</i> 9 or 18 mg/kg. The standards group received losartan 2.25 mg/kg or 4.5 mg/kg (full dose).</p><p><strong>Results: </strong>Blood pressure was measured using the tail-cuff method. <i>C. sativus</i> significantly attenuated angiotensin II-induced hypertension as observed in groups receiving <i>C. sativus</i> at 9, 18, 27, and 36 mg/kg at 30 minutes after induction showed the average change (Δ) of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with respect to time zero were 28.8/18.3, 24.8/15.8, 22.8/15.5, and 11.5/9.0 mmHg, respectively. Whereas the average change (Δ) of SBP and DBP in the rats receiving the combination of half doses of <i>C. sativus</i> and losartan were 8.8/9.0 mmHg, respectively. These diminished effects were better than a full dose of <i>C. sativus</i> and comparable with a full dose of losartan (6.5/7.8 mmHg).</p><p><strong>Conclusion: </strong>The present findings indicate that <i>C. sativus</i> dose-dependently blocks blood pressure elevation induced by angiotensin II. The combination of half dose of <i>C. sativus</i> and losartan has an additive effect in lowering blood pressure.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 4","pages":"298-306"},"PeriodicalIF":1.4,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic Effect of Standardized <i>Chrysanthemum rubellum</i> Hydroethanolic Extract by Targeting α-Glucosidase and the PTP-1B Signaling Pathway for Alleviating Diabetes in Experimental Model.","authors":"Bichitrananda Tripathy, Nityananda Sahoo, Sudhir Kumar Sahoo","doi":"10.3831/KPI.2023.26.4.319","DOIUrl":"10.3831/KPI.2023.26.4.319","url":null,"abstract":"<p><strong>Objectives: </strong>The study's goal was to find out whether <i>Chrysanthemum rubellum</i> extract has anti-diabetic properties by concentrating on α-glucosidase and the PTP-1B signaling pathway. <i>C. rubellum</i> flowers were used for extraction using Methanol/water (80/20) as solvent.</p><p><strong>Methods: </strong>LC-MS techniques was used to check the presence of phytoconstituents present in <i>C. rubellum</i> extract. In vitro antidiabetic activity was evaluated using α-glucosidase inhibitory activity and PTP-1B signaling pathway. On Streptozotocin (STZ)-induced rats with diabetes, the in vivo antidiabetic efficacy was assessed using a test for oral glucose tolerance.</p><p><strong>Results: </strong>The phytoconstituents identified in the extract of <i>C. rubellum</i> were apigenin, diosmin, myricetin, luteolin, luteolin-7-glucoside, and Quercitrin as compound 1-6, respectively. Results showed that diosmin exhibited highest α-glucosidase inhibitory activity i.e. 90.39%. The protein level of PTP-1B was lowered and the insulin signalling activity was directly increased by compounds 1-6. The maximum blood glucose levels were seen in all groups' OGTT findings at 30 minutes following glucose delivery, followed by gradual drops. In comparison to the control group, the extract's glucose levels were 141 mg/dL at 30 minutes before falling to 104 mg/dL after 120 minutes. The current study has demonstrated, in summary, that extract with phytoconstituents reduce blood sugar levels in rats.</p><p><strong>Conclusion: </strong>This finding suggests that extract may reduce the chance of insulin resistance and shield against disorders like hyperglycemia.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 4","pages":"319-326"},"PeriodicalIF":1.4,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Trends of Pharmacopuncture: a bibliometric analysis using VOSviewer (2007-2023).","authors":"Chan-Young Kwon","doi":"10.3831/KPI.2023.26.3.227","DOIUrl":"10.3831/KPI.2023.26.3.227","url":null,"abstract":"<p><strong>Objectives: </strong>Pharmacopuncture is considered a unique new type of acupuncture in Korean medicine (KM). This study was performed to investigate the research trends regarding pharmacopuncture through a bibliometric analysis using VOSviewer.</p><p><strong>Methods: </strong>The Web of Science Core Collection was searched for this study. The search terms were pharmacopuncture and pharmaco-puncture. The search was conducted on May 23, 2023, and 185 studies retrieved up to this date were included. Software VOSviewer version 1.6.19 was used to perform the bibliometric analysis. After data clearing, keyword co-occurrence and cooperation pattern analyses were performed.