Medicinska istrazivanja最新文献_第10页

Multiple sclerosis in children and adolescents 儿童和青少年多发性硬化症

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1803007j

J. Jančić, B. Nikolić, S. Mesaros, M. Mostarica‐Stojković, T. Pekmezović, J. Drulovic

引用次数: 3

Antibiotic ointment in the management of recurrent, community-acquired bacterial cystitis in women: Observational study 抗生素软膏治疗复发性社区获得性细菌性膀胱炎:观察性研究

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1501012a

P. Aleksić, Vladimir Bančević, Aleksandra Aleksić, M. Bancevic

{"title":"Antibiotic ointment in the management of recurrent, community-acquired bacterial cystitis in women: Observational study","authors":"P. Aleksić, Vladimir Bančević, Aleksandra Aleksić, M. Bancevic","doi":"10.5937/medist1501012a","DOIUrl":"https://doi.org/10.5937/medist1501012a","url":null,"abstract":"Acute bacterial cystitis is the most common form of community-acquired urinary tract infections in women. Uri-nary tract infections are the second most common reason for antibiotic prescription in the USA. There is a need for alternative treatments that would help to avoid the use of systematic antimicrobials thus reducing the incidence of microbial resistance and side effects of the drugs. The aim of this study is to evaluate the role of antibiotic ointment treatment in recurrent UTIs in women. We followed up 34 non-pregnant women with a previous history of recurrent UTIs who were instructed to apply antibiotic ointment Bacitracin/Neomycin, locally, on the external urethral meathus area, once a day, for 30 days. 88% of patients responded to the treatment, with no further recurrences in 67.6% of cases and there was a reduced (< 3 cases per year) recurrence in 20.5% of patients. Bacitracin/Neomycin ointment could be a safe, cheap and successful tool for recurrent UTIs in women. To our best knowledge, this is the first published pilot-study of topical antibiotic ointment usage in management and prevention of recurrent urinary tract infections. We need a double blinded, randomized study with a larger number of patients in order to collect more evidence to support this conclusion.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122464748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular age and carotid intima-media thickness 血管年龄和颈动脉内膜-中膜厚度

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1501053t

Brankica Tepavčević, Sandra Radak

引用次数: 0

Transient tachypnea of the newborn: Need for supplemental oxygen and possible complications 新生儿短暂性呼吸急促:需要补充氧气和可能的并发症

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medi55-37226

Tamara Šljivančanin-Jakovljević, S. Stankovic, V. Mandić-Marković, D. Vučević, Z. Mikovic

引用次数: 0

Surgical treatment of anorectal anomalies in children: Experience with 224 patients 224例儿童肛肠畸形的外科治疗体会

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1601006l

M. Lukač, Sanja Sinđić-Antunović, D. Vujović, Z. Krstić, Ivana Petronić-Marković, Mirjana Raičević

{"title":"Surgical treatment of anorectal anomalies in children: Experience with 224 patients","authors":"M. Lukač, Sanja Sinđić-Antunović, D. Vujović, Z. Krstić, Ivana Petronić-Marković, Mirjana Raičević","doi":"10.5937/medist1601006l","DOIUrl":"https://doi.org/10.5937/medist1601006l","url":null,"abstract":"Anorectal anomalies (ARA) are congenital malformations that are represented by a wide spectrum of defects. This report describes the authors' experience and results of surgical treatment of ARA. The aim of this study was to analyse the functional outcome in patients following standardized surgical treatment of ARA. A total of 224 patients (115 girls and 109 boys) were treated from 1988 to 2015 and the data were analysed. All patients underwent a follow-up by the author. Postoperative anorectal function was evaluated based on the ability to have voluntary bowel movement, soiling and constipation. In cases of faecal incontinence bowel management program was applied. In our series of 224 operated patients 52 (24%) had faecal incontinence. Bowel management program was implemented in those patients, with a success rate of 90,6 % immediately after the treatment started in hospital, with a decrease to 83,7 % at home. In puberty success rate increased to 95%. Malone's antegrade enema procedure (ACE procedure) was done in 9 patients. It was successful in 100% of cases in the first year, with complication rate of 44% afterwards (conduit stenosis and leakage). Bowel management program offers significant benefits to children with faecal incontinence after surgical treatment of ARA. The ACE procedure can be implemented in patients after successful bowel management. Although patients are satisfied with ACE procedure, complications are very common.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"276 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127381783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between functional status, natriuretic peptide levels and echocardiographic parameters in patients with precapillary pulmonary hypertension 毛细血管前肺动脉高压患者功能状态、利钠肽水平与超声心动图参数的关系