</p><p><strong>Results: </strong>The number of studies on pharmacopuncture have gradually increased since the mid-2000s, with the most published in 2020 (46 studies). The quality of the studies has also steadily increased, and recently, several randomized controlled trials of pharmacopuncture have been conducted. Moreover, this treatment has been investigated in the context of KM clinical practice guideline development in Korea. The scope of pharmacopuncture studies to date seems to be limited to musculoskeletal pain and bee venom pharmacopuncture. The researchers from Jaseng Medical Foundation have been the core researchers in the field of pharmacopuncture in Korea. They collaborated with researchers from universities or government-funded research institutes. However, small-scale research teams from KM clinics and university researchers were also identified as independent clusters.</p><p><strong>Conclusion: </strong>Pharmacopuncture research has grown both quantitatively and qualitatively, but the scope needs to be further expanded. There is also a gap between the use of pharmacopuncture by KM doctors in clinical settings and pharmacopuncture research. Based on these findings, some suggestions for future studies in this field are discussed. Furthermore, these findings may be used as data to expand and globalize pharmacopuncture research in the future.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"227-237"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/5b/jop-26-3-227.PMC10547818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiarthritic Activity and Inflammatory Mediators Modulation Effect of Traditional Ajmodadi Churna on Arthritis Experimental Model.","authors":"Vikash Sharma,&nbsp;Shiv Shankar Shukla,&nbsp;Bina Gidwani,&nbsp;Ravindra Kumar Pandey","doi":"10.3831/KPI.2023.26.3.257","DOIUrl":"10.3831/KPI.2023.26.3.257","url":null,"abstract":"<p><strong>Objectives: </strong>The study was designed to evaluate anti-arthritic activity of Ajmodadi Churna (AC) and its effect on Complete freund's adjuvant (CFA)-induced arthritis in Wistar rats.</p><p><strong>Methods: </strong>Arthritis was induced by injecting 0.2 mL CFA into sub plantar surface of left hind paw. Test sample AC-1 and AC-2, 200 and 400 mg/kg, respectively was given to the animals for 21 consecutive days. The increase in swelling was observed after induction of arthritis. The paw edema was measured on 0, 3, 7, 14 and 21 day using Vernier calliper after the induction of arthritis. The collected blood samples further used for the estimation of red blood cells (RBC), white blood cells (WBC), erythrocytes sedimentation rate (ESR), and hemoglobin (Hb), using hematology analyzer. Serum concentration of IL-6 and TNF-α were also measured using rat ELISA kits.</p><p><strong>Results: </strong>Results showed that a significant reduction in paw edema was observed in AC-2 treated rats. The paw edema was restored on day 21 was 4.48 mm for AC-2, which is near to the control group. The arthritis score in treated rats was found to be considerably lower than in the control group i.e. 0.83 for AC-2 and 1.50 for AC-1. A decrease in levels of RBC and hemoglobin were observed in arthritic rats. Inflammation was significantly reduced and serum levels of IL-6 and TNF-α were lowered after treatment with the test drug.</p><p><strong>Conclusion: </strong>It can be concluded from the study that AC possess significant anti-arthritic activity. Furthermore, this condition was linked to a reduction in abnormal humoral immune responses.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"257-264"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/ff/jop-26-3-257.PMC10547820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41131278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Vancomycin Resistant <i>Enterococci</i> and Drug Ligand Interaction between <i>vanA</i> of <i>E. faecalis</i> with the Bio-Compounds from <i>Aegles marmelos</i>.","authors":"Jayavarsha V,&nbsp;Smiline Girija A S,&nbsp;Shoba Gunasekaran,&nbsp;Vijayashree Priyadharsini J","doi":"10.3831/KPI.2023.26.3.247","DOIUrl":"10.3831/KPI.2023.26.3.247","url":null,"abstract":"Objectives Enterococcus faecalis is a gram positive diplococci, highly versatile and a normal commensal of the gut microbiome. Resistance to vancomycin is a serious issue in various health-care setting exhibited by vancomycin resistant Enterococci (VRE) due to the alteration in the peptidoglycan synthesis pathway. This study is thus aimed to detect the VRE from the patients with root caries from the clinical isolates of E. faecalis and to evaluate the in-silico interactions between vanA and the Aegles marmelos bio-compounds. Methods E. faecalis was phenotypically characterized from 20 root caries samples and the frequency of vanA and vanB genes was detected by polymerase chain reaction (PCR). Further crude methanolic extracts from the dried leaves of A. marmelos was assessed for its antimicrobial activity. This is followed by the selection of five A. marmelos bio-compounds for the computational approach towards the drug ligand interactions. Results 12 strains (60%) of E. faecalis was identified from the root caries samples and vanA was detected from two strains (16%). Both the stains showed the presence of vanA and none of the strains possessed vanB. Crude extract of A. marmelos showed promising antibacterial activity against the VRE strains. In-silico analysis of the A. marmelos bio-compounds revealed Imperatonin as the best compound with high docking energy (–8.11) and hydrogen bonds with < 140 TPSA (Topological polar surface area) and zero violations. Conclusion The present study records the VRE strains among the root caries with imperatorin from A. marmelos as a promising drug candidate. However the study requires further experimentation and validation.","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"247-256"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/34/jop-26-3-247.PMC10547814.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41136693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture as an Additional Method of Rehabilitation Post-COVID-19: a randomized controlled trial.","authors":"Indira Omarova, Assiya Akanova, Almagul Kurmanova, Gaukhar Kurmanova, Natalya Glushkova, Amina Seidanova, Kuatzhan Turysbekov","doi":"10.3831/KPI.2023.26.3.238","DOIUrl":"10.3831/KPI.2023.26.3.238","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to evaluate the effectiveness of complex rehabilitation with and without acupuncture in a hospital setting.</p><p><strong>Methods: </strong>A randomized clinical trial was performed at Rehabilitation center \"Kamenskoe Plato\" in Almaty, Kazakhstan. 160 patients with Post COVID-19 condition were randomly equally divided into an acupuncture with complex rehabilitation methods and a only complex rehabilitation methods group in the period from March 1, 2022 to July 1, 2022. Either groups was performed for an 10-14 days period. The outcome measures were the Bartel index, the Borg scale, Modified Dyspnea Scale and the 6-minute walking test. Adverse events also were monitored and documented.</p><p><strong>Results: </strong>We found statistically significant improvement after the rehabilitation course with acupuncture in the all scales. And in the group without acupuncture, only on two scales MDS and Borg scale.</p><p><strong>Conclusion: </strong>Rehabilitation with acupuncture is possible and effective in patients recovering from post-COVID-19. Our findings may be useful to guide clinicians taking care of patients with post-COVID-19.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"238-246"},"PeriodicalIF":1.2,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/61/jop-26-3-238.PMC10547817.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41120771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Activity of Selected Fruit Juices against Multidrug-Resistant Bacterial Pathogens Involved in Urinary Tract and Sexually Transmitted Infections among Tribal Women in Madhya Pradesh, India.","authors":"Poonam Sharma,&nbsp;Juhi,&nbsp;Vaishali Halwai,&nbsp;Sainivedita Rout,&nbsp;Rambir Singh","doi":"10.3831/KPI.2023.26.3.265","DOIUrl":"10.3831/KPI.2023.26.3.265","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the effect of fruit juices on Multi-Drug Resistant (MDR) bacterial pathogens involved in Urinary Tract Infections (UTIs) and Sexually Transmitted Infections (STIs) among tribal women in the district Anuppur, Madhya Pradesh, India.