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medi56-42864

Ivan Stanković, Katarina Grujičič, M. Cerović, Ivona Vranić, Branka Gakovic, M. Panić, R. Cvjetan, M. Zlatković, Srđan Raspopović, A. Neskovic

{"title":"The relationship between functional status, natriuretic peptide levels and echocardiographic parameters in patients with precapillary pulmonary hypertension","authors":"Ivan Stanković, Katarina Grujičič, M. Cerović, Ivona Vranić, Branka Gakovic, M. Panić, R. Cvjetan, M. Zlatković, Srđan Raspopović, A. Neskovic","doi":"10.5937/medi56-42864","DOIUrl":"https://doi.org/10.5937/medi56-42864","url":null,"abstract":"Introduction/Aim While echocardiography plays an important role in the follow-up of patients with precapillary pulmonary hypertension (PH), several studies have identified World Health Oganization's functional class (WHO FC), 6-minute walk distance (6MWD) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) as the strongest prognostic markers. We investigated the relationship between echocardiographic indices, functional status and NT-proBNP in patients with precapillary PH. Material and Methods A total of 23 patients were included in this retrospective study. Data were collected from routine risk assessments, including WHO FC, 6MWD, NT-proBNP, standard, strain and three-dimensional echocardiography. The echocardiographic data were analysed in terms of the patients' functional status as determined by WHO FC, 6MWD and NT-proBNP values. Results Patients in WHO FC III or IV had a shorter 6MWD [180 (interquartile range 85-240 m)] than patients in WHO FC I or II [409 (interquartile range 364-494 m), p=0.02)], while the difference in NT-proBNP was not statistically significant [FC I or II: 1297 (interquartile range 283-3196) versus FC III or IV: 343 (interquartile range 274-598) pg/ml, p=0.146]. There were inverse correlations between 6MWD and left and right ventricular longitudinal strain and a direct correlation between 6MWD and pulmonary acceleration time (r=0.73; p=0.001). NT-proBNP measurements were directly correlated with right heart dimensions and right ventricular strain and inversely correlated with pulmonary acceleration time (r=-0.70; p=0.004). Conclusion Standard and advanced echocardiographic indices of right ventricular structure, function and hemodynamics correlate with functional status and natriuretic peptide levels in a heterogeneous cohort of patients with precapillary PH and may be useful ancillary parameters in clinical practice.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125251049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the nitric oxide synthases in brain ischemia during carotid endarterectomy 一氧化氮合酶在颈动脉内膜切除术中脑缺血中的作用

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1501040b

Nikola Bogdanović, M. Obradović, N. Jasnić, B. Spremo-Potparević, D. Unić-Stojanović, Đ. Radak, E. Isenovic

{"title":"The role of the nitric oxide synthases in brain ischemia during carotid endarterectomy","authors":"Nikola Bogdanović, M. Obradović, N. Jasnić, B. Spremo-Potparević, D. Unić-Stojanović, Đ. Radak, E. Isenovic","doi":"10.5937/medist1501040b","DOIUrl":"https://doi.org/10.5937/medist1501040b","url":null,"abstract":"According to the World Health Organization, 15 million people per year are affected by stroke. The most common cause of stroke is brain ischemia, which occurs in almost 85% of cases. Ischemia caused by thromboembolism is defined as permanently or temporarily decreased blood flow which prevents an adequate delivery of oxygen, glucose and other important nutrients, leading progressively to metabolic changes and cell apoptosis. Carotid endarterectomy (CEA) can cause hypoxic - ischemic states of the brain or acute brain ischemia (ABI) leading eventually to stroke. The main cause of ABI as a result of CEA is cerebral hypoperfusion caused by clamping of carotid arteries, when hypoxia occurs.. Hypoxia per se is one of the triggers of complex physiological responses in the body, including the release of various mediators of inflammation. One of these inflammatory mediators is nitric oxide (NO), a free radical which has numerous physiological effects and also plays an important role in the immune response of the organism. However, NO may be very harmful and cause cell and tissue damage. The lack of literature data on the role of endothelial NOS (eNOS) and inducible NOS (iNOS) during CEA, as well as the mechanisms of their regulation in ischemic conditions, suggest that intensifying future research in this field is very important. An insight into molecular mechanisms of iNOS activity and expression regulation will certainly help to develop new therapeutic strategies for treating harmful effects of free radicals, especially uncontrolled production of NO.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125871724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flat-Back Syndrome as post traumatic or post scoliosis treatment disorder of the spine 平背综合征作为创伤后或脊柱侧凸后的治疗障碍

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1301051m

L. Meccariello, S. Cioffi, P. Grubor, Raffaele Franzese, R. Cioffi, Giacinto di

引用次数: 0

The impact of obesity on development of cardiovascular diseases: Mini review 肥胖对心血管疾病发展的影响:综述

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medist1502033s

Sanja Soskić, A. Panic, E. Isenovic

引用次数: 0

The association of glutathione transferase omega polymorphisms with laboratory inflammatory parameters in COVID-19 谷胱甘肽转移酶多态性与COVID-19实验室炎症参数的关系

Medicinska istrazivanja Pub Date : 1900-01-01 DOI: 10.5937/medi55-38002

Tatjana Đukić, G. Stevanović, V. Ćorić, Z. Bukumirić, M. Plješa-Ercegovac, M. Matić, Đurđa Jerotić, M. Ašanin, M. Ercegovac, J. Ranin, I. Milošević, T. Simić, A. Savić-Radojević

{"title":"The association of glutathione transferase omega polymorphisms with laboratory inflammatory parameters in COVID-19","authors":"Tatjana Đukić, G. Stevanović, V. Ćorić, Z. Bukumirić, M. Plješa-Ercegovac, M. Matić, Đurđa Jerotić, M. Ašanin, M. Ercegovac, J. Ranin, I. Milošević, T. Simić, A. Savić-Radojević","doi":"10.5937/medi55-38002","DOIUrl":"https://doi.org/10.5937/medi55-38002","url":null,"abstract":"In a view of important functions of glutathione transferase omega (GSTO) class in redox homeostasis and innate immunity, it was proposed that interindividual differences in COVID-19 clinical manifestations might be affected by GSTO1 (rs4925) and GSTO2 (rs156697) polymorphisms. To assess the potential association of these polymorphisms with biochemical, coagulation and inflammatory laboratory parameters in the group of mild and severe COVID-19 patients. GSTO1 and GSTO2 single nucleotide polymorphisms were determined by qPCR in 251 samples of COVID-19 patients. Biochemical, coagulation and inflammatory laboratory parameters of COVID-19 participants were procured from routine laboratory practice on the day of admission. Polymorphisms of GSTO1 and GSTO2 affect laboratory biochemical profile of COVID-19 patients. GSTO1*C allele was associated with increased levels of C-reactive protein (CRP) (p=0.035), interleukin-6 (IL-6) (p=0.047), D-dimer (p=0.014) and lactate dehydrogenase LDH (p=0.002), whereas GSTO2*G allele was associated with CRP (p=0.033). COVID-19 patients homozygous for variant GSTO1*A allele and GSTO2*G had the highest levels of serum Fe (p=0.019, p=0.052, respectively). Our findings regarding the influence of GSTO1 and GSTO2 polymorphisms on inflammation and coagulation parameters might be of clinical importance. In future, these findings could aid in a more personalized approach for better recognition of patients prone to thrombosis and excessive immune response.","PeriodicalId":167411,"journal":{"name":"Medicinska istrazivanja","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128239446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0