</p><p><strong>Methods: </strong>Fresh juices of lemon (<i>Citrus limon</i>), amla/Indian gooseberry (<i>Phyllanthus emblica</i>), pineapple (<i>Ananas comosus</i>), mosambi/sweet lime (<i>Citrus limetta</i>), orange (<i>Citrus sinensis</i>), kiwi (<i>Actinidia deliciosa</i>), and pomegranate (<i>Punica granatum</i>) fruits were evaluated for in vitro antibacterial activity against bacterial pathogens involved in UITs and STIs among tribal women. Physico-chemical analysis of fresh fruits was also carried out by measuring the pH, moisture, protein, fat, crude fibre, carbohydrate, and ascorbic acid content.</p><p><strong>Results: </strong>Lemon and amla juice showed better antibacterial activity against the pathogens as compared to other juices. MIC results fruit juices against UTIs and STIs pathogens vary depending on the specific pathogen and juice chemical constituents. The physico-chemical analysis showed that the moisture content was highest in mosambi (90%), followed by orange (87%). Ascorbic acid content was found highest in amla (540 mg/100 g), followed by kiwi (90.3 mg/100 g). Pomegranate showed highest concentration of carbohydrate (15.28 g/100 g), fat (1.28 g/100 g), and protein (1.65 g/100 g). Lemon juice had lowest pH of 2.20, followed by amla 2.67.</p><p><strong>Conclusion: </strong>The lemon juice showed highest antibacterial activity against MDR bacterial pathogens involved in UTIs and STIs among tribal women in district Anuppur, Madhya Pradesh, India. The low pH of lemon may be responsible for its high antibacterial activity as compared to other juices.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"265-275"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/b9/jop-26-3-265.PMC10547819.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Acupuncture on Crohn's Disease: a systematic review and meta-analysis.","authors":"Joon Hyun Bae,&nbsp;Seo Young Kang,&nbsp;Si Eun You,&nbsp;Hye In Jeong,&nbsp;Soobin Jang,&nbsp;Kyeong Han Kim","doi":"10.3831/KPI.2023.26.3.211","DOIUrl":"10.3831/KPI.2023.26.3.211","url":null,"abstract":"<p><strong>Objectives: </strong>Crohn's disease is a chronic gastrointestinal disease that belongs to inflammatory bowel disease. This systematic review aims to assess the level of evidence in randomized controlled trials (RCTs) on the effects of acupuncture for Crohn's disease.</p><p><strong>Methods: </strong>We searched 12 databases from the date of the establishment of each database up to May, 2023 for relevant RCTs. The risk of bias of each study was assessed independently by three reviewers. The level of evidence of meta-analysis was assessed using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation).</p><p><strong>Results: </strong>A total of 12 studies were included. The effective rate (odds ratio [OR] 3.23, 95% confidence interval [CI] 1.43, 7.30) for mild to moderate Crohn's disease patients showed a significant difference between the acupuncture with moxibustion group and the sham-acupuncture with sham-moxibustion group. CDAI change (mean difference [MD] -74.15, 95% CI -93.28, -55.01) for mild to moderate Crohn's disease showed a significant difference between the acupuncture with moxibustion group and the sham-acupuncture with sham-moxibustion group.</p><p><strong>Conclusion: </strong>Although acupuncture with moxibustion showed significant effects compared to sham-acupuncture with sham-moxibustion, the effect of acupuncture alone is inconclusive. Moreover, only the effect of acupuncture treatment on mild to moderate Crohn's disease patients was derived as a remarkable result. To confirm the effectiveness of acupuncture treatment for Crohn's disease, studies using only acupuncture for intervention or more RCTs targeting various Crohn's disease patients according to the CDAI are required.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"211-226"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/28/jop-26-3-211.PMC10547815.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41099581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for Attenuating Frontal Lobe α Band Asymmetry Induced by Anger: a pilot study.","authors":"Sung-A Kim,&nbsp;Yujin Choi,&nbsp;Seung-Hun Cho","doi":"10.3831/KPI.2023.26.3.276","DOIUrl":"10.3831/KPI.2023.26.3.276","url":null,"abstract":"<p><strong>Objectives: </strong>Previous studies have shown that anger can lead to frontal lobe α (8-13 Hz) band asymmetry (FAA) in electroencephalogram (EEG), in accordance with motivational direction. This pilot study aimed to investigate the impact of acupuncture on FAA elicited by anger.</p><p><strong>Methods: </strong>Thirty-four right-handed participants scoring above 75 points on the Novaco Anger Scale were included. Baseline EEG signals were recorded for eight minutes using a 32-channel cap under comfortable conditions. Anger was induced through a nine-minute sequence of Articulated Thoughts in Simulated Situations (ATSS) task. Following that, participants received acupuncture at GB20 and GB21 for 10 minutes. Fast Fourier transform was employed for frequency analysis, and repeated measure ANOVA was conducted for statistical analysis.</p><p><strong>Results: </strong>The results revealed that participants exhibited significantly higher FAA (p = 0.026), particularly in the left hemisphere, after the ATSS task sequence compared to the baseline. During acupuncture treatment, the greater left-sided FAA was significantly reduced (p = 0.027) and reversed. Upon the cessation of acupuncture, FAA returned to a value between the baseline and the anger-evoked stage (p = 0.046).</p><p><strong>Conclusion: </strong>The EEG results of this study revealed that anger stimulation induced an increase in left-sided FAA, which was effectively alleviated by acupuncture. This led to an immediate restoration of FAA asymmetry induced by anger. These findings suggest the potential of acupuncture as a treatment option for reducing FAA associated with anger.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 3","pages":"276-284"},"PeriodicalIF":1.4,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/ed/jop-26-3-276.PMC10547816.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41136243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Silico</i> Studies of Indole Derivatives as Antibacterial Agents.","authors":"Mridul Shah,&nbsp;Adarsh Kumar,&nbsp;Ankit Kumar Singh,&nbsp;Harshwardhan Singh,&nbsp;Balasubramanian Narasimhan,&nbsp;Pradeep Kumar","doi":"10.3831/KPI.2023.26.2.147","DOIUrl":"https://doi.org/10.3831/KPI.2023.26.2.147","url":null,"abstract":"<p><strong>Objectives: </strong>Molecular docking and QSAR studies of indole derivatives as antibacterial agents.</p><p><strong>Methods: </strong>In this study, we used a multiple linear regressions (MLR) approach to construct a 2D quantitative structure activity relationship of 14 reported indole derivatives. It was performed on the reported antibacterial activity data of 14 compounds based on theoretical chemical descriptors to construct statistical models that link structural properties of indole derivatives to antibacterial activity. We have also performed molecular docking studies of same compounds by using Maestro module of Schrodinger. A set the molecular descriptors like hydrophobic, geometric, electronic and topological characters were calculated to represent the structural features of compounds. The conventional antibiotics sultamicillin and ampicillin were not used in the model development since their structures are different from those of the created compounds. Biological activity data was first translated into pMIC values (i.e. -log MIC) and used as a dependent variable in QSAR investigation.</p><p><strong>Results: </strong>Compounds with high electronic energy and dipole moment were effective antibacterial agents against <i>S. aureus</i>, indole derivatives with lower κ₂ values were excellent antibacterial agents against MRSA standard strain, and compounds with lower R value and a high ²χ^v value were effective antibacterial agents against MRSA isolate.</p><p><strong>Conclusion: </strong>Compounds 12 and 2 showed better binding score against penicillin binding protein 2 and penicillin binding protein 2a respectively.</p>","PeriodicalId":16769,"journal":{"name":"Journal of Pharmacopuncture","volume":"26 2","pages":"147-157"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/12/jop-26-2-147.PMC10315882